LOCUS       NM_182939               4857 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus protein phosphatase 4, regulatory subunit 2 (Ppp4r2),
            transcript variant 1, mRNA.
ACCESSION   NM_182939 XM_916600 XM_924330 XM_924333 XM_924335 XM_924337
            XM_924340
VERSION     NM_182939.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4857)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4857)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4857)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4857)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   5  (bases 1 to 4857)
  AUTHORS   Yoon,Y.S., Lee,M.W., Ryu,D., Kim,J.H., Ma,H., Seo,W.Y., Kim,Y.N.,
            Kim,S.S., Lee,C.H., Hunter,T., Choi,C.S., Montminy,M.R. and
            Koo,S.H.
  TITLE     Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic
            subunit (PP4C) is a key regulator of hepatic gluconeogenesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (41), 17704-17709 (2010)
   PUBMED   20876121
REFERENCE   6  (bases 1 to 4857)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4857)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155648.14.
            
            On Mar 17, 2023 this sequence version replaced NM_182939.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082539.1, AK084169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC155648.14        89338-89620
            284-365             AC155648.14        90420-90501
            366-536             AC155648.14        108188-108358
            537-630             AC155648.14        117113-117206
            631-668             AC155648.14        118826-118863
            669-743             AC155648.14        120382-120456
            744-887             AC155648.14        120777-120920
            888-1183            AC155648.14        121491-121786
            1184-4857           AC155648.14        121960-125633
FEATURES             Location/Qualifiers
     source          1..4857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 46.93 cM"
     gene            1..4857
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="protein phosphatase 4, regulatory subunit 2"
                     /db_xref="GeneID:232314"
                     /db_xref="MGI:MGI:3027896"
     exon            1..283
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1503
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase 4 regulatory subunit
                     2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 2 isoform a"
                     /protein_id="NP_891984.1"
                     /db_xref="CCDS:CCDS20391.1"
                     /db_xref="GeneID:232314"
                     /db_xref="MGI:MGI:3027896"
                     /translation="MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQ
                     FKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQ
                     RLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSP
                     NYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSKDSELQLSEEKGHSDSSAS
                     ESEVSLLSPVKNKHPDEDAVESEEHEVKRLKFDKEGDVRETASQTVSGEVSSVRAEET
                     ETAAPPPDKDRESRTRQHCTEEEEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDA
                     LTVNEETSEESHQMEGSGVSPAQTDSTSERSDSAGASRSGSDCLETQESGGPPSSKTG
                     ESVSVPSSMESEEAAEVTDDPMEQD"
     exon            284..365
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..536
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..630
