LOCUS       NM_001304991            2084 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protein phosphatase 3, catalytic subunit, gamma
            isoform (Ppp3cc), transcript variant 1, mRNA.
ACCESSION   NM_001304991 XM_011244992
VERSION     NM_001304991.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Miyata H, Oura S, Morohoshi A, Shimada K, Mashiko D, Oyama Y,
            Kaneda Y, Matsumura T, Abbasi F and Ikawa M.
  TITLE     SPATA33 localizes calcineurin to the mitochondria and regulates
            sperm motility in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34446558
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Ambrozkiewicz MC, Borisova E, Schwark M, Ripamonti S, Schaub T,
            Smorodchenko A, Weber AI, Rhee HJ, Altas B, Yilmaz R, Mueller S,
            Piepkorn L, Horan ST, Straussberg R, Zaqout S, Jahn O, Dere E,
            Rosario M, Boehm-Sturm P, Borck G, Willig KI, Rhee J, Tarabykin V
            and Kawabe H.
  TITLE     The murine ortholog of Kaufman oculocerebrofacial syndrome protein
            Ube3b regulates synapse number by ubiquitinating Ppp3cc
  JOURNAL   Mol Psychiatry 26 (6), 1980-1995 (2021)
   PUBMED   32249816
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Chaya T, Tsutsumi R, Varner LR, Maeda Y, Yoshida S and Furukawa T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Hoffman A, Taleski G and Sontag E.
  TITLE     The protein serine/threonine phosphatases PP2A, PP1 and
            calcineurin: A triple threat in the regulation of the neuronal
            cytoskeleton
  JOURNAL   Mol Cell Neurosci 84, 119-131 (2017)
   PUBMED   28126489
  REMARK    Review article
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG and Cooper TA.
  TITLE     Extensive alternative splicing transitions during postnatal
            skeletal muscle development are required for calcium handling
            functions
  JOURNAL   Elife 6, e27192 (2017)
   PUBMED   28826478
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2084)
  AUTHORS   Ueki K, Muramatsu T and Kincaid RL.
  TITLE     Structure and expression of two isoforms of the murine
            calmodulin-dependent protein phosphatase regulatory subunit
            (calcineurin B)
  JOURNAL   Biochem Biophys Res Commun 187 (1), 537-543 (1992)
   PUBMED   1325794
REFERENCE   7  (bases 1 to 2084)
  AUTHORS   Giri PR, Marietta CA, Higuchi S and Kincaid RL.
  TITLE     Molecular and phylogenetic analysis of calmodulin-dependent protein
            phosphatase (calcineurin) catalytic subunit genes
  JOURNAL   DNA Cell Biol 11 (5), 415-424 (1992)
   PUBMED   1318721
REFERENCE   8  (bases 1 to 2084)
  AUTHORS   Muramatsu T, Giri PR, Higuchi S and Kincaid RL.
  TITLE     Molecular cloning of a calmodulin-dependent phosphatase from murine
            testis: identification of a developmentally expressed nonneural
            isoenzyme
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 529-533 (1992)
   PUBMED   1309945
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 May 15;89(10):4779]
REFERENCE   9  (bases 1 to 2084)
  AUTHORS   Giri PR, Higuchi S and Kincaid RL.
  TITLE     Chromosomal mapping of the human genes for the calmodulin-dependent
            protein phosphatase (calcineurin) catalytic subunit
  JOURNAL   Biochem Biophys Res Commun 181 (1), 252-258 (1991)
   PUBMED   1659808
REFERENCE   10 (bases 1 to 2084)
  AUTHORS   Kincaid RL, Giri PR, Higuchi S, Tamura J, Dixon SC, Marietta CA,
            Amorese DA and Martin BM.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY716864.1 and BC046617.1.
            
            [WARNING] On Sep 27, 2023 this sequence was replaced by
            NM_001304991.2.
