LOCUS       NM_001080771            3200 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus PR domain containing 13 (Prdm13), mRNA.
ACCESSION   NM_001080771 XM_131309 XM_884367 XM_907402 XM_920394 XM_977082
            XM_977119
VERSION     NM_001080771.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Tsuji,S., Brace,C.S., Yao,R., Tanie,Y., Tada,H., Rensing,N.,
            Mizuno,S., Almunia,J., Kong,Y., Nakamura,K., Furukawa,T., Ogiso,N.,
            Toyokuni,S., Takahashi,S., Wong,M., Imai,S.I. and Satoh,A.
  TITLE     Sleep-wake patterns are altered with age, Prdm13 signaling in the
            DMH, and diet restriction in mice
  JOURNAL   Life Sci Alliance 6 (6), e202301992 (2023)
   PUBMED   37045472
  REMARK    GeneRIF: Sleep-wake patterns are altered with age, Prdm13 signaling
            in the DMH, and diet restriction in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Coolen,M., Altin,N., Rajamani,K., Pereira,E., Siquier-Pernet,K.,
            Puig Lombardi,E., Moreno,N., Barcia,G., Yvert,M., Laquerriere,A.,
            Pouliet,A., Nitschke,P., Boddaert,N., Rausell,A., Razavi,F.,
            Afenjar,A., Billette de Villemeur,T., Al-Maawali,A., Al-Thihli,K.,
            Baptista,J., Beleza-Meireles,A., Garel,C., Legendre,M., Gelot,A.,
            Burglen,L., Moutton,S. and Cantagrel,V.
  TITLE     Recessive PRDM13 mutations cause fatal perinatal brainstem
            dysfunction with cerebellar hypoplasia and disrupt Purkinje cell
            differentiation
  JOURNAL   Am J Hum Genet 109 (5), 909-927 (2022)
   PUBMED   35390279
  REMARK    GeneRIF: Recessive PRDM13 mutations cause fatal perinatal brainstem
            dysfunction with cerebellar hypoplasia and disrupt Purkinje cell
            differentiation.
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Yu,H., Rubinstein,M. and Low,M.J.
  TITLE     Developmental single-cell transcriptomics of hypothalamic POMC
            neurons reveal the genetic trajectories of multiple
            neuropeptidergic phenotypes
  JOURNAL   Elife 11, e72883 (2022)
   PUBMED   35044906
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Watanabe,S., Sanuki,R., Sugita,Y., Imai,W., Yamazaki,R., Kozuka,T.,
            Ohsuga,M. and Furukawa,T.
  TITLE     Prdm13 regulates subtype specification of retinal amacrine
            interneurons and modulates visual sensitivity
  JOURNAL   J Neurosci 35 (20), 8004-8020 (2015)
   PUBMED   25995483
  REMARK    GeneRIF: Targeted deletion of Prdm13 leads to a specific reduction
            of amacrine cells and changes visual sensitivity.
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Satoh,A., Brace,C.S., Rensing,N. and Imai,S.
  TITLE     Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene,
            mimics age-associated changes in sleep quality and adiposity
  JOURNAL   Aging Cell 14 (2), 209-218 (2015)
   PUBMED   25546159
  REMARK    GeneRIF: Findings indicate that Prdm13/Nkx2-1-mediated signaling in
            the DMC declines with advanced age, leading to decreased sleep
            quality and increased adiposity.
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Hanotel,J., Bessodes,N., Thelie,A., Hedderich,M., Parain,K., Van
            Driessche,B., Brandao Kde,O., Kricha,S., Jorgensen,M.C.,
            Grapin-Botton,A., Serup,P., Van Lint,C., Perron,M., Pieler,T.,
            Henningfeld,K.A. and Bellefroid,E.J.
  TITLE     The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj
            downstream target that suppresses glutamatergic and promotes
            GABAergic neuronal fate in the dorsal neural tube
  JOURNAL   Dev Biol 386 (2), 340-357 (2014)
   PUBMED   24370451
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Chang,J.C., Meredith,D.M., Mayer,P.R., Borromeo,M.D., Lai,H.C.,
            Ou,Y.H. and Johnson,J.E.
  TITLE     Prdm13 mediates the balance of inhibitory and excitatory neurons in
            somatosensory circuits
  JOURNAL   Dev Cell 25 (2), 182-195 (2013)
   PUBMED   23639443
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017632.1 and BB665287.1.
