LOCUS       NM_001373949            4411 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B', gamma
            (Ppp2r5c), transcript variant 16, mRNA.
ACCESSION   NM_001373949 XM_006515917
VERSION     NM_001373949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4411)
  AUTHORS   Yang,C., Gong,Y., Liu,S., Sun,C., Wang,T., Chen,X., Liu,W.,
            Zhang,X., Yang,Y. and Zhang,M.
  TITLE     LincR-PPP2R5C deficiency enhancing the fungicidal activity of
            neutrophils in pulmonary cryptococcosis is linked to the
            upregulation of IL-4
  JOURNAL   mBio 15 (10), e0213024 (2024)
   PUBMED   39287443
  REMARK    GeneRIF: LincR-PPP2R5C deficiency enhancing the fungicidal activity
            of neutrophils in pulmonary cryptococcosis is linked to the
            upregulation of IL-4.
REFERENCE   2  (bases 1 to 4411)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4411)
  AUTHORS   Sents,W., Meeusen,B., Kalev,P., Radaelli,E., Sagaert,X.,
            Miermans,E., Haesen,D., Lambrecht,C., Dewerchin,M., Carmeliet,P.,
            Westermarck,J., Sablina,A. and Janssens,V.
  TITLE     PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes
            Cancer Development
  JOURNAL   Cancer Res 77 (24), 6825-6837 (2017)
   PUBMED   29046336
REFERENCE   4  (bases 1 to 4411)
  AUTHORS   Varadkar,P., Abbasi,F., Takeda,K., Dyson,J.J. and McCright,B.
  TITLE     PP2A-B56gamma is required for an efficient spindle assembly
            checkpoint
  JOURNAL   Cell Cycle 16 (12), 1210-1219 (2017)
   PUBMED   28562161
  REMARK    GeneRIF: Inactivation of only the PP2A-B56gamma subunit can affect
            the efficiency of the spindle assembly checkpoint.
REFERENCE   5  (bases 1 to 4411)
  AUTHORS   Varadkar,P., Despres,D., Kraman,M., Lozier,J., Phadke,A.,
            Nagaraju,K. and Mccright,B.
  TITLE     The protein phosphatase 2A B56gamma regulatory subunit is required
            for heart development
  JOURNAL   Dev Dyn 243 (6), 778-790 (2014)
   PUBMED   24425002
  REMARK    GeneRIF: The PP2A B56gamma regulatory subunit controls PP2A
            substrate specificity in vivo in a manner that cannot be fully
            compensated for by other B56 subunits.
REFERENCE   6  (bases 1 to 4411)
  AUTHORS   Gotz,J., Probst,A., Mistl,C., Nitsch,R.M. and Ehler,E.
  TITLE     Distinct role of protein phosphatase 2A subunit Calpha in the
            regulation of E-cadherin and beta-catenin during development
  JOURNAL   Mech Dev 93 (1-2), 83-93 (2000)
   PUBMED   10781942
REFERENCE   7  (bases 1 to 4411)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 4411)
  AUTHORS   Lan,Y., Jiang,R., Shawber,C., Weinmaster,G. and Gridley,T.
  TITLE     The Jagged2 gene maps to chromosome 12 and is a candidate for the
            lgl and sm mutations
  JOURNAL   Mamm Genome 8 (11), 875-876 (1997)
   PUBMED   9341252
REFERENCE   9  (bases 1 to 4411)
  AUTHORS   Francia,G., Mitchell,S.D., Moss,S.E., Hanby,A.M., Marshall,J.F. and
            Hart,I.R.
  TITLE     Identification by differential display of annexin-VI, a gene
            differentially expressed during melanoma progression
  JOURNAL   Cancer Res 56 (17), 3855-3858 (1996)
   PUBMED   8752144
REFERENCE   10 (bases 1 to 4411)
  AUTHORS   Tehrani,M.A., Mumby,M.C. and Kamibayashi,C.
  TITLE     Identification of a novel protein phosphatase 2A regulatory subunit
            highly expressed in muscle
  JOURNAL   J Biol Chem 271 (9), 5164-5170 (1996)
   PUBMED   8617797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591582.32 and AC152827.4.
