LOCUS       NM_144880               3082 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B', alpha
            (Ppp2r5a), mRNA.
ACCESSION   NM_144880 XM_916762 XM_924458 XM_924463 XM_924466 XM_924469
            XM_924472
VERSION     NM_144880.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3082)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3082)
  AUTHORS   Glaser,D., Heinick,A., Herting,J.R., Massing,F., Muller,F.U.,
            Pauls,P., Rozhdestvensky,T.S., Schulte,J.S., Seidl,M.D.,
            Skryabin,B.V., Stumpel,F. and Kirchhefer,U.
  TITLE     Impaired myocellular Ca2+ cycling in protein phosphatase
            PP2A-B56alpha KO mice is normalized by beta-adrenergic stimulation
  JOURNAL   J Biol Chem 298 (9), 102362 (2022)
   PUBMED   35963431
REFERENCE   4  (bases 1 to 3082)
  AUTHORS   Keating,L., Touati,S.A. and Wassmann,K.
  TITLE     A PP2A-B56-Centered View on Metaphase-to-Anaphase Transition in
            Mouse Oocyte Meiosis I
  JOURNAL   Cells 9 (2), 390 (2020)
   PUBMED   32046180
  REMARK    GeneRIF: A PP2A-B56-Centered View on Metaphase-to-Anaphase
            Transition in Mouse Oocyte Meiosis I.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3082)
  AUTHORS   El Refaey,M., Musa,H., Murphy,N.P., Lubbers,E.R., Skaf,M., Han,M.,
            Cavus,O., Koenig,S.N., Wallace,M.J., Gratz,D., Bradley,E.,
            Alsina,K.M., Wehrens,X.H.T., Hund,T.J. and Mohler,P.J.
  TITLE     Protein Phosphatase 2A Regulates Cardiac Na+ Channels
  JOURNAL   Circ Res 124 (5), 737-746 (2019)
   PUBMED   30602331
  REMARK    GeneRIF: Regulatory subunit (B56alpha) of the PP (protein
            phosphatase) 2A holoenzyme regulates Nav1.5 activity in mouse
            cardiomyocytes.
REFERENCE   6  (bases 1 to 3082)
  AUTHORS   Marshall,M., Anilkumar,N., Layland,J., Walker,S.J., Kentish,J.C.,
            Shah,A.M. and Cave,A.C.
  TITLE     Protein phosphatase 2A contributes to the cardiac dysfunction
            induced by endotoxemia
  JOURNAL   Cardiovasc Res 82 (1), 67-76 (2009)
   PUBMED   19201758
  REMARK    GeneRIF: Protein phosphatase 2A contributes to the cardiac
            dysfunction induced by endotoxemia.
REFERENCE   7  (bases 1 to 3082)
  AUTHORS   Cunha,S.R. and Mohler,P.J.
  TITLE     Obscurin targets ankyrin-B and protein phosphatase 2A to the
            cardiac M-line
  JOURNAL   J Biol Chem 283 (46), 31968-31980 (2008)
   PUBMED   18782775
REFERENCE   8  (bases 1 to 3082)
  AUTHORS   Bhasin,N., Cunha,S.R., Mudannayake,M., Gigena,M.S., Rogers,T.B. and
            Mohler,P.J.
  TITLE     Molecular basis for PP2A regulatory subunit B56alpha targeting in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (1), H109-H119 (2007)
   PUBMED   17416611
REFERENCE   9  (bases 1 to 3082)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3082)
  AUTHORS   Martens,E., Stevens,I., Janssens,V., Vermeesch,J., Gotz,J.,
            Goris,J. and Van Hoof,C.
  TITLE     Genomic organisation, chromosomal localisation tissue distribution
            and developmental regulation of the PR61/B' regulatory subunits of
            protein phosphatase 2A in mice
  JOURNAL   J Mol Biol 336 (4), 971-986 (2004)
   PUBMED   15095873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124664.14
            and AC115896.9.