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..668
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            669..743
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            744..887
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1183
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..4857
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3429..3434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3446
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="major polyA site"
     regulatory      4811..4816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="hexamer: AATAAA"
     regulatory      4836..4841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4853
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="major polyA site"
     polyA_site      4857
                     /gene="Ppp4r2"
                     /gene_synonym="C230060M08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctgacgtgc cgggcgccat gttggagggc tggtggtagc ggctcgggga ggttctcgct
       61 ctgtccgtct cgctccgtct ctcgcttccc cccgccccgg ctcccttcgg gacccccctc
      121 cccggtcgcc ggcgtgtggc ggagtgtgtg cgagggcggg ggcgggcgtc cgggggggcg
      181 ggggcgggcg ccgcggcccc cgggacggcg gccgagggag gcgccggcgg cgagggactg
      241 cgcggcgcca tggacgtcga gaggctgcag gaggcgctga aagattttga gaagagaggg
      301 aaaaaggaag tttgtcctgt actggatcag tttctctgtc atgtagctaa aactggagaa
      361 acaatgattc agtggtccca atttaaaggc tatttcattt tcaaactgga gaaagtgatg
      421 gatgatttca gaacttcagc tcctgaacca agaggtcctc ccaatcctaa tgttgaatat
      481 attccctttg atgaaatgaa ggaaagaata ctgaaaattg tcactggatt taatggtatc
      541 ccttttacta ttcagcggct atgtgaattg ctaacggatc cgagaagaaa ctatacagga
      601 acagacaagt ttctcagagg agtagagaag aatgtgatgg ttgttagctg cgtttgtcca
      661 tcctcagaga agaacaattc taatagctta aatagaatga atggtgttat gtttcctgga
      721 aactcaccaa actatactga caggtctaat ataaacgggc ctggaacacc taggccactt
      781 aatcgaccaa agctttcttt gtcagccccc ttgacaacaa atggtttgcc tgagagcaca
      841 gatagcaaag attctgagct gcagctaagt gaagagaaag gccacagtga ttcttcagcc
      901 tctgaatcag aagtttcctt actgagccct gttaaaaata aacatccaga tgaagatgct
      961 gtggagtctg aggaacatga ggtgaaaaga ctgaagtttg acaaagaagg tgacgtcaga
     1021 gagacagcta gccaaacggt gtctggtgaa gtctcttcag ttagagcaga ggaaacggaa
     1081 acagcagctc cccctcctga caaggacaga gaaagtcgaa ccaggcagca ctgtacagaa
     1141 gaggaggagg aggaggagga agaagaggaa gaggaggagg aagaatcgtt tatgacacca
     1201 agagaaatgg tcccagaaag aaaaaatcaa gaaaaggaat ctgatgacgc cttaactgtg
     1261 aatgaagaga cttcagagga gagccatcag atggaaggct ctggtgtgtc tccagctcag
     1321 acagactcca cttcagaaag gagtgacagt gcaggggcct caaggagtgg ctctgactgc
     1381 ctggagacac aggagtcagg agggccccct tccagtaaga ctggagagag tgtgtcagtg
     1441 ccgtcgtcca tggagagtga ggaagccgca gaagtcacag atgacccaat ggagcaagac
     1501 taactactca gaaacactta gaggcagtat tttacataca gttctggttt tacactgtat
     1561 aagactttta agtaataaag tggaccttta gttttacaag agaaacaggc tgtaaaataa
     1621 agaaccttaa gaataaaccc tgaaggttgt atgtggaaga gctgtgagta cggctcctct
     1681 gggtcccgct tagtgctgat tttcttgttt ggtttggttt tttgtttgct tttttcctgg
     1741 tgtactcaaa tcagtggttt gtgtatagat tttttttttt aatttagaat taaagttttt
     1801 aaactggaag ataattataa ttttgaaaac tttaaagatg atctcatttg gtttatacat
     1861 acacaaggaa gatttttgtc ttgtctctag cagtttccat attttggtca tagtttaaac
     1921 atgttaacat gtgaattaat agggtttcat gtggtttcag atttttattg ttcgactgta
     1981 caatggaacc ttaagtcata tatacatata tagattatcc tgagggggga tgttatattt
