LOCUS       NM_177242               4611 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus PTC7 protein phosphatase homolog (Pptc7), mRNA.
ACCESSION   NM_177242
VERSION     NM_177242.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4611)
  AUTHORS   Niemi,N.M., Serrano,L.R., Muehlbauer,L.K., Balnis,C.E., Wei,L.,
            Smith,A.J., Kozul,K.L., Forny,M., Connor,O.M., Rashan,E.H.,
            Shishkova,E., Schueler,K.L., Keller,M.P., Attie,A.D.,
            Friedman,J.R., Pagan,J.K., Coon,J.J. and Pagliarini,D.J.
  TITLE     PPTC7 maintains mitochondrial protein content by suppressing
            receptor-mediated mitophagy
  JOURNAL   Nat Commun 14 (1), 6431 (2023)
   PUBMED   37833277
  REMARK    GeneRIF: PPTC7 maintains mitochondrial protein content by
            suppressing receptor-mediated mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4611)
  AUTHORS   Niemi,N.M., Wilson,G.M., Overmyer,K.A., Vogtle,F.N., Myketin,L.,
            Lohman,D.C., Schueler,K.L., Attie,A.D., Meisinger,C., Coon,J.J. and
            Pagliarini,D.J.
  TITLE     Pptc7 is an essential phosphatase for promoting mammalian
            mitochondrial metabolism and biogenesis
  JOURNAL   Nat Commun 10 (1), 3197 (2019)
   PUBMED   31324765
  REMARK    GeneRIF: Pptc7 is an essential phosphatase for promoting mammalian
            mitochondrial metabolism and biogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4611)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4611)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4611)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC127266.4 and
            AC093473.6.
            
            On Nov 17, 2006 this sequence version replaced NM_177242.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068149.1, AK135118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AC127266.4         1868-2379           c
            513-692             AC093473.6         45562-45741         c
            693-891             AC093473.6         40079-40277         c
            892-1015            AC093473.6         36638-36761         c
            1016-1145           AC093473.6         34029-34158         c
            1146-4611           AC093473.6         29591-33056         c
FEATURES             Location/Qualifiers
     source          1..4611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.28 cM"
     gene            1..4611
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /note="PTC7 protein phosphatase homolog"
                     /db_xref="GeneID:320717"
                     /db_xref="MGI:MGI:2444593"
     exon            1..512
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1204
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /EC_number="3.1.3.16"
                     /note="T-cell activation protein phosphatase 2C"
                     /codon_start=1
                     /product="protein phosphatase PTC7 homolog"
                     /protein_id="NP_796216.2"
                     /db_xref="CCDS:CCDS39255.1"
                     /db_xref="GeneID:320717"
                     /db_xref="MGI:MGI:2444593"
                     /translation="MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGGGGSSGDYGLVT
                     AGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGT
