LOCUS       NM_008913               4862 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus protein phosphatase 3, catalytic subunit, alpha
            isoform (Ppp3ca), transcript variant 1, mRNA.
ACCESSION   NM_008913 XM_131226
VERSION     NM_008913.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Wan,X., Zhao,S., Dai,Y., Zhang,J., Shen,Y., Gong,L. and Le,Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   2  (bases 1 to 4862)
  AUTHORS   Delint-Ramirez,I., Konada,L., Heady,L., Rueda,R., Jacome,A.S.V.,
            Marlin,E., Marchioni,C., Segev,A., Kritskiy,O., Yamakawa,S.,
            Reiter,A.H., Tsai,L.H. and Madabhushi,R.
  TITLE     Calcineurin dephosphorylates topoisomerase IIbeta and regulates the
            formation of neuronal-activity-induced DNA breaks
  JOURNAL   Mol Cell 82 (20), 3794-3809 (2022)
   PUBMED   36206766
  REMARK    GeneRIF: Calcineurin dephosphorylates topoisomerase IIbeta and
            regulates the formation of neuronal-activity-induced DNA breaks.
REFERENCE   3  (bases 1 to 4862)
  AUTHORS   Miura,E. and Watanabe,M.
  TITLE     Coexpression of calcineurin A and B subunits in various subcellular
            and synaptic compartments of cerebellar neurons and glia with
            particular abundance at parallel fiber-Purkinje cell synapses
  JOURNAL   Neurosci Res 180, 13-22 (2022)
   PUBMED   35247520
  REMARK    GeneRIF: Coexpression of calcineurin A and B subunits in various
            subcellular and synaptic compartments of cerebellar neurons and
            glia with particular abundance at parallel fiber-Purkinje cell
            synapses.
REFERENCE   4  (bases 1 to 4862)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4862)
  AUTHORS   Sidoli,M., Reed,C.B., Scapin,C., Paez,P., Cavener,D.R.,
            Kaufman,R.J., D'Antonio,M., Feltri,M.L. and Wrabetz,L.
  TITLE     Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B
            Demyelinating Neuropathy
  JOURNAL   J Neurosci 41 (20), 4536-4548 (2021)
   PUBMED   33879538
REFERENCE   6  (bases 1 to 4862)
  AUTHORS   Gaestel,M., Benndorf,R., Hayess,K., Priemer,E. and Engel,K.
  TITLE     Dephosphorylation of the small heat shock protein hsp25 by
            calcium/calmodulin-dependent (type 2B) protein phosphatase
  JOURNAL   J Biol Chem 267 (30), 21607-21611 (1992)
   PUBMED   1328240
REFERENCE   7  (bases 1 to 4862)
  AUTHORS   Giri,P.R., Marietta,C.A., Higuchi,S. and Kincaid,R.L.
  TITLE     Molecular and phylogenetic analysis of calmodulin-dependent protein
            phosphatase (calcineurin) catalytic subunit genes
  JOURNAL   DNA Cell Biol 11 (5), 415-424 (1992)
   PUBMED   1318721
REFERENCE   8  (bases 1 to 4862)
  AUTHORS   Kincaid,R.L., Giri,P.R., Higuchi,S., Tamura,J., Dixon,S.C.,
            Marietta,C.A., Amorese,D.A. and Martin,B.M.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
REFERENCE   9  (bases 1 to 4862)
  AUTHORS   Guerini,D. and Klee,C.B.
  TITLE     Cloning of human calcineurin A: evidence for two isozymes and
            identification of a polyproline structural domain
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9183-9187 (1989)
   PUBMED   2556704
REFERENCE   10 (bases 1 to 4862)
  AUTHORS   Kincaid,R.L., Nightingale,M.S. and Martin,B.M.
