LOCUS       NM_024209               1702 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus protein phosphatase 6, catalytic subunit (Ppp6c),
            mRNA.
ACCESSION   NM_024209
VERSION     NM_024209.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Kondo,A., Tanaka,H., Rai,S., Shima,H., Matsumura,I. and Watanabe,T.
  TITLE     Depletion of Ppp6c in hematopoietic and vascular endothelial cells
            causes embryonic lethality and decreased hematopoietic potential
  JOURNAL   Exp Hematol 133, 104205 (2024)
   PUBMED   38490577
  REMARK    GeneRIF: Depletion of Ppp6c in hematopoietic and vascular
            endothelial cells causes embryonic lethality and decreased
            hematopoietic potential.
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Ito,M., Tanuma,N., Kotani,Y., Murai,K., Kondo,A., Sumiyoshi,M.,
            Shima,H., Matsuda,S. and Watanabe,T.
  TITLE     Oncogenic K-RasG12V cannot overcome proliferation failure caused by
            loss of Ppp6c in mouse embryonic fibroblasts
  JOURNAL   FEBS Open Bio 14 (4), 545-554 (2024)
   PUBMED   38318686
  REMARK    GeneRIF: Oncogenic K-Ras[G12V] cannot overcome proliferation
            failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Matsuoka,M., Sakai,D., Shima,H. and Watanabe,T.
  TITLE     Neuron-specific loss of Ppp6c induces neonatal death and decreases
            the number of cortical neurons and interneurons
  JOURNAL   Biochem Biophys Res Commun 693, 149353 (2024)
   PUBMED   38101002
  REMARK    GeneRIF: Neuron-specific loss of Ppp6c induces neonatal death and
            decreases the number of cortical neurons and interneurons.
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Zou,Y., Zheng,Q., Jiang,B., Liu,Y., Xu,Y., Ma,L., Hu,Z., Wu,M. and
            Song,H.
  TITLE     Deficiency of PPP6C protects TNF-induced necroptosis through
            activation of TAK1
  JOURNAL   Cell Death Dis 13 (7), 618 (2022)
   PUBMED   35842423
  REMARK    GeneRIF: Deficiency of PPP6C protects TNF-induced necroptosis
            through activation of TAK1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Shen,Y., Wang,Y., Sheng,K., Fei,X., Guo,Q., Larner,J., Kong,X.,
            Qiu,Y. and Mi,J.
  TITLE     Serine/threonine protein phosphatase 6 modulates the radiation
            sensitivity of glioblastoma
  JOURNAL   Cell Death Dis 2 (12), e241 (2011)
   PUBMED   22158480
  REMARK    GeneRIF: PP6 regulates the sensitivity of GBM cells to radiation,
            and suggest small molecules disrupting or inhibiting PP6
            association with DNA-PK is a potential radiosensitizer for GBM.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Prickett,T.D. and Brautigan,D.L.
  TITLE     The alpha4 regulatory subunit exerts opposing allosteric effects on
            protein phosphatases PP6 and PP2A
  JOURNAL   J Biol Chem 281 (41), 30503-30511 (2006)
   PUBMED   16895907
  REMARK    GeneRIF: alpha4 expression differentially increased or decreased
            phosphorylation of endogenous phosphoproteins, consistent with
            opposing effects on PP2A and PP6 [PP6]
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Stefansson,B. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 subunit with conserved Sit4-associated
            protein domain targets IkappaBepsilon
  JOURNAL   J Biol Chem 281 (32), 22624-22634 (2006)
   PUBMED   16769727
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD546325.1, BY197919.1, AK002764.1, AK009104.1 and BE634938.1.
