LOCUS       NM_001123362            2471 bp    mRNA    linear   ROD 19-DEC-2023
DEFINITION  Mus musculus PR domain containing 12 (Prdm12), mRNA.
ACCESSION   NM_001123362 XM_355325 XM_914950
VERSION     NM_001123362.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San Jose AS,
            Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B,
            Brunet JF and Bellefroid EJ.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo
            MV, Epstein DJ and Camara PG.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   3  (bases 1 to 2471)
  AUTHORS   Latragna A, Sabate San Jose A, Tsimpos P, Vermeiren S, Gualdani R,
            Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha
            S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris
            L and Bellefroid EJ.
  TITLE     Prdm12 modulates pain-related behavior by remodeling gene
            expression in mature nociceptors
  JOURNAL   Pain 163 (8), e927-e941 (2022)
   PUBMED   34961757
  REMARK    GeneRIF: Prdm12 modulates pain-related behavior by remodeling gene
            expression in mature nociceptors.
REFERENCE   4  (bases 1 to 2471)
  AUTHORS   Rienzo M, Di Zazzo E, Casamassimi A, Gazzerro P, Perini G, Bifulco
            M and Abbondanza C.
  TITLE     PRDM12 in Health and Diseases
  JOURNAL   Int J Mol Sci 22 (21), 12030 (2021)
   PUBMED   34769459
  REMARK    GeneRIF: PRDM12 in Health and Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2471)
  AUTHORS   Kokotovic T, Langeslag M, Lenartowicz EM, Manion J, Fell CW,
            Alehabib E, Tafakhori A, Darvish H, Bellefroid EJ, Neely GG, Kress
            M, Penninger JM and Nagy V.
  TITLE     PRDM12 Is Transcriptionally Active and Required for Nociceptor
            Function Throughout Life
  JOURNAL   Front Mol Neurosci 14, 720973 (2021)
   PUBMED   34646120
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2471)
  AUTHORS   Thelie A, Desiderio S, Hanotel J, Quigley I, Van Driessche B,
            Rodari A, Borromeo MD, Kricha S, Lahaye F, Croce J, Cerda-Moya G,
            Ordono Fernandez J, Bolle B, Lewis KE, Sander M, Pierani A,
            Schubert M, Johnson JE, Kintner CR, Pieler T, Van Lint C,
            Henningfeld KA, Bellefroid EJ and Van Campenhout C.
  TITLE     Prdm12 specifies V1 interneurons through cross-repressive
            interactions with Dbx1 and Nkx6 genes in Xenopus
  JOURNAL   Development 142 (19), 3416-3428 (2015)
   PUBMED   26443638
REFERENCE   7  (bases 1 to 2471)
  AUTHORS   Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M,
            Themistocleous AC, Strom TM, Samara C, Moore AW, Cho LT, Young GT,
            Weiss C, Schabhuttl M, Stucka R, Schmid AB, Parman Y, Graul-Neumann
            L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner
            M, Valente EM, Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C,
            Wieland T, Stafford F, Reimann F, von Au K, Finke C, Willems PJ,
            Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G,
            McAleer MA, Cilio MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB,
            Windhager R, Weis J, Bergmann C, Rautenstrauss B, Baets J, De
            Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T,
            Bennett DL, Woods CG and Senderek J.
  TITLE     Transcriptional regulator PRDM12 is essential for human pain
            perception
  JOURNAL   Nat Genet 47 (7), 803-808 (2015)
   PUBMED   26005867
  REMARK    Erratum:[Nat Genet. 2015 Aug;47(8):962. PMID: 26220135]
REFERENCE   8  (bases 1 to 2471)
  AUTHORS   Draganova K, Zemke M, Zurkirchen L, Valenta T, Cantu C, Okoniewski
            M, Schmid MT, Hoffmans R, Gotz M, Basler K and Sommer L.
  TITLE     Wnt/beta-catenin signaling regulates sequential fate decisions of
            murine cortical precursor cells
  JOURNAL   Stem Cells 33 (1), 170-182 (2015)
   PUBMED   25182747
REFERENCE   9  (bases 1 to 2471)
  AUTHORS   Yang CM and Shinkai Y.
  TITLE     Prdm12 is induced by retinoic acid and exhibits anti-proliferative
            properties through the cell cycle modulation of P19 embryonic
            carcinoma cells
  JOURNAL   Cell Struct Funct 38 (2), 197-206 (2013)
   PUBMED   23856557
  REMARK    GeneRIF: Prdm12 is induced by the retinoic acid signaling in vivo,
            and may regulate neural differentiation during animal development.
REFERENCE   10 (bases 1 to 2471)
  AUTHORS   Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T
            and Moore AW.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732564.12.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001123362.2.
