LOCUS       NM_001002842            2290 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus PML-RAR alpha-regulated adaptor molecule 1 (Pram1),
            transcript variant 1, mRNA.
ACCESSION   NM_001002842 XM_128537
VERSION     NM_001002842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Rolan,H.G., Durand,E.A. and Mecsas,J.
  TITLE     Identifying Yersinia YopH-targeted signal transduction pathways
            that impair neutrophil responses during in vivo murine infection
  JOURNAL   Cell Host Microbe 14 (3), 306-317 (2013)
   PUBMED   24034616
  REMARK    GeneRIF: A yopH mutant survived better in the absence of
            neutrophils, indicating that neutrophil inactivation by YopH by
            targeting PRAM-1/SKAP-HOM and SLP-76/Vav/PLCgamma2 signaling hubs
            may be critical for Yersinia survival.
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Huang,Y., Hou,J.K., Chen,T.T., Zhao,X.Y., Yan,Z.W., Zhang,J.,
            Yang,J., Kogan,S.C. and Chen,G.Q.
  TITLE     PML-RARalpha enhances constitutive autophagic activity through
            inhibiting the Akt/mTOR pathway
  JOURNAL   Autophagy 7 (10), 1132-1144 (2011)
   PUBMED   21673516
  REMARK    GeneRIF: autophagy contributes to the anti-apoptotic function of
            the PML-RARalpha protein through inhibiting the Akt/mTOR pathway
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Chan,I.T., Kutok,J.L., Williams,I.R., Cohen,S., Moore,S.,
            Shigematsu,H., Ley,T.J., Akashi,K., Le Beau,M.M. and Gilliland,D.G.
  TITLE     Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute
            promyelocytic leukemia-like disease
  JOURNAL   Blood 108 (5), 1708-1715 (2006)
   PUBMED   16675706
  REMARK    GeneRIF: Transgenic mice expressing PML-RAR alpha develop acute
            promyelocytic leukemia with long latency, low penetrance, and
            acquired cytogenetic abnormalities.
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Clemens,R.A., Newbrough,S.A., Chung,E.Y., Gheith,S., Singer,A.L.,
            Koretzky,G.A. and Peterson,E.J.
  TITLE     PRAM-1 is required for optimal integrin-dependent neutrophil
            function
  JOURNAL   Mol Cell Biol 24 (24), 10923-10932 (2004)
   PUBMED   15572693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY195251.1, AY665714.1 and BE987906.1.
            
            On Aug 5, 2009 this sequence version replaced NM_001002842.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY665714.1, BC141100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BY195251.1         1-84
            85-1728             AY665714.1         1-1644
            1729-1777           BE987906.1         192-240
            1778-2290           AY665714.1         1694-2206
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2290
                     /gene="Pram1"
                     /note="PML-RAR alpha-regulated adaptor molecule 1"
                     /db_xref="GeneID:378460"
                     /db_xref="MGI:MGI:3576625"
     exon            1..122
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1575
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1642
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1719
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1777
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1883
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2046
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2080
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2115
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2278
                     /gene="Pram1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pram1"
                     /note="hexamer: TATAAA"
     polyA_site      2278
                     /gene="Pram1"
                     /note="major polyA site"
ORIGIN      
        1 agcccaacag ctccgacttg gtgtgtcagc ccgtggagca gaaaccacac ttaacttcct
       61 caaggcagaa gcctaagctc agagctcatt caccctgtgg ttcatcatcc cctgaagcca
      121 tggggagcaa tcaggacttc cgaaacctcc aagctaagtt ccaaacctct cagccagaac
      181 ttggagaact gttcagaaaa accccaaagc ctgagttaaa caaagtcctg aagaaatttc
      241 cacagactga gttaagtgag cagcccaaga agtcctcaca gtctgagctc agtgcagtgt
      301 ctttgaaacc actgcagctg cagtttgcag acctccccag gaagccccca cagcctggag
      361 ttcttaaaaa gtcaccacag cctgagttcc ctcatctagc caacaagcct gtacaggctg
      421 aattcccaag gaagcctcta catccagagt tcacaggtct caaaaagcct tcccaggctg
      481 agttcacaga tctcaagaag cccccacagc cccagtttgc cagcctcccc aagaagcccc
      541 caaaacctga gtttggagag ctctccaaga gacctccaca gcttgagaca ccccaggagc
      601 ctagtgctcc tcctgcccag aagctcctga agcccgagcc taacaatcct gccaggcctc
      661 taggagagct caaacccaag atgttttggc accttgaggc caatgaggca cctaagaggc
      721 ccttgccatc tgaatccagt acttttccca agaagccact gcagcctgag gctgttgttg
      781 gtttctctag gaagtcccag ccacagtcag agtccatcga agtttctcag acatccccct
      841 ctaagtgtgg gtccagggag cttgactctc actccccaca gcctgacatc agtacctttc
      901 ctaagaacaa tgagaacttt aggaaacctt catatcctca agccactggt tgccccaagt
      961 ccccaaagca gcccatgttc tatgagttcc cccagacacc ccctcggaag cctgagtcat
     1021 gtaaccccca gtctcactcc ccgctgccag acttcaatgc attccctaag aagcatccac
     1081 agctccagcc aagtgacctt accagggcat cctcggagcc tgaagtctgc aaggttccca
     1141 aaaagactca gaagccagac cccaatgtgc tttctcagaa gccctcacag ccagaattgg
     1201 gtcacctccc tagaacatcc tcggaccccg agttcaactc gctcccgagg aagtttctgc
     1261 agcctcaaca cggcaagttc ttccagcctg agttccccaa gggtctgcct agaaagccca
     1321 agcttcctgg ttcagtgtct gaatgctccc tgccctctgc tagtgcgggc tccagccccc
     1381 agtgccctct cagccctggg cttatagtcc ctgggatacc ccgctggaga tcagaagact
     1441 tccaagtcca gcgcccaccc cgacggcggc ccctgccctc agccagcagc ctgggacacc
     1501 ccccagccaa gcccgcacta ccacctggcc ccatcaatat ccaaagcttc aggagagccg
     1561 cagcaacagc cgcagcggta ctgaagacag gctcttctac tgggacccac ttccaagctc
     1621 aacaacctca acatattgca cagaacccgg atgagatcta cgaactgtat gatgctgtgg
     1681 aggccacaga tgactctagt atcagcccca gaggcagaga tgaaatgctg tctacccagc
     1741 aagccaccag atggcctcaa caggagccag agctcaggaa gaaggccact cagccacagc
     1801 agctgccagc tacagacccc aagctgctga aacagatcag gaaggcagaa aaggctgaga
     1861 gagagtttag aaagaagttt aagtttgaag gtgagattgt gattcacacg aagatgatga
     1921 ttgaccccaa tgccaagacc cggcgtgggg gtggcaagca cctgggcatc cggcgtggag
     1981 agatcctaga ggtgatcgag ttcactagca aggatgagat gctctgccgg gaccccaagg
     2041 gcaagtatgg ctatgtgccc agaactgcac tgttgccctt ggaaacagag gtatatgatg
     2101 acgtcagctt tggggaccct ctggacatgc aaccatttcc tcggtgacag tatggaacag
     2161 cagataagtg ggttccagga ccaacagtcc agctactgct cactcaggag cccgggatcc
     2221 cagcctggca aacagacacc caaaggcatg tgcttatata aaactcctct ttaaaataaa
     2281 aaaaaaaaaa
//