  TITLE     Characterization of a cDNA clone encoding the calmodulin-binding
            domain of mouse brain calcineurin
  JOURNAL   Proc Natl Acad Sci U S A 85 (23), 8983-8987 (1988)
   PUBMED   2848250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116384.9, AC124177.2, AC129775.4 and AI835974.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_008913.6.
            
            On Jun 11, 2014 this sequence version replaced NM_008913.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05479.1, BC138612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-836               AC116384.9         10398-11233         c
            837-1037            AC124177.2         134859-135059       c
            1038-1162           AC124177.2         64059-64183         c
            1163-1274           AC124177.2         56585-56696         c
            1275-1420           AC124177.2         55010-55155         c
            1421-1560           AC124177.2         51245-51384         c
            1561-1638           AC124177.2         44761-44838         c
            1639-1733           AC124177.2         42255-42349         c
            1734-1859           AC124177.2         29557-29682         c
            1860-1934           AC124177.2         27412-27486         c
            1935-2019           AC124177.2         10868-10952         c
            2020-2117           AC124177.2         4166-4263           c
            2118-2147           AC124177.2         745-774             c
            2148-4578           AC129775.4         22474-24904
            4579-4862           AI835974.1         1-284               c
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.34 cM"
     gene            1..4862
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /note="protein phosphatase 3, catalytic subunit, alpha
                     isoform"
                     /db_xref="GeneID:19055"
                     /db_xref="MGI:MGI:107164"
     exon            1..836
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     CDS             779..2344
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcineurin A alpha; protein phosphatase 3 catalytic
                     subunit alpha; CAM-PRP catalytic subunit; PP2BA alpha;
                     PP2B alpha 1; CNA alpha"
                     /codon_start=1
                     /product="protein phosphatase 3 catalytic subunit alpha
                     isoform 1"
                     /protein_id="NP_032939.1"
                     /db_xref="CCDS:CCDS17860.1"
                     /db_xref="GeneID:19055"
                     /db_xref="MGI:MGI:107164"
                     /translation="MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVD
                     ILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLF
                     EVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYF
                     TFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRF
                     KEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLS
                     ILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF
                     NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAAR
                     KEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVE
                     AIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETN
                     GTDSNGSNSSNIQ"
     exon            837..1037
