LOCUS       NM_008914               3848 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus protein phosphatase 3, catalytic subunit, beta isoform
            (Ppp3cb), transcript variant 1, mRNA.
ACCESSION   NM_008914 XM_127612
VERSION     NM_008914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Qiu,X., Jiang,Z., Luo,Y., Tian,D., Song,T. and Li,Q.
  TITLE     PPP3CB Inhibits Cell Proliferation and the Warburg Effect in
            Bladder Cancer by Blocking PDHK1
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 48 (2024)
   PUBMED   38420800
  REMARK    GeneRIF: PPP3CB Inhibits Cell Proliferation and the Warburg Effect
            in Bladder Cancer by Blocking PDHK1.
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Miura,E. and Watanabe,M.
  TITLE     Coexpression of calcineurin A and B subunits in various subcellular
            and synaptic compartments of cerebellar neurons and glia with
            particular abundance at parallel fiber-Purkinje cell synapses
  JOURNAL   Neurosci Res 180, 13-22 (2022)
   PUBMED   35247520
  REMARK    GeneRIF: Coexpression of calcineurin A and B subunits in various
            subcellular and synaptic compartments of cerebellar neurons and
            glia with particular abundance at parallel fiber-Purkinje cell
            synapses.
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Nolze,A., Kohler,C., Ruhs,S., Quarch,K., Stratz,N., Gekle,M. and
            Grossmann,C.
  TITLE     Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular
            remodelling by potentiating EGFR signalling in mice
  JOURNAL   Acta Physiol (Oxf) 233 (3), e13715 (2021)
   PUBMED   34228904
  REMARK    GeneRIF: Calcineurin (PPP3CB) regulates angiotensin II-dependent
            vascular remodelling by potentiating EGFR signalling in mice.
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3848)
  AUTHORS   Li,X., Li,J., Martinez,E.C., Froese,A., Passariello,C.L.,
            Henshaw,K., Rusconi,F., Li,Y., Yu,Q., Thakur,H., Nikolaev,V.O. and
            Kapiloff,M.S.
  TITLE     Calcineurin Abeta-Specific Anchoring Confers Isoform-Specific
            Compartmentation and Function in Pathological Cardiac Myocyte
            Hypertrophy
  JOURNAL   Circulation 142 (10), 948-962 (2020)
   PUBMED   32611257
  REMARK    GeneRIF: Calcineurin Abeta-Specific Anchoring Confers
            Isoform-Specific Compartmentation and Function in Pathological
            Cardiac Myocyte Hypertrophy.
            Erratum:[Circulation. 2020 Sep 8;142(10):e153. doi:
            10.1161/CIR.0000000000000917.. PMID: 32897744]
REFERENCE   6  (bases 1 to 3848)
  AUTHORS   Gaestel,M., Benndorf,R., Hayess,K., Priemer,E. and Engel,K.
  TITLE     Dephosphorylation of the small heat shock protein hsp25 by
            calcium/calmodulin-dependent (type 2B) protein phosphatase
  JOURNAL   J Biol Chem 267 (30), 21607-21611 (1992)
   PUBMED   1328240
REFERENCE   7  (bases 1 to 3848)
  AUTHORS   Ueki,K., Muramatsu,T. and Kincaid,R.L.
  TITLE     Structure and expression of two isoforms of the murine
            calmodulin-dependent protein phosphatase regulatory subunit
            (calcineurin B)
  JOURNAL   Biochem Biophys Res Commun 187 (1), 537-543 (1992)
   PUBMED   1325794
REFERENCE   8  (bases 1 to 3848)
  AUTHORS   Giri,P.R., Marietta,C.A., Higuchi,S. and Kincaid,R.L.
  TITLE     Molecular and phylogenetic analysis of calmodulin-dependent protein
            phosphatase (calcineurin) catalytic subunit genes
  JOURNAL   DNA Cell Biol 11 (5), 415-424 (1992)
   PUBMED   1318721
REFERENCE   9  (bases 1 to 3848)
  AUTHORS   Giri,P.R., Higuchi,S. and Kincaid,R.L.
  TITLE     Chromosomal mapping of the human genes for the calmodulin-dependent
            protein phosphatase (calcineurin) catalytic subunit
  JOURNAL   Biochem Biophys Res Commun 181 (1), 252-258 (1991)
   PUBMED   1659808
REFERENCE   10 (bases 1 to 3848)
  AUTHORS   Kincaid,R.L., Giri,P.R., Higuchi,S., Tamura,J., Dixon,S.C.,
            Marietta,C.A., Amorese,D.A. and Martin,B.M.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ112318.1, AC146594.3, BC066000.1, BM219132.2 and BQ175555.1.
