LOCUS       NM_011155               2031 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein phosphatase 5, catalytic subunit (Ppp5c),
            transcript variant 1, mRNA.
ACCESSION   NM_011155
VERSION     NM_011155.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2031)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2031)
  AUTHORS   Li,J., Cui,P., Sun,Q., Du,Z., Chen,Z., Li,Z., Liu,C., Cao,Y.,
            Yang,Z., Liu,R. and Luo,M.
  TITLE     PSPC1 regulates CHK1 phosphorylation through phase separation and
            participates in mouse oocyte maturation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (11), 1527-1537 (2021)
   PUBMED   34490876
  REMARK    GeneRIF: PSPC1 regulates CHK1 phosphorylation through phase
            separation and participates in mouse oocyte maturation.
REFERENCE   3  (bases 1 to 2031)
  AUTHORS   Gergs,U., Jahn,T., Werner,F., Kohler,C., Kopp,F., Grossmann,C. and
            Neumann,J.
  TITLE     Overexpression of protein phosphatase 5 in the mouse heart: Reduced
            contractility but increased stress tolerance - Two sides of the
            same coin?
  JOURNAL   PLoS One 14 (8), e0221289 (2019)
   PUBMED   31425567
  REMARK    GeneRIF: During inflammatory response to the bacterial LPS in the
            heart of transgenic mouse model with cardiac myocyte directed
            overexpression of protein phosphatase 5 (PP5) basal cardiac
            contractility was reduced, but LPS-induced cardiac dysfunction was
            less pronounced compared to wild type mice. PP5 increases stress
            tolerance of cardiac myocytes by downregulation of NF-kappaB
            signaling and upregulation of HSP25 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2031)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2031)
  AUTHORS   Wang,J., Shen,T., Zhu,W., Dou,L., Gu,H., Zhang,L., Yang,Z.,
            Chen,H., Zhou,Q., Sanchez,E.R., Field,L.J., Mayo,L.D., Xie,Z.,
            Xiao,D., Lin,X., Shou,W. and Yong,W.
  TITLE     Protein phosphatase 5 and the tumor suppressor p53 down-regulate
            each other's activities in mice
  JOURNAL   J Biol Chem 293 (47), 18218-18229 (2018)
   PUBMED   30262665
  REMARK    GeneRIF: PP5 directly interacts with and dephosphorylates p53 at
            multiple serine/threonine residues, resulting in inhibition of
            p53-mediated transcriptional activity.
REFERENCE   6  (bases 1 to 2031)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
REFERENCE   7  (bases 1 to 2031)
  AUTHORS   Shirato,H., Shima,H., Nakagama,H., Fukuda,H., Watanabe,Y.,
            Ogawa,K., Matsuda,Y. and Kikuchi,K.
  TITLE     Expression in hepatomas and chromosomal localization of rat protein
            phosphatase 5 gene
  JOURNAL   Int J Oncol 17 (5), 909-912 (2000)
   PUBMED   11029491
REFERENCE   8  (bases 1 to 2031)
  AUTHORS   Ollendorff,V. and Donoghue,D.J.
  TITLE     The serine/threonine phosphatase PP5 interacts with CDC16 and
            CDC27, two tetratricopeptide repeat-containing subunits of the
            anaphase-promoting complex
  JOURNAL   J Biol Chem 272 (51), 32011-32018 (1997)
   PUBMED   9405394
REFERENCE   9  (bases 1 to 2031)
  AUTHORS   Chinkers,M.
  TITLE     Mapping of Ppp5c, the gene encoding protein phosphatase 5, to mouse
            chromosome 7
  JOURNAL   Mamm Genome 8 (7), 538-539 (1997)
   PUBMED   9196006
REFERENCE   10 (bases 1 to 2031)
  AUTHORS   Chinkers,M.
  TITLE     Targeting of a distinctive protein-serine phosphatase to the
            protein kinase-like domain of the atrial natriuretic peptide
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11075-11079 (1994)
   PUBMED   7972012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148976.3.
