LOCUS       NM_001163318             816 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus photoreceptor disc component (Prcd), mRNA.
ACCESSION   NM_001163318 XM_001476103 XM_001477353
VERSION     NM_001163318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 816)
  AUTHORS   Remez,L., Cohen,B., Nevet,M.J., Rizel,L. and Ben-Yosef,T.
  TITLE     TULP1 and TUB Are Required for Specific Localization of PRCD to
            Photoreceptor Outer Segments
  JOURNAL   Int J Mol Sci 21 (22), 8677 (2020)
   PUBMED   33213002
  REMARK    GeneRIF: TULP1 and TUB Are Required for Specific Localization of
            PRCD to Photoreceptor Outer Segments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 816)
  AUTHORS   Sechrest,E.R., Murphy,J., Senapati,S., Goldberg,A.F.X., Park,P.S.
            and Kolandaivelu,S.
  TITLE     Loss of PRCD alters number and packaging density of rhodopsin in
            rod photoreceptor disc membranes
  JOURNAL   Sci Rep 10 (1), 17885 (2020)
   PUBMED   33087780
  REMARK    GeneRIF: Loss of PRCD alters number and packaging density of
            rhodopsin in rod photoreceptor disc membranes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 816)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 816)
  AUTHORS   Allon,G., Mann,I., Remez,L., Sehn,E., Rizel,L., Nevet,M.J.,
            Perlman,I., Wolfrum,U. and Ben-Yosef,T.
  TITLE     PRCD is concentrated at the base of photoreceptor outer segments
            and is involved in outer segment disc formation
  JOURNAL   Hum Mol Genet 28 (24), 4078-4088 (2019)
   PUBMED   31628458
  REMARK    GeneRIF: This study has important implications for understanding
            the function of PRCD in the retina, as well as for future
            development of treatment modalities for PRCD deficiency in humans.
REFERENCE   5  (bases 1 to 816)
  AUTHORS   Spencer,W.J., Ding,J.D., Lewis,T.R., Yu,C., Phan,S., Pearring,J.N.,
            Kim,K.Y., Thor,A., Mathew,R., Kalnitsky,J., Hao,Y., Travis,A.M.,
            Biswas,S.K., Lo,W.K., Besharse,J.C., Ellisman,M.H., Saban,D.R.,
            Burns,M.E. and Arshavsky,V.Y.
  TITLE     PRCD is essential for high-fidelity photoreceptor disc formation
  JOURNAL   Proc Natl Acad Sci U S A 116 (26), 13087-13096 (2019)
   PUBMED   31189593
  REMARK    GeneRIF: Study in Prcd knockout mice found that Prcd functions at
            the site of photoreceptor disc morphogenesis where it is required
            to keep newly forming discs flat as they protrude from the plasma
            membrane. Without Prcd, the newly forming discs bulge and release
            extracellular vesicles, which accumulate in the extracellular space
            and ultimately lead to retinal pathology.
REFERENCE   6  (bases 1 to 816)
  AUTHORS   Murphy,J. and Kolandaivelu,S.
  TITLE     Palmitoylation of Progressive Rod-Cone Degeneration (PRCD)
            Regulates Protein Stability and Localization
  JOURNAL   J Biol Chem 291 (44), 23036-23046 (2016)
   PUBMED   27613864
  REMARK    GeneRIF: Disrupting PRCD palmitoylation eliminating the modified
            cysteine dramatically affects the stability of PRCD.
REFERENCE   7  (bases 1 to 816)
  AUTHORS   Spencer,W.J., Pearring,J.N., Salinas,R.Y., Loiselle,D.R.,
            Skiba,N.P. and Arshavsky,V.Y.
  TITLE     Progressive Rod-Cone Degeneration (PRCD) Protein Requires
            N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor
            Outer Segment Localization and Maintaining Intracellular Stability
  JOURNAL   Biochemistry 55 (36), 5028-5037 (2016)
   PUBMED   27509380
  REMARK    GeneRIF: demonstrated this interaction to be critically important
            for supporting the intracellular stability of PRCD, as the knockout
            of rhodopsin caused a drastic reduction in the photoreceptor
            content of PRCD
REFERENCE   8  (bases 1 to 816)
  AUTHORS   Skiba,N.P., Spencer,W.J., Salinas,R.Y., Lieu,E.C., Thompson,J.W.
            and Arshavsky,V.Y.
