LOCUS       NM_001302396            1710 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus palmitoyl-protein thioesterase 2 (Ppt2), transcript
            variant 5, mRNA.
ACCESSION   NM_001302396 XM_006524635 XM_006525418 XM_006536665 XM_006537396
VERSION     NM_001302396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1710)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1710)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1710)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1710)
  AUTHORS   Cho,S.K., Gao,N., Pearce,D.A., Lehrman,M.A. and Hofmann,S.L.
  TITLE     Characterization of lipid-linked oligosaccharide accumulation in
            mouse models of Batten disease
  JOURNAL   Glycobiology 15 (6), 637-648 (2005)
   PUBMED   15647513
REFERENCE   5  (bases 1 to 1710)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   6  (bases 1 to 1710)
  AUTHORS   Gupta,P., Soyombo,A.A., Shelton,J.M., Wilkofsky,I.G.,
            Wisniewski,K.E., Richardson,J.A. and Hofmann,S.L.
  TITLE     Disruption of PPT2 in mice causes an unusual lysosomal storage
            disorder with neurovisceral features
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12325-12330 (2003)
   PUBMED   14528005
  REMARK    GeneRIF: PPT2 deficiency in mice causes an unusual form of neuronal
            ceroid lipofuscinosis with striking visceral manifestations. All
            PPT2-deficient mice displayed a neurodegenerative phenotype with
            spasticity and ataxia by 15 mo.
REFERENCE   7  (bases 1 to 1710)
  AUTHORS   Gupta,P., Soyombo,A.A., Atashband,A., Wisniewski,K.E.,
            Shelton,J.M., Richardson,J.A., Hammer,R.E. and Hofmann,S.L.
  TITLE     Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in
            knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13566-13571 (2001)
   PUBMED   11717424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX202053.1, CX217389.1, CT009767.6, CX201936.1 and CO044617.1.
            
            On or before Oct 22, 2014 this sequence version replaced
            XM_006537396.1, XM_006524635.1, XM_006525418.1, XM_006536665.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All the variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2179339.1,
                                           SRR7652917.958308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CX202053.1         1-48
            49-720              CX217389.1         1-672
            721-793             CX217389.1         674-746
            794-852             CX217389.1         748-806
            853-853             CT009767.6         175122-175122       c
            854-875             CX217389.1         807-828
            876-1140            CX201936.1         345-609
            1141-1166           CX201936.1         611-636
            1167-1709           CO044617.1         18-560              c
            1710-1710           CT009767.6         174089-174089       c
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.19 cM"
     gene            1..1710
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /note="palmitoyl-protein thioesterase 2"
                     /db_xref="GeneID:54397"
                     /db_xref="MGI:MGI:1860075"
     exon            1..111
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            112..302
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1028
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /EC_number="3.1.2.22"
                     /note="lysosomal thioesterase PPT2"
                     /codon_start=1
                     /product="lysosomal thioesterase PPT2 precursor"
                     /protein_id="NP_001289325.1"
                     /db_xref="CCDS:CCDS28652.1"
                     /db_xref="GeneID:54397"
                     /db_xref="MGI:MGI:1860075"
                     /translation="MPGLWRQRLPSAWALLLLPFLPLLMPAAPAAHRGSYKPVIVVHG
                     LFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAP
                     EGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSN
                     LYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVG
                     RLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRC
                     PMAGISHTTWHSNRTLYDTCIEPWLS"
     exon            303..456
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            457..552
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            553..660
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..744
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..829
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..884
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1710
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="Ppt2"
                     /gene_synonym="0610007M19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtccgtcatc ccactgcgcg ctctccttgt ccccctatcc ccgtatccgg tggattacag
       61 actaggtaca agtaaacagc tggcggaacg aagcctccag acacagacca ggtgggagca
      121 tgccggggct atggaggcag aggcttcctt cggcttgggc tttgcttctc ctgccgttcc
      181 tgccgctgct gatgcccgca gcccccgcag cccaccgcgg gtcctacaag cccgtgatcg
      241 tggtgcacgg gctctttgac agttcataca gcttccgcca cctgctggac tatatcaatg
      301 agacacacac cgggactgtg gtgacagtgc ttgatctctt cgatggcaga gagagtttgc
      361 ggcccctgtg ggaacaggta caagggttcc gagaggctgt ggtccccatc atggaaaagg
      421 cccctgaagg agtgcacctc atctgctact cccagggggg cctggtgtgc cgtgctttgc
      481 tgtctgtcat ggataaccac aatgtggact ctttcatctc cctctcctcc ccacagatgg
      541 gccagtatgg agacacggac tatttgaaat ggctcttccc cacgtccatg cggtctaacc
      601 tctatcgggt ctgctatagt ccttggggcc aggaattttc catttgcaac tactggcacg
      661 atcctcacca cgatgacttg tacctcaatg ccagcagctt tctggccctc atcaatgggg
      721 aaagagacca tcccaatgcc actgcatggc ggaagaactt ccttcgcgtg ggccgtctgg
      781 tgctgattgg gggtcctgat gatggcgtta tcactccctg gcaatctagc ttctttggtt
      841 tctatgatgc caatgagaca gttctggaga tggaggagca gccggtgtat cttcgagatt
      901 cttttgggtt gaagactctc ctggcccggg gggccatagt gaggtgtccc atggctggca
      961 tctctcacac cacgtggcac tctaaccgta cgctctacga tacttgcatt gagccgtggc
     1021 tctcctgaag atgtcctcag tggtctccag gaattcccca gcccagagat caagcggtgg
     1081 ccttgggaag cagatgccag gctctggcat gcctgcaacc atcttgtcat tcccacactg
     1141 cccgaccccc accagggctc ccctcccccc tccccccctg ctcctctgtg aatgacaagt
     1201 cctggtcccc tacctcatgt cctcacttgg ggacgcctcc acgctctccc tttctgccac
     1261 ggctgaggtt gggaagcaag tgccaggttt ttaactgtgg cttcaccgct gctgttgctt
     1321 ctccgggtct ggctgtatcg gaggagaacc cagcccctgc ccacctcagg ggtcttcttc
     1381 caggccactc aggacatttt tagcttctgt tatccccgtt tccctctttt ctcaacttcc
     1441 ctgtggctag cctccccacc aagaggggca cccataagag ggggtgttct gaggctcccc
     1501 tatggggaca attccacttt tgaagtgtca gtgttgggga atatctgtgg cctgcaaggc
     1561 ccatctcagg tttggggatc ccccagtccc tatgatcagt gttggggtat cccctgggag
     1621 cctaggttct ttgaggcccc agcccctctt ttaactaccc ttgagtgggt ggtccctgta
     1681 tttatagaaa taaaagatcc atttcctcag
//
