LOCUS       NM_198168               2708 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B', beta
            (Ppp2r5b), mRNA.
ACCESSION   NM_198168
VERSION     NM_198168.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Dyson,J.J., Abbasi,F., Varadkar,P. and McCright,B.
  TITLE     Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates
            a genetic interaction and conserved function for these PP2A B
            subunits
  JOURNAL   FASEB Bioadv 4 (4), 273-282 (2021)
   PUBMED   35415460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Beg,M., Srivastava,A., Shankar,K., Varshney,S., Rajan,S., Gupta,A.,
            Kumar,D. and Gaikwad,A.N.
  TITLE     PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte
            insulin resistance
  JOURNAL   Mol Cell Endocrinol 437, 97-107 (2016)
   PUBMED   27521959
  REMARK    GeneRIF: PPP2R5B, a B subunit of PP2A is a negative regulator of
            Akt phosphorylation contributing partly to the chronic
            hyperinsulinemia induced insulin resistance in adipocytes.
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Rodgers,J.T., Vogel,R.O. and Puigserver,P.
  TITLE     Clk2 and B56beta mediate insulin-regulated assembly of the PP2A
            phosphatase holoenzyme complex on Akt
  JOURNAL   Mol Cell 41 (4), 471-479 (2011)
   PUBMED   21329884
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Van Kanegan,M.J. and Strack,S.
  TITLE     The protein phosphatase 2A regulatory subunits B'beta and B'delta
            mediate sustained TrkA neurotrophin receptor autophosphorylation
            and neuronal differentiation
  JOURNAL   Mol Cell Biol 29 (3), 662-674 (2009)
   PUBMED   19029245
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Martens,E., Stevens,I., Janssens,V., Vermeesch,J., Gotz,J.,
            Goris,J. and Van Hoof,C.
  TITLE     Genomic organisation, chromosomal localisation tissue distribution
            and developmental regulation of the PR61/B' regulatory subunits of
            protein phosphatase 2A in mice
  JOURNAL   J Mol Biol 336 (4), 971-986 (2004)
   PUBMED   15095873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171178.1.
            
            On Apr 6, 2007 this sequence version replaced NM_198168.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171178.1, BC058977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2708              AK171178.1         2-2709
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.35 cM"
     gene            1..2708
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /note="protein phosphatase 2, regulatory subunit B', beta"
                     /db_xref="GeneID:225849"
                     /db_xref="MGI:MGI:2388480"
     exon            1..329
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            330..796
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..2091
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform"
                     /protein_id="NP_937811.1"
                     /db_xref="CCDS:CCDS29499.1"
                     /db_xref="GeneID:225849"
                     /db_xref="MGI:MGI:2388480"
                     /translation="METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRS
                     HSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEV
                     KRAALNELVECVGCTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEP
                     SWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILH
                     RVYGKFLGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILGSIINGFALPLKTEHKQ
                     FLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVM
                     FLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIED
                     NCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQE
                     QQKAQERQELWRGLEELRLRRLQGTQGAKEAPVPRPTPQVAASGGQS"
     exon            797..993
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1095
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1188
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1319
