LOCUS       NM_012024               6260 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B', epsilon
            (Ppp2r5e), mRNA.
ACCESSION   NM_012024
VERSION     NM_012024.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6260)
  AUTHORS   Dyson,J.J., Abbasi,F., Varadkar,P. and McCright,B.
  TITLE     Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates
            a genetic interaction and conserved function for these PP2A B
            subunits
  JOURNAL   FASEB Bioadv 4 (4), 273-282 (2021)
   PUBMED   35415460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6260)
  AUTHORS   Brandt,N., Franke,K., Johannes,S., Buck,F., Harder,S., Hassel,B.,
            Nitsch,R. and Schumacher,S.
  TITLE     B56beta, a regulatory subunit of protein phosphatase 2A, interacts
            with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching
  JOURNAL   FASEB J 22 (7), 2521-2533 (2008)
   PUBMED   18385213
REFERENCE   3  (bases 1 to 6260)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   4  (bases 1 to 6260)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6260)
  AUTHORS   Martens,E., Stevens,I., Janssens,V., Vermeesch,J., Gotz,J.,
            Goris,J. and Van Hoof,C.
  TITLE     Genomic organisation, chromosomal localisation tissue distribution
            and developmental regulation of the PR61/B' regulatory subunits of
            protein phosphatase 2A in mice
  JOURNAL   J Mol Biol 336 (4), 971-986 (2004)
   PUBMED   15095873
REFERENCE   6  (bases 1 to 6260)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 6260)
  AUTHORS   Witherden,A.S., Hafezparast,M., Nicholson,S.J., Ahmad-Annuar,A.,
            Bermingham,N., Arac,D., Rankin,J., Iravani,M., Ball,S., Peters,J.,
            Martin,J.E., Huntley,D., Hummerich,H., Sergot,M. and Fisher,E.M.
  TITLE     An integrated genetic, radiation hybrid, physical and transcription
            map of a region of distal mouse chromosome 12, including an
            imprinted locus and the 'Legs at odd angles' (Loa) mutation
  JOURNAL   Gene 283 (1-2), 71-82 (2002)
   PUBMED   11867214
REFERENCE   8  (bases 1 to 6260)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 6260)
  AUTHORS   Gotz,J., Probst,A., Mistl,C., Nitsch,R.M. and Ehler,E.
  TITLE     Distinct role of protein phosphatase 2A subunit Calpha in the
            regulation of E-cadherin and beta-catenin during development
  JOURNAL   Mech Dev 93 (1-2), 83-93 (2000)
   PUBMED   10781942
REFERENCE   10 (bases 1 to 6260)
  AUTHORS   Okamoto,K., Kamibayashi,C., Serrano,M., Prives,C., Mumby,M.C. and
            Beach,D.
  TITLE     p53-dependent association between cyclin G and the B' subunit of
            protein phosphatase 2A
  JOURNAL   Mol Cell Biol 16 (11), 6593-6602 (1996)
   PUBMED   8887688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132432.1 and AC124414.3.
