LOCUS       NM_178250               1860 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PRAME like 7 (Pramel7), mRNA.
ACCESSION   NM_178250
VERSION     NM_178250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Graf,U., Casanova,E.A., Wyck,S., Dalcher,D., Gatti,M.,
            Vollenweider,E., Okoniewski,M.J., Weber,F.A., Patel,S.S.,
            Schmid,M.W., Li,J., Sharif,J., Wanner,G.A., Koseki,H., Wong,J.,
            Pelczar,P., Penengo,L., Santoro,R. and Cinelli,P.
  TITLE     Pramel7 mediates ground-state pluripotency through
            proteasomal-epigenetic combined pathways
  JOURNAL   Nat Cell Biol 19 (7), 763-773 (2017)
   PUBMED   28604677
  REMARK    GeneRIF: Pramel7 (PRAME-like 7), a protein highly expressed in the
            inner cell mass but expressed at low levels in embryonic stem
            cells, targets proteasomal degradation of UHRF1, a key factor for
            DNA methylation maintenance.
            Erratum:[Nat Cell Biol. 2017 Jul 28;19(8):1003. doi:
            10.1038/ncb3572.. PMID: 28752849]
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Casanova,E.A., Shakhova,O., Patel,S.S., Asner,I.N., Pelczar,P.,
            Weber,F.A., Graf,U., Sommer,L., Burki,K. and Cinelli,P.
  TITLE     Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem
            cells
  JOURNAL   Stem Cells 29 (3), 474-485 (2011)
   PUBMED   21425410
  REMARK    GeneRIF: Pramel7 represents a central and essential factor in the
            signaling network regulating pluripotency and self-renewal in
            embryonic stem cells.
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Cinelli,P., Casanova,E.A., Uhlig,S., Lochmatter,P., Matsuda,T.,
            Yokota,T., Rulicke,T., Ledermann,B. and Burki,K.
  TITLE     Expression profiling in transgenic FVB/N embryonic stem cells
            overexpressing STAT3
  JOURNAL   BMC Dev Biol 8, 57 (2008)
   PUBMED   18500982
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Kaji,K., Nichols,J. and Hendrich,B.
  TITLE     Mbd3, a component of the NuRD co-repressor complex, is required for
            development of pluripotent cells
  JOURNAL   Development 134 (6), 1123-1132 (2007)
   PUBMED   17287250
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Bortvin,A., Eggan,K., Skaletsky,H., Akutsu,H., Berry,D.L.,
            Yanagimachi,R., Page,D.C. and Jaenisch,R.
  TITLE     Incomplete reactivation of Oct4-related genes in mouse embryos
            cloned from somatic nuclei
  JOURNAL   Development 130 (8), 1673-1680 (2003)
   PUBMED   12620990
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF490343.1.
            
            On Jun 3, 2003 this sequence version replaced NM_178250.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF490343.1, BC052825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849384,
                                           SAMN01164137 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.86 cM"
     gene            1..1860
                     /gene="Pramel7"
                     /note="PRAME like 7"
                     /db_xref="GeneID:347712"
                     /db_xref="MGI:MGI:2156391"
     CDS             1..1440
                     /gene="Pramel7"
                     /note="preferentially expressed antigen in melanoma like
                     7"
                     /codon_start=1
                     /product="preferentially expressed antigen in
                     melanoma-like protein 7"
                     /protein_id="NP_839981.1"