            
            On Jul 14, 2015 this sequence version replaced NM_008914.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066000.1, M81483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CJ112318.1         1-2
            3-3                 AC146594.3         107195-107195
            4-29                CJ112318.1         4-29
            30-1852             BC066000.1         1-1823
            1853-3155           BC066000.1         1825-3127
            3156-3187           BM219132.2         243-274             c
            3188-3848           BQ175555.1         1-661               c
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..3848
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="protein phosphatase 3, catalytic subunit, beta
                     isoform"
                     /db_xref="GeneID:19056"
                     /db_xref="MGI:MGI:107163"
     exon            1..218
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1711
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CAM-PRP catalytic subunit; PP2BA beta; CNA beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2B
                     catalytic subunit beta isoform isoform 1"
                     /protein_id="NP_032940.1"
                     /db_xref="CCDS:CCDS26846.1"
                     /db_xref="GeneID:19056"
                     /db_xref="MGI:MGI:107163"
                     /translation="MAAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVF
                     DMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHG
                     QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNH
                     ECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTL
                     DDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCE
                     FLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE
                     NNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGED
                     QFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
                     RQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSL
                     NTAHTTENHGTGNHSAQ"
     exon            219..419
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            420..544
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            545..656
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            657..802
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            803..942
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1020
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1115
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1241
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1319
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1404
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1502
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1532
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..3831
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="hexamer: AATAAA"
     polyA_site      3166
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="major polyA site"
     regulatory      3313..3318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="hexamer: CATAAA"
     polyA_site      3336
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="hexamer: AATAAA"
     polyA_site      3516
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
                     /note="hexamer: ATTAAA"
     polyA_site      3831
                     /gene="Ppp3cb"
                     /gene_synonym="1110063J16Rik; Calnb; Cnab; CnAbeta"
ORIGIN      
        1 gacggtctta gcccctctga agggaaagag ggtccgccat gttccccggc ggcgccgccg
       61 cttggctctg gtagccgccg cccccgcccc caaccccgcc cgtcccggca cctagccgag
      121 ccccgggccc agcatggccg ccccggagcc ggcccgggcc gcgccgcccc cgcccccgcc
      181 cccaccgccc cctctcgggg ccgaccgcgt cgtcaaagct gttccttttc ccccaactca
      241 tcggctgaca tctgaagaag tgtttgatat ggatgggata cccagggttg atgttctgaa
      301 gaaccacttg gtaaaagaag ggcgggtgga tgaagaaatt gcactaagaa ttatcaatga
      361 gggtgctgcc atacttcggc gggagaaaac catgatagaa gtagaagctc caattacagt
      421 gtgtggtgac atccatggcc aattttttga tctgatgaaa ctttttgaag taggaggatc
      481 acctgctaat acacgatacc tttttcttgg tgattatgtg gacagaggtt attttagtat