            
            On Feb 8, 2019 this sequence version replaced NM_012024.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132432.1, BC085149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2202              AK132432.1         2-2203
            2203-2203           AC124414.3         88555-88555
            2204-4587           AK132432.1         2205-4588
            4588-6260           AC124414.3         90940-92612
FEATURES             Location/Qualifiers
     source          1..6260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.75 cM"
     gene            1..6260
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="protein phosphatase 2, regulatory subunit B',
                     epsilon"
                     /db_xref="GeneID:26932"
                     /db_xref="MGI:MGI:1349473"
     exon            1..598
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            599..762
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             606..2009
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="protein phosphatase 2A subunit beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit epsilon isoform"
                     /protein_id="NP_036154.1"
                     /db_xref="CCDS:CCDS25983.1"
                     /db_xref="GeneID:26932"
                     /db_xref="MGI:MGI:1349473"
                     /translation="MSSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIE
                     LTPLPLLKDVPTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITI
                     SRGCLTEQTYPEVVRMVSCNIFRTLPPSDSNEFDPEEDEPTLEASWPHLQLVYEFFIR
                     FLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIR
                     KQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRS
                     LSLFHAQLAYCIVQFLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEP
                     SQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNEYIMSLIEENSNVILPIMFSSLY
                     RISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKL
                     EDLELKRGLRRDGIIPT"
     exon            763..959
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1061
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1154
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1285
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1345
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1454
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1508
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1559
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1679
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1807
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1909
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..6260
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="hexamer: AATAAA"
     polyA_site      3236
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="major polyA site"
     regulatory      5690..5695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="hexamer: TATAAA"
     polyA_site      5706
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
     regulatory      6239..6244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
                     /note="hexamer: AATAAA"
     polyA_site      6260
                     /gene="Ppp2r5e"
                     /gene_synonym="4633401M22Rik; B56beta"
ORIGIN      
        1 ggttgcgcct gtgccatgga ctcagccgcc cggtgatatt gacaatagga gagagaaagg
       61 ggcattgacg gggaccctgc gcgggtagcg aacggcggct ctggcagcgg cggctcaggc
      121 ggctccaact cttcctcccg actcccgcgc ttgctgccgc tgcaaatcca ggcttcctcc
      181 ctcctccccc tccccgcgtc gccgccgccg ccgccgccgc caccaccgcc gccgggtccg
      241 gtgcaacgag cagaggcgcc gcccgccggg aatgtgaacg aagagccacc ggccgcgccg
