LOCUS       NP_001355774            1150 aa            linear   ROD 14-FEB-2025
DEFINITION  PR domain zinc finger protein 10 isoform 1 [Mus musculus].
ACCESSION   NP_001355774 XP_006510527
VERSION     NP_001355774.1
DBSOURCE    REFSEQ: accession NM_001368845.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1150)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1150)
  AUTHORS   Han,J., Ke,C., Jiang,B., Zhou,H., Xu,H. and Xie,X.
  TITLE     Down-regulation of PR/SET domain 10 underlies natural killer cell
            dysfunction in hepatocellular carcinoma
  JOURNAL   Clin Exp Immunol 206 (3), 366-377 (2021)
   PUBMED   34562314
  REMARK    GeneRIF: Down-regulation of PR/SET domain 10 underlies natural
            killer cell dysfunction in hepatocellular carcinoma.
REFERENCE   3  (residues 1 to 1150)
  AUTHORS   Woo,J., Jin,B.H., Lee,M., Lee,E.Y., Moon,H.S., Park,J.Y. and
            Cho,Y.E.
  TITLE     Investigation of PRDM10 and PRDM13 Expression in Developing Mouse
            Embryos by an Optimized PACT-Based Embryo Clearing Method
  JOURNAL   Int J Mol Sci 22 (6), 2892 (2021)
   PUBMED   33809237
  REMARK    GeneRIF: Investigation of PRDM10 and PRDM13 Expression in
            Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing
            Method.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1150)
  AUTHORS   Han,B.Y., Seah,M.K.Y., Brooks,I.R., Quek,D.H.P., Huxley,D.R.,
            Foo,C.S., Lee,L.T., Wollmann,H., Guo,H., Messerschmidt,D.M. and
            Guccione,E.
  TITLE     Global translation during early development depends on the
            essential transcription factor PRDM10
  JOURNAL   Nat Commun 11 (1), 3603 (2020)
   PUBMED   32681107
  REMARK    GeneRIF: Global translation during early development depends on the
            essential transcription factor PRDM10.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1150)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (residues 1 to 1150)
  AUTHORS   Park,J.A. and Kim,K.C.
  TITLE     Expression patterns of PRDM10 during mouse embryonic development
  JOURNAL   BMB Rep 43 (1), 29-33 (2010)
   PUBMED   20132732
  REMARK    GeneRIF: PRDM10 might be a transcriptional regulator for normal
            tissue differentiation during mouse embryonic development.
REFERENCE   7  (residues 1 to 1150)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025678.6 and AC167244.2.
            
            On Aug 25, 2022 this sequence version replaced XP_006510527.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.77 cM"
     Protein         1..1150
                     /product="PR domain zinc finger protein 10 isoform 1"
                     /note="PR domain zinc finger protein 10; PR
                     domain-containing protein 10"
                     /calculated_mol_wt=129931
     Region          <167..194
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          197..328
                     /region_name="PR-SET_PRDM10"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 10 (PRDM10) and similar proteins; cd19194"
                     /db_xref="CDD:380971"
     Site            order(212..213,230,266,279..283,285,294..295,319)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380971"
     Site            order(212..213,279..283,285,319)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380971"
     Region          399..504
                     /region_name="Tristanin_u2"
                     /note="Unstructured region on methyltransferase between
                     zinc-fingers; pfam16638"
                     /db_xref="CDD:465211"
     Region          526..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(531,533,535,537..538,541..542,545,561,563,567..568,
                     571..572,575,589,591,593,595..596,599..600,603)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          556..576
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          584..604
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          612..632
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(617,619,621,623..624,627..628,631,645,647,651..652,
                     655..656,659,673,675,677,679..680,683..684,688)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          638..660
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          640..660
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          668..689
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          723..749
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          768..785
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <838..>1012
                     /region_name="SP1-4_N"
                     /note="N-terminal domain of transcription factor
                     Specificity Proteins (SP) 1-4; cl41773"
                     /db_xref="CDD:425404"
     CDS             1..1150
                     /gene="Prdm10"
                     /gene_synonym="Gm1112; tristanin"
                     /coded_by="NM_001368845.2:241..3693"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:382066"
                     /db_xref="MGI:MGI:2682952"
ORIGIN      
        1 mdpkdesahv wptsadheqs taqvhfvpda gtvaqivytd dqvrppqqvv ytadgasyts
       61 vdgpehtlvy ihpveaaqtl ftdpaqvayv qqdataqqvl psiesvhgsd platlqnpia
      121 rldakeeeee eedededtee eeeedaedtd vddwqpdppr pfdphdlwce ecnnahssvc
      181 pkhgplhpip nrpvltrara slplvlyidr flggvfskrr ipkrtqfgpv egplvrgsel
      241 kdcyihlkvs ldkgdrkdrd lhedlwfels detlcnwmmf vrpaqnhleq nlvayqyghh
      301 vyyttiknve pkqelkvwya asyaefvnqk ihdiseeerk vlreqeknwp cyecnrrfis
      361 seqlqqhlns hdekldvftr trgrgrgrgk rrfgpgrrpg rppkfirlei tsengeksdd
      421 gtqdllhfpt keqfdeaepa tlngldqpeq asipipqlpq etppsleqep ethtlhlqpq
      481 qeeslvptqt tltaddmrra krirlelqna alqhlfirks frpfkclqcg kafrekdkld
      541 qhlrfhgreg ncpltcdlcn kgfissasle shmklhsdqk tyscifcpes fdrldllkdh
      601 vaihvndgcf tcptckkrfp dfiqvkkhvr sfhsekiyqc tecdkafcrp dklrlhmlrh
      661 sdrkdflcst cgkqfkrkdk lrehmqrmhn pereakkadr isrsktfkpr itstdydsft
      721 fkcrlcmmgf rrrgmlvnhl skrhpdmkie evpeltlpii kpnrdyfcqy cdkvyksask
      781 rkahilknhp gaelppsirk lrpagpgepd pmlsthtqlt gtiatppvcc phcskqyssk
      841 tkmvqhirkk hpeyaqlpnt ihtplttavi satpavlttd satgetvvtt dlltqamtel
      901 sqtlttdyrt pqgdyqriqy ipvsqsasgl qqpqhiqlqv vqvapatsph qsqqstvdvg
      961 qlhdpqtytq haiqvqhiqv tepapaapsa sqvagqplsp saqqvqqgls pshiqgssst
     1021 qgqalqqqqn ssvqhtylpn awnsfrgyss eiqmmtlppg qfvitdsgva tpvtsgqvka
     1081 vtpghyvlse sqpeleekqa salsgavqvq psahsdslds tgpsqqqttq yiittttngn
     1141 ggsevhitkp
//
