LOCUS       NM_001114131            3813 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus protein phosphatase 4, regulatory subunit 1 (Ppp4r1),
            transcript variant 2, mRNA.
ACCESSION   NM_001114131
VERSION     NM_001114131.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Xu,W., Hua,Z., Wang,Y., Tang,W., Ou,W., Liu,F., Yang,Y., Ding,W.,
            Wang,Z., Cui,L., Ge,W., Gu,Y., Wang,X., Chen,Y., Liu,C.Y. and Du,P.
  TITLE     AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c
            mediated IKK dephosphorylation in an autophagy-independent manner
  JOURNAL   Cell Death Differ 31 (5), 618-634 (2024)
   PUBMED   38424148
  REMARK    GeneRIF: AMBRA1 promotes intestinal inflammation by antagonizing
            PP4R1/PP4c mediated IKK dephosphorylation in an
            autophagy-independent manner.
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Zhu,X., Chen,X., Shen,X., Liu,Y., Fu,W., Wang,B., Zhao,L., Yang,F.,
            Mo,N., Zhong,G., Jiang,S. and Yang,Z.
  TITLE     PP4R1 accelerates the malignant progression of NSCLC via
            up-regulating HSPA6 expression and HSPA6-mediated ER stress
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119588 (2024)
   PUBMED   37739270
  REMARK    GeneRIF: PP4R1 accelerates the malignant progression of NSCLC via
            up-regulating HSPA6 expression and HSPA6-mediated ER stress.
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Wang,S., Li,L., Chen,X., Huang,X., Liu,J., Sun,X., Zhang,Y.,
            Shen,T., Guo,J., Man,Y., Tang,W., Dou,L. and Li,J.
  TITLE     miR-338-3p mediates gluconeogenesis via targeting of PP4R1 in
            hepatocytes
  JOURNAL   Mol Med Rep 18 (4), 4129-4137 (2018)
   PUBMED   30132533
  REMARK    GeneRIF: miR3383p may be involved in TNFalphamediated
            gluconeogenesis via targeting of PP4R1 in hepatocytes.
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Hwang,J., Lee,J.A. and Pallas,D.C.
  TITLE     Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein
            Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and
            Differentially Regulates the Stable Formation of Different PP4
            Holoenzymes
  JOURNAL   J Biol Chem 291 (40), 21008-21019 (2016)
   PUBMED   27507813
  REMARK    GeneRIF: LCMT-1 homozygous knock-out MEFs exhibited
            hyperphosphorylation of HDAC3, a reported target of the
            methylation-dependent PP4R1-PP4c complex. Collectively, our data
            suggest that LCMT-1 coordinately regulates the carboxyl methylation
            of PP2A-related phosphatases and, consequently, their holoenzyme
            assembly and function.
REFERENCE   6  (bases 1 to 3813)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 3813)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3813)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3813)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139751.2, AK166418.1, CX568699.1, AK133969.1, BC026489.1,
            AV275830.1 and BI135060.1.
            
            Transcript Variant: This variant (2) lacks an in-frame segment in
            the 5' coding region, compared to variant 1. The resulting isoform
            (b) lacks an internal segment, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133969.1, SRR1660817.77079.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC139751.2         24570-24612         c
            44-612              AK166418.1         2-570
            613-1046            CX568699.1         393-826
            1047-2036           AK133969.1         969-1958
            2037-3729           BC026489.1         1061-2753
            3730-3795           AV275830.1         134-199
            3796-3813           BI135060.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 35.26 cM"
     gene            1..3813
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /note="protein phosphatase 4, regulatory subunit 1"
                     /db_xref="GeneID:70351"
                     /db_xref="MGI:MGI:1917601"
