LOCUS       NP_001361553             620 aa            linear   ROD 13-DEC-2024
DEFINITION  protein regulator of cytokinesis 1 isoform 4 [Mus musculus].
ACCESSION   NP_001361553 XP_006540919
VERSION     NP_001361553.1
DBSOURCE    REFSEQ: accession NM_001374624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 620)
  AUTHORS   Masui,O., Corbel,C., Nagao,K., Endo,T.A., Kezuka,F.,
            Diabangouaya,P., Nakayama,M., Kumon,M., Koseki,Y., Obuse,C.,
            Koseki,H. and Heard,E.
  TITLE     Polycomb repressive complexes 1 and 2 are each essential for
            maintenance of X inactivation in extra-embryonic lineages
  JOURNAL   Nat Cell Biol 25 (1), 134-144 (2023)
   PUBMED   36635505
  REMARK    GeneRIF: Polycomb repressive complexes 1 and 2 are each essential
            for maintenance of X inactivation in extra-embryonic lineages.
REFERENCE   3  (residues 1 to 620)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 620)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   5  (residues 1 to 620)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 620)
  AUTHORS   Murphy,L.A., Wilkerson,D.C., Hong,Y. and Sarge,K.D.
  TITLE     PRC1 associates with the hsp70i promoter and interacts with HSF2
            during mitosis
  JOURNAL   Exp Cell Res 314 (11-12), 2224-2230 (2008)
   PUBMED   18570919
REFERENCE   7  (residues 1 to 620)
  AUTHORS   Puschendorf,M., Terranova,R., Boutsma,E., Mao,X., Isono,K.,
            Brykczynska,U., Kolb,C., Otte,A.P., Koseki,H., Orkin,S.H., van
            Lohuizen,M. and Peters,A.H.
  TITLE     PRC1 and Suv39h specify parental asymmetry at constitutive
            heterochromatin in early mouse embryos
  JOURNAL   Nat Genet 40 (4), 411-420 (2008)
   PUBMED   18311137
REFERENCE   8  (residues 1 to 620)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 620)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   10 (residues 1 to 620)
  AUTHORS   Tarabykin,V., Britanova,O., Fradkov,A., Voss,A., Katz,L.S.,
            Lukyanov,S. and Gruss,P.
  TITLE     Expression of PTTG and prc1 genes during telencephalic neurogenesis
  JOURNAL   Mech Dev 92 (2), 301-304 (2000)
   PUBMED   10727870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109232.17 and AC136740.10.
            
            On Oct 7, 2019 this sequence version replaced XP_006540919.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927938.3992260.1,
                                           SRR7345562.2432549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.62 cM"
     Protein         1..620
                     /product="protein regulator of cytokinesis 1 isoform 4"
                     /calculated_mol_wt=71958
     Region          16..474
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..620
                     /gene="Prc1"
                     /gene_synonym="D7Ertd348e"
                     /coded_by="NM_001374624.1:106..1968"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS90258.1"
                     /db_xref="GeneID:233406"
                     /db_xref="MGI:MGI:1858961"
ORIGIN      
        1 mrrsevlade sitclqkalt hlreiwelig ipeeqrlqrt evvkkhikdl ldrmiaeees
       61 lrerllksis icqkelstlc selqvkpfqe ekdttilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqeqe lrdilcmppc dvdstsvptl eelklfrqrv atlretkesr reefvnikkq
      181 iilcmeeleh spdtsferdv vcedesafcl sleniatlqk llkqlemkks qneaeceglr
      241 tqirelwdrl qipeeerepv eaimtgsktk irnalklevd rleelkmqni kqviekirve
      301 laqfwdqcfy sqeqrqafap yysedytenl lhlhdaeivr lrnyydvhke lfqgvqkwee
      361 swklflefer kasdpgrftn rggnllkeek eraklqktlp kleeelkari eqweqehsta
      421 fvvngqkfme yvteqwelhr lekerakqer qlknkkqtea emlygstprt pskrpgqtpk
      481 ksgkvrkmnt ttmssatpns sirpvfggsv yrspmsrlpp sgsksvvtsl csgkktpraa
      541 qlrankenld lngsilsggy pgstplqhnc siksvastys efskdpslsd sstvglqrel
      601 skasrsdats rilnstniqs
//