                     LMRTCERLVKEGRFVPSNPVGILTTSYCELLQNKVPLLGSSTACIVVLDRSSHRLHTA
                     NLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDV
                     QLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQRTARSIAEQAHELAYDPNYM
                     SPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD"
     exon            513..692
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            693..891
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1015
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1145
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..4611
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /note="hexamer: AATAAA"
     polyA_site      4611
                     /gene="Pptc7"
                     /gene_synonym="9130017A15Rik; TA-PP2C"
                     /note="major polyA site"
ORIGIN      
        1 cggaagatgg cggcggcggc ggcggctgca gccgggaccc cagtgtggtt gaggcggagg
       61 agccgccggc tctgacctcg ctctggctcc agtgcgtgcg gtagagcgtg tgcgaggccc
      121 cgtgcggcgg gcaggggcgg cagtggccag tgcgcgccgc cctgaggaac gccccggcgg
      181 cgcggctgcg gcggaggaga gagccggctc cgggcctcgg cgtcctccgg cgccccgggc
      241 cccgcgcctc ctcggggggg cggcggcggc gatgttctcg gtcttgtcgt atggacgcct
      301 ggtggcccgt gccgtgctcg gcggcctgtc gcagaccgac cccagggcgg gcggcggcgg
      361 cggcggcggt ggtggcagca gcggcgacta cgggttggtg acggcgggct gcggcttcgg
      421 caaggacttc cgtaagggcc tgctcaagaa gggcgcgtgc tacggggacg acgcgtgttt
      481 cgtggcccgc caccgctcgg ccgacgtcct gggagttgcg gatggcgtcg gagggtggag
      541 agactatgga gtggacccat ctcagttctc agggacttta atgcgaacat gcgagcggtt
      601 agtgaaagaa ggacgctttg tccccagcaa tcctgttggg attctcacca cgagctactg
      661 tgagttgctg caaaacaaag ttcctttgct gggtagcagc acagcctgca tcgtggtgct
      721 ggacagaagt agccaccgct tgcacacagc gaacctgggt gactcgggct tcctggtggt
      781 ccggggcggc gaggttgtgc accggtctga cgagcagcag cactacttca acactccatt
      841 ccagctctcc atcgcccctc ctgaggccga gggggttgtc ctgagcgaca gcccagacgc
      901 tgctgatagc acatctttcg atgtccagtt aggagatatc atcctgacag caacagatgg
      961 gctctttgac aacatgcctg attacatgat cctccaggag ctgaaaaaac tgaagaattc
     1021 aaattatgag agtatacagc ggactgcaag aagcattgct gagcaagcgc atgagctggc
     1081 ctatgaccca aattatatgt caccttttgc acagtttgca tgtgacaatg gattaaatgt
     1141 gagaggtgga aagccagatg acatcaccgt cctcctctca atagtggctg agtacacgga
     1201 ctgatgggcc acactggtga ctcctgcctt tcccctgtct cccgacttct ccctgccaca
     1261 tgtgctgatc ctgctggcag gaccacattt ctttgccact gatctcagtg gccaatgatg
     1321 gatgctctgg cccatgtttg agacccatca agatccttgt tgagaaccac tgctgtcacc
     1381 cgctagcccg tacccactgg tgacccactg agagaaaaag cgaggtgacc tctcccttct
     1441 cctggaggtt ttcaaagtct tttacttttc aaaagcagtt gaagttttga aaagaagtaa
     1501 tgttggtaaa gtgaactcaa aatgtcagtg tgttaaaggg atgttaacat tcaacaagta
     1561 gtaaatagcg gcacctcggc caaaaaacac gcggatcatc ccaggagaag ccctgtgtcc
     1621 cccaggcgca ggctctgcga ggactgctgg ggctttgtgt tttctgtttg ccaggagccc
     1681 acagtcctgc tctatcctgt gctgggtcat gacatcccaa ccccagcagc ggacggtttt
     1741 ggtcacaaat tggaagaaaa tttttgttct atggatgcag atattttgtg ctttttaaaa
     1801 gatgcttaat tgtgcccctg tgactgcagc tgtggcagtc tgttgatttg tccaggtcac
     1861 aggctagagg cctggcccac aggagaggga caggggaagg agactcctta ccaaaatcta
     1921 gtaatggaaa taccacgcaa aatttcagaa ctcctcaaag cctgggaatc aaatgctgta
