LOCUS       NM_172894               3812 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 6, regulatory subunit 1 (Ppp6r1),
            mRNA.
ACCESSION   NM_172894
VERSION     NM_172894.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3812)
  AUTHORS   Dziegielewski,J., Bonkowska,M.A., Poniecka,E.A., Heo,J., Du,K.,
            Crittenden,R.B., Bender,T.P., Brautigan,D.L. and Larner,J.M.
  TITLE     Deletion of the SAPS1 subunit of protein phosphatase 6 in mice
            increases radiosensitivity and impairs the cellular DNA damage
            response
  JOURNAL   DNA Repair (Amst) 85, 102737 (2020)
   PUBMED   31751917
  REMARK    GeneRIF: Deletion of the SAPS1 subunit of protein phosphatase 6 in
            mice increases radiosensitivity and impairs the cellular DNA damage
            response.
REFERENCE   2  (bases 1 to 3812)
  AUTHORS   Stefansson,B. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 subunit with conserved Sit4-associated
            protein domain targets IkappaBepsilon
  JOURNAL   J Biol Chem 281 (32), 22624-22634 (2006)
   PUBMED   16769727
REFERENCE   3  (bases 1 to 3812)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053076.1.
            
            On Sep 9, 2003 this sequence version replaced NM_172894.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053076.1, SRR11927932.2464788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.68 cM"
     gene            1..3812
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /note="protein phosphatase 6, regulatory subunit 1"
                     /db_xref="GeneID:243819"
                     /db_xref="MGI:MGI:2442163"
     exon            1..470
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..703
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..3047
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /note="SAPS domain family, member 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 1"
                     /protein_id="NP_766482.2"
                     /db_xref="CCDS:CCDS39737.1"
                     /db_xref="GeneID:243819"
                     /db_xref="MGI:MGI:2442163"
                     /translation="MFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNRKL
                     LDFLLQPSHLQAMVAWVTQEPPASGEERLRYKYPSVACEILTSDVPQINDALGADESL
                     LNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTS
                     AIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDI
                     IRLSREQMIQGQDSPEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLL
                     EPRRPRSDSVTMNNFFSSVDGQLELLAQGALDDALSSMGALHALRPRLDRFHQLLLEP
                     PKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSANAAALTQELLVLDVPNTLLDLFFH
                     YVFNNFLHAQVEVCVSAMLSSGPPPDSSSETPVPNPIVKHLLQHCRLVERILASWEEN
                     DRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSG
                     PLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFI
                     DHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEE
                     EEEEEGQGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEDEEEDEEEDEG
                     AEQAACGRTSPSSFPSPSTQPPGPSWTATFDTVPMDAPTGPPVSKEADMSSIQIPSSP
                     PAHGSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSSL
                     DSATRDPSTSVPDFKAHQSPQTMEGKRSPEHLGLPQSQSALEMPNGSTPGGPISSGSQ
                     "
     exon            704..890
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1028
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1094
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1207
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1321
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1484
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1637
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1772
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1837
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1953
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2039
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2129
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2227
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2285
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2458
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2589
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2722
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2793
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2875
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2986
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3043
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3793
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3772..3777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /note="hexamer: AATAAA"
     polyA_site      3793
                     /gene="Ppp6r1"
                     /gene_synonym="2010309P17Rik; B430201G11Rik;