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1162
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1274
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1420
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1560
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1638
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1733
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1859
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1934
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2019
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2117
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2147
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..4846
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaggcggg ggcggtgagg aggaagggga ggaggcggag gcgggcgcgg tggtggcggc
       61 ggccggcgcg gcggcggagg cgaggttgtg ccccggactg tgtccaccga gctcagcggc
      121 tgttgcctgt gcgtggagaa gcagcggcgc cgcgaggcag aggaggatcg cggacgagcg
      181 cggcggcggg acgtctacgg ctgccgcggc cccggcggcg cccggcgaca atcggcgtgg
      241 ggaagcagcg gcggccgcag cggcagccgc ctctccagca ccgggaagcc gaggcgcggc
      301 tggcggcgct gacatccgcg gccctgcctc tcctccctcg cccccggccc tccccatgtg
      361 atcggtctta atcccgaccg tgtgcgcgcg tgggggctcc attgcgcggc gcccggtgtc
      421 ggtgccgggg tgggtgctcg cgtgtgcttc tcctccccat cccccgcccc gtccccaaga
      481 ataaaagaag aaccgggagg cgtgctcaga aaataaataa ataaccagca cacacgcgca
      541 gcccggagcg aggcggcggg gctggcggcg gcggaggagg agtgaaggcg gcggcggcgg
      601 aggagggacg cgcggagccg gcagtaactt tcgagccagc ccagagccca gagctccagc
      661 cgagcggttt gcagcgcggc ggcggcggcg ctgagtgtct ggcccgccgg tgcggtcggg
      721 gtgtgcagtc ggacgggacg agcagcgcgt cgctgtcccc ccctcccggt ggctggagat
      781 gtccgagccc aaggcgattg atcccaagtt gtcgacgacc gacagggtgg tgaaagccgt
      841 tccatttcca ccaagtcacc ggctgacagc aaaggaagtg tttgataatg atgggaaacc
      901 tcgtgtggat atcttaaaag cacatctcat gaaggagggc aggctggaag aaagtgttgc
      961 attgagaata ataacagagg gtgcttcgat tctccgacag gaaaaaaact tgctggatat
     1021 cgacgcacca gtcacagttt gtggggacat ccatggacaa ttctttgact tgatgaagct
     1081 ctttgaagtg ggaggatctc ctgccaacac tcgctacctc ttcttagggg actatgttga
     1141 cagagggtac ttcagtatcg aatgtgtgct gtatttgtgg gccttgaaaa ttctttaccc
     1201 caaaacactg tttttacttc gcggaaacca tgaatgtagg cacctcacag agtatttcac
     1261 gtttaaacaa gaatgtaaaa taaagtattc agaacgcgtt tatgacgcct gtatggatgc
     1321 cttcgactgc cttcccctgg ctgcgctaat gaaccagcag ttcctgtgtg tacacggtgg
     1381 tttgtctcca gagattaaca ctctagatga catcagaaaa ttagaccgat tcaaagaacc
     1441 acctgcttat gggcccatgt gtgacatcct atggtcagac cccctggagg actttggaaa
     1501 tgagaagact caggaacatt tcactcacaa cacagtcaga ggctgttcgt acttctacag
     1561 ttacccagct gtgtgtgact tcctgcagca caataatttg ttgtccatac tccgcgccca
     1621 cgaagcccag gatgcagggt accgcatgta caggaaaagc caaacaacag gcttcccgtc
     1681 tctaattaca atcttctcgg caccaaatta cttagatgtg tacaataaca aagctgcagt
     1741 gttgaagtac gagaacaatg tgatgaacat caggcagttc aactgctccc cgcatccgta
     1801 ctggctccca aatttcatgg atgttttcac ctggtcgctg ccatttgttg gggagaaagt
     1861 gactgagatg ctggtcaatg ttctcaacat ctgctccgac gatgaactgg ggtcagaaga
     1921 agatggattt gacggagcca cggccgcagc ccggaaggaa gtcatcagaa acaagatccg
     1981 agcaataggc aaaatggcca gagtgttctc agttctcaga gaagagagtg agagtgtcct
     2041 gacactgaag ggcctgaccc caactggcat gctccccagc ggagtgctct ctggcgggaa
     2101 acagactctg caaagcgcta ctgttgaggc tattgaggct gatgaagcca tcaaaggatt