     1981 gctgaagtcg tccgtgctgc ctgtaagatg ccacgggcct tccagggcta gagtgtgcag
     2041 ctgcagcttg ggatggggtt ggctgtggac agcctgctcc ttccctcagg agcctcccac
     2101 ccttagagca tgccccacct gcgctgtgtc ctcaaggtga tggtgtggtg gctgcagctc
     2161 ccagagccca caggaaagct agtggtgacc tgacattcac agtgaccgca gctgagtgtg
     2221 gggccctgag tccagcttaa tgtttacagt tccaatagcc atttgcagta ggtaacgttc
     2281 cttctcagat ttccccatta cctgcgagcg caaacttatt tttaaggttt atgtacaatt
     2341 gactgctgta aagatatata tatatttttg ggtccgttct tttccttcat taacttggtg
     2401 gtagaaaagc cgtatatact tagaaaccct taagttaaag ccgtgtttct gtgcaagtca
     2461 gatgacgctg gtgtgaagat ggtgtgagca gccgtgcagc ccttcctctg caggagacac
     2521 tggctccctg gttactgcat tgaacttgtg tttgaggtta cctcaacttg tttttaaaag
     2581 gttttgtctg tctgtgcgtt tgtatatttg agtagctgtc tctgttttat ttaaactgtt
     2641 taccatgtac catgtacatg tcagtgctct cagtgcatca tgcttgtaac aggcattcat
     2701 tcatgagaat gagttactca tttgtaagct cttcagtaat ttatctacta ttcctaaatt
     2761 ggcataatgt tagattccta ttttgaatca cctttaatta catgtcagaa tgccttaact
     2821 cccctaacct gacaacactg agttagttct ctggtatgga gggagactgg ataaggagat
     2881 gtcgcactct gttgatcctg gggcgtgagg ggcacgtggt gggtatttat tttgcacaaa
     2941 ctctttgcag tgtctgtgtt taaaacagta aggttgcatc cagatggggt gtgtgactct
     3001 aggactgagg acttcagctc ttctgtgtgg tttgtaatta gttcttggtc agaggtgttg
     3061 tagccttaca atctggatat attttgcatt aattttccaa tgccgacatt taattcctgc
     3121 taagagcaga gctggtcaag tcactggctt ttttctgctc tcatttagcc catcaaccaa
     3181 tgtttgtaaa agtagattgg tgtgttttat acaacttact tttagtcaac tcacttttct
     3241 gagcagtgat tgtaagaaac agacaggcag tatggctgtt ctagtaaact gaaaaccacg
     3301 aggcagacgt caggattcag tgacagttcc tcaggcctgg cgtgtggact ggtgacatcg
     3361 tatattccat ttgcttctcc ctgtcctttt tgttacacac ttaattttat aactgtcgag
     3421 aggtcaggca gagcaaacgc tgctcacact cactgaggcc aggggctcca tcacacaccc
     3481 ctcgccaggt ctgatctgga acctggtgtg cgcgtgagtt gtattttaaa tcaagcaatg
     3541 taagcactca tatttgtctc acagagtgaa cttttataac aaaagagaaa atttgggttt
     3601 taatttacaa atggcaaatt atttatccct ctggatgcac caaagaccag taaagtttat
     3661 agcttttcca tctatattta taaagcaata ctgtattata aaaaaatcac tatttttatc
     3721 acatgcttga aatttttatt ttgttctgtt ttaaaaatgt gcactctaaa catatcagaa
     3781 ccttatttct tcctatgaac ttaagctgcc tgcgcacaaa aagtataaaa ttatcaagtg
     3841 gagatgaagt agctagagtc ttacaaacag agagaagtga ggggaacaag tcatgtatcc
     3901 cgagttatct gtgtgcttgg ctactcactc acagagaatt cattccaggt atgtgtctgg
     3961 gttgggctgg gtctggagag actgggtata agctccaagg caggagagtg ccctccaccg
     4021 ctgccgctgc cgctgccttt gttctggata gagtagccag cagatggaaa cagggcagga
     4081 gtggtttgga ggcggctggc gggattggcg agattggctg aagctgtgcg tgtctgagta
     4141 ggttcatggc tctgtgtcac tgtacagcag ctctctttgg caaagttgta acactcactt
     4201 tcttggaaat tgtcacagtt ttacatttaa aaaaatttgc aatagcaaaa aaaaaaaaaa
     4261 aaaaaaaaag aaaagaaaaa cataaaacaa cataatatga aacagaagac atttggattc
     4321 tatttctttc aaaaaagtaa atttatcaca aaattgaact tctcaataaa gcagtgtcca
     4381 tgtcaaaaca taactgttag taggtagtct gtggcaacga tgagtaaatg acgaagcaag
     4441 tctgagtctg tgtgtactga tgcgctgcct tttctgttga gactatcatc gtgcgtccta
     4501 ccagaggcaa tgacccgaat cgatgttgga aatataactt atgcaggaat agttctgtaa
     4561 atacatttaa ataaactgta aagatattta ataaatatag tatttatact a
//