      541 agagtgtgtc ttatatttat gggtcttgaa gattctatac ccaagcacat tattccttct
      601 gagaggcaac catgaatgca gacaccttac tgaatatttt acctttaagc aggaatgtaa
      661 aattaaatat tcagaaagag tctatgaagc ttgtatggag gcttttgaca gcttgcccct
      721 tgctgcactt ctaaaccaac aatttctttg tgttcatggt ggactttcac cagaaataca
      781 cacactggat gatattagga gattagatag atttaaagag ccacctgcat ttggaccaat
      841 gtgtgacttg ctatggtctg atccttctga agactttgga aatgaaaaat cacaagaaca
      901 ttttagtcat aatacagttc gaggatgttc ttatttttat aactatccag cagtgtgtga
      961 atttttgcaa aacaataatt tgttatcgat tattagagct catgaagctc aagatgcagg
     1021 ctatagaatg tacagaaaaa gtcaaactac agggtttcct tcattaataa caattttttc
     1081 ggcacctaat tacttagatg tctacaataa taaagctgct gtactaaagt atgaaaataa
     1141 tgtgatgaac attcgacagt ttaattgctc tccacatcct tattggttgc ccaattttat
     1201 ggatgtcttt acatggtctt taccatttgt tggagaaaaa gtgacagaaa tgttggtaaa
     1261 tgttctgagt atttgttctg atgatgaact aatgacagaa ggtgaagacc agtttgatgt
     1321 aggttcagct gcagcccgga aagaaatcat aagaaacaag atccgagcaa ttggcaagat
     1381 ggcaagagtc ttctctgttc tcagggagga gagtgaaagc gtgctgacac tcaagggcct
     1441 gactcccaca gggatgttgc ctagtggagt gttggctgga ggacggcaga ccttgcaaag
     1501 tgccacagtt gaggctattg aggctgaaaa agcaatacga ggattctctc caccacatag
     1561 aatctgcagt tttgaagagg caaagggttt ggataggatc aatgagagaa tgccaccccg
     1621 gaaagatgct gtgcagcaag atggtttcaa ttccctgaac accgcacata ccactgagaa
     1681 ccacgggact ggcaaccata gtgcccagtg accagcggct tcccagggac tctcacatct
     1741 tgggccccaa atggacagat cacttcaagg agctggaggg gttgaccaag gtgatgataa
     1801 atgtcataat ctctctgaag aaaccattgt gctttctgag atccgtgccc ccttcctgga
     1861 tggaggcttg agggccctgg gacttgtgcc gtctataaga ttgggtaatc gctgccacag
     1921 aggagagcag tgagcaaggg gcttggggca atttccagtg gaggatatct acacctccat
     1981 ttatgcttgt ggttcacaca tttacgttta caaatgagat ttcctttgtt tttcccctca
     2041 gtagaattag acatttttca accatgactt taaatacaat ctttagagat aacgtggaac
     2101 tccccccatc accctcaccc catgaaatgt ctttaaaagg atggattagc atggtcttaa
     2161 aatatatttc tgaggttact agatgtattt tgacttgtag acaaaatctg agaaacccag
     2221 ttggtgttta tataaaatgc tgacctcagg ttatagttct taaatgtggc taattctgta
     2281 acatagtctt ggtatttttc aattatgaat gcataaacta tttctaagaa gactcttact
     2341 tgaacaaaat ccaaaaacca atttagattc ttttttgccc atatcttttg tgatttacac
     2401 cccagagatt taaggaaaaa acaaaaacaa aacaaaatga aattttaaaa ttatgaagaa
     2461 ttacagaatt actcatttaa ggtactttaa aagaagtttg tacattgtca aagtaaattt
     2521 taattcaaat catgtctgta aaacttgacg tattttgtgt atgcatgttt tcattttgca
     2581 aatatttaat atatagacct atgatgtaca ggtacaacat gtataggtta cgtagatatt
     2641 atgagaaatt ttagtttatt gtgagtactc cagttgcttt aaaaaccacc agggtgattt
     2701 gctgctggct ttgtatcatc tttatgttta aatgcaaagg aaattaaaaa tgtctggaaa
     2761 tgtttttgac taagtaatgc agcctagaag caatggttct cttcaaccct tcagatgtct
     2821 agtggaagca taaaagtcaa gactgcatgt cgaaatttta cttttgatag ttacagaact
     2881 gcttggttaa actaaatgga accatgtgct aattttacag tgactgacct gtactgatta
     2941 ccactgtagt ttggtatttc cctttacttt ggtggcctgc ttccctcatg ccctggagta
     3001 cagctcatag caccaggcag cggaaccatc tgttgttttg tttgccagaa agtgcagcct
     3061 gtatggtctt ctgtctaagt tggaaatatt atgcatgtgc aggactattc aagtatttta
     3121 taaacagtag cacacaataa attccatgca tgggccgctg ctcctatctc tgtgttgggt
     3181 tttatttgga agatgtagtc tgatataacc tttttatgca aattgtaaaa tctctgttaa
     3241 caaagctagg atatttttag aaattatcct atagataatt aatgatgatt tcatgagtta
     3301 aattcttgtc tccataaatt ttgttttccc cttcaacttt tgttatactt ttttatttaa
     3361 tatgagtagt tgagtattaa agaactttgg attcctataa taattttcca aaatataata
     3421 taatattgga gtggtagggt gcttgtcagt catgtgcaaa gctccaggtt ctacacctag
     3481 tactatatgt aaaataaaag tcactatttt caccaactct gggttagaag agatgttcta
     3541 gtcttgaact ttgttagagt gatactgata aattgggtat tttagcaata agccaaaata
     3601 ctaatagtag cttgctttgc ctcctctgcc attgttgaat tgagtataac attgtgcaaa
     3661 ttgagaaatt actcacaata tataatatgg caagtaactt taaacagtgg ctatgagaca
     3721 cataaggcat cgttttatat caaaatgtat attctaggca aattccagtt aaaaacaatc
     3781 taaattgttt attatagtgt ctaatgcaat attaaattgt aaaccaatcc aaaaaaaaaa
     3841 aaaaaaaa
//