            
            On Feb 20, 2015 this sequence version replaced XM_011244992.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046617.1, SRR17784649.866892.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               BY716864.1         2-221
            221-2084            BC046617.1         1-1864
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.3 cM"
     gene            1..2084
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /note="protein phosphatase 3, catalytic subunit, gamma
                     isoform"
                     /db_xref="GeneID:19057"
                     /db_xref="MGI:MGI:107162"
     exon            1..317
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1837
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CAM-PRP catalytic subunit; calcineurin, testis-specific
                     catalytic subunit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2B
                     catalytic subunit gamma isoform isoform 1"
                     /protein_id="NP_001291920.1"
                     /db_xref="CCDS:CCDS88703.1"
                     /db_xref="GeneID:19057"
                     /db_xref="MGI:MGI:107162"
                     /translation="MSVRRPQFSTTERVIKAVPFPPTRRLTLKEVFENGKPKMDLLKN
                     HLVKEGRVEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMKLFEVGG
                     SPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQ
                     ECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPP
                     AFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRA
                     HEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSP
                     HPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMNVTDEEDHYISSCPKGATT
                     GRKEVIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVLSGGKQTIETAK
                     QEAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGRMHSHSHPPH
                     PQASRRTDHGKKAL"
     exon            318..515
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            516..640
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            641..752
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            753..898
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1038
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1116
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1211
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1337
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1406
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1433
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1515
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1613
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1643
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2056
                     /gene="Ppp3cc"
                     /gene_synonym="Calnc; PP2BA gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcgcgc acgcggggcc ccagccgcgc gcagccgcgg tctccctagt tgtgtccctc
       61 agccgcggtc gccgtagctc tcgacgcggt cgtccccgcc gagccgcggg cgccgccgca
      121 gggagggagc ggcgctgcgg ccgccgccgt ccgaggacgc cccgtattcc ggggcccggc
      181 acggtggctg cccgctcgcc gagcgcagcc cgcctaggag gaaggcggcg gcttgcgtcc
      241 agcgggccgc cggagccggg aggagaccat gtccgtgagg cgccctcagt tctccacgac
      301 cgagcgcgtc atcaaagctg tcccctttcc tccaacccga cggctaactt tgaaggaagt
      361 ttttgagaat gggaaaccta aaatggatct tttgaaaaac catttagtaa aagaaggtcg
      421 ggtggaagag gaggtggcct taaagatcat caatgatggg gctgccatcc tgaagcagga
      481 gaagaccatg atagaggtgg aggctccgat cacagtgtgt ggtgatgttc atggacaatt
      541 ctttgacctg atgaagttgt ttgaagttgg gggatcacct agtaatactc gctacctctt
      601 cctgggtgac tatgtggaca gaggctattt cagtatagag tgtgtgctgt atctatggag
      661 cttaaagatt aaccatccta aaacattgtt tctgcttcga ggaaatcatg aatgcaggca
      721 tcttacagag tacttcacct tcaaacagga atgtcggatc aagtattcag agatggtgta
      781 cgatgcgtgc atgcacactt tcgactgtct tcctcttgct gccctcttaa accagcagtt
      841 tctctgtgta catggaggaa tgtctcctga aattacttgt ttagaggaca ttaggaaatt
      901 agataggttt tctgagcctc ctgcttttgg gccagtgtgt gacctgctgt ggtctgatcc
      961 cttagaggac tacggcagcg agaagaccct ggagcactat acccacaaca ctgtccgagg
     1021 ctgctcctac ttcttcagtt accctgcagt ttgtgaattt ttacagaaca acagtttatt
     1081 atcaataatc agagcccatg aagcccagga tgcggggtac cgaatgtata ggaagaacca
     1141 agcaactggc tttccgtcac ttattacgat tttctctgcc cctaattacc tagatgtcta
     1201 taacaataaa gctgcagtgt tgaagtatga aaacaatgtc atgaacatca ggcagttcaa
     1261 ctgttcccca cacccctact ggctcccaaa cttcatggat gttttcacgt ggtctttgcc
     1321 ttttgttgga gagaaagtga cagagatgct ggtcaatatt ctcaacatat gctcggatga
     1381 agaaatgaac gtaaccgatg aagaagatca ctacatttca agctgtccaa aaggagctac
     1441 tacaggtcga aaagaagtca tcaagaataa aatccgagcc attgggaaaa tggcccgggt
     1501 ctttacggtt cttcgggaag agagtgagaa tgtgctgacc ctcaagggcc tcactcccac
     1561 aggcacactc ccactggggg tcctctctgg aggaaagcag accattgaga ctgccaaaca
     1621 agaagccgca gaggagcggg aagccatcag aggttttaca attgcacaca ggatccgaag
     1681 ttttgaagaa gcccgaggtc tagaccgaat taatgagaga atgccacccc gaaaagaggc
     1741 ttcatatcat catgatgcag ggaggatgca ctcacactcg catccgccac acccacaggc
     1801 gtcaagaagg accgaccatg gaaagaaagc cctgtaatga ctcagggccc tgtgcagcac
     1861 agatgggtcc caaccctatg agcaaatcac atttatttat actggaaatg aaacaggaac
     1921 aactcaaaca acttaaactt ggaggtgcat ttgtaattca gtcgcattta ttctgtaaga
     1981 aaaatgacca ttttataaat tcttctaatt tatgttcaat atatatatat atataaaata
     2041 cttttgtttt gtttccaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