      301 caaccgggtc ggtgccgatt tgatgggacg ggcccgcggg ggaggctcgt gaggccgccg
      361 ctgccactgc cggagcgctg aggttagggg ccagccgaga ggcctagaaa cactgccgct
      421 accgcggaac cggagggacg tcgccccgga cggccgtagt agcccggggc tctccgccgc
      481 tgcctggacc tccccccgtg cgtcccgggc cgtcgcccgc ccccgccgcg gcccctagct
      541 cgcagcccac tccgcgcagc cacagatcat cttccgattc tttcccagga gcttcaagta
      601 gggatatgtc ctcagcacca actactcctc catcagtgga taaagtagac ggattttctc
      661 ggaagtccgt cagaaaagcc agacagaaga ggtcgcaaag ctcctcccag ttcaggtctc
      721 aaggcaagcc cattgagctc acgcctctgc cactgctgaa agacgttcca acctcagagc
      781 agcctgaact gttcctaaag aaacttcagc agtgctgtgt catttttgac ttcatggaca
      841 cgctatctga tcttaaaatg aaagaataca agcgctccac tcttaatgaa ctggtggact
      901 acattacaat aagcagaggc tgtctgacag agcagactta ccctgaagta gttagaatgg
      961 tatcttgcaa tatattcaga actctccctc ctagtgacag caatgaattc gacccagaag
     1021 aagatgaacc taccctcgag gcatcatggc cccacttaca gcttgtatat gaatttttca
     1081 taagattttt ggaaagccaa gaattccaac ccagcattgc caaaaaatac atagatcaga
     1141 aatttgtatt acagcttttg gagctatttg acagtgaaga ccctcgagaa cgggactatt
     1201 taaaaacagt cttgcacagg atttatggca agtttctcgg gcttagagca tttatccgaa
     1261 aacaaattaa caatattttt ctaaggtttg tttatgaaac agaacacttc aatggtgtag
     1321 ctgaactgct ggaaatatta ggaagtatta tcaatggctt tgctttacca ctcaaggcag
     1381 aacacaaaca gttcctggtg aaagtgttga tccctctaca cactgtcagg agcttgtcac
     1441 tctttcatgc acagctggcg tattgtatag tacagtttct ggagaaagac ccttccctta
     1501 cagaaccagt tattaggggg ctaatgaaat tttggcctaa aacatgcagt caaaaagagg
     1561 tcatgttcct cggggagctg gaagaaatct tggatgtgat tgaaccgtca caatttgtta
     1621 aaatccaaga acctttgttt aaacaaattg ccaagtgtgt ttctagcccc cattttcagg
     1681 tggcagaaag ggcactctat tattggaata atgaatacat catgagtttg atagaagaaa
     1741 actctaacgt catccttccc atcatgttct ccagccttta taggatttca aaagagcatt
     1801 ggaatccggc cattgtggca ttggtgtaca acgtgttgaa ggcatttatg gaaatgaaca
     1861 gcactatgtt tgatgagctg acagccacat acaagtcaga tcgtcagcgt gagaaaaaga
     1921 aagaaaagga gcgagaagaa ctgtggaaaa aattggagga tctggagtta aagagaggtc
     1981 ttagacgcga tgggataatt ccaacttaac aacagcctga cagcgacaca ctaacccgtg
     2041 ggtcacacgc ttatgtagta gaaggatgga gcaacagttt tctgtattgt gcaactttac
     2101 agtagatttc acatttgtct cattattaca gcagcactgt atatacctgt ctctaagtaa
     2161 aggaaaacat aaggacttca aagtgtggac agtagatgga ctctcagaac tttgcaaaca
     2221 taatcattgt tctaaccctc tttaaaaaca aacaaacaaa caaaaggtct acagagatct
     2281 gtcggggaaa ttgctatgtt aaaattccat tatcaggagt tccttattta tcactagcag
     2341 agagtatgat acaattttca aatgtgaaca atcttaaatt tagcttgtct ttctgctaag
     2401 ctgttaaatg tatttatagt aaaggaagaa aagattgtca tttctttata agtttgtata
     2461 gcgccctcct ctggacatga ctgtaacgtg atatcctttc cttttgcaca tcttcatgag
     2521 tcaagtgtcc acatggaccg gggctgtgag tcagaggtct ctgaggaaag gttgtctgct
     2581 ggatgaacat cttcccagct gccaggtcct ggtactcctt tagttttcag attaggagta
     2641 aaaagaagag gtgataagca tggtagcgaa gggaatgttg gacttcatat cagatatggt
     2701 gagtccaaat cagtgtcttg aatcctttga aaacaggcag tgggacgcgc aggcttcagc
     2761 acctgcagca ttagctgcag acataagtgt gcatccagac cagagacaac ttagaaatgt
     2821 cagagaacat cctttcggat cctgtggagt aagagagaga gcactaagcg atagaaccgt
     2881 gaagccgagc accaggaccg cgcatccact tgggaaccga gttgagcaaa cagcatgaac
     2941 tgtttgcagt tgatgcctta cttcctaatg tgtacttaca aagtatttca gcagaagagg
     3001 atgcagggtg cagcctctgg gaggaacatc ctccttctct agctcaccac agcgccagcc
     3061 ctgtttttag ccagaaagga ttcaggatca acattatgcg ttctgaattg gatgcatatt
     3121 cctaactact gtatttgtta ccaaaagtgg ttctacaaat gctactgaaa aaaatctgga
     3181 aattcctaat gtcctgagta ttaataataa agtttaaaaa atgcttttat atcaaaggtg
     3241 catcgtgacc aaattgttta agttaaaaac aaaacaaaac caaaccaacc cgagggctgt