            
            On Sep 5, 2019 this sequence version replaced XM_006515917.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL591582.32        70605-70766
            163-228             AL591582.32        71353-71418
            229-400             AL591582.32        89230-89401
            401-600             AL591582.32        145872-146071
            601-711             AL591582.32        167456-167566
            712-804             AC152827.4         47498-47590
            805-935             AC152827.4         47674-47804
            936-995             AC152827.4         52965-53024
            996-1104            AC152827.4         54688-54796
            1105-1158           AC152827.4         56746-56799
            1159-1329           AC152827.4         63201-63371
            1330-1457           AC152827.4         69631-69758
            1458-1559           AC152827.4         70857-70958
            1560-1632           AC152827.4         72599-72671
            1633-1749           AC152827.4         76648-76764
            1750-4411           AC152827.4         82304-84965
FEATURES             Location/Qualifiers
     source          1..4411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.56 cM"
     gene            1..4411
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /note="protein phosphatase 2, regulatory subunit B',
                     gamma"
                     /db_xref="GeneID:26931"
                     /db_xref="MGI:MGI:1349475"
     exon            1..162
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1881
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /note="isoform p is encoded by transcript variant 16;
                     B56/PP2A gamma; Band 8A"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform p"
                     /protein_id="NP_001360878.1"
                     /db_xref="GeneID:26931"
                     /db_xref="MGI:MGI:1349475"
                     /translation="MPNKNKKEKEPPKPVKSGKGPKEGQDTAETEIASRKNSLTVVQS
                     STSTKIKVPIPQPVVVPVKKDKRQNSSRFNASNNRELQKLPSLKDVPPADQEKLFIQK
                     LRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEAVHMFAVNM
                     FRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQ
                     KFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHN
                     GIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEK
                     DSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCV
                     SSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNA
                     LKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASA
                     VSIPVAMETDGPQFEDVQMLKKTVSDEARQAQKELKKDRPLVRRKSELPQDPHTEKAL
                     EAHCRASELLSQDGR"
     exon            163..228
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            229..400
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            401..600
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            601..711
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            712..804
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            805..935
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            936..995
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1104
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1158
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1329
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1457
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1559
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1632
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1749
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..4411
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /note="hexamer: AATAAA"
     polyA_site      4175
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /note="hexamer: AATAAA"
     polyA_site      4411
                     /gene="Ppp2r5c"
                     /gene_synonym="2610043M05Rik; 2700063L20Rik; D12Bwg0916e"
                     /note="major polyA site"
ORIGIN      
        1 agtccccggg cggcggctgc agcggcggcg gcggcggccg gggcggcgcg acggccgggc
       61 cgggggcgct tctgctgctg cagcggcagt ggcggcgggc ggaggcaggg gcggcggcgg
      121 cggcccgcac cagccatgcc gaataaaaac aagaaggaga aagaaccacc aaaaccggtg
      181 aaaagtggaa aaggtccaaa agaaggacaa gatacagcag aaacagagat agccagcagg
      241 aaaaatagcc tcacggttgt ccagtcttcg acatctacta aaataaaagt accaatccct
      301 caacccgtcg tcgtccctgt gaagaaagac aaacggcaga attcttcacg gtttaatgcc
      361 agcaataata gagagctaca aaaactccca tctttaaaag atgttcctcc tgcggatcaa
      421 gagaagcttt ttatccagaa gctacgccag tgttgtgtcc tctttgactt tgtctctgac
      481 ccactgagtg acctgaagtg gaaggaagta aagcgcgctg cgctgagcga gatggtggag
      541 tatatcaccc acaaccggaa cgtgatcacg gagcccattt accccgaggc cgtccacatg