     exon            1..95
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2893
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine-protein phosphatase 4 regulatory subunit
                     1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 1 isoform b"
                     /protein_id="NP_001107603.1"
                     /db_xref="CCDS:CCDS50167.1"
                     /db_xref="GeneID:70351"
                     /db_xref="MGI:MGI:1917601"
                     /translation="MADLSLLQEDLPEDADGPLDFVSQDEMLTPLGRLDKYAASENVF
                     NRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQE
                     NRPSIPYAFSKYLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVL
                     IDLTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAA
                     NFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLS
                     ALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQCFKDESKNSEDSSAEDKDRMR
                     DNDVVEEEHRRPEDAPSDLSAPHSSARLESLEGCAAKTPGHSAGDVPAPVDSSLLCTL
                     SSESPQEAASNDENGRKPDTNSKSASRPDAGTSSPEATPLDQDMFNSFHFWRTPLPKI
                     DLDKELQQDPEERLSPERTGDVPAAPLPGPPNITMATRKELEEMIENLEPHMDDPDVK
                     AQVDVLSAALRASSLDAHEETGGVEQRSELQDEVCVSELPDCNISHDTCVPLISAAEE
                     NAEATPDYVHGGADVSPGDGFSPDEDRRPKVQDVVPQALLDQYLSMTDPSRAQTVDTE
                     IAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQL
                     TAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNW
                     RFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHT
                     ATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLT
                     LANDRVPNVRVLLAKTLRQTLLEKEYFLASASCHQEAVEQTIMALQMDRDSDVKYFAS
                     IHPSSTKLSEDAMSTASSTY"
     exon            96..140
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..225
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..332
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..475
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..622
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..730
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..796
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..955
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1083
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1613
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1786
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1882
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2068
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2230
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2331
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2452
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2587
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2729
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..3799
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3698..3703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /note="hexamer: AATAAA"
     polyA_site      3725
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /note="major polyA site"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="Ppp4r1"
                     /gene_synonym="3110001J10Rik; Pp4r1"
ORIGIN      
        1 cgccggcccg cgcgcgccca ccggctctct acttgagcgg ctcgcggagc gggatcccgg
       61 gagacgagga ggcgggggcg agcacaagat ggcggacctc tccctgctcc aggaggacct
      121 gccggaggac gcggacggac ccctggactt cgtctcacaa gatgaaatgt tgacaccctt
      181 ggggaggctg gacaagtatg ctgcaagtga gaacgtattt aacagacaaa tggtggcccg
      241 gagtttgctg gatactctga gggaagtctg cgatgatgag agagactgca ttgctgtctt
      301 ggaaagaatt agccgattag ctgatgactc cgaaccaact gtgagagcgg agctgatgga
      361 acaagtgccg cacattgcac tgttttgtca agagaaccgg ccttctatac cgtatgcttt
      421 ttccaagtac ttactaccaa ttgtggtcag atacctcgca gaccagaata accaggtgag
      481 gaaaaccagt caggcagctt tgctggctct gctggagcag gaactgattg agcgatttga
      541 cgtggagacc aaggtgtgcc ctgtcctcat agacctgact gccccagaca gcaatgatga