     3301 gctctagctg ggcttactgt ctctgtactg ggtccccctg ggtaggtaag ttgctgatgt
     3361 acaggtgtgc agtatgtatt cacccgatgt gttgcatcgc tgtgtattgg caagtgtgtg
     3421 ttgtggggtt tgtttccagg aagctttttc ttgttagaga caggacagtg gtgagcccat
     3481 aaccccgagc catcacatcc agcagtgttc atggcataga gccgactctg tgttcatatg
     3541 ttgagttgtg attatagcta acatgaacac acatgagcta ttgttgctct tagtagaaat
     3601 acagtataaa tatgggcttg tatattttct tccttccttt taaatgtaaa gtagaatata
     3661 tagagctttg ttgtttccaa ggaaaaggag gggaaaagcc actgacctat ttcacttatg
     3721 aagtatttcc agattgtcag tcacaatgtg tacataaatg taagctaatt atggatattt
     3781 tcatttaggt acctttgttc tcttgttttt taaaggtatg cgtaccacca agtccaagat
     3841 ggttcagtgg aataaatagg actcttaaag agcgttaagg agggttccat ctgaggacct
     3901 ggaaagtgtg agcagagctg catgttcaca tattgatgct aagaagcaaa ccatagcaca
     3961 tctcccttag ctgtcttagc cgtttccatc ttcattacac atatctttga tagtgtagac
     4021 cttgcttgct gtggtccctc tggggatgac atgtgctcat ttgacatgag gaaggtcagg
     4081 acctctttct gcaccgtgtc ctgtcctcag agctaagggt cagtgttgtc tgttggtcat
     4141 tcccaactga gaggaatgaa gctaagcttt agactattta aagatgtgat gagagctgaa
     4201 tgtcagaact cacagggcaa tctctgagaa gaaacactca tttccctttt aaccaaaagt
     4261 gacaatgtga cctctgtcat gttgtgtgtg gtgaggagaa gctagcccag gtgacttgat
     4321 tgttgcacta tgtgacatat ttaaggacat acttgctgca tttgcagcag cccccctgtc
     4381 tgacctccct gggcaatcct gctgtcactc aatgtgagtt aactgtgaca aactcagctc
     4441 tgtgttatat tttgtttgct tcatagtttc cagaactata tataaatata ttttttcaat
     4501 agcaaatatt gtagttagtg agtggtgacc acttcaacct tatccctacc atattggttt
     4561 cagggatggg actaagaatg tccttggaat aaaaaaatta aaatataacc ctgtgattta
     4621 gaatgatgcc gaggttgcag gttgcagcct gcagcagctg tgtgagcgaa gtgaccgtct
     4681 cctctggatc aagcgtccac tcctcattgt gcccaggccc cagtgctcct tcatcactgt
     4741 ttagttattg tccgctgtgg ttttgattat attttgctct tcctgacatt gactgttttt
     4801 ttttaataaa agaaaataaa aagtaaatga ataacccctg aatgtgactg gatgcaggga
     4861 taagcccctc cctcctcctt gggctctttc cctaagtggc aggatcgcgc tggctctgta
     4921 tctcccgtgc gtgcggcagt ccaaggtgca gacctaggga gcacttgtca tcacacctcc
     4981 tatactgaac acataaccct aggctcaatc actttatgga aagggaaata aagtagactt
     5041 tattttaggg atggagccgg ggagtggtgt gtggatggga ggctggtatc aacatcacta
     5101 agtattccga aggtcttctt gctttgtttt tccattttaa ttgatacact gacctggccc
     5161 aggaaaggaa gagccgctct cctttgatgt tattagccaa cattcccaca aagtgacggt
     5221 cacctgtctc agaaaggcaa caggagatat gatccgtgac attttatttg cacatgaata
     5281 ttttattttt gtattctggc tcagctgctt ctcttcgtgg agttagggag gagccataaa
     5341 ggacttttgt aataagtaat attggcaacg cattttatac tcctctatgt ttacttttga
     5401 gaacctgaaa gaaggggtgt gcgtccgaga ggagggtgag cggagcttga gccagcggaa
     5461 tgttccattt gtctgccgct tgtgcacgag agcggccagc tgtagcgtct cctggaaacc
     5521 aacgccccgt gctatgacgt ctgtgagcct aggtttcctt tcctcccctc ccttccccca
     5581 tcctctcctc cattttcttt ctttctcaac ccatcccttt ttttttttaa atcacttact
     5641 gtaaataagt tgtaatctaa acctcatgta tcaatgggga aatttcaaat ataaatatta
     5701 ccaacacgtt ttcttgttgt ctggcttttg attggagtgt aatgagaatg gcatgcccat
     5761 ctcctcaggc ctgagggttt catctcagct ccagcctctc ctctccctca tttcattgtt
     5821 gtggcaggag agggcagcac acgttcattt ttccccccgc taggaagcca cagtgttagc
     5881 tgtggatgag tgtttttctt aagttttcaa aacatccgtt ggtgcataga tgtgaaaatg
     5941 aaacaatatg aaaagttgca tatgaaaaat gacagactgg tttagccagg cagggaagcc
     6001 ttctgatcca cttcaaagta aaaaattacc caagacactt ccagcccctg ttgaaccaga
     6061 cttcttccgt ttcaaacagc aggatgcagg tggcagctta cacacttgga aataagcgtt
     6121 catctttgaa aataatatac tctctcaaaa gtggttacag actaagcaga ggtgctcccc
     6181 aaagcaatgt aatcctcccg ttgacagcta tgtgagattc tgtactgtgg gtgtccctaa
     6241 taaataagca ctgaagggtg
//