            
            On Nov 17, 2006 this sequence version replaced NM_144880.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059026.1, BK000647.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-806               AC124664.14        111321-112126       c
            807-1003            AC124664.14        87555-87751         c
            1004-1105           AC124664.14        83726-83827         c
            1106-1198           AC124664.14        77334-77426         c
            1199-1329           AC124664.14        74010-74140         c
            1330-1389           AC124664.14        72877-72936         c
            1390-1498           AC124664.14        71972-72080         c
            1499-1552           AC124664.14        71419-71472         c
            1553-1603           AC124664.14        70108-70158         c
            1604-1629           AC124664.14        69921-69946         c
            1630-1723           AC115896.9         1-94
            1724-1851           AC115896.9         178-305
            1852-1953           AC115896.9         861-962
            1954-3082           AC115896.9         1727-2855
FEATURES             Location/Qualifiers
     source          1..3082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..3082
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /note="protein phosphatase 2, regulatory subunit B',
                     alpha"
                     /db_xref="GeneID:226849"
                     /db_xref="MGI:MGI:2388479"
     exon            1..806
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..2086
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit alpha isoform"
                     /protein_id="NP_659129.2"
                     /db_xref="CCDS:CCDS15620.1"
                     /db_xref="GeneID:226849"
                     /db_xref="MGI:MGI:2388479"
                     /translation="MSSPSPPAPVACAAISASEKVDGFTRKSVRKAQRQKRSQGSSQF
                     RSQGSQAELHPLPQLKDATSNEQQELFCQKLQQCCVLFDFMDSVSDLKSKEIKRATLN
                     ELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQ
                     LVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKF
                     LGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVL
                     IPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIE
                     EILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKIL
                     PIMFASLYKISKEHWNQTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELE
                     REELWKKLEELQLKKALEKQNNAYNMHSIRSSTSAK"
     exon            807..1003
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1105
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1198
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1329
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1389
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1498
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1552
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1603
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1723
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1851
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1953
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..3082
                     /gene="Ppp2r5a"
                     /gene_synonym="PR61alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccctcac ccgaaccagc caccctctca agttgtagca gttgcttccc gggcgtgctc
       61 cgtgggcggc cggtgggcgc gggaggctga gcgagggcga cgctccaggg atccaaggat
      121 ccaaggatcg gggtacgggt ggccgccccg ggcgatgagg ggccatcgct gacaggagaa
      181 cgagcgctcg gcagcggctc gcgcggaccc gcgatggaag cgccccggga ggaggctccc
