LOCUS       NM_019674               1410 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c),
            transcript variant 2, mRNA.
ACCESSION   NM_019674
VERSION     NM_019674.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Xu,W., Hua,Z., Wang,Y., Tang,W., Ou,W., Liu,F., Yang,Y., Ding,W.,
            Wang,Z., Cui,L., Ge,W., Gu,Y., Wang,X., Chen,Y., Liu,C.Y. and Du,P.
  TITLE     AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c
            mediated IKK dephosphorylation in an autophagy-independent manner
  JOURNAL   Cell Death Differ 31 (5), 618-634 (2024)
   PUBMED   38424148
  REMARK    GeneRIF: AMBRA1 promotes intestinal inflammation by antagonizing
            PP4R1/PP4c mediated IKK dephosphorylation in an
            autophagy-independent manner.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Ma,X.S., Hou,Y., Schatten,H.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     PPP4C facilitates homologous recombination DNA repair by
            dephosphorylating PLK1 during early embryo development
  JOURNAL   Development 149 (10) (2022)
   PUBMED   35546066
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Han,F., Dong,M.Z., Lei,W.L., Xu,Z.L., Gao,F., Schatten,H.,
            Wang,Z.B., Sun,X.F. and Sun,Q.Y.
  TITLE     Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient
            mice
  JOURNAL   Mol Hum Reprod 27 (1) (2021)
   PUBMED   33543287
  REMARK    GeneRIF: Oligoasthenoteratospermia and sperm tail bending in
            PPP4C-deficient mice.
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Mourtada-Maarabouni,M., Kirkham,L., Jenkins,B., Rayner,J.,
            Gonda,T.J., Starr,R., Trayner,I., Farzaneh,F. and Williams,G.T.
  TITLE     Functional expression cloning reveals proapoptotic role for protein
            phosphatase 4
  JOURNAL   Cell Death Differ 10 (9), 1016-1024 (2003)
   PUBMED   12934076
  REMARK    GeneRIF: Protein phosphatase 4 has a role in apoptosis.
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Hu,M.C., Shui,J.W., Mihindukulasuriya,K.A. and Tan,T.H.
  TITLE     Genomic structure of the mouse PP4 gene: a developmentally
            regulated protein phosphatase
  JOURNAL   Gene 278 (1-2), 89-99 (2001)
   PUBMED   11707325
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Hu,M.C., Tang-Oxley,Q., Qiu,W.R., Wang,Y.P.,
            Mihindukulasuriya,K.A., Afshar,R. and Tan,T.H.
  TITLE     Protein phosphatase X interacts with c-Rel and stimulates
            c-Rel/nuclear factor kappaB activity
  JOURNAL   J Biol Chem 273 (50), 33561-33565 (1998)
   PUBMED   9837938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124505.4.
            
            On Feb 3, 2018 this sequence version replaced NM_019674.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF088911.1, BC001993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC124505.4         133191-133315       c
            126-288             AC124505.4         132829-132991       c
            289-340             AC124505.4         129792-129843       c
            341-391             AC124505.4         129152-129202       c
            392-493             AC124505.4         128885-128986       c
            494-667             AC124505.4         128205-128378       c
            668-794             AC124505.4         127988-128114       c
            795-984             AC124505.4         127140-127329       c
            985-1410            AC124505.4         126634-127059       c
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1410
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /note="protein phosphatase 4, catalytic subunit"
                     /db_xref="GeneID:56420"
                     /db_xref="MGI:MGI:1891763"
     exon            1..125
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            126..288
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1114
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase X"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4 catalytic
                     subunit"
                     /protein_id="NP_062648.1"
                     /db_xref="CCDS:CCDS21844.1"
                     /db_xref="GeneID:56420"
                     /db_xref="MGI:MGI:1891763"
                     /translation="MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQR
                     VDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKV
                     RYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKI
                     FCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFG
                     SDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELD
                     EHLQKDFIIFEAAPQETRGIPSKKPVADYFL"
     exon            289..340
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            341..391
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            392..493
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            494..667
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            668..794
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            795..984
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1410
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1391..1396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /note="hexamer: AATAAA"
     polyA_site      1408
                     /gene="Ppp4c"
                     /gene_synonym="1110002D08Rik; PP-X; pp4; PP4C; Ppx"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgcgag agcactggtt tccctttgct tccgcggcga ggccggaagt agaagcggcg
       61 gtggcggagg cccaaagcgg agggaagtgg ggagtcgaag agactcagcc ggagtctccg
      121 cggcggagac ccctgtgcgg tccggagggg gcggcggccc cgactctgac ccgcgccggg
      181 ggggtgggcc atggcggaga tcagcgacct ggaccggcag atcgagcagc tacggcgctg
      241 cgagctgatc aaagagagcg aagtcaaggc cctgtgcgcc aaggccagag aaatcttggt
      301 agaagagagc aacgtgcaga gggtggactc gccagtcaca gtatgcggtg acatccatgg
      361 acaattctat gacctcaagg agctgttcag agtaggtggc gatgtccctg agaccaacta
      421 cctcttcatg ggagactttg tggaccgtgg tttctacagt gttgaaacct tcctcctcct
      481 gctggctctt aaggttcgct atcctgacag aatcactttg atccggggca atcatgagag
      541 tcgccagatt acccaggtct atgggttcta tgatgagtgc ttacggaaat atggttcagt
      601 gactgtatgg cgctactgta ctgagatctt tgactacctc agcctgtctg ccatcattga
      661 tggcaagatc ttctgtgtgc atggaggtct ttccccttcc atccagacct tggaccagat
      721 ccggacaatt gaccgaaagc aagaggtacc ccatgatgga cccatgtgcg acctcctgtg
      781 gtctgaccct gaagacacaa caggctgggg agtgagcccc cgcggggcag gttacctgtt
      841 tggcagtgac gtggtcgccc agttcaatgc agccaacgac attgatatga tctgccgtgc
      901 ccaccaatta gtgatggaag gctacaagtg gcacttcaat gagaccgtgc ttactgtgtg
      961 gtcagcgcct aattactgct accgctgtgg caatgtggca gccatcttag aactggatga
     1021 gcacctccag aaagatttca tcatcttcga ggctgcaccc caagagacac gtggcatccc
     1081 ctccaaaaag ccagtggccg actatttcct gtgactcctt ggccccagcc cctctggccc
     1141 ttggaccact gtgactgccc tctgcccagt cggaggctgg gtctgagggg ctgcctggct
     1201 ttgcttgccc cagggtgcgg acttgctctg gagaggtgga gccttggctc ctggcttcct
     1261 ctcctttctc ccacttgatc catgaagttt tcagtcattt tttttttctt ttttcctttt
     1321 ttttcctttc ttttttcttt ttgtttttgt ttttagataa aacattttga gaaaaaaaga
     1381 aaaaaattct aataaaagaa gaaaaataga
//
