LOCUS       NM_009475                639 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proline-rich acidic protein 1 (Prap1), mRNA.
ACCESSION   NM_009475
VERSION     NM_009475.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 639)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   2  (bases 1 to 639)
  AUTHORS   Peng,H., Chiu,T.Y., Liang,Y.J., Lee,C.J., Liu,C.S., Suen,C.S.,
            Yen,J.J., Chen,H.T., Hwang,M.J., Hussain,M.M., Yang,H.C. and
            Yang-Yen,H.F.
  TITLE     PRAP1 is a novel lipid-binding protein that promotes lipid
            absorption by facilitating MTTP-mediated lipid transport
  JOURNAL   J Biol Chem 296, 100052 (2021)
   PUBMED   33168624
  REMARK    GeneRIF: PRAP1 is a novel lipid-binding protein that promotes lipid
            absorption by facilitating MTTP-mediated lipid transport.
REFERENCE   3  (bases 1 to 639)
  AUTHORS   Wolfarth,A.A., Liu,X., Darby,T.M., Boyer,D.J., Spizman,J.B.,
            Owens,J.A., Chandrasekharan,B., Naudin,C.R., Hanley,K.Z.,
            Robinson,B.S., Ortlund,E.A., Jones,R.M. and Neish,A.S.
  TITLE     Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal
            Epithelium From Irradiation-Induced Apoptosis
  JOURNAL   Cell Mol Gastroenterol Hepatol 10 (4), 713-727 (2020)
   PUBMED   32629119
  REMARK    GeneRIF: Proline-Rich Acidic Protein 1 (PRAP1) Protects the
            Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
REFERENCE   4  (bases 1 to 639)
  AUTHORS   Khalife,M., Young,R., Passet,B., Halliez,S., Vilotte,M.,
            Jaffrezic,F., Marthey,S., Beringue,V., Vaiman,D., Le Provost,F.,
            Laude,H. and Vilotte,J.L.
  TITLE     Transcriptomic analysis brings new insight into the biological role
            of the prion protein during mouse embryogenesis
  JOURNAL   PLoS One 6 (8), e23253 (2011)
   PUBMED   21858045
REFERENCE   5  (bases 1 to 639)
  AUTHORS   Diao,H., Xiao,S., Zhao,F. and Ye,X.
  TITLE     Uterine luminal epithelium-specific proline-rich acidic protein 1
            (PRAP1) as a marker for successful embryo implantation
  JOURNAL   Fertil Steril 94 (7), 2808-11 (2010)
   PUBMED   20674898
  REMARK    GeneRIF: PRAP1 is a marker for successful embryo implantation.
REFERENCE   6  (bases 1 to 639)
  AUTHORS   Lepourcelet,M., Tou,L., Cai,L., Sawada,J., Lazar,A.J.,
            Glickman,J.N., Williamson,J.A., Everett,A.D., Redston,M., Fox,E.A.,
            Nakatani,Y. and Shivdasani,R.A.
  TITLE     Insights into developmental mechanisms and cancers in the mammalian
            intestine derived from serial analysis of gene expression and study
            of the hepatoma-derived growth factor (HDGF)
  JOURNAL   Development 132 (2), 415-427 (2005)
   PUBMED   15604097
REFERENCE   7  (bases 1 to 639)
  AUTHORS   Tou,L., Liu,Q. and Shivdasani,R.A.
  TITLE     Regulation of mammalian epithelial differentiation and intestine
            development by class I histone deacetylases
  JOURNAL   Mol Cell Biol 24 (8), 3132-3139 (2004)
   PUBMED   15060137
REFERENCE   8  (bases 1 to 639)
  AUTHORS   Zhang,J., Rajkumar,N. and Hooi,S.C.
  TITLE     Characterization and expression of the mouse pregnant specific
            uterus protein gene and its rat homologue in the intestine and
            uterus
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 526-530 (2000)
   PUBMED   10899595
REFERENCE   9  (bases 1 to 639)
  AUTHORS   Schorpp-Kistner,M., Wang,Z.Q., Angel,P. and Wagner,E.F.
  TITLE     JunB is essential for mammalian placentation
  JOURNAL   EMBO J 18 (4), 934-948 (1999)
   PUBMED   10022836
REFERENCE   10 (bases 1 to 639)
  AUTHORS   Kasik,J. and Rice,E.
  TITLE     A novel complementary deoxyribonucleic acid is abundantly and
            specifically expressed in the uterus during pregnancy
  JOURNAL   Am J Obstet Gynecol 176 (2), 452-456 (1997)
   PUBMED   9065197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA060392.1 and BC051092.1.
            
            On May 15, 2008 this sequence version replaced NM_009475.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051092.1, CJ048089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AA060392.1         1-12
            13-639              BC051092.1         1-627
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.1 cM"
     gene            1..639
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /note="proline-rich acidic protein 1"
                     /db_xref="GeneID:22264"
                     /db_xref="MGI:MGI:893573"
     exon            1..73
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..515
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /note="uterine-specific proline-rich acidic protein;
                     pregnancy-specific uterine protein"
                     /codon_start=1
                     /product="proline-rich acidic protein 1 precursor"
                     /protein_id="NP_033501.2"
                     /db_xref="CCDS:CCDS21963.1"
                     /db_xref="GeneID:22264"
                     /db_xref="MGI:MGI:893573"
                     /translation="MKRFLLATCLVAALLWEAGAAPAHQVPVKTKGKHVFPEQETEKV
                     WDTRALEPLEKDNQLGPLLPEPKQKPAAAEEKRPDAMTWVETEDILSHLRSPLQGPEL
                     DLDSIDHPMSDDVQDEEVPQSRPILYRQVLQGPEEDLDHLAHSMEDS"
     exon            74..140
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /inference="alignment:Splign:2.1.0"
     exon            141..193
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /inference="alignment:Splign:2.1.0"
     exon            194..300
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /inference="alignment:Splign:2.1.0"
     exon            301..622
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /note="hexamer: AATAAA"
     polyA_site      621
                     /gene="Prap1"
                     /gene_synonym="Upa"
                     /note="major polyA site"
ORIGIN      
        1 ggcacctgga ccctgagatc tacagcttcg ccattcgcct agagcactga aaaggagccc
       61 cagtcatgaa gaggtttctc ctggccacct gtttggtggc tgcactgctg tgggaggcag
      121 gcgcagctcc agcacaccag gtccctgtca agaccaaagg caaacatgtg ttccctgaac
      181 aggaaacaga gaaggtctgg gatactagag ccctggagcc tcttgaaaag gacaaccagc
      241 tggggccact gcttcctgaa cccaaacaga agcctgcagc tgccgaggaa aagcgtccag
      301 atgccatgac ctgggtggag actgaggata tcctgagcca tcttcgcagt cctcttcagg
      361 gtccagaact ggatcttgac agcatagacc atcccatgtc tgacgatgtc caggatgaag
      421 aagtgcccca gtcacggccc atcctgtatc gtcaggtgct gcagggacca gaggaggacc
      481 ttgaccacct cgcccactct atggaggatt cttgaaagcc ctaaccactc ttccactcct
      541 ttcctgaggt ctaggctgtt gtgaccactg agtctcccca gctagtaaaa aaaaaaaata
      601 aatacctgaa aattggtggg agaaaaaaaa aaaaaaaaa
//