            
            On or before Apr 13, 2008 this sequence version replaced
            XM_914950.3, XM_355325.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2441412.1,
                                           SRR7652917.128618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL732564.12        188621-188905
            286-476             AL732564.12        190787-190977
            477-632             AL732564.12        192371-192526
            633-744             AL732564.12        200435-200546
            745-2471            AL732564.12        202653-204379
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.85 cM"
     gene            1..2471
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /note="PR domain containing 12"
                     /db_xref="GeneID:381359"
                     /db_xref="MGI:MGI:2685844"
     exon            1..285
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1160
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /note="PR domain-containing protein 12"
                     /codon_start=1
                     /product="PR domain zinc finger protein 12"
                     /protein_id="NP_001116834.1"
                     /db_xref="CCDS:CCDS50562.1"
                     /db_xref="GeneID:381359"
                     /db_xref="MGI:MGI:2685844"
                     /translation="MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNV
                     LGEQLLEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPVEVIIAQSSIPGEGLGI
                     FSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSW
                     MTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGL
                     EEEQKKNKHEDFHPADSATGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFC
                     NRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHS
                     PALPAPHAHAPALAAAAAAAAAAHHLPAMVL"
     exon            286..476
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /inference="alignment:Splign:2.1.0"
     exon            477..632
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /inference="alignment:Splign:2.1.0"
     exon            633..744
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /inference="alignment:Splign:2.1.0"
     exon            745..2471
                     /gene="Prdm12"
                     /gene_synonym="Gm998"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccacctct ccggagtcca cctagccgtc cttcggcgcc cgcggcgagc cctccgccgc
       61 ccatgatggg ctctgtgctc ccagctgagg ccctggtgct caaaacaggg ctgaaggctc
      121 cggggttggc gctggcagag gtcatcacct ccgacatcct gcacagtttc ttatatggcc
      181 gatggcgcaa cgtgctaggc gaacagctgc tggaagacaa gagccaccac gccagcccaa
      241 aaacggcctt cacggccgag gtcctggcgc agtccttctc aggagaggtg cagaagctat
      301 ctagcctggt gctgccggtg gaagtgatta tcgctcagag ttccatccca ggcgagggcc
      361 ttggcatctt ctccaagacg tggatcaagg caggcacgga gatgggcccc ttcactggcc
      421 gcgtcattgc cccagagcat gtggatatct gcaaaaacaa caacctcatg tgggaggtat
      481 tcaacgagga tggtacagta cgctacttca tcgatgccag ccaggaagac caccgaagct
      541 ggatgaccta catcaagtgt gcccggaatg agcaggagca gaacctggag gtggtccaga
      601 taggcacgag catcttctac aaggccatag agatgatccc tccagaccag gagctgctgg
      661 tgtggtatgg aaattcccac aacaccttcc tgggcatccc aggtgtgcca ggcctggagg
      721 aggaacagaa gaaaaacaag catgaggact tccacccggc ggactccgcg accggcaccg
      781 cgggccgcat gcgctgcgtc atctgccacc gcggcttcaa ctcgcgcagc aacctgcgct
      841 cgcacatgcg tatccacacg ctggacaagc ccttcgtgtg ccgcttctgc aaccgccgct
      901 tcagccagtc gtccacgctg cgcaaccacg tgcgcctgca cacgggcgag cgtccctaca
      961 agtgccaggt gtgccagagc gcctactcgc agctggccgg cctgcgcgcg caccagaaga
     1021 gcgcgcgcca ccggccgccc agcaccgcgc tgcaagcgca ctcgcccgca ctacccgcgc
     1081 cccacgctca cgcgcccgcg cttgccgccg ccgccgctgc cgccgccgcg gcacaccacc
     1141 tgccggccat ggtgctgtga gcgccgcgca cgcgccccac gcgcacgcgc ctcccagccg
     1201 cctccgcgac ggacccgacc ccccgcgctg cgcgccgctg aggcaccggc tacccggaac
     1261 ccactcctga tccgtcttgc agaggaggac gccgaggggc gacgtcccct ttgcccaggc
     1321 cacccggctg gtgtggctgc tgccctgtcc tctcttcttg agagtcggtc cccacgcccg
     1381 gccccatctc ggagtgtccc tcctgcaggg ccgcgtctcc acgcggacat ctctgtccta
     1441 gatgacagga gagggggaac agacgatctc caaagagagc tgagtagttg ggagtggaag
     1501 agagagctac ctccttggcc cagagtgggc ttggggaggg caatgcttat ctctgcctcc
     1561 tgggaatggt gtcttgatgt gtcacgagtg gagggaatga cgttgaccct tggctgtgat
     1621 tggagcccta aagtgattag cacagaccgg gagagacctg atcattcggg gggccctgct
     1681 ttccttcagg ctactttccc tagcctccag ctcccaggga aggacaagac gacaatatat
     1741 tttttgaagt gtgctgggca gattgagagt ggagtcacaa gagacattta ccacagcccg
     1801 tgggcaagac cctgaccctt ttggggcttc agtttcccca tctatagaac gcagtaatta
     1861 gatcagtgct ccctctccta aatctctcct gtcttctgag tttaggaatg gagaggcact
     1921 ctcacttcca tcctattaag tccccaaaca agagaatgag cgaccatacg gggctgtctg
     1981 gagccgaggt tggcttctcc gcccagaaag tttgtctgag gtgcgcggag ggcccccagg
     2041 tttcttcccc acgaagccca cattcccacg cgcctctgcc cacgccgttc cctgatctgt
     2101 ccgtgggcgc cctctggtgt catttcaaac cttgtcattt accagaattc tcgtcccctc
     2161 caatacacac acacacacac acacacacac acacacacac actccatcca aacaccaggg
     2221 cgtttgtaat aataattaaa aaaacccaca aaactataat aatattaaca aaaagtataa
     2281 catgtataga gttttcaaga aagtgtgttc tactcccaga aaacagtcac tttaactttg
     2341 taaatgttta tctaagatga tatttacgaa actgtgatat atattatttg attgtatatg
     2401 taaactgtaa atacatttgt acttctcttg tattctaaaa taaaaattac ttggaacatg
     2461 tatcacttgg c
//