            
            On or before Jan 26, 2007 this sequence version replaced
            XM_907402.2, XM_920394.2, XM_884367.2, XM_131309.6, XM_977119.1,
            XM_977082.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB665287.1, BY731300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               BC017632.1         1-180
            181-727             BB665287.1         1-547
            728-3200            BC017632.1         799-3271
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 8.78 cM"
     gene            1..3200
                     /gene="Prdm13"
                     /note="PR domain containing 13"
                     /db_xref="GeneID:230025"
                     /db_xref="MGI:MGI:2448528"
     exon            1..453
                     /gene="Prdm13"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2430
                     /gene="Prdm13"
                     /note="PR domain-containing protein 13"
                     /codon_start=1
                     /product="PR domain zinc finger protein 13"
                     /protein_id="NP_001074240.1"
                     /db_xref="CCDS:CCDS38699.1"
                     /db_xref="GeneID:230025"
                     /db_xref="MGI:MGI:2448528"
                     /translation="MPAHVTPRTEDARRGAGPSSACGCSWFCHLRPVEDPASPSVCLA
                     AVATMHGTSRTSATSVNADCCIPAGLRLGPVPGTFKLGKYLSDRREPGPKKKVRMVRG
                     ELVDESGGSPLEWIGLIRAARNPQEQTLEAIADLPGGQIFYRALRDVQPGEELTVWYS
                     NSLAQWFDIPTTATPTHDEKGEERYICWYCWRTFRYPNSLKAHLRFHCVLSGGGGRAF
                     LPQEHAARPGASPVAEGLGLPPKPTVPDLTAPVQAIALRPQAPAAQLAQACGARESIK
                     REASLAPLATSPPPGKWGTPKKGKEQPDRAHSQFLGIVGGSSGGGGGLPFYPGVRSAF
                     KPAGLARAAAQSDPYREEGGGKGPGLALGRLLGGGRAGGRPGSGESPAGHHHHHHHAH
                     HHHHHHPKCLLAGEPPPAGLPCPGALRAFPLLAGHPEEASAFKHVERAPPAAATTSLP
                     SARYAALPAPGLPVERCALQPLDGGSLKAYPGGGGGGECSPLPAVMPAFTVYSGDLLY
                     GPPAAYYPLKLHLGGLLKYPESISYLSGPAAAAAAAAAAAAAAAAIGPAELGSLASID
                     REIAMHTQQLSEMAAGKSRARLDSGTLPPAVVAATGPGGGGGGGSAAGKPKTGHLCLY
                     CGKLYSRKYGLKIHMRTHTGYKPLKCKVCLRPFGDPSNLNKHIRLHAEGNTPYRCEFC
                     GKVLVRRRDLERHVKSRHPGQSLMAKAGDGPGPEPSYALEPGDPKSEDSDVDVCFTDD
                     QSDPEAGGRGEHDS"
     exon            454..585
                     /gene="Prdm13"
                     /inference="alignment:Splign:2.1.0"
     exon            586..706
                     /gene="Prdm13"
                     /inference="alignment:Splign:2.1.0"
     exon            707..3174
                     /gene="Prdm13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3150..3155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prdm13"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="Prdm13"
                     /note="major polyA site"
ORIGIN      
        1 gccattcaga ggcctcgatt atgcaggggg ctgagggaac cactccatgt gaccctctcg
       61 ggtgggactc tgcagctgct tcacagcgca actctctcac caaactccgc gcccttgcgc
      121 tcgcagtgcc aaaaggcgcc cgcccggatt gaaaaggcgc agtgcatgcc cgcccacgtc
      181 actccgcgga cagaagacgc acgtcggggt gcgggtccct cctctgcatg cggctgctcc
      241 tggttctgtc acttgcgccc cgtggaggac cccgcgagcc ccagcgtctg cctggcggcg
      301 gtggcaacaa tgcacggaac ttctcgcact tcggccacca gcgtgaacgc tgactgctgc
      361 atcccggctg gcttgcgcct tgggccggtg cctggcacct tcaagctggg caagtacctg
      421 tcagatcgca gggaaccagg gcccaagaaa aaggtgcgca tggtgagagg ggagctggtg