     2161 ttcaccacaa cataagatca ctagcttcga ggaggccaag ggcttagacc gaattaacga
     2221 gaggatgcca cctcgcagag acgccatgcc ctctgacgcc aaccttaact ccatcaacaa
     2281 ggctctcgcc tcagagacta acggcacgga cagcaatggc agtaatagca gcaatatcca
     2341 gtgaccactt cctgttcact tttttttttt ttgagctgca gggcatgatg ggattgctgc
     2401 atctcagcag ttggatgttc ttgcctctga aggtagcttg tttgctctgg gggccaggaa
     2461 ttggattcag tttacactat catgaaaaat aaaaataaaa aaagagggag agagataata
     2521 aactatattt tggtgagggt ggtgattaaa cacctctttt gggtatgcct ttaaaaaatg
     2581 cttctaggga aaaaaagttt taaaaagaaa gctaatgcta gtctatactg caatgttagg
     2641 ggaatgaacg cgttttccta ctgcactggg gacttttaga taggttaatg aaaggccttt
     2701 tattctgtta ctggacacga aaactttgtc taatttctta tactctattg tacgtttaca
     2761 gtcgcagcac taaaatggaa gacatcaaac atttttaaca gaaaaaaaaa aagatgtaaa
     2821 aactaactaa ggactattta ttgataatgt tttgctactc ctgtcagaca atggctataa
     2881 actgaattag gcagtcttaa aaaaaaaaaa aagaaaaaaa gaaaaaagaa aaaaagaaaa
     2941 gaaaaagaaa aaaaaaacct ggaaaaaaaa gaatgttgca aatttgttaa aatgccaaaa
     3001 aataaaaaat aaaaaaaaat acgacagttt aattttgtat agatcatgct tacctcaggt
     3061 ttctttagtt tgcttgaatg cccttctttc catagaacat tattaatttg gcagtgaata
     3121 cattttcttt aagttttaaa aaaactggaa taattatacc catctttttt gctgtttata
     3181 tttaggggtt ttgttgataa atcaagtctt ggttgtggct tgctgaattc aatatttatg
     3241 agtggtgcat ttttaagtat agtgaacacg acaccatagt gcagtgatga agcctctata
     3301 ttctgtaaaa aacaaaaaca aacaaaaaaa ttctgcctat gcatgttttt taaggaaaaa
     3361 aaaataaaat aaaatggctg taccggcctg tatggactgt aacgcgcttc gtggcctgac
     3421 atttactgga aatgtatgta tactggcgtg tgctttatat tctcgaaaat gcttaatgcc
     3481 tttgaaattt tgtaatcaaa acaaaagctt tgaaaaaatc taaaggggag agtattctta
     3541 aaagttttta acataagctt gtcagtgcac acatagatgg ttggcatgtt tagcaaactt
     3601 tgtgaaattt aaataagttt gtagttacat gtgtaactct aaatgcatgg taaccgttaa
     3661 tgtcatacca gtttagttat gtcgttctgt tctgtcatgt gccacaaaat acgtactttt
     3721 ttcacttttt ttccctttgt atattagtta cgggttacta ctggttcatt ctgaaaacaa
     3781 caaccaacca caaaagtcca ttcatatttt ttaacaattg tctaagtgcc caggtcattc
     3841 actacagcct caagccttgc ctttgtaatt tgacttcgga aatgttgacg atcaaagcat
     3901 gcacctgtac caatgacaaa gaaaaagcat tttatattac tactcaataa aatgtgcatg
     3961 aacttaaaga atgcgcatcc tttcactgag tctgctcaag gggatgttgt gcacagccac
     4021 catggtgtcc tctgggtgct ggccctccac caccctgcac acttagggta ggctgcttcc
     4081 caagggcctc atgatccaag gagtggtacc cacttctgct gtaaaagtcg tggtgggttt
     4141 gtgtctcaaa aaaatcaggc aagagaagtc tacttacaga gcaaatgcca tcttctggct
     4201 cccttacatg aaggactgat ttaagaaacc agaccattcc tttactttga aaacaatagt
     4261 cttcaattgg ttgtcaggtt gttttggttg tatgggacac ctcccagctc cagcaaaaag
     4321 cactagtctc ctaagcccat ttccaaccca gacgggctgt gtttatactg ataagaagtt
     4381 tgtattcacg tgctttttag ttgttatcct gcggagattt agaaggcacc acatttcagt
     4441 ttgtttctaa cattgttcat ttttcactgc actttgttta tgtaataaat tatgcctatt
     4501 atattaagta atgagagtgt ggcgattaat aataaagtgt accaaaacaa agatatattc
     4561 gctgacaaaa acctccccgt ggttatttga aggagtcaaa acgtttctcc tgtgggtatt
     4621 tccccacaaa cgtgacatcc aaggaaaaca gatgcaactt gctagaatgc tgtgaaagaa
     4681 atgatcattc ttctatcaat gtgtgtgttt tctttcttct aactacagag aaaatatccc
     4741 cccaaaatat taataatgat cagggttttt tttggattcc tttcttttgc aaattgtgct
     4801 aaggaaacta tggcatagaa ataaacattt gacattgaaa taagcaaaaa aaaaaaaaaa
     4861 aa
//
