LOCUS       NP_001074240             754 aa            linear   ROD 11-DEC-2024
DEFINITION  PR domain zinc finger protein 13 [Mus musculus].
ACCESSION   NP_001074240 XP_131309 XP_889460 XP_912495 XP_925487 XP_982176
            XP_982213
VERSION     NP_001074240.1
DBSOURCE    REFSEQ: accession NM_001080771.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 754)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (residues 1 to 754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 754)
  AUTHORS   Tsuji,S., Brace,C.S., Yao,R., Tanie,Y., Tada,H., Rensing,N.,
            Mizuno,S., Almunia,J., Kong,Y., Nakamura,K., Furukawa,T., Ogiso,N.,
            Toyokuni,S., Takahashi,S., Wong,M., Imai,S.I. and Satoh,A.
  TITLE     Sleep-wake patterns are altered with age, Prdm13 signaling in the
            DMH, and diet restriction in mice
  JOURNAL   Life Sci Alliance 6 (6), e202301992 (2023)
   PUBMED   37045472
  REMARK    GeneRIF: Sleep-wake patterns are altered with age, Prdm13 signaling
            in the DMH, and diet restriction in mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 754)
  AUTHORS   Coolen,M., Altin,N., Rajamani,K., Pereira,E., Siquier-Pernet,K.,
            Puig Lombardi,E., Moreno,N., Barcia,G., Yvert,M., Laquerriere,A.,
            Pouliet,A., Nitschke,P., Boddaert,N., Rausell,A., Razavi,F.,
            Afenjar,A., Billette de Villemeur,T., Al-Maawali,A., Al-Thihli,K.,
            Baptista,J., Beleza-Meireles,A., Garel,C., Legendre,M., Gelot,A.,
            Burglen,L., Moutton,S. and Cantagrel,V.
  TITLE     Recessive PRDM13 mutations cause fatal perinatal brainstem
            dysfunction with cerebellar hypoplasia and disrupt Purkinje cell
            differentiation
  JOURNAL   Am J Hum Genet 109 (5), 909-927 (2022)
   PUBMED   35390279
  REMARK    GeneRIF: Recessive PRDM13 mutations cause fatal perinatal brainstem
            dysfunction with cerebellar hypoplasia and disrupt Purkinje cell
            differentiation.
REFERENCE   5  (residues 1 to 754)
  AUTHORS   Yu,H., Rubinstein,M. and Low,M.J.
  TITLE     Developmental single-cell transcriptomics of hypothalamic POMC
            neurons reveal the genetic trajectories of multiple
            neuropeptidergic phenotypes
  JOURNAL   Elife 11, e72883 (2022)
   PUBMED   35044906
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 754)
  AUTHORS   Watanabe,S., Sanuki,R., Sugita,Y., Imai,W., Yamazaki,R., Kozuka,T.,
            Ohsuga,M. and Furukawa,T.
  TITLE     Prdm13 regulates subtype specification of retinal amacrine
            interneurons and modulates visual sensitivity
  JOURNAL   J Neurosci 35 (20), 8004-8020 (2015)
   PUBMED   25995483
  REMARK    GeneRIF: Targeted deletion of Prdm13 leads to a specific reduction
            of amacrine cells and changes visual sensitivity.
REFERENCE   7  (residues 1 to 754)
  AUTHORS   Satoh,A., Brace,C.S., Rensing,N. and Imai,S.
  TITLE     Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene,
            mimics age-associated changes in sleep quality and adiposity
  JOURNAL   Aging Cell 14 (2), 209-218 (2015)
   PUBMED   25546159
  REMARK    GeneRIF: Findings indicate that Prdm13/Nkx2-1-mediated signaling in
            the DMC declines with advanced age, leading to decreased sleep
            quality and increased adiposity.
REFERENCE   8  (residues 1 to 754)
  AUTHORS   Hanotel,J., Bessodes,N., Thelie,A., Hedderich,M., Parain,K., Van
            Driessche,B., Brandao Kde,O., Kricha,S., Jorgensen,M.C.,
            Grapin-Botton,A., Serup,P., Van Lint,C., Perron,M., Pieler,T.,
            Henningfeld,K.A. and Bellefroid,E.J.