      601 tttgcagtta acatgttccg aaccttgcca ccttcctcca atcccacggg agcagaattc
      661 gacccagaag aggatgaacc aacgttagaa gcagcctggc ctcatctgca gcttgtttat
      721 gaatttttct taagattttt agagtctcca gatttccaac ccaatatagc aaagaaatat
      781 attgatcaga agtttgtatt gcagcttcta gagctgtttg acagcgagga tcctcgggag
      841 agagattttc taaaaaccac cctgcacaga atctatggga agttcttagg cctgcgtgct
      901 tacatcagga aacagatcaa taatatattt tataggttta tctatgagac agagcatcac
      961 aatggcatag cggagttact ggagatcctg ggaagtataa ttaatggatt tgccttacca
     1021 ctgaaggagg aacacaagat tttcctgctg aaggtgttgc tgcccttgca caaagtgaag
     1081 tccctgagtg tctaccatcc ccagctggcg tactgtgtcg tgcagttttt agagaaggac
     1141 agcaccctca ctgaaccagt ggtaatggca cttctcaaat actggccaaa gactcacagt
     1201 ccaaaagaag taatgttctt aaatgaatta gaagaaattt tagatgtaat tgaaccatca
     1261 gagtttgtga agatcatgga gcctcttttc cgacagttag ccaaatgtgt ttccagccct
     1321 cacttccagg tggccgagcg ggcgctctat tactggaaca acgagtacat catgagttta
     1381 atcagtgaca acgcagcgaa gattctgccc atcatgtttc cgtccttata ccgcaactca
     1441 aagacccact ggaacaagac aatacacggc ttgatataca acgccctgaa actcttcatg
     1501 gagatgaacc aaaaactctt cgatgactgc actcagcagt tcaaagcaga gaaactcaaa
     1561 gagaagctaa aaatgaaaga gcgagaagaa gcatgggtta aaatagaaaa tctagccaaa
     1621 gcgaatcccc agtatgcagt gtatagtcaa gccagcgccg tgagcattcc ggtcgcaatg
     1681 gagacagatg ggcctcagtt tgaagatgtg cagatgctga aaaagacagt gagcgacgag
     1741 gctcgtcagg cacagaagga gctgaagaag gatcgtcccc tcgtgcgccg caagtccgag
     1801 ctgcctcagg acccccacac cgagaaagcc ttggaagctc actgcagagc cagtgagctg
     1861 ctctcccagg acgggcgcta gcgtctggag cagcacgccg agctgggcct gtcggttctc
     1921 ttctggatgc tgtagaaaag acatactgtg tgtgccatac cagtcagtta cactcaatgt
     1981 caaagcttcc tctgaccccg ttctgtaggc aataatgcac gtccgcctca gctcgagatt
     2041 aggagttcaa acaatggtgg cttctctggc cctgctggcc aagcaggggg ctgggggagt
     2101 cggtgacagt gtcatcacca tgttgtcacc accccagcac agccctgagt gagatccaaa
     2161 gtcagagctg taggaaagca ccctgactgt caccttctcg tacccagtag accctgtggt
     2221 cctctgaaat agggattctg tggtaggtaa caccgatgct gtggcaaatc aaacgcacat
     2281 ggtaaaaggt gtctcctccc tttacaaccc tgacgctgtc cccacgcttg ctgtgccagc
     2341 cgcccgtggt ggttggttag gtctctcaga gatggctcct cgctttcccg ttctagctgc
     2401 ctgccgggaa agaggccaac ttttgcgctg gggccgtcca cagtgtttct ttcctttggt
     2461 taatggcacg gtcaccatgt cctgcttacc ttaatgtcta ccgaaagcca tatttcatag
     2521 tctgtggtag aggccagggt tccacctcag cgcaagggag ggttctgaga agtgcttcct
     2581 cagcccacct tgaggagaac cgccacgttg gaatgacgtg ttcatgttag ttgcagaatc
     2641 agtttttcac ctacttacac atgatccttc aacaaggctc tcgagtggat aaagatcaca
     2701 ggatctaaga attccacatt ggtagaaagt gacagtaaac tcagcccctt ggcctagtgc
     2761 agcctgcagc tgcctgtggc ctgactgcgg gccgcactgt gtgggcgccc tcagtgagcc
     2821 tttctttctg ttggaaaaag cacatgtcac caagctcgcg aggaaaggcg cggtgcccgc
     2881 gttcgcacca gtctccacat gctgctccgg ccttcacaga attcttgcat ggattaagct
     2941 tctgttttag atgggatagc acgaggagat acatccttaa acttagtgct ttgtcttctt
     3001 gtcctctcag ggtggccagt attttgactt atttatcctg ctcaaaagct gcttgaaatg
     3061 tgtgctgctc tctgaacagt ggcgagtctt ctcttgtctc cagcatatat ataactcagt
     3121 gttacatgtc ttgatgcata agataggtta aaaaaaaaga agaagaagaa aaatggggct
     3181 tcttttaaaa cctgatttta atcgtggtct cagggatccg tgaaaaagtt gtgaaatcag
     3241 acattgctct ctcgcggcct tggaggcggg tcccacgggg aagaagggca tgtgcaggga
     3301 gggagagcca gcacggctag tcaaaaaggc ggccccagct gagggtgaac aggttggcca
     3361 cttgggtgag aacacttcct gagaaacttg acaagtacct atccacttta ccattatgaa
     3421 atctataatt aaaaaaaaaa agttgagatg ccttctcctt ttgagggaaa aagggtgctt
     3481 ttattgtata aagcagtgtc tctgtgtttt gatagcccac tgtttgaact ctcgtcttta
     3541 gctggtagag tctcagatat ccctgacgtg tggggcattc cgagtgtggt gagaggtccc
     3601 aagaggctcc tttgccctgc gtgaagagca tgctatcagt gtacgggtga ttgtgcaaag
     3661 ctcagcgcgg gggagcatct tctgctctag gttttatttc tgctctttat tgaagacaaa
     3721 cattcgccaa taaagaaaag ggaaaaaaat gttttgagag aaactaattt tctttggcaa
     3781 aagtattact taaatttttg gcctattaag gttcccctag ttagtactcg gattccccat
     3841 gctaattgtt cagcttgtat gttgttaaga cactgttgat tctgtaccag actggtttca
     3901 aaacaaaaaa agtaccacgt tgaaaataaa ctggtgactg tttttcttca tatggctcta
     3961 gtttggcacc ttcactcttt ccaaaacgtg tctgtgcgcc agagatgtca cagttcaagt
     4021 gtctttctag tgtggctttg tatggcttcc tttgaacatt gtacatacat tgtatctttg
     4081 ttttatggta ataagtaata aaaaatgtag acttcgtatt ttgtacaaaa tgtcctatgt
     4141 acagaataaa aaaaagttca tagaaacagc aaaaataggt taagtggcac agttattttt
     4201 ctttagaaaa tatctgtaac tttatgcttt agtgaaacgt taagtaccaa catatttttt
     4261 aacattttgt aattcaaaac ttttttgttt tgacattgtt tatgaagaaa gacttcatgc
     4321 acttgccatt taatatgctc ttttatctaa ttttaaagaa ctctttaaaa tggtgtatta
     4381 tatggactaa ataaagaaca tgtgaatttt a
//
