LOCUS       NM_031390               3673 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus PRAME like 3A (Pramel3a), mRNA.
ACCESSION   NM_031390
VERSION     NM_031390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3673)
  AUTHORS   Luo M, Zhou J, Leu NA, Abreu CM, Wang J, Anguera MC, de Rooij DG,
            Jasin M and Wang PJ.
  TITLE     Polycomb protein SCML2 associates with USP7 and counteracts histone
            H2A ubiquitination in the XY chromatin during male meiosis
  JOURNAL   PLoS Genet 11 (1), e1004954 (2015)
   PUBMED   25634095
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3673)
  AUTHORS   Zhou J, McCarrey JR and Wang PJ.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    GeneRIF: Pramel3 is found within a region of the X chromosome, that
            when deleted as part of a 1.1 Mb segmental deletion, causes meiotic
            failure in male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3673)
  AUTHORS   Shin YH, Choi Y, Erdin SU, Yatsenko SA, Kloc M, Yang F, Wang PJ,
            Meistrich ML and Rajkovic A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3673)
  AUTHORS   Gallardo TD, John GB, Shirley L, Contreras CM, Akbay EA, Haynie JM,
            Ward SE, Shidler MJ and Castrillon DH.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
REFERENCE   5  (bases 1 to 3673)
  AUTHORS   Wang PJ, Page DC and McCarrey JR.
  TITLE     Differential expression of sex-linked and autosomal
            germ-cell-specific genes during spermatogenesis in the mouse
  JOURNAL   Hum Mol Genet 14 (19), 2911-2918 (2005)
   PUBMED   16118233
  REMARK    GeneRIF: Germ-cell-specific sex-linked genes, like Pramel3, are
            subject to meiotic sex-chromosome inactivation (MSCI) during
            spermatogenesis.
REFERENCE   6  (bases 1 to 3673)
  AUTHORS   Wang PJ, McCarrey JR, Yang F and Page DC.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
  REMARK    GeneRIF: Pramel3 is a gene that is expressed in testis that was
            identified in a genome-wide cDNA subtraction screen.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731676.5.
            
            On Dec 12, 2009 this sequence version replaced NM_031390.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments. An in-frame AUG is located 1
            codon upstream of the annotated translation start site but is not
            being annotated as a start site since it is not conserved and is in
            a weak Kozak sequence context.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY004873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL731676.5         116860-116982
            124-250             AL731676.5         117181-117307
            251-550             AL731676.5         121877-122176
            551-1135            AL731676.5         123481-124065
            1136-3673           AL731676.5         124643-127180
FEATURES             Location/Qualifiers
     source          1..3673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.84 cM"
     gene            1..3673
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /note="PRAME like 3A"
                     /db_xref="GeneID:83565"
                     /db_xref="MGI:MGI:1890657"
     exon            1..123
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /inference="alignment:Splign:2.1.0"
     exon            124..250
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /inference="alignment:Splign:2.1.0"
     exon            251..550
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1649
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /note="PRAME like 3"
                     /codon_start=1
                     /product="preferentially expressed antigen in
                     melanoma-like 3"
                     /protein_id="NP_113567.1"
                     /db_xref="CCDS:CCDS30403.1"
                     /db_xref="GeneID:83565"
                     /db_xref="MGI:MGI:1890657"
                     /translation="MDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAF
                     TGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLR
                     ILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPM
                     ELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKC
                     VDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSHMNHLKEL
                     SLSSFCLTDHLETVLRVLSTDLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNP
                     IYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQI
                     TMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEA
                     ERSDMNWITYSD"
     exon            551..1135
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..3673