      601 tgtgaagaca gaagctgtgg ctataatgtg caagatggcc cccatggttg ggaaggacat
      661 tacggagcgc ctcatcctcc ccaggttctg cgagatgtgc tgtgactgtc gaatgtttca
      721 tgtccggaag gtctgcgctg ccaattttgg agatatttgc agtgtagttg gccaacaagc
      781 aacagaagaa atgttgctgc ccaggttctt ccagctgtgc tctgataacg tgtggggcgt
      841 ccgaaaggcc tgtgctgagt gcttcatggc tgtctcctgt gcaacatgtc aagaaatccg
      901 acggacaaag ttatcagcac tatttattaa cttgatcagt gatccttcac gttgggttcg
      961 ccaagcagcc tttcagtctc tggggccttt catatccacg tttgctaatc catcaagctc
     1021 gggccagtgc tttaaagatg agagcaagaa ctcagaagac tcctcggcag aagacaaaga
     1081 caggatgaga gacaatgatg tcgtagaaga agagcatcgc aggccagagg acgctccttc
     1141 agacctcagt gcccctcact ccagcgccag gctggagagc ctcgaaggct gtgctgccaa
     1201 gacacctggg cactctgcag gtgacgtgcc tgctccagtg gacagctcct tactctgtac
     1261 tttgtcctca gagtctcctc aggaagcagc tagcaatgat gagaatggta gaaagcctga
     1321 caccaacagc aagtctgcgt cccggccaga cgctggcacc agctccccag aggccactcc
     1381 cttagaccag gacatgttca actccttcca tttctggagg actcctctac ctaaaataga
     1441 tcttgataaa gagctccagc aggaccccga ggagagactc agcccagaga gaacaggaga
     1501 tgtacctgca gcccctctac caggccctcc caatatcacc atggctaccc ggaaggaact
     1561 agaagaaatg atagaaaacc ttgagccaca catggatgac ccggatgtga aagcacaggt
     1621 ggacgtgctg tcggctgccc tgcgagcttc cagcctggat gctcacgaag agactggtgg
     1681 tgtagagcag cggagtgagc tacaagatga agtgtgtgtc agtgagcttc cagactgtaa
     1741 cataagtcac gacacttgtg tgcctttgat cagcgctgct gaggagaatg cggaggccac
     1801 tcctgattat gtccatggag gtgcagacgt aagccctggt gatggcttca gcccggatga
     1861 agataggaga cccaaagtcc aggatgttgt accacaagcg ttactggatc agtacttgtc
     1921 aatgaccgac ccttctcgag cacagacagt tgacactgag atcgctaagc actgtgcata
     1981 cagtctgccg ggtgtggccc tgactcttgg cagacagaac tggcactgct tgagggagac
     2041 ttacgagacc ctagcgtcgg acatgcagtg gaaagttcga aggactctag ccttctccat
     2101 ccatgagctt gcagtgatcc ttggggacca gctgacagct gcagacctgg ttccaatctt
     2161 caatggattt ttaaaagacc tcgatgaagt caggataggt gttcttaaac acttgcatga
     2221 ctttctgaag cttcttcaca ttgataaaag aagagagtac ctttatcagc tccaggagtt
     2281 tttggtgaca gacaacagta gaaattggcg ctttcgagct gaactggcag aacagctgat
     2341 tttacttctg gagttataca gtcccagaga tgtttatgat tacctacgac ccatcgctct
     2401 gaatctgtgt gcagacaaag tttcttcagt ccgctggatt tcctacaagt tggtcagtga
     2461 aatggtgaag aaactccaca cagcaacacc accaaccttc ggagtagatc tcatcaatga
     2521 gctggtagag aattttggca ggtgtccaaa atggtctggt cggcaagcct ttgtctttgt
     2581 ctgccagact gtcattgaag acgactgcct ccccatggac cagtttgctg tgcacttgat
     2641 gccacatttg ctgaccttgg caaatgacag ggttcccaat gttagagtgc tgcttgcgaa
     2701 aaccctgcga cagactctgc tggagaaaga gtacttctta gcctctgcca gctgtcacca
     2761 ggaggccgtg gagcagacaa tcatggccct gcagatggac cgagacagtg atgtcaagta
     2821 ctttgcaagc attcacccct ccagtaccaa actctctgaa gatgcaatga gcacagcttc
     2881 ctccacctac tgacccacgg tgtccatcct gcatccgcaa gagcctggcc tcgactgcct
     2941 gcaccactcg ggacagctgt ggtgggggcc ttcctcctgc caactcattc gcaggtgcag
     3001 gttgcctact cccaatacca gtggttttaa gagtcaagag aaagtacagt aaacactatt
     3061 atcttatctt gacttaaggg aaagtaaatc tcagaggatt ataattgtca ccaaagcctt
     3121 aactcgttcc ttcatcttcc tgactgatgg cttgaattgg cagagcattt tcccttcggg
     3181 aaggatgagg ttcccagaga cctgcgttgc tttcttctgg ttttatttaa cggctgataa
     3241 atgacattct tacggccaga aggtggatgt gcaccggaca ggaaaggcct tcagtattag
     3301 cctaagcatt tcttctaggt gctgagcctg ttcagctcct tggctgccct gcccagccca
     3361 gccctaagtg tgaatagttc ttggcgtgta taaatgacaa aggagttttt cctctcctaa
     3421 gggcttgatg ttaacactaa atagaatctg attttgactc ctaatgcagc acattgctgt
     3481 acacatttac agaatgtttg cagaatctct cctgatattt ttcatgctgg tcatgacctg
     3541 aaggaaattt cttagcacga atattgtgtc aggtattttt aacttgatca tggtcagctc
     3601 tgaggtgcaa ctgtgtcttc ccgtgctgca cccctgtgac cactctgggg tgtgcagcct
     3661 gaatcatgct gttagaactg ttgtggtaca agctccaaat aaaatttatt aataggatct
     3721 ataaagagag acaccaccca ctttgtttcc taaatgtcta caaataaatg cagtatgtgg
     3781 cctgtattac ttagcataaa aaaaaaaaaa aaa
//