  TITLE     The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj
            downstream target that suppresses glutamatergic and promotes
            GABAergic neuronal fate in the dorsal neural tube
  JOURNAL   Dev Biol 386 (2), 340-357 (2014)
   PUBMED   24370451
REFERENCE   9  (residues 1 to 754)
  AUTHORS   Chang,J.C., Meredith,D.M., Mayer,P.R., Borromeo,M.D., Lai,H.C.,
            Ou,Y.H. and Johnson,J.E.
  TITLE     Prdm13 mediates the balance of inhibitory and excitatory neurons in
            somatosensory circuits
  JOURNAL   Dev Cell 25 (2), 182-195 (2013)
   PUBMED   23639443
REFERENCE   10 (residues 1 to 754)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017632.1 and BB665287.1.
            
            On or before Jan 26, 2007 this sequence version replaced
            XP_912495.1, XP_925487.1, XP_889460.1, XP_131309.4, XP_982213.1,
            XP_982176.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB665287.1, BY731300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 8.78 cM"
     Protein         1..754
                     /product="PR domain zinc finger protein 13"
                     /note="PR domain-containing protein 13"
                     /calculated_mol_wt=78575
     Region          66..167
                     /region_name="PR-SET_PRDM13"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 13 (PRDM13) and similar proteins; cd19197"
                     /db_xref="CDD:380974"
     Site            order(74..76,94,117..121,123,132..133,159..160,162..163,
                     166..167)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380974"
     Site            order(74..76,117..121,123,159)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380974"
     Region          185..208
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Region          185..207
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Site            order(185,192,194..196,198..199,203,206)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     Region          279..304
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9PZZ1.1)"
     Region          345..404
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9PZZ1.1)"
     Region          622..642
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          622..642
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          <625..700
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Site            order(627,629,631,633..634,637..638,641,655,657,661..662,
                     665..666,669,684,686,688,690..691,694..695)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          635..>653
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          650..670
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          679..697
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          694..754
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9PZZ1.1)"
     CDS             1..754
                     /gene="Prdm13"
                     /coded_by="NM_001080771.1:166..2430"
                     /db_xref="CCDS:CCDS38699.1"
                     /db_xref="GeneID:230025"
                     /db_xref="MGI:MGI:2448528"
ORIGIN      
        1 mpahvtprte darrgagpss acgcswfchl rpvedpasps vclaavatmh gtsrtsatsv
       61 nadccipagl rlgpvpgtfk lgkylsdrre pgpkkkvrmv rgelvdesgg splewiglir
      121 aarnpqeqtl eaiadlpggq ifyralrdvq pgeeltvwys nslaqwfdip ttatpthdek
      181 geeryicwyc wrtfrypnsl kahlrfhcvl sggggraflp qehaarpgas pvaeglglpp
      241 kptvpdltap vqaialrpqa paaqlaqacg aresikreas laplatsppp gkwgtpkkgk
      301 eqpdrahsqf lgivggssgg ggglpfypgv rsafkpagla raaaqsdpyr eegggkgpgl
      361 algrllgggr aggrpgsges paghhhhhhh ahhhhhhhpk cllagepppa glpcpgalra
      421 fpllaghpee asafkhvera ppaaattslp saryaalpap glpvercalq pldggslkay
      481 pggggggecs plpavmpaft vysgdllygp paayyplklh lggllkypes isylsgpaaa
      541 aaaaaaaaaa aaaigpaelg slasidreia mhtqqlsema agksrarlds gtlppavvaa
      601 tgpggggggg saagkpktgh lclycgklys rkyglkihmr thtgykplkc kvclrpfgdp
      661 snlnkhirlh aegntpyrce fcgkvlvrrr dlerhvksrh pgqslmakag dgpgpepsya
      721 lepgdpksed sdvdvcftdd qsdpeaggrg ehds
//