            
            On Feb 14, 2018 this sequence version replaced NM_024209.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CD546325.1         103-124
            23-50               BY197919.1         2-29
            51-1147             AK002764.1         2-1098
            1148-1568           AK009104.1         1117-1537
            1569-1702           BE634938.1         1-134               c
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.44 cM"
     gene            1..1702
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /note="protein phosphatase 6, catalytic subunit"
                     /db_xref="GeneID:67857"
                     /db_xref="MGI:MGI:1915107"
     exon            1..183
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1026
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6 catalytic
                     subunit"
                     /protein_id="NP_077171.1"
                     /db_xref="CCDS:CCDS16017.1"
                     /db_xref="GeneID:67857"
                     /db_xref="MGI:MGI:1915107"
                     /translation="MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPV
                     STPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAK
                     WPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQIL
                     CVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGA
                     KVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
                     VNTREPKLFRAVPDSERVIPPRTTTPYFL"
     exon            184..279
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     exon            280..345
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     exon            346..487
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     exon            488..567
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     exon            568..777
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1697
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /note="hexamer: AATAAA"
     polyA_site      1569
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /note="major polyA site"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="Ppp6c"
                     /gene_synonym="2310003C10Rik; Pp6C"
ORIGIN      
        1 actcacggat cggacgtgac gtaaggaggg ttccggattc ggcctccgcc gctgcctccg
       61 ctactacagc cgctgccgct gctgtcgccg cggcttgttc ttcctaaaat ggcgccgctg
      121 gatctggaca agtatgtgga gatagcgcgg cagtgcaagt accttcccga gaacgacctg
      181 aagaggctat gtgactatgt ttgtgatctg ctcttggaag agtcgaatgt tcagccagtg
      241 tcaacgccag taacagtgtg tggtgacata cacggacagt tttatgatct ttgtgaactg
      301 ttcagaactg gaggtcaggt tcctgacaca aactacatat ttatgggtga ttttgtagac
      361 agaggttact atagtttgga gaccttcact tatcttcttg cactaaaggc taagtggcct
      421 gaccgtatta cacttttaag aggaaatcat gagagtagac agataacaca ggtgtatgga
      481 ttttatgatg agtgccaaac caaatatgga aatgctaatg cctggagata ctgtaccaaa
      541 gtttttgata tgctcacagt agcagcttta atagatgagc agattttgtg tgttcatggc
      601 ggtttatctc ctgatatcaa aacactggat caaattcgaa ctattgaacg aaatcaggaa
      661 attcctcaca aaggagcatt ttgtgacttg gtgtggtcag atcctgaaga tgtggacact
      721 tgggcaatca gtcccagagg agcaggttgg ctatttggag caaaagtcac aaatgagttt
      781 gttcatatca acaacttaaa actcatctgc agagcacatc agcttgtgca cgaaggctat
      841 aagtttatgt ttgacgagaa gctggtcaca gtgtggtctg ctcctaacta ctgctatcgc
      901 tgtggaaaca ttgcttccat catggtcttc aaagatgtca atacgagaga accaaagtta
      961 ttccgagcag ttccagattc agaacgtgtt attcctccca gaaccacgac gccgtatttc
     1021 ctttgaggcc tttgccatcc cactggccca ctttttgccc tcttttaccc caactttctt
     1081 gtaccctcta caatatactt tttattgagc actttgctgc tgaaatgctg cctcttgcct
     1141 ttttttttaa ttttaaatta tctaaattta ttgtttgtta tggtgtcaat agcagtgttt
     1201 ttctatcagt tttgtcactc ctcctacccc accttggact cgtttgagaa gacttgagaa
     1261 atgtcttaat actcacattg ctgcatgtag ctcttgcttt tttgctgttc tggggagaca
     1321 ggaagcattt cttttttaaa aaagccaatt gacaatgact tggaagtcct cctcatttgt
     1381 atcagccagc cttctgtttt tgtttggtag gatttaaaaa atttcagcag caaagttgcc
     1441 cagtgggcag gatggactgc atatgcctga gtcgtgtacc cttgtcaacc cggctgtaaa
     1501 cctcactgtc ctttgttgga tgataatttg atgttttaaa agggtataaa ataaattggt
     1561 ctaaagggct gccctccttg ttgtgttttt aaattttagt taaaaactgc tacagctatg
     1621 actttgtaca ttaagataat tgtactgatc ttttttcaga aatcttgtat tttttaataa
     1681 aataatctta aaacccaaaa aa
//
