LOCUS       NM_001374624            3042 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus protein regulator of cytokinesis 1 (Prc1), transcript
            variant 4, mRNA.
ACCESSION   NM_001374624 XM_006540856
VERSION     NM_001374624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Masui,O., Corbel,C., Nagao,K., Endo,T.A., Kezuka,F.,
            Diabangouaya,P., Nakayama,M., Kumon,M., Koseki,Y., Obuse,C.,
            Koseki,H. and Heard,E.
  TITLE     Polycomb repressive complexes 1 and 2 are each essential for
            maintenance of X inactivation in extra-embryonic lineages
  JOURNAL   Nat Cell Biol 25 (1), 134-144 (2023)
   PUBMED   36635505
  REMARK    GeneRIF: Polycomb repressive complexes 1 and 2 are each essential
            for maintenance of X inactivation in extra-embryonic lineages.
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Murphy,L.A., Wilkerson,D.C., Hong,Y. and Sarge,K.D.
  TITLE     PRC1 associates with the hsp70i promoter and interacts with HSF2
            during mitosis
  JOURNAL   Exp Cell Res 314 (11-12), 2224-2230 (2008)
   PUBMED   18570919
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Puschendorf,M., Terranova,R., Boutsma,E., Mao,X., Isono,K.,
            Brykczynska,U., Kolb,C., Otte,A.P., Koseki,H., Orkin,S.H., van
            Lohuizen,M. and Peters,A.H.
  TITLE     PRC1 and Suv39h specify parental asymmetry at constitutive
            heterochromatin in early mouse embryos
  JOURNAL   Nat Genet 40 (4), 411-420 (2008)
   PUBMED   18311137
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Tarabykin,V., Britanova,O., Fradkov,A., Voss,A., Katz,L.S.,
            Lukyanov,S. and Gruss,P.
  TITLE     Expression of PTTG and prc1 genes during telencephalic neurogenesis
  JOURNAL   Mech Dev 92 (2), 301-304 (2000)
   PUBMED   10727870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109232.17 and AC136740.10.
            
            On Oct 7, 2019 this sequence version replaced XM_006540856.4.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927938.3992260.1,
                                           SRR7345562.2432549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC109232.17        196700-196815
            117-249             AC136740.10        75332-75464
            250-372             AC136740.10        76068-76190
            373-606             AC136740.10        79392-79625
            607-777             AC136740.10        79712-79882
            778-927             AC136740.10        80949-81098
            928-1075            AC136740.10        81406-81553
            1076-1212           AC136740.10        82590-82726
            1213-1308           AC136740.10        84424-84519
            1309-1455           AC136740.10        85772-85918
            1456-1566           AC136740.10        86101-86211
            1567-1677           AC136740.10        87248-87358
            1678-1854           AC136740.10        88063-88239
            1855-1896           AC136740.10        88558-88599
            1897-3042           AC136740.10        90145-91290
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.62 cM"
     gene            1..3042
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /note="protein regulator of cytokinesis 1"
                     /db_xref="GeneID:233406"
                     /db_xref="MGI:MGI:1858961"
     exon            1..116
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1968
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="protein regulator of cytokinesis 1 isoform 4"
                     /protein_id="NP_001361553.1"
                     /db_xref="CCDS:CCDS90258.1"
                     /db_xref="GeneID:233406"
                     /db_xref="MGI:MGI:1858961"
                     /translation="MRRSEVLADESITCLQKALTHLREIWELIGIPEEQRLQRTEVVK
                     KHIKDLLDRMIAEEESLRERLLKSISICQKELSTLCSELQVKPFQEEKDTTILQLEKD
                     LRTQVELMRKQKKERKQELKLLQEQEQELRDILCMPPCDVDSTSVPTLEELKLFRQRV
                     ATLRETKESRREEFVNIKKQIILCMEELEHSPDTSFERDVVCEDESAFCLSLENIATL
                     QKLLKQLEMKKSQNEAECEGLRTQIRELWDRLQIPEEEREPVEAIMTGSKTKIRNALK
                     LEVDRLEELKMQNIKQVIEKIRVELAQFWDQCFYSQEQRQAFAPYYSEDYTENLLHLH
                     DAEIVRLRNYYDVHKELFQGVQKWEESWKLFLEFERKASDPGRFTNRGGNLLKEEKER
                     AKLQKTLPKLEEELKARIEQWEQEHSTAFVVNGQKFMEYVTEQWELHRLEKERAKQER
                     QLKNKKQTEAEMLYGSTPRTPSKRPGQTPKKSGKVRKMNTTTMSSATPNSSIRPVFGG
                     SVYRSPMSRLPPSGSKSVVTSLCSGKKTPRAAQLRANKENLDLNGSILSGGYPGSTPL
                     QHNCSIKSVASTYSEFSKDPSLSDSSTVGLQRELSKASRSDATSRILNSTNIQS"
     exon            117..249
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            250..372
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            373..606