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1379
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1488
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1542
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1593
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1713
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1841
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1943
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2708
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2708
                     /gene="Ppp2r5b"
                     /gene_synonym="B'beta"
                     /note="putative"
ORIGIN      
        1 gtcatcctga gcagctgggc ggcgggtgcc ggtgcgcagc gagccggggc tcccgctgcg
       61 ctgcaccgcg ctgatctgag tcccgggata tctgccgagg gtcgcgtgct gccggggccc
      121 agcccagagc ccaccgagtg cccgacccct tttggggctg agctgggggc atgctccagc
      181 acccccagag cctgggagcg aacccaggag cgccgccgcc cagccccagc gccccgagcg
      241 gcagaaccac cgctaaggac ccttgaaccg tcgtctcttc caccgaggca acctctaggg
      301 tcggcgacca aagtctgggt ttctgagaaa agagccagcg tgggaaccct gactggaact
      361 cttctggatc cccaggaaag acctgagcca ttgcctttct accttacctg cccccccagg
      421 actgggcagt tgccagaggc cctggggggg tcaggactgt ggccgtgcct cccccacccc
      481 ctgaaacatg ctggacagga tgggtcccag ttagtgtgtg tggcctcatt caacttactc
      541 cagacccaca aggagccccc tgggctctga aagattgacc cgtgttgtcc actggccatg
      601 gagacgaagc tgccccctgc gagcaccccc acaagcccct cctccccagg gctgtctcca
      661 gtgccaccac cagacaaggt ggatggcttc tcccgcaggt ccctccgcag ggcccggccc
      721 cgtcgctcac acagctcttc tcagttccgc tatcagagca accagcaaga gctcactcca
      781 ctgcccctgc tcaaagatgt gccagcctct gagttgcatg agttgctgag ccggaaactg
      841 gcccaatgtg gggtgatgtt tgacttcttg gactgcgtgg ctgacctcaa ggggaaggag
      901 gtgaagcgtg cagccctcaa tgaactggtg gaatgtgtgg gttgcacccg gggtgtgctc
      961 atcgagcccg tctacccaga catcatccgc atgatatcag taaatatctt ccggaccctg
     1021 ccacccagcg agaaccctga gtttgaccct gaagaagatg agcccaacct tgagccctcg
     1081 tggccacatc tgcagctggt atatgagttt ttcctgcgtt tcttggagag tccagatttc
     1141 cagccctctg tggccaagag atacgtggat caaaagtttg tcctaatgct cctggagcta
     1201 tttgacagcg aggacccccg ggaacgtgag tacctcaaga ccatcttgca tcgggtgtac
     1261 ggcaagttcc tgggtctccg ggcctacatc cgcaaacagt gcaaccacat cttcctccgg
     1321 ttcatctacg agctggaaca cttcaatggt gtggctgagc tcttagagat cttaggaagc
     1381 atcatcaatg gctttgcgct gcccctgaag actgagcaca agcagttcct ggttcgagtc
     1441 ctgatcccct tgcactctgt caagtcacta tctgtttttc atgctcagct ggcatactgt
     1501 gtggtgcagt tcctggagaa ggatgcaacc ttgacagagc atgttatccg ggggcttctc
     1561 aaatactggc ctaaaacctg cacccagaag gaggtgatgt tcctggggga gatggaagag
     1621 attcttgatg tcatcgagcc ctcccagttt gtgaagatcc aggagcccct cttcaagcag
     1681 gtggctcgct gtgtctccag cccccatttc caggttgcag agcgggctct gtatttctgg
     1741 aacaatgagt acatcctgag cctcattgag gacaactgcc acactgtgct gcctgcggta
     1801 tttgggaccc tctaccaagt gtccaaggag cactggaatc aaaccatcgt gtccctgatc
     1861 tacaacgtgc tcaagacttt catggagatg aacggaaagc tgtttgacga gctcacagcc
     1921 tcctacaagc tggaaaaaca acaggagcag cagaaggccc aggagcggca ggagctatgg
     1981 cgaggcttgg aggaactgcg gctacgccgg ctacagggga cccaaggggc caaggaagcc
     2041 cccgtcccac ggcctacgcc ccaggtggct gccagtgggg gtcagagcta gatacaccta
     2101 gaacaggaga tgctaaaccc agagctatca gcccctccat ccctctgccc aggggcccag
     2161 tgaggcccac gcctccccgt ggccttgccg gagtggctct aggactccct accagccccg
     2221 tgggaacagc tttcacggag ggggaaacaa gaaggcaaga tggtagtctt ggcagcagaa
     2281 ctctcaggcc tttgtggcaa gattctggca agactagacc agggcaagta tgcaactggg
     2341 aagctgccat cagggatcct cccctgccct acacagccag gctccaggcg gcagctaggc
     2401 ctctacccct gctcccagcc tggggcatgg acactcagcg cctggccagg gccttcctca
     2461 tccccaccat gggggcacag tctatttatt ctgcccagct cacccccaac aagaccttgt
     2521 ccagggacat tctcctatcc tctccctggc cctgactccc ttatcccctt tttatttatt
     2581 gggcaggggg aggggtgagg gcacaggcaa gaagattcac attgtcctgg ggtgaggggg
     2641 gaggtcacag taatcatggt ctgccccctt cacctggctg ggggcagatt taataaagag
     2701 cgaaactc
//