                     /db_xref="CCDS:CCDS16293.1"
                     /db_xref="GeneID:347712"
                     /db_xref="MGI:MGI:2156391"
                     /translation="MVSAPPTLQDQAFRSLVRNEVLTVSDAECLIREFFPPLFKEAST
                     QKKPKTIMILVEHWPYPCLHVGLLIDKPNFQIFQAILDGVDTWLKRKYRPRMGRLKKV
                     DFRDAQHHASLDMQDEREGRDYLVGTLPKKQIVEDHSRTRKERLKLFHDLSFMSSLHE
                     DKHQTLLLEWAKERTSFLHLCCEKLEIGAVEVSKVRNVLKFLQPELIKELKLNTVGNL
                     SKLAKFVPFIRKMRNLQKLMLVRTFGTRTFTQEEKQNISKIISLFCKLSCLRHLTIDD
                     VYFLTDQMKELLRCLEAPLVSLKITLCQLSQSDLESFAQRWNYSQLKHLCLRGVTLTN
                     LDVTPLRDFLKRVAANLQTLDLEDCRMDDSHFRTLLPALIKCTQLTSINLYDNDISED
                     VLENFLHRTTNLSQLTTEMYPAPSEVYNESNYVIVEIFIQICSELMNKLMEVRQANSV
                     CFGSSSCYDCDNRYLYEDDGDVTLCLCQE"
     exon            1..284
                     /gene="Pramel7"
                     /inference="alignment:Splign:2.1.0"
     exon            285..866
                     /gene="Pramel7"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1860
                     /gene="Pramel7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtcagtg ccccacccac actccaggat caggctttca ggagcctggt gaggaatgaa
       61 gtattgaccg tctctgatgc ggagtgccta ataagggaat tcttcccacc tctgttcaag
      121 gaggccagca ctcaaaaaaa accaaagaca attatgatcc tggtggagca ctggccctac
      181 ccttgccttc atgttgggtt gttgattgat aaacccaact ttcagatctt ccaggctata
      241 ctggatggag tagacacatg gctgaaacgg aagtatcgcc ccaggatggg aaggcttaaa
      301 aaggttgact tcagggatgc acagcatcat gcttccttag atatgcagga tgagagagag
      361 ggtagagact acttagtagg aactttgcct aagaagcaaa tagtggagga ccactcaaga
      421 acaaggaaag agcgtttgaa gctgttccat gacctttcct ttatgtcttc tctgcatgag
      481 gataaacacc aaacactgtt attggagtgg gcaaaggaaa ggacgagttt cctgcatctg
      541 tgctgtgaga agttggagat aggagcagta gaagtgtcta aggtcaggaa tgtattaaaa
      601 tttctacagc cagagctcat caaggagttg aaactgaata cagtggggaa tctgtccaaa
      661 ctggcaaaat tcgtaccttt cattagaaag atgagaaacc ttcagaaact catgctagta
      721 cgcacctttg gaacaaggac tttcactcaa gaggagaagc agaacatcag caagatcatt
      781 tctctgttct gcaaactcag ctgtctccgg catctcacta ttgatgatgt ctattttctc
      841 acagatcaga tgaaagagtt gctcaggtgt ctggaggccc cattggtgtc cctcaagatc
      901 accctgtgcc agctctctca gtcagacttg gagtcatttg cccagcgctg gaactacagt
      961 cagcttaaac atctatgctt gagaggtgtc actttaacta acctagatgt cacgcctcta
     1021 agagatttct taaagcgtgt tgcagctaac ctgcagactc tggacttaga agactgtagg
     1081 atggatgatt ctcacttcag gacccttctt cctgccctga tcaaatgcac ccagctcact
     1141 agcatcaatt tgtatgacaa tgacatctcc gaggatgtcc tggagaactt tttgcaccgc
     1201 actaccaatc tgagccagct gaccacagaa atgtatcctg ctccatcaga ggtctataat
     1261 gagtccaact atgttatagt agagatattt attcagattt gttctgaact tatgaacaaa
     1321 ctcatggaag tcaggcaggc caattcagtg tgctttggtt cctcttcctg ttatgactgt
     1381 gataatcgtt atttatatga agatgatggg gatgtcacac tttgtttgtg ccaggagtaa
     1441 caacaggaat attcctttgg ggtactaaga aattcctagg gactggtctc tcatccagag
     1501 aacccacatg gctttggaca tttttcaatg tgatgaaaca atggtccaaa tcaggactga
     1561 ctcttcactg gctttctgct atctatgaaa ttatggtcag atcctaaaaa cctgctattc
     1621 tctctgtgct tccagtcatt agttggtcct caagattgta gtcagaacag ttctttgtac
     1681 acagtaatgg agggatagga tgtttaacct tgtttcacat aacctctcaa tgtgcaatgg
     1741 ggatattctg atatttcccc cttctgcatc tgcctggtgg gtgggtcatg tgtaaaagtc
     1801 ttcaaagtag caatgtatgc caagccaaat ccttttttta aataaagatt tatttattta
//