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            607..777
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            778..927
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1075
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1212
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1308
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1455
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1566
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1677
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1854
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1896
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..3042
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /note="hexamer: AATAAA"
     polyA_site      3042
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /note="major polyA site"
ORIGIN      
        1 agtggagacg gactccgggt gaagtctgct gcggctggtt accgttctcc gtcccgcgcg
       61 tggcaagtgg agggtctcga ttctggacag cttggagcgt ccaccatgag gagaagtgag
      121 gtgctagcag atgagtctat cacatgcctg cagaaagctc taactcacct ccgggaaata
      181 tgggaactaa ttgggattcc agaggagcag aggctacaaa gaaccgaggt tgtaaagaag
      241 catataaagg atcttctgga tagaatgatt gctgaagagg agagcctgag ggaaaggctg
      301 ctcaaaagca tatccatctg tcagaaggag ctgagtaccc tgtgcagtga gctacaagtg
      361 aagccatttc aggaagaaaa agatacaacc atcttgcaac tagaaaaaga tttgcgcact
      421 caagtagaat tgatgagaaa acagaaaaag gagagaaagc aggaactgaa gctacttcag
      481 gaacaggagc aagaactccg tgacatcctc tgtatgccgc cctgtgatgt ggacagcacc
      541 tctgtcccca ccttagaaga gctgaagcta ttccgacagc gtgtggcaac gctgagggag
      601 acaaaggaat cgaggcgtga agaatttgtc aacattaaga aacaaatcat attgtgtatg
      661 gaagaattag aacactctcc agatacaagc tttgaaagag atgtggtgtg tgaagatgaa
      721 agtgcttttt gtttatcact ggagaacatt gcaacattac agaagttgct gaagcagctg
      781 gaaatgaaaa aatcacaaaa tgaagcagaa tgtgaggggc tccgcactca aatccgagag
      841 ctctgggata ggttacaaat acctgaagaa gagagagagc ctgtggaggc aattatgact
      901 ggatcaaaaa ccaaaatcag gaatgcgctg aaattagaag tggatcggtt agaagaactg
      961 aaaatgcaaa acataaagca agtgattgag aaaatccgag tggagctggc tcaattctgg
     1021 gaccagtgtt tttatagcca ggaacagagg caggcttttg ccccttacta ttctgaggac
     1081 tacacagaaa acctgctcca tcttcatgat gccgagattg tacggttaag aaactactat
     1141 gacgttcaca aggagctgtt ccaaggcgtc cagaagtggg aagagagctg gaaacttttc
     1201 ctagagtttg agagaaaagc ttcagatcca ggtcgattta caaaccgagg gggaaatctt
     1261 ttaaaagaag aaaaggaacg agcaaagctc cagaaaacac tccctaagct ggaagaggag
     1321 ttgaaagcac ggattgaaca gtgggaacag gagcactcaa cagcatttgt ggtgaatggg
     1381 cagaaattca tggagtatgt tacagaacag tgggaattac atcggctgga gaaagagcga
     1441 gccaaacagg agaggcaact gaagaacaag aaacagacag aggcagagat gctgtatggc
     1501 agtactcccc ggacacctag caaaagacca ggacagacgc ccaagaagtc tggcaaagta
     1561 cgcaagatga acactaccac catgtctagt gctacaccca acagtagcat tcggcctgtc
     1621 tttggtggat cagtgtaccg gtcacctatg tctcgactac ccccttctgg cagcaagtca
     1681 gttgtcactt ctctgtgttc tggaaagaaa acacctcgag ctgcccagct tagggccaac
     1741 aaggagaact tggacctcaa tggcagcatc ctgagcggtg ggtaccctgg ctcgacgccc
     1801 ctccagcaca actgcagcat taagtctgtt gccagcacct attctgagtt ttcgaaggac
     1861 ccgtccctct ctgacagctc cactgttggg cttcagcgag aactttcaaa ggcttccaga
     1921 tctgatgcta cgtctcgaat cctcaattca accaacatcc agtcctgaga gtccttgtcc
     1981 agttaggcag ctggggcttc ctgtgcctgg actggactga cggatacgta gacaaggagt
     2041 gacatataca tttccatcag tttagatgtt tgaaactacc ttgggcaggt tctattaact
     2101 gcacctaact cagacgtgag taggacagaa ggaagctgtc ccgggcgaac tgaggtcaca
     2161 aagacttgct tttgattcaa gagagacctt aaaggctagt tatgatagtt aagtacaagt
     2221 tttaacatct ggtagctaac tttttttctc taccccgtaa ttctactatg actgctcttc
     2281 tagaggtcct gagttcaaat cccagcaacc acatggtggc tcacaaccat ctataatggg
     2341 atctgatgcc ctcttctggt gtgcagaaat aatttttttt ttaattctac ttatttcaat
     2401 actatatatt agaaaatgaa aaaacgattg tggcctgctt tggcatacag gggtacaaga
     2461 catgaagtaa ttctggtaac atctaaaaat atatatattt ttgttcgcgg acatttgatt
     2521 aatgctgtag ctatggaagc tttgatgtca cccagaggcg tgtacctggc tggcactatc
     2581 ccagtgaggg tttcttgagt tccagtatga gatggcctga cctgctgcca aaaagagtag
     2641 cagtcatttc tgtagtgcaa tttcttgagg tatatgtgtg aacacacatg cttgtctgac
     2701 ctgttgagtt tttctccagt ctcccaaccc tgtgctcatt aggcccagtc tgttccctgt
     2761 agatgacaac cacatagaga ggctgtctgg tgggctgggc cattcctgtc atggagtcag
     2821 caactttgca catctacaag ttatctgtgt aatcacgtcc acaatgaggc tctccaaacc
     2881 catcactact cttccccaaa gcactatatt tattctgtct gtctgtgcca gttctgccca
     2941 cactgactga tcttgaaaac ctgtcagtct gctcttcaca cacatatatg ttgtttttaa
     3001 atgtatgaaa ataaaatgtg tatagttacc ttttaaatac ta
//