      481 gacgagtcag ggggctcccc tctggagtgg atagggttaa tccgggcagc caggaatccc
      541 caggaacaga ctctggaagc tattgcagac ttaccaggag gacagatctt ctatcgggca
      601 ttgcgagacg tccagcctgg ggaagagctg actgtgtggt attctaactc cttggctcag
      661 tggtttgaca tccctacaac tgcgactcca acgcatgatg agaaagggga ggagcgctac
      721 atctgctggt actgctggag gacctttcgc taccctaaca gcctcaaggc acacctgcgg
      781 ttccactgcg tcctcagtgg cggcgggggc cgtgctttcc tgccccagga gcacgcggcc
      841 cggcccggcg cttccccggt ggcagaaggc ctcggcctcc ctccgaaacc caccgtcccg
      901 gacttgacgg cgcccgtcca ggcaatcgct ttgcgacccc aagctccggc cgctcagctc
      961 gcccaggcgt gcggggcgcg ggagagcatc aagcgggagg cttccctggc gcccctggcc
     1021 acctccccgc cgccgggcaa gtggggaacg cccaagaagg gcaaggagca gccggaccgc
     1081 gcgcacagtc aattcctggg gatagtgggc ggctcctcgg gcggcggcgg aggcctgcca
     1141 ttctacccag gcgtgcgctc ggctttcaag ccggccggcc tggcccgggc ggctgcgcag
     1201 agcgacccct accgggaaga gggcggcggc aagggaccgg ggctggcgct agggcggctg
     1261 ctgggcgggg gccgggccgg cgggcgtccg ggcagtgggg agagcccggc gggccaccac
     1321 caccatcacc accacgctca ccaccaccac caccaccatc ccaagtgcct gctggccggg
     1381 gagccgccgc cggcgggcct gccgtgtccc ggggccctga gagccttccc cctgctcgcc
     1441 ggccacccgg aagaggcgtc ggccttcaag cacgtggagc gggctccgcc cgccgccgcc
     1501 accacctccc tgccctccgc gcgctacgcc gctctcccgg cgcccgggct ccctgtggag
     1561 cgctgcgcgc tgcagcccct cgacggcggc agcctcaagg cttaccccgg cggcggtggc
     1621 ggcggcgagt gcagccccct gcccgccgtc atgccggcct tcacggtgta cagcggagac
     1681 ctgctctacg gccctccggc cgcctattac cctctcaagc tgcacttggg cgggctgctc
     1741 aaataccccg agtccatctc ctatctgagt ggccccgcgg cggcagcggc ggcggcggca
     1801 gcggcagcgg cggcggcggc ggcgatcggg ccggccgaac tgggctccct ggccagcatc
     1861 gaccgcgaga tcgccatgca cacacagcag ctgtccgaga tggcagccgg gaagagtcgc
     1921 gcccgcctgg actcggggac gctgcctcca gccgtagtgg cggcgacggg ccccgggggt
     1981 ggcggcggtg gcgggagcgc ggcaggcaag cccaagacag gccacttgtg cctctactgt
     2041 ggcaagctgt actcgcgcaa gtacgggctc aagatccaca tgcggacgca cacgggctac
     2101 aagccgctca agtgcaaagt gtgcctgcgg cccttcggcg accccagcaa tctcaacaag
     2161 cacatccgac tccacgccga gggcaatacg ccctaccgct gcgagttctg cggcaaggtg
     2221 ctggtgcgcc gccgagacct ggagcgtcac gtcaagtccc gccacccagg ccagagcctg
     2281 atggccaagg cgggcgacgg cccgggcccg gagcccagct atgctctgga gcctggggat
     2341 cccaagagcg aggacagtga tgtggatgtc tgcttcactg acgatcagag cgaccccgag
     2401 gctgggggtc gtggcgagca cgactcctaa cgcgccttcc agggactgag cagggacgag
     2461 gacacagtag agagtgaagt ggggacaaga agggcttcat tgatattgtc gcaattctgg
     2521 ggatggtgtc ggattaggaa cagtgagccg ctccagttct cgagtggagc aaagtttaac
     2581 gaagggttga agaaacacag ccaactaaca gcacataggt tgtggttctc tatcattaag
     2641 acccctagac tctggcatag cctctcattc tgaaagcatt ctggccttga ggttcaggat
     2701 cacgtcaata taagcatctc agtgcgctca aaggtgatga tttttactgc cacacatttt
     2761 taaaacgctc ttgtctgtgg aggaaatcgt gccttttgaa aagatgttcc gtgtgaattt
     2821 tatgttaagc atttcactgc atagcaagca aaacagtaga tgtgacaccc acacacctgt
     2881 ttccgtttcc tatctgttct cctgtcaaag aacactcctt gccacattga gtatatcgtg
     2941 gtagtggatg tataaattgg tcaagttgca attatttatg agagaataat gataaatgta
     3001 aaatgacgca tgaatataag agcacgcaat atataaattt aaaaaatcct atttggtaga
     3061 gtccaaatgt ttatgttgtt ttataatgaa cgatgtacag tggatacagt actttgccct
     3121 tgcttccatt ttgtgcaatc tgtaagaata ataaagatac aaaggagagt tctaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa
//