            
            On Feb 27, 2023 this sequence version replaced NM_011155.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003744.1, AF018262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC148976.3         89697-89891         c
            196-437             AC148976.3         84419-84660         c
            438-585             AC148976.3         77402-77549         c
            586-707             AC148976.3         71879-72000         c
            708-773             AC148976.3         70997-71062         c
            774-872             AC148976.3         70618-70716         c
            873-978             AC148976.3         69730-69835         c
            979-1121            AC148976.3         69108-69250         c
            1122-1209           AC148976.3         68911-68998         c
            1210-1250           AC148976.3         68336-68376         c
            1251-1429           AC148976.3         68064-68242         c
            1430-1511           AC148976.3         67265-67346         c
            1512-2031           AC148976.3         66656-67175         c
FEATURES             Location/Qualifiers
     source          1..2031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2031
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /note="protein phosphatase 5, catalytic subunit"
                     /db_xref="GeneID:19060"
                     /db_xref="MGI:MGI:102666"
     exon            1..195
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1574
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase 5; protein
                     phosphatase T; ANP receptor"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 5 isoform
                     1"
                     /protein_id="NP_035285.2"
                     /db_xref="CCDS:CCDS20859.1"
                     /db_xref="GeneID:19060"
                     /db_xref="MGI:MGI:102666"
                     /translation="MAMAEGERTECAETPRDEPPADGTLKRAEELKTQANDYFKAKDY
                     ENAIKFYSQAIELNPGNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRR
                     AASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRS
                     VVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKE
                     VLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRG
                     SFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEV
                     FEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ
                     NGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPN
                     YCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM"
     exon            196..437
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            438..585
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            586..707
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            708..773
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..872
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            873..978
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1121
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1209
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1250
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1429
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1511
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..2031
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /note="hexamer: AATAAA"
     polyA_site      2031
                     /gene="Ppp5c"
                     /gene_synonym="PP5"
                     /note="major polyA site"
ORIGIN      
        1 actcggcact ccttcgcgac ggttcggcct ggtgccgcga gcggccgttg ccagggtggg
       61 ggtcgctttg cggcatggcg atggcggagg gcgagcggac tgagtgtgct gagacccccc
      121 gggacgaacc cccggccgat ggcactctga agcgggcaga ggagctcaag acacaggcca
      181 acgactactt caaagccaag gactacgaga acgcgatcaa gttctacagt caggccatcg
      241 agttgaaccc cggcaatgcc atctactatg gcaaccgcag cctggcctac ctgcgcactg
      301 agtgctatgg ctatgcactg ggcgacgcca cacgggccat cgagcttgac aagaagtaca
      361 tcaaaggcta ctaccgccgg gcggccagca acatggcact gggcaagttc cgggctgccc
      421 tgcgtgacta cgagacggtg gtgaaagtga agcctaatga caaggatgcc aagatgaagt
      481 accaggagtg cagcaagatt gtgaagcaga aggcctttga gagggccatt gcgggtgacg
      541 agcacagacg ctctgtcgtg gactctctgg acattgaaag catgaccatt gaagatgagt
      601 acagcgggcc caagcttgag gatggcaaag tgacaatcac cttcatgaaa gacctcatgc
      661 agtggtacaa ggatcagaag aaactgcacc ggaagtgcgc ctaccagatc ctagtacagg
      721 tgaaagaagt cctctgcaag ctgagcacgc tggtggagac gacgctgaaa gagacagaga
      781 agattacagt gtgcggggac acccatggcc agttctacga cctcctcaac atatttgagc
      841 tcaacggttt accctcagag accaacccct atatatttaa tggcgatttt gtggaccgtg
      901 gttccttctc cgttgaagtg atcctcaccc tcttcggctt taagctcctg tatccagatc
      961 atttccatct acttcgaggc aaccacgaga cagacaacat gaaccagatc tacgggttcg
     1021 agggcgaggt gaaggccaag tacacagccc agatgtatga gctcttcagc gaggtgttcg
     1081 agtggcttcc gctggcgcag tgtatcaatg gcaaagtgct gatcatgcac ggaggcctat
     1141 tcagcgaaga tggtgtcact ctggatgaca tccgaaagat tgagcggaat cggcagcccc
     1201 cagactcagg tcccatgtgt gacctgctgt ggtcagatcc ccagccacag aatgggcgct
     1261 ccgtcagcaa gcgtggtgtg agttgccagt ttgggcctga tgtcaccaag gccttcctgg
     1321 aggagaatca actggactat atcatccgca gccatgaagt caaagccgag ggctacgagg
     1381 tggcccatgg tggccgctgt gtcactgtct tttctgcccc caactattgt gaccagatgg
     1441 gaaacaaagc ctcctacatc cacctccagg gctccgacct gcggccccag ttccaccaat
     1501 tcacagcagt gcctcacccc aatgtcaagc ccatggcata cgccaacacg cttctgcagc
     1561 taggaatgat gtgaggctgt cagcagcagt gagccgggac ttgcccagct gaatggcccc
     1621 gccctcggcc tgctgccccg ccccagggca acgttggacc cccttttact ttgtaaagtt
     1681 tgtatttatt cccctttagg ttgcagaggg ggtgggggca gcgtggggca gcagacgaca
     1741 ggctcctggt cagagaaagg agactggagg tagggcacag cctgggcatt tggaggaagg
     1801 ccagcctggg taggggtggg gccaagagga ggtcttgccc cttcacctgc atggctcctc
     1861 ccctggtaaa gcaataggac cctgccatag gaagacccca aaagagggtc atcagggagg
     1921 cctcctcctg gtagcctcag ggtggggcaa ggctggggcc caccccccag ctattttatg
     1981 ttctgtaatt aactatgtta aaataaaata aagtcattat tgtaagtcaa a
//