                     /gene="Pramel3a"
                     /gene_synonym="Pramel3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtggccat tacaggagcc gtcgccatta tgactatggt gcccccgcta cagggaaagc
       61 ctcgcggata acgaggggct gccaaagtgg aggacatgga agtcagaggg cttaactgct
      121 tgggttctcc atataacctt taacctcctc ttcaaaaatt tatattcctg agaaggactt
      181 ggtgacattt caaagactgt ggcacgaggt tttgaagttc tacgtcaacc tacattaacg
      241 tggtgagaag gttcattatg atggacacca aggacccgcc cacactattg gatcttgcta
      301 cacagagtct attgagtaat gagcatgcag caatccaagc cctggaggag atcccaaggg
      361 agctttttgt ccctttgttc actgctgcct tcacgggtag acacaagaat atactgacag
      421 caattgtgaa agcttggcct tttgcctgtc tccacattgg ggcattaagt gtgcaggaac
      481 ctgagcgtga actcctgaaa gccttgattg agagtcttca gttcctccct gccctgaact
      541 cagctactag gagccctaaa ctgaggatcc tagatttaag gcaggatgct ggctgcaaga
      601 ccgtatgtcc tgagatcagt actaattcga caatttgctt tcgttcttgt gctcactctg
      661 agcactctat cttcaaaatt gaaggccagg agagtctttc aagttccaag tctgaagctc
      721 agccctctag gctgcctatg gaattgatag tggacatttc ccttgatggc actttgaggg
      781 aaaggaattt ttttgctttg cttcagaata aagtagagca gagcctaggc tctctgcacc
      841 tgtgctgcag agatttgcaa attaataact tgtgtgaatg cagacatgca ttaagccatc
      901 tggatctgaa atgtgttgat caccttgcag ttgatgagtc tcctcttact gaagtcacca
      961 aacttttatc tcatacaata cagctggaca gtcttagcct gtctaaaatc gcttgtagat
     1021 ctttgaatgg gagaaccttt agaaatttta tcacccaact gagtcatatg aaccacctga
     1081 aggagctcag cttgtcttca ttctgcctca cagatcatct tgaaactgtc ctgagagtac
     1141 tatctactga tttggagttc ttatatctac cgttctgtgg actttcttac agtgacttca
     1201 agtttctctc tgagtgctct caagtcagtc atttaaagtt gctgaatgtc aacaacaatc
     1261 caatatattg ggaagattgt gagccatttt attatctcct gcagaatgtt tctagcacct
     1321 tgcagcatct gaaaatttgt tattgctttt taacagattc tacaatctct gttcttatcc
     1381 cagccctaac ccggtgttct caacttcgag tgcttcactt ttattcaaat caaattacca
     1441 tgggcatgct tatgagaatt cttgagctat taacaccatt gaaggagctt aaacatgtga
     1501 tctatcccat ccctgtccat tgctatggga ggtggcattt tcaaggcagt ttagatagac
     1561 agaaggttga agatgtgcag agacaattga acttaatgct acaggaggca gaaaggagtg
     1621 atatgaattg gatcacttac tctgattaaa ttacaaagtc caacacagtt tcaacttgat
     1681 atgttcccat taagggcttt tttcttaatg ccatagacag aatatataag gttcttatgt
     1741 tgtaggagaa tacaattaag aagtataggt tgtaactgat ttctatagag aataatttac
     1801 aagaagatag aggacgttga gattacctat gtgtctctca gctattgttg tggatagcat
     1861 ttcatctcac caaataaatt gtaagtagag gatatggaaa gtttttgtta tgaaatacta
     1921 acaacaccct gtcctcactg agatttgcct gtggatactt agtgcagttg tgacaatata
     1981 acttttcctg catgtgaatt tggaggcagg tggcaattga agacaacact ttttattgca
     2041 tacgttgtat taagtttcta tatttcagct gtcttcagtt gtttaaagga aaccatctgg
     2101 atttaacagt gagaaaaatt atttgtaact actaccatta agtggttcaa tttttatttc
     2161 atattcattg attaaggatt agtttgaaat attattactg aaccactgac tgtggtttat
     2221 cggttgttaa agcaactaga aaggtgttgt acacacttag acccccaagc ttcatcttcc
     2281 cagctcttag tacatattct cttccatgca aaacggactt tatgatgttg gatctcctca
     2341 gcaggattca gggattcaac atcgccatct tggaggcatg ctctcacatc tgtttgatat
     2401 ctaccatctg gcctcctgca aaatgcctgg tatagtagac tggtagggaa gagaactttg
     2461 tttctttgtt ttagacgttt cactaaggtt gttggactcc actctttggg accttgccaa
     2521 gacagaatat gattaggagt tttgacagag ggagttcctt tcaactcatg aggccaggga
     2581 gcagacagag aagcctgagt ccccacacag ccatcaggag tgcaatttca ttgatttgca
     2641 tccttgaact accctgacat aaagtttcta ccacctaccc tggagcgttt cttgaactat
     2701 cctgctcaaa gatttcaact gcctgcattg gaaccatcag cttgagacca atatgaactt
     2761 ggaaagacag gagtccagcc acaacaacga ctattattcc ttttgaaatt ttttttcttt
     2821 taccactagt tccttcatgg tatacttgac tcagtttgaa attctgattt ttttgtatgg
     2881 aactttccac atttgccata atactgtgta gcaaatgcat tatgcatgga gctgtttaga
     2941 gttgaaactt caaatacgat taccataaat agaaaagcat gtagtttgct caacacatag
     3001 tgtgaacaaa gcatatatac ctatcaatta ggatgctatt tttgttaatg tattgaaaag
     3061 ttaatacact acattgcaaa aacatagaaa agtgtataca tttagtttgt tcctgtatat
     3121 gtctacatca ctgcatttta atgacatata agtttaatga aaaaaatcct ttatggggtc
     3181 tttttataaa taaagctaac tgcatttaaa aatctaataa gaaaaccaga agcaacagtg
     3241 tgtctatatt gctgtaagtt tgaaattata ctggatttca gatcaactaa ataaaactgg
     3301 ggttaaaagc tacagaattt tgttaacagt tctcacatgt caagatgata ctgaactata
     3361 ctgtagagat acagagcact aaaatttatc tggaaaatta acatttgtgt tgattacatt
     3421 tatttgttaa tagattttca aattcaagta gcaacttaaa caaaagccat gtgcaaaatt
     3481 ctggtgtatg atttgttaac aaagcatttg aaagactcaa aagcaagaat ggagaattaa
     3541 tgacattcat ctttttcata ttgcttatat attaaaatgc agaatttaat attccaatgt
     3601 caatgtaacc agcaaatgtt ttataatgct ttcttgttaa catcacatta ttttgtcatc
     3661 tttgagtaag taa
//