  TITLE     Proteomic identification of unique photoreceptor disc components
            reveals the presence of PRCD, a protein linked to retinal
            degeneration
  JOURNAL   J Proteome Res 12 (6), 3010-3018 (2013)
   PUBMED   23672200
REFERENCE   9  (bases 1 to 816)
  AUTHORS   Zangerl,B., Goldstein,O., Philp,A.R., Lindauer,S.J.,
            Pearce-Kelling,S.E., Mullins,R.F., Graphodatsky,A.S., Ripoll,D.,
            Felix,J.S., Stone,E.M., Acland,G.M. and Aguirre,G.D.
  TITLE     Identical mutation in a novel retinal gene causes progressive
            rod-cone degeneration in dogs and retinitis pigmentosa in humans
  JOURNAL   Genomics 88 (5), 551-563 (2006)
   PUBMED   16938425
REFERENCE   10 (bases 1 to 816)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ390337.1, CK620045.1 and AI846736.1.
            
            On or before Jul 18, 2009 this sequence version replaced
            XM_001476103.1, XM_001477353.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ390337.1, CK620045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DQ390337.1         1-54
            55-714              CK620045.1         1-660
            715-816             AI846736.1         1-102               c
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.46 cM"
     gene            1..816
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /note="photoreceptor disc component"
                     /db_xref="GeneID:100038570"
                     /db_xref="MGI:MGI:3649529"
     exon            1..200
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..291
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /note="progressive rod-cone degeneration protein homolog;
                     progressive rod cone degeneration protein"
                     /codon_start=1
                     /product="photoreceptor disk component PRCD"
                     /protein_id="NP_001156790.1"
                     /db_xref="CCDS:CCDS48987.1"
                     /db_xref="GeneID:100038570"
                     /db_xref="MGI:MGI:3649529"
                     /translation="MCTTLFLFSLAMLWRRRFTNRVEPEPSRVDGTVVGSGSDTDLQS
                     TGREKGPVK"
     exon            201..269
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /inference="alignment:Splign:2.1.0"
     exon            270..348
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /inference="alignment:Splign:2.1.0"
     exon            349..443
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /inference="alignment:Splign:2.1.0"
     exon            444..801
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /inference="alignment:Splign:2.1.0"
     regulatory      758..763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /note="hexamer: AATAAA"
     polyA_site      801
                     /gene="Prcd"
                     /gene_synonym="Gm11744"
                     /note="major polyA site"
ORIGIN      
        1 taatcccttc ccaggaactt caggaaacac agcggtggct tgggagaggt aggctggcca
       61 ttgtggctcc ccggccctgt ggccttcttc agcggagttg gtcgtcggtg gggatggggc
      121 agctgagcca tgtgcaccac cctcttcctg ttcagcttgg ccatgctgtg gcgccgtaga
      181 tttaccaacc gagtggaacc agagcccagc agagtggacg ggacagtcgt gggcagcggc
      241 tcagacacag accttcaatc taccggcagg gagaaaggac ctgtgaagta gaccgtcact
      301 ccttcaggca gcccggctct gcggactgcg gcccgtcggc cctgacagct ggagtcctgg
      361 ttcacctccc atctaggaag atggtgtggg gctggaagcg gaggcaggga ggaaagaaaa
      421 cgggagaaac ggtcatggag aagcccatcc tcagagggat ttggctcttg ctctgagggg
      481 agcctcacag attccagacg gccgtggcaa gtccaagcat cgcgtctcta ccatgtccca
      541 gagccagaag agaggctgtt gtttggaaag gcaagaagaa ttccccaaac ttggccagaa
      601 ttgtattgta gacaagatgg aggaggaaca gtttacagga aggcctccaa cgcgcctgca
      661 cacagatgca cttcctgtga aagcactggt gcagatgctc tgagtgtaag cagccagtgt
      721 cttggaggca tcagcaaccc tccttcatga ccttattaat aaagtccaag attcccttcg
      781 caattaagaa gggagcatca aaaaaaaaaa aaaaaa
//