                     D030074N20Rik; mKIAA1115; Pp6r1; Saps1"
                     /note="major polyA site"
ORIGIN      
        1 cggctggggc cggggagacc cagccgcttc gggtgacagt aaagccgagg ggacgggcgt
       61 cggctctcgg tgcaattctg cacccgtcgg gctgcggagg cttctttttc ctgtcccgcg
      121 ggtgccggcg tgtcagtgtg taacccgcgg cgacttcccc cgtcgccctg cttcggaggc
      181 gcctgcgcgg gcctcgcgtc ggccacggag ctctgcggtg gaacgagtgc gcctactttt
      241 tcgcgacgac ccgaactcgt cgaagctcgg tggtgaggca ggggattccc tgtgactgga
      301 gggcgcttgc gcgggttcgc gagctccggc ccgggcgcct gcgcgagccc accggcgccg
      361 cccccgcccc tcttagccgg cccctcgaca gggccggagc cgccggcggc ggggcggcag
      421 gggcgccccg atgagccccg agtgcgagga gccgccgccc ccccgcgcag ggcgccatgt
      481 tttggaagtt tgatctgcac acaagctctc acctggacac actgctggag aaggaggacc
      541 tgagcctgcc tgagctgctg gatgaggagg atgtgctgca ggagtgcaag gtggtcaatc
      601 ggaagctcct agacttcctg ctacagccgt cccacctgca ggccatggtg gcctgggtta
      661 cccaggagcc cccagccagt ggggaggagc ggctacgcta caagtaccct agtgtagcct
      721 gtgaaatcct gacctctgat gtgccccaga tcaacgatgc cctgggtgca gatgagtccc
      781 tcctgaaccg actctatggc ttcctgcaga gtggtgacag cctcaacccg ctgcttgcta
      841 gctttttcag caaagtcatg ggcattctta tcaatcgcaa gacagaccag cttgtgtcct
      901 tcctgcgcaa gaaagatgac tttgtggacc tgttgctgcg gcacattggt acctcagcca
      961 tcatggatct cctgttgcgt ctgctgactt gtgtggagcg gcctcagctg cggcaggatg
     1021 tcttcaattg gctcaacgaa gagaagattg tccagcggct aattgagcag attcacccat
     1081 caaaggatga caatcaacat tccaatgcat ctcagtccct gtgtgacatc atccgcctaa
     1141 gccgcgagca gatgatccaa ggccaggaca gcccggagcc agaccagctg ttggccacct
     1201 tggagaagca ggagaccatc gagcagctcc tcagtaacat gtttgaggga gagcagtgcc
     1261 agtctgtcat tgtcagtggg atccaggtgt tgctcaccct cctggaacct aggaggccaa
     1321 ggtctgactc tgtgaccatg aacaacttct ttagcagtgt ggatgggcag ttggagctcc
     1381 tggctcaggg agccctggat gatgcactgt ctagtatggg tgccttgcat gccctgcgtc
     1441 cccggcttga tcgcttccat cagctcctgc ttgagcctcc caagctggag cctctgcaga
     1501 tgacgtgggg cagtctggcg ccaccactgg gtaacacgag gttacacgtg gtcaagctcc
     1561 tggccagtgc cctgagtgcc aacgccgctg ccttgacgca ggagcttttg gtgctggatg
     1621 tgcccaacac cttactggac ctcttcttcc actatgtatt caacaacttc ctgcatgctc
     1681 aagtggaagt gtgtgtgagc gcaatgctga gttccgggcc ccctccagac agcagctctg
     1741 agacacctgt cccaaaccct atcgtgaaac atctccttca gcactgccgc ctggtggagc
     1801 gcattctggc atcctgggag gagaacgacc gtgtgcagtc tggagggggc ccaaggaaag
     1861 gctacatggg ccacctgact cgggtggcca atgctgtggt gcagaatgca gaacaggggc
     1921 ccaatgctga acaactggga caactgctaa aggagctgcc agaggagcag cagcagcgat
     1981 gggaagcatt tgtgtcagga cccctggccg agaccaacaa gaagaacaca gtggatctgg
     2041 taaacactca ccacctgcat tcttccagtg atgatgagga tgaccgcctc aaggagttca
     2101 acttccctga ggaggctgta ttgcaacagg ccttcatgga cttccagatg caacgcatga
     2161 cctcagcctt cattgaccac tttggcttta atgatgagga atttggggag caggaagaaa
     2221 gtgtgaatgc accatttgac aagactgcca acattacctt ctccctaaat gctgacgatg
     2281 aaaatcccaa tgccaacctg cttgagatat gctacaagga ccggatccag cagtttgatg
     2341 atgaggaaga agaggaagag gagggccaag gctcagcaga gtcagatgga gagtatggtg
     2401 cctggcaggg cagccagcca gtgagagcgt cccaggcaag ccagccccct ggtgtgcgga
     2461 gtggaggaag cacagacagc gaggaggagg acgaggagga ggacgaggag gaggatgagg
     2521 gggctgagca ggcagcctgt ggaagaacca gcccttcctc cttccccagc cccagcactc
     2581 agcctcctgg cccaagttgg actgctacct ttgacacagt gcctatggat gccccaacag
     2641 gtcccccagt ttctaaggag gcagacatgt cctctatcca gatcccatcc agccctccag
     2701 cccacggttc cccacagctc aggtctcagg accccacaca tccctcagca cctcaggaag
     2761 tcacagatag cagcaaagta gcagagccct tggccccctg ccaggccttg gttagtgttg
     2821 cggatgtcca ggccacactg catgggatgc gctctgcccc cagctccttg gacagtgcaa
     2881 ccagagaccc ctctacctct gtcccagact tcaaggccca ccagtctcct cagaccatgg
     2941 aggggaaaag gagcccagaa catttggggc ttccccaaag ccagagtgcc cttgagatgc
     3001 ccaatggctc taccccagga gggcctattt catcgggttc ccagtagctg cctggtgaca
     3061 gtggtggcca aatcctctgt cctccctgtg gaatccctct gtggggcagg atgagtcctt
     3121 tggtggccct ctactctatt gtcccacacc ctacattctc tcctctggac tcccaaggag
     3181 gctggtgcca gggagatgcc ctcacccacc cccatttgca ctgagaagag aaactatgga
     3241 gttttgtctc caagaataaa gatagagagt cacatagaaa ggaaagagag agagagagcg
     3301 agagagagag agaagtatat tatatattat atatatatat atatatatat atatatatat
     3361 atatatatat atatatatat atatatatat acatatacat atatatgttg agggaggagt
     3421 aagaaagaaa gccaggacaa taactgggcc agcagctctg aagcacacct tccccgtctg
     3481 tcccagtagg ggctggcgct ggggttggag gccgctggcc tgtgctctgg tgcagatgct
     3541 cttacccagc ttcactcagg accaccttgg ggtgtaacag agggtgtcat ccggcccctg
     3601 gccctgggga acatccctag aggcccagaa tgggggttgc tgggtacccc atgccctgag
     3661 ggttccagca ctgctgccaa gtggccttgt cccagctccc cctgcccccc ccaaggctgg
     3721 tgtgagtgtg caagtatgtg tgcagagctt gtgtttcata ctgcagatat aaataaagga
     3781 agatagcaga acaaaaaaaa aaaaaaaaaa aa
//
