LOCUS       NM_001252529            1119 bp    mRNA    linear   ROD 10-MAY-2023
DEFINITION  Mus musculus polyglutamine binding protein 1 (Pqbp1), transcript
            variant 3, mRNA.
ACCESSION   NM_001252529
VERSION     NM_001252529.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Liu W, Xie H, Liu X, Xu S, Cheng S, Wang Z, Xie T, Zhang ZC and Han
            J.
  TITLE     PQBP1 regulates striatum development through balancing striatal
            progenitor proliferation and differentiation
  JOURNAL   Cell Rep 42 (3), 112277 (2023)
   PUBMED   36943865
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X,
            Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M and Okazawa H.
  TITLE     Tau activates microglia via the PQBP1-cGAS-STING pathway to promote
            brain inflammation
  JOURNAL   Nat Commun 12 (1), 6565 (2021)
   PUBMED   34782623
  REMARK    GeneRIF: Tau activates microglia via the PQBP1-cGAS-STING pathway
            to promote brain inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Shen Y, Zhang ZC, Cheng S, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia
            Z, Xie W and Han J.
  TITLE     PQBP1 promotes translational elongation and regulates hippocampal
            mGluR-LTD by suppressing eEF2 phosphorylation
  JOURNAL   Mol Cell 81 (7), 1425-1438 (2021)
   PUBMED   33662272
  REMARK    GeneRIF: PQBP1 promotes translational elongation and regulates
            hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Yang SS, Ishida T, Fujita K, Nakai Y, Ono T and Okazawa H.
  TITLE     PQBP1, an intellectual disability causative gene, affects bone
            development and growth
  JOURNAL   Biochem Biophys Res Commun 523 (4), 894-899 (2020)
   PUBMED   31959475
  REMARK    GeneRIF: PQBP1, an intellectual disability causative gene, affects
            bone development and growth.
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S,
            Saito T, Saido T, Muramatsu SI, Fujita K and Okazawa H.
  TITLE     The intellectual disability gene PQBP1 rescues Alzheimer's disease
            pathology
  JOURNAL   Mol Psychiatry 23 (10), 2090-2110 (2018)
   PUBMED   30283027
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Waragai M, Junn E, Kajikawa M, Takeuchi S, Kanazawa I, Shibata M,
            Mouradian MM and Okazawa H.
  TITLE     PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract,
            interacts with U5-15kD/dim1p via the carboxyl-terminal domain
  JOURNAL   Biochem Biophys Res Commun 273 (2), 592-595 (2000)
   PUBMED   10873650
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Means GD, Toy DY, Baum PR and Derry JM.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Derry JM, Gormally E, Means GD, Zhao W, Meindl A, Kelley RI, Boyd Y
            and Herman GE.
  TITLE     Mutations in a delta 8-delta 7 sterol isomerase in the tattered
            mouse and X-linked dominant chondrodysplasia punctata.
            jderry@immunex.com
  JOURNAL   Nat Genet 22 (3), 286-290 (1999)
   PUBMED   10391218
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa
            I, Kawabata M, Mouradian MM and Okazawa H.
  TITLE     PQBP-1, a novel polyglutamine tract-binding protein, inhibits
            transcription activation by Brn-2 and affects cell survival
  JOURNAL   Hum Mol Genet 8 (6), 977-987 (1999)
   PUBMED   10332029
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Imafuku I, Waragai M, Takeuchi S, Kanazawa I, Kawabata M, Mouradian
            MM and Okazawa H.
  TITLE     Polar amino acid-rich sequences bind to polyglutamine tracts
  JOURNAL   Biochem Biophys Res Commun 253 (1), 16-20 (1998)
   PUBMED   9875212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ550428.1, AK077652.1 and AW488646.1.
            
            [WARNING] On Dec 7, 2023 this sequence was replaced by
            NM_001252529.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            initiates translation at an upstream, in-frame start codon,
            compared to variant 1. The encoded isoform (2) is longer and has a
            distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051673.1, AK077652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BQ550428.1         6-48
            44-1005             AK077652.1         3-964
            1006-1119           AW488646.1         1-114               c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.56 cM"
     gene            1..1119
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /note="polyglutamine binding protein 1"
                     /db_xref="GeneID:54633"
                     /db_xref="MGI:MGI:1859638"
     exon            1..101
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..912
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     polyglutamine tract-binding protein 1; 38 kDa nuclear
                     protein containing a WW domain; scurfy candidate 2"
                     /codon_start=1
                     /product="polyglutamine-binding protein 1 isoform 2"
                     /protein_id="NP_001239458.1"
                     /db_xref="GeneID:54633"
                     /db_xref="MGI:MGI:1859638"
                     /translation="MRPVNCTWGESRSLLCFKPRALRCWSGQLPTMPLPVALQTRLAK
                     RGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETD
                     LVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHE
                     KADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPK
                     NKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPS
                     PGAVLRANAEASRTKQQD"
     exon            102..187
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..299
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..412
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..691
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..755
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1104
                     /gene="Pqbp1"
                     /gene_synonym="npw38; PQBP-1; Sfc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacatccg ttccatgtaa gcgtcggatg cgaccagtta attgcacctg gggagagtcg
       61 aggagcctgt tgtgctttaa accaagagcc cttcggtgtt ggtctggtca gctacccact
      121 atgccgcttc ctgttgcgct gcagacccgc ttggcgaaga ggggcatcct caaacatctg
      181 gagccggagc cagaggaaga gattattgct gaagactacg atgatgatcc tgttgactat
      241 gaggccaccc ggatagaggg tctgccaccg agctggtaca aggtgtttga cccttcttgc
      301 ggactccctt actattggaa tgtggagaca gaccttgtgt cgtggctctc accacatgat
      361 cctaactttg tcgttaccaa atccgccaag aaagtcagga acaataatgc agatgctgag
      421 gacaagtcgg accggaatct tgaaaaggtg gacagaaatc atgagaagtc agatcgtagt
      481 catgagaagc cagacaggag ccacgagaag gcagaccgaa accacgagaa gaatgacaga
      541 gaacgagagc gcaactacga caaagtggat agagagagag atcgggacag ggaacgagag
      601 cgggcatttg acaaggcaga ccgggaagag ggcaaagacc gacgccacca tcgcagagag
      661 gaactggctc cttaccccaa gaacaagaaa gcgacgagcc gcaaagatga agaattagac
      721 cccatggacc ccagctcata ctcagatgca ccccggggca catggtcaac aggactcccc
      781 aagaggaacg aggccaagac aggtgctgac accacggcag ctgggcccct cttccagcag
      841 cgcccttacc cttccccggg cgctgtgctc cgcgccaatg cagaagcctc ccgaaccaaa
      901 cagcaggact gactgacccc ttgttccctg tagctttggc agtttgcgtt tctgtgtttc
      961 ttccttgtgg ctctgggaca ggagccatgg cttctatgtg ctgcattatt attccaccag
     1021 tgagctacac tcccggcccc tttagtgttg tttgtaaaca acaagccctt gttgtttaat
     1081 aaaagctttt tttgtggaac atataaaaaa aaaaaaaaa
//