     2041 ttctgtttct ataagagatg aatacagtgg atactttttt attggtaatg actgagttca
     2101 cttctttcag aagacatctt ctcttctgag tagttgagac aaaaatctgg cccctgtgag
     2161 accctgggaa tctttcagtc tgttgaaata ccaggttaaa cacattccaa gagatctgtg
     2221 caaactaaat tcttttgtat acttctaagg tgcctgagac aacaagactt catttattta
     2281 tggaaagtgt gctttatctt gggagttgtg ctcaagcatt agcttgctgt ctgtagaatg
     2341 agtgcttcgg agcctgacat gaaaccatct caagagccca caggtcccat aacattcggt
     2401 tgcttttctg aacactgtca acatcacatc tgtctttctg aataatccta tatgccgcat
     2461 ggcactggtg tgaaacatca ctgtactgga agaattagta gaggacttca gtaatgtacc
     2521 tgagctaaaa tgaccgaggc gttaggggtg cacagaaacc accatgattt gtataacatt
     2581 ttgaagtgaa ttaatatttt tgaacatgct tcttcaacag ccagtgttat atttttcaga
     2641 tcaacacaaa gcacaatggt tactactcta taaactcaat attttcaaat tcacatattt
     2701 aaagtcatgc aagctgcaac ttccctgtca gaattactgg ctgccaaatt tatacctgtt
     2761 tcttcagctg tactttttga tatttagaat ttttaaattt ctgtaaagta ggttttgtag
     2821 actgtaatgt gttcactgcc tttgtgaagc ggtatattgt ataatttcgt gtgtaactga
     2881 atgcttgggc tttcaataca gtattcatat aaagcaataa atattaatgt tatgaaatat
     2941 tggagtacat ttttatcaaa atacaaaatc tcttttttag tttcagacat ctgaggtaca
     3001 gggatggacc taatagctga tacaaacagt ttctcacact ttatctatcc taagcttcgg
     3061 gtgatcagag ggaaaccaca aggtttgcat tttgactgct tagacgttac tatggctaaa
     3121 aagatatttg gctccgtttg ttcataaagt aatatgctac tgactgatga ccttcaggtt
     3181 cacagcagct ggacagtaga tttatgaatc tgtctagtaa aactgtcgat ttactgtacc
     3241 caaaggggtg aaagtcaaat gtaacttcaa gttttttggc aaaaagatta aaatgaagca
     3301 aaatttaagt gtgacattca tttgtaatgg cctgttagag ttgagggatt gacagtaaga
     3361 gcagatttta aacattttag gtttagagtt tttgagattt tccttaggat atttatgagg
     3421 ttgttgtcaa taaacctgtt ctctaagctc ctgtgacctt tgatagtctt tatttatggt
     3481 gccatggacc atttacaaac aagtcagttt gctgttggtt aaaagttgaa gatttcgcat
     3541 catgaataga ggtctgtggc tttatttgta aacttgcaat tgctatcttt gcaaggggaa
     3601 gtgtatttct ttattaaata aagtacaatt aataatggtg aatgtaccaa aatgacatca
     3661 ctcaattcta tgagaggtct gcattttaac ctatagttta atagctttaa tatttattag
     3721 ctattcctat gttgatcata gatgaaagtt gttgctgttt atacagatac acgtaggata
     3781 ctggtgaagg gtctctaggg cagttgtaat attcatcacc gtgtgaggcc atgttcagac
     3841 tgtggatgca ttggtccctt ggaagtccat ttccacacgt ggtgttagat gcacttacag
     3901 gagactgcag gaaagtgtca gttctaatga gcactgagtc ctttgtgagt gacagaatga
     3961 gacccaagag ggagggtcaa gccgtcccgt ggctgaagta gctggctctt tgatgttgaa
     4021 cagattccta accgggttct cctttcccaa gcctaactca gatctgggca gtgctgatgg
     4081 tgctgacaga atacacatga catggttttg ccacccctcc cttttaaaaa gtgaaaacat
     4141 tttgaaaact ctataaagtt ctgtacatgt agaacagaag tgagtagtga aaatatattt
     4201 tgaggattag taaacttaat ccacttaatt gtcacaactc cggtctttcc catatgtagc
     4261 cagagcaatg gagttacaac tctggctttc gaaagctatt ccagaaaccc tgccccagaa
     4321 agtcttaaag cattgagatc cttgtgtttt attttggcag tgtagatagg catgtattta
     4381 tgcatttgta aaatcaattt ttttcaaata atgtatgtaa tgtactagct taaacggtac
     4441 tgggcagagc ctagagctac tgcgaggatt gaatgtgaag ccggtatcgc gggtggaaat
     4501 gtacctgcag agctacagca aactattccg ggtagtgttt caggctgcct ttgagcagga
     4561 gtttcttaga tctattggtt ttgacaaact gaagatcagt tcttgagatt tgtgttaatc
     4621 atgagatgaa tggatgcaaa aaacaccttg taatttcatg tggaattatg aaaattagct
     4681 tgatgggata ttggcctaac aaggatgatg gtatgtactg gctagaatac atatatttca
     4741 catataaaaa ataatccgga caccagaatt ctcttctttc aatttggagc ctagatcgat
     4801 cactttgcca aataaatgta ttattttcat aatgcaataa agtgtaaact agatgaa
//
