LOCUS       NM_024459               2829 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus protein phosphatase 3, regulatory subunit B, alpha
            isoform (calcineurin B, type I) (Ppp3r1), mRNA.
ACCESSION   NM_024459
VERSION     NM_024459.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Tapella,L., Dematteis,G., La Vitola,P., Leva,S., Tonelli,E.,
            Raddi,M., Delconti,M., Dacomo,L., La Macchia,A., Murari,E.,
            Talmon,M., Malecka,J., Chrostek,G., Grilli,M., Colombo,L.,
            Salmona,M., Forloni,G., Genazzani,A.A., Balducci,C. and Lim,D.
  TITLE     Genetic deletion of astrocytic calcineurin B1 prevents cognitive
            impairment and neuropathology development in acute and chronic
            mouse models of Alzheimer's disease
  JOURNAL   Glia 72 (5), 899-915 (2024)
   PUBMED   38288580
  REMARK    GeneRIF: Genetic deletion of astrocytic calcineurin B1 prevents
            cognitive impairment and neuropathology development in acute and
            chronic mouse models of Alzheimer's disease.
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Wu,B., Post,L., Lin,Z. and Schonewille,M.
  TITLE     PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the
            Vestibulo-ocular Reflex during Juvenile Development
  JOURNAL   J Neurosci 44 (17), e1211232024 (2024)
   PUBMED   38527808
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Berber,M., Leng,S., Wengi,A., Winter,D.V., Odermatt,A.,
            Beuschlein,F., Loffing,J., Breault,D.T. and Penton,D.
  TITLE     Calcineurin regulates aldosterone production via dephosphorylation
            of NFATC4
  JOURNAL   JCI Insight 8 (14), e157027 (2023)
   PUBMED   37310791
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Teramoto,H., Hirashima,N. and Tanaka,M.
  TITLE     Calcineurin B1 Deficiency Reduces Proliferation, Increases
            Apoptosis, and Alters Secretion in Enteric Glial Cells of Mouse
            Small Intestine in Culture
  JOURNAL   Cells 12 (14), 1867 (2023)
   PUBMED   37508531
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Lam,N.T., Nguyen,N.U.N., Ahmed,M.S., Hsu,C.C., Rios Coronado,P.E.,
            Li,S., Menendez-Montes,I., Thet,S., Elhelaly,W.M., Xiao,F.,
            Wang,X., Williams,N.S., Canseco,D.C., Red-Horse,K., Rothermel,B.A.
            and Sadek,H.A.
  TITLE     Targeting calcineurin induces cardiomyocyte proliferation in adult
            mice
  JOURNAL   Nat Cardiovasc Res 1 (7), 679-688 (2022)
   PUBMED   39196243
REFERENCE   6  (bases 1 to 2829)
  AUTHORS   Yang,S.A. and Klee,C.B.
  TITLE     Low affinity Ca2+-binding sites of calcineurin B mediate
            conformational changes in calcineurin A
  JOURNAL   Biochemistry 39 (51), 16147-16154 (2000)
   PUBMED   11123943
REFERENCE   7  (bases 1 to 2829)
  AUTHORS   Rusnak,F. and Mertz,P.
  TITLE     Calcineurin: form and function
  JOURNAL   Physiol Rev 80 (4), 1483-1521 (2000)
   PUBMED   11015619
  REMARK    Review article
REFERENCE   8  (bases 1 to 2829)
  AUTHORS   Liu,J., Koyano-Nakagawa,N., Amasaki,Y., Saito-Ohara,F., Ikeuchi,T.,
            Imai,S., Takano,T., Arai,N., Yokota,T. and Arai,K.
  TITLE     Calcineurin-dependent nuclear translocation of a murine
            transcription factor NFATx: molecular cloning and functional
            characterization
  JOURNAL   Mol Biol Cell 8 (1), 157-170 (1997)
   PUBMED   9017603
REFERENCE   9  (bases 1 to 2829)
  AUTHORS   Loh,C., Shaw,K.T., Carew,J., Viola,J.P., Luo,C., Perrino,B.A. and
            Rao,A.
  TITLE     Calcineurin binds the transcription factor NFAT1 and reversibly
            regulates its activity
  JOURNAL   J Biol Chem 271 (18), 10884-10891 (1996)
   PUBMED   8631904
REFERENCE   10 (bases 1 to 2829)
  AUTHORS   Ueki,K., Muramatsu,T. and Kincaid,R.L.
  TITLE     Structure and expression of two isoforms of the murine
            calmodulin-dependent protein phosphatase regulatory subunit
            (calcineurin B)
  JOURNAL   Biochem Biophys Res Commun 187 (1), 537-543 (1992)
   PUBMED   1325794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137249.1 and AK160938.1.
