LOCUS       NM_009358               2926 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B', delta
            (Ppp2r5d), transcript variant 1, mRNA.
ACCESSION   NM_009358
VERSION     NM_009358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Domenech Omella,J., Cortesi,E.E., Verbinnen,I., Remmerie,M., Wu,H.,
            Cubero,F.J., Roskams,T. and Janssens,V.
  TITLE     A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma
            Induced by Diethylnitrosamine and Loss of Ppp2r5d
  JOURNAL   Cancers (Basel) 15 (16), 4193 (2023)
   PUBMED   37627221
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Dyson,J.J., Abbasi,F., Varadkar,P. and McCright,B.
  TITLE     Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates
            a genetic interaction and conserved function for these PP2A B
            subunits
  JOURNAL   FASEB Bioadv 4 (4), 273-282 (2021)
   PUBMED   35415460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Lambrecht,C., Libbrecht,L., Sagaert,X., Pauwels,P., Hoorne,Y.,
            Crowther,J., Louis,J.V., Sents,W., Sablina,A. and Janssens,V.
  TITLE     Loss of protein phosphatase 2A regulatory subunit B56delta promotes
            spontaneous tumorigenesis in vivo
  JOURNAL   Oncogene 37 (4), 544-552 (2018)
   PUBMED   28967903
  REMARK    GeneRIF: Ppp2r5d knockout mice are predisposed to spontaneous tumor
            development, providing the first in vivo evidence that validates a
            single PP2A complex as a bona fide tumor suppressor.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Li,J.J., Tay,H.L., Maltby,S., Xiang,Y., Eyers,F., Hatchwell,L.,
            Zhou,H., Toop,H.D., Morris,J.C., Nair,P., Mattes,J., Foster,P.S.
            and Yang,M.
  TITLE     MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness
            by reducing protein phosphatase 2A activity
  JOURNAL   J Allergy Clin Immunol 136 (2), 462-473 (2015)
   PUBMED   25772595
  REMARK    GeneRIF: MiR-9 regulates GR signaling and steroid-resistant airway
            hyperresponsiveness by reducing protein phosphatase 2A activity.
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Tadmouri,A., Kiyonaka,S., Barbado,M., Rousset,M., Fablet,K.,
            Sawamura,S., Bahembera,E., Pernet-Gallay,K., Arnoult,C., Miki,T.,
            Sadoul,K., Gory-Faure,S., Lambrecht,C., Lesage,F., Akiyama,S.,
            Khochbin,S., Baulande,S., Janssens,V., Andrieux,A., Dolmetsch,R.,
            Ronjat,M., Mori,Y. and De Waard,M.
  TITLE     Cacnb4 directly couples electrical activity to gene expression, a
            process defective in juvenile epilepsy
  JOURNAL   EMBO J 31 (18), 3730-3744 (2012)
   PUBMED   22892567
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Ortega-Lazaro,J.C. and del Mazo,J.
  TITLE     Expression of the B56delta subunit of protein phosphatase 2A and
            Mea1 in mouse spermatogenesis. Identification of a new B56gamma
            subunit (B56gamma4) specifically expressed in testis
  JOURNAL   Cytogenet Genome Res 103 (3-4), 345-351 (2003)
   PUBMED   15051958
  REMARK    GeneRIF: A comparative expression study of Ppp2r5d and Mea1 in
            spermatogenesis.
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ042073.1, AK160587.1 and CT030702.11.
            
            On Apr 18, 2009 this sequence version replaced NM_009358.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010716.1, AB053464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CJ042073.1         2-61
            61-2244             AK160587.1         2-2185
            2245-2926           CT030702.11        186191-186872
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..2926
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /note="protein phosphatase 2, regulatory subunit B',
                     delta"
                     /db_xref="GeneID:21770"
                     /db_xref="MGI:MGI:2388481"
     exon            1..170
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1928
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed gene 271"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit delta isoform isoform 1"
                     /protein_id="NP_033384.2"
                     /db_xref="CCDS:CCDS28836.1"
                     /db_xref="GeneID:21770"
                     /db_xref="MGI:MGI:2388481"
                     /translation="MSYKLKKDKEPSKLAKGTAKPSSSSKDGGGENTDEAQPQPQSQS
                     PSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSFPFNLNKNRELQKLPALKDSP
                     TQEREELFIQKLRQCCVLFDFVSDPLSDLKCKEVKRAGLNEMVEYITHSRDVVTEAIY
                     PEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDF
                     QPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIF
                     YRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKVFLVRVLLPLHKVKSLSVYHPQ
                     LAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVM
                     EPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYRNSKSHW
                     NKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLN
                     PQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSE
                     LPQDVYTIKALEAHKRAEEFLTASQEAL"
     exon            171..248
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            249..441
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            442..641
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            642..752
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            753..845
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            846..976
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1145
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1199
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1370
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1498
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1600
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1673
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1790
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2926
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /note="hexamer: AATACA"
     polyA_site      2247
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /note="major polyA site"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Ppp2r5d"
                     /gene_synonym="B'delta; TEG-271; Tex271"
ORIGIN      
        1 gttcgggcca attggaagcg cagccacggc tcggcccggg cgcagcgcgc aggcggtggc
       61 gaagagacgc cgagcgggcc gagtgtggcc gagcagagcc ggagcggggc cgcaggagcc
      121 gggccgggtg tggaccggcc gagatgtcct ataaactgaa gaaggataag gaaccctcca
      181 agcttgccaa aggcacagcc aagcccagca gctcaagcaa ggatggtgga ggggagaaca
      241 ccgatgaggc ccagccccag ccccagtctc agtcaccatc atccaacaag cgacccagca
      301 acagtacacc acccccaaca caactcagca aaatcaagta ctcaggggga ccccagattg
      361 tcaagaaaga acgacgccaa agctccttcc ccttcaacct caacaagaac cgggagctac
      421 aaaaacttcc tgccttgaaa gactcaccaa cccaggaacg tgaggagctg tttatccaga
      481 agctacgcca gtgctgtgtc ctctttgact tcgtgtcaga cccactcagt gacctcaaat
      541 gcaaagaggt gaagcgggca ggactcaatg agatggtgga gtatatcacc cacagccgtg
      601 atgttgtcac tgaggccatc taccctgagg ctgtcaccat gttttcagtg aatctcttcc
      661 ggacgctgcc tccttcatcg aatcccacag gagcagagtt tgaccctgag gaagatgagc
      721 caaccttgga agctgcctgg ccgcatctcc agctcgtgta cgagtttttc ttacgtttct
      781 tggagtctcc agatttccag ccaaatatag ccaagaagta cattgaccag aagtttgtac
      841 ttgctctcct ggacctattc gatagtgaag accctagaga gcgggatttt ctcaagacca
      901 ttttgcatcg catctatggc aagtttttgg ggctccgggc ttatattcgt aggcagatca
      961 accacatctt ctacaggttt atctatgaga ctgagcatca caatgggatt gcggagctgc
     1021 tggagatcct gggcagcatc atcaatggct ttgccttgcc ccttaaggaa gaacacaagg
     1081 tgtttctcgt ccgtgtcctg cttccacttc acaaagtcaa gtctctgagt gtataccacc
     1141 ctcagttggc gtactgtgtg gtgcagttcc tggagaagga gagcagtctc actgagccgg
     1201 tgattgtggg acttctcaag ttttggccta agacccacag ccccaaggag gtgatgtttc
     1261 tgaacgagct ggaggagatt ctagatgtca ttgaaccctc ggagttcagt aaagtcatgg
     1321 agccgctctt ccgccagctt gccaaatgtg tttccagccc ccatttccag gtggcggagc
     1381 gcgccctcta ctactggaac aatgagtaca tcatgagcct catcagcgac aatgctgccc
     1441 gcatcctccc catcatgttt cctgcactct ataggaactc caaaagccac tggaacaaga
     1501 caatccatgg actcatctac aatgccctga agctcttcat ggagatgaac cagaagctgt
     1561 ttgacgactg cacacagcag tacaaggcgg agaagcagaa gggcaggttc cgaatgaagg
     1621 agagagagga gatgtggcag aagatcgagg agctggcccg gctcaatccc cagtacccta
     1681 tgtttcgggc tcctccgcca ctgccccctg tgtactccat ggagacagag acgcccacag
     1741 cagaggacat tcagctcctg aagaggacgg tggagacaga ggccgtgcag atgctgaagg
     1801 acatcaagaa ggacaaagtg ctgctccgga ggaagtcaga gctgccacag gacgtgtaca
     1861 ccatcaaggc actagaggcg cacaagcggg cagaagagtt cctgactgcc agccaggagg
     1921 ccctctgacc ccctcacctt cccttcccac aggattccag cccactcagc cctgggatgc
     1981 agcccagccc tccaccctct gctcctcatc ggctgacctg gggcagaacg gcacctctct
     2041 ggctactcta gaggatgcag gcactggaag cgggatgccc agagcgctcc ctcttctccc
     2101 ctaaacgtgt tcatgcctcc ctgtggctag tacagacagg ctgagcactg agtgctcagt
     2161 gcttagacaa cctgggggtg cctgtccccc tgctcctaac cccacagctg cctgaaactg
     2221 ttctgagaaa tacacacagg aatcacatgt ccctctctac ccccttaatc ctcatctgaa
     2281 gttgaggtgt ctctcctctc cctgcagagt acaacaggag actgtcacca aagtcacgtt
     2341 aagctccgtt ggccccttga gcgaagagct ggagggaacc aatccccagc agcacaaata
     2401 ggcccctaga cccagcttta tgcaggcggg ggtggtagtg tgtttctttg tatcctatac
     2461 ctaaccaaga caacacagag gacaaacaag ttacggacac tagatgacta gtgggcccgg
     2521 tggggagaaa gaaccatctg ccttgccctc tctggcaagc agcagtcctg ggatcacaca
     2581 tttgcaaggg accaccctgt ggctgactgc tttcccttgt gctcttggtt cccagagcta
     2641 taaagaagga ggcaggagca gtgctccaag catggctccc tgctgtgcct gtttatttcc
     2701 tggtttctgc tgacgctggg ctgggcgggt cctcacctgt accctctagg cgctcagaaa
     2761 caaaagcctg gggagggctg gaccaggatt caggagcaca ggcggtgtgg cttctggctg
     2821 tgtacacagg gtgctttatt ctccacagag tgatacatgc taaggtgggc tgggcttggg
     2881 ccgatgtccc catatgtaca gaactgaata aagtgggtct ctgaga
//