      241 ggccgggcgg acagcgcggg cggcagccgc tgaagacctg tccggactcc gcgcgctaag
      301 gggccgcgag gcgcgcccgg cgtccgcacc cgcgcgctcg ccccagccgt ccaaacttcg
      361 ggctcgcctc cgcccgccct cgtcgccggg cgtcagcaac ttgtgcggcc cgcgcgcccc
      421 cgccctcccc tccgccagcc ccgggaggcg gccgcgcggc gcggggatgc ggccgtgagg
      481 cgctgtcggg tgaggagcag ctcgcggagc gcgagggcgg cgcggccggg gcccggggcg
      541 caggggcgca ggcccgccgt gcccgtcccc cgccgattgc ccgggccagc cgccgcggga
      601 ggcgccgatc gcccgggtcg ccgagatgtc gtcgccgtcg ccgcccgcac cagttgcctg
      661 cgccgccatc tcggcctcgg agaaagtgga cggcttcacc cggaaatcgg tgcgcaaggc
      721 gcagaggcag aagcgctctc agggctcgtc gcagttccgc agccagggca gccaggcgga
      781 gctgcacccc ctgccccagc tcaaagatgc cacttcaaat gaacagcaag agcttttctg
      841 ccagaagcta caacagtgct gtgtactgtt tgatttcatg gactctgtct cagacttgaa
      901 gagcaaagaa attaaaagag cgacgctgaa tgaactggtt gagtatgttt caactaatcg
      961 tggtgtaatt gttgaatcag cgtattctga tatagtaaaa atgatcagtg ctaacatctt
     1021 ccggacactt cctccaagtg ataatccaga ttttgacccg gaagaggatg agcccacact
     1081 tgaggcctct tggcctcaca tacagttggt gtatgaattc ttcttgagat tcttggagag
     1141 tcctgatttc cagcccagca ttgcaaagcg atacattgat cagaagtttg tccaacagct
     1201 cctggagctt tttgatagtg aagatccacg ggagcgcgac ttcctgaaga ccgtcctgca
     1261 tcggatttac ggcaagttcc ttggcctgag agcgttcatc agaaagcaaa ttaacaacat
     1321 tttcctcagg tttatatatg aaacggaaca tttcaatggt gtggctgagc tcctggaaat
     1381 attgggaagt atcatcaatg gctttgcatt gccactgaaa gcagagcata agcagtttct
     1441 aatgaaggtt cttattccta tgcatactgc aaaaggattg gccttgtttc acgcacagct
     1501 ggcgtactgt gttgtgcagt tcctggagaa agacacaacg ctgacagagc cggtgatcag
     1561 aggactgctg aaattttggc caaaaacatg cagtcagaaa gaggtgatgt ttttaggaga
     1621 aattgaagag atcttagatg tcattgaacc aacacaattc aaaaaaattg aagagccgct
     1681 ttttaagcag atatccaagt gcgtctccag ctctcatttc caggttgcag aaagagcact
     1741 gtacttctgg aataatgaat atattcttag tttgattgaa gagaatattg ataaaatcct
     1801 gccaatcatg tttgccagct tgtataaaat ttccaaagaa cactggaatc agactattgt
     1861 agcactggtg tacaatgtgc tgaaaaccct catggagatg aacggcaagc tttttgacga
     1921 ccttactagt tcctacaaag ccgaaagaca gagagagaag aagaaagaac tggaacggga
     1981 agagttgtgg aaaaaactag aggagctgca gctgaagaag gctctagaga aacagaacaa
     2041 tgcttacaac atgcacagta ttcgcagcag taccagtgcc aaataaagat cagctccccc
     2101 tgctgggcgg tcgttttgta cacttttttt tttttttgaa tatataaaaa cttcagagca
     2161 gacctcatca gtataatata attaggaggc cagtttttcc tggcaagcgt aaaagcgaaa
     2221 gaattatgga ctaaaacata gccctgtgct gtatcacggc cacagtatat tgtaaactct
     2281 gtctaatcat ggattgtgtc actgtctctg ttgagtgagg tgatcgtggg agtggcaagc
     2341 gtgtgttgcg acttgagccc ggttgtgctg cacacacaga tgaagccgtc ctctgcacac
     2401 ttcctttatc atgtgttttc accgtgctgc acaccttggt gctgcacacc ttgagtacat
     2461 ctgaggaaag agcctcgtaa gataagcgga ggggttgccc ttccctcacc tctcctagag
     2521 aggtgtgggc aggggacaag agcccagcct cattaaagac actgccatac tctgggtttt
     2581 acaacatctg acatttccag gcttctgaag cacaaagtat taaagttggg ggggggaagt
     2641 aaaccaaaat tctgatgttc ccaaatcccc ccttcagcag cggctccccg gagcgtgtgc
     2701 ggagcagcac aggccacggg tggacccgag gctcacctcc ttcattcctc tcctccaagg
     2761 ctggaggcag ggccttccca gtcctcaccc tgccagtccc caggcctgcc tgcctgcagg
     2821 gtggagctct gggtccctcc cacagtgtga tgcagactgc tagctgtcac tgcctggctt
     2881 tatttaaagg aactgcagca ggtgtcctca gagctgacta tgtagaagct ttgtctgttt
     2941 ttacctggtc aggtattttt cacactgttg ttaccagtac cattccagcc tcttgccttg
     3001 cagttgtatg gaaaactgtt ttataatgag agatctttac tgaggattga gcagcattta
     3061 ataaagtcta tgtttgtatt tt
//