            
            On Jan 12, 2006 this sequence version replaced NM_024459.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160938.1, SRR1660821.128901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY137249.1         1-15
            16-2829             AK160938.1         2-2815
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 9.71 cM"
     gene            1..2829
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /note="protein phosphatase 3, regulatory subunit B, alpha
                     isoform (calcineurin B, type I)"
                     /db_xref="GeneID:19058"
                     /db_xref="MGI:MGI:107172"
     exon            1..245
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..755
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2B regulatory subunit 1;
                     protein phosphatase 3 regulatory subunit B alpha; PP2B
                     beta 1"
                     /codon_start=1
                     /product="calcineurin subunit B type 1"
                     /protein_id="NP_077779.2"
                     /db_xref="CCDS:CCDS24448.1"
                     /db_xref="GeneID:19058"
                     /db_xref="MGI:MGI:107172"
                     /translation="MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFM
                     SLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMD
                     KDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGL
                     DIHKKMVVDV"
     exon            246..285
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..462
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..522
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..707
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2829
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      903
                     /gene="Ppp3r1"
                     /gene_synonym="CaNB1; Cnb1; MCIP1"
ORIGIN      
        1 tctgcgcgcc ctgttccgtg ccttgaggtt gcggtcagcg cgagccgctg caacgagtcg
       61 gggccgcctg tgagcgtgag gctgcaaccc tctcctcccg ccgacgcatc tccaaccggg
      121 actccgcccg cctcgctccg ggcccaggcc ccgttgcacc ccgcccggcg ccggacagca
      181 aagccgccgt cgccgcgtcc cgaggatcct acagccgccg ccagcgccgc ccgccgagca
      241 agatgggaaa tgaggcgagt taccctttgg aaatgtgctc acactttgat gctgatgaaa
      301 ttaaaaggct aggaaagaga ttcaagaagc ttgatttgga caattctggt tctttgagcg
      361 tggaagagtt catgtctctg cctgagttac agcagaaccc tttagtacag cgggtaatag
      421 atatattcga cacagacggc aacggagaag tggacttcaa agaattcatt gaaggagtgt
      481 ctcagttcag tgtcaaaggc gataaggaac agaagttgag gtttgctttt cgtatctatg
      541 acatggataa agatggctat atttccaatg gagaactctt ccaggtgttg aagatgatgg
      601 tgggcaacaa tctgaaagat acacaattac agcagattgt agacaaaacc ataataaatg
      661 cagataagga tggagatgga agaatatcct ttgaggaatt ctgtgctgtc gtaggtggcc
      721 tagatatcca caaaaagatg gtggtggatg tgtgactctt tgaagaatac cacccaacac
      781 ttttgctttc ttctccatct ctgaagatct gctcaagacg tccagcaatg ctctctgtgt
      841 atttaaatgg aagtattttt ctctgtgaag ccacattttc caacatgagc ctcatgaagc
      901 caactaagtg ttattgaact cctactctct caataactca gtgtagcact ttaaagtttg
      961 aaggacagca gcatgaaaga gcatatcagt atggtggaga aagggaaggg gttggctctt
     1021 taatttattt ttcttcatct tttataacaa gaaagtatct atatatacat atgtaaatat
     1081 ttatatatag atatatgtag ctttctatat atttagtagg ttggctttaa tttaatatac
     1141 ttgattcaga aacaaaatgt tagagtacaa aagtgccaag cagaacataa accatcctta
     1201 cttttatttc acacggtttt atatgtagat agaagattgt acaatttgcg ccaggtatta
     1261 ggccagctct tttcctttct ctgtgctttc tcctttgaga gattgataaa gcatttgtta
     1321 atgccctatt atttacctta cacttttgta acgagtctgt aactttattt atatctctga
     1381 ctatctttcc agggactgtg tcttattgct gagcagcgtt taatccatct ctgttggagg
     1441 tctagttcag tgctgttgcc aagagtgggt tcttgtgtcc atagaactgc atatgctatg
     1501 gctgcttcag gctgatactt tttaagtagt cactgttatt tttattaagt gtccctgaga
     1561 aaatgtaatt agcagttgtg attttataaa ggtcagaagt tttctgaggc agtcatgact
     1621 tttttaaatg tattatttag tgaagaaaac ccaaagtaat catgcagtgg cttaaaatat
     1681 ccttgttcca ttatacacaa gggaaaccat gtgaaatact tgtcactgaa ctgtaaatca
     1741 tggactcatt tttcttctgc atttcaaaag acacagttaa cctaaaaaaa tgaactgata
     1801 cttcatgagc acatgtttat gtaaaattcc gtctgtggtt aagatggggg agtatcttgc
     1861 taatctacac gccacaggag agcagatttt gtccatagtc acatctttaa aatttctctg
     1921 ccagatatcg gcaagatagc acatgatgga tttttgtttt gcccgtacaa ctagtgatgg
     1981 atgatgattt aatagatttg tgtgacataa aagtgcgtca tgtcctacca cttgacatta
     2041 tcccttccct tttctgcaaa ggtactgttg atcggaagaa agagattctg gctagtttta
     2101 tatggcagtc ttccctacac agtttttcta taccaattgg ttttataatc atgaatggta
     2161 aagggtgggt tgaatcaagg tgagagaata ttaaattgag tctacctgcc tgccaccgct
     2221 gtcccttcaa ctgagtgctg cacatcatgg gctctgtctg tgagagaaac cccggtgctt
     2281 ggtgtctctg catgacatgg agttttgcat gtagatcaat ttaaaatgta cctcttgttt
     2341 acataatctg cataatttaa aaagatgatg ttgccaaact ttggaaatgt taatactcaa
     2401 aacgaaaatc tccactccat gtaactactt tctccctctg gatcagtaca tggcttgcaa
     2461 tcccagccag tggtttgatc tgtcccagtg tcaaccgcca tgtgctctgc ttcaagaggg
     2521 aactagtctt ttgtgaattt ttttgtacat aattatttgt tacaaatatt ttagcaaatg
     2581 ctttctatat ctcttgcttg tgcatatctt ggctggcgtt gtggaaaaaa atagtgcaaa
     2641 ctatttcaaa ctatttcctt actggggaat gaggggtttt cttttttagt ttgtgtgagg
     2701 gaggtgggga gggcatggtt tatgttgaat gtttaaattt tcttctgcat gatacatgtc
     2761 atgttgtgaa atctttagag aacttcatac tgtatgagta agaaaataaa atatttgaaa
     2821 cttggcttg
//
