LOCUS       NM_011154               4180 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus protein phosphatase 2 (formerly 2A), regulatory
            subunit B'', delta (Ppp2r3d), transcript variant 2, mRNA.
ACCESSION   NM_011154 XM_001471965 XM_001472005 XM_001472345 XM_918782
VERSION     NM_011154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Nishi,A., Matamales,M., Musante,V., Valjent,E., Kuroiwa,M.,
            Kitahara,Y., Rebholz,H., Greengard,P., Girault,J.A. and Nairn,A.C.
  TITLE     Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation
            of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
  JOURNAL   J Biol Chem 292 (4), 1462-1476 (2017)
   PUBMED   27998980
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Zwaenepoel,K., Louis,J.V., Goris,J. and Janssens,V.
  TITLE     Diversity in genomic organisation, developmental regulation and
            distribution of the murine PR72/B' subunits of protein phosphatase
            2A
  JOURNAL   BMC Genomics 9, 393 (2008)
   PUBMED   18715506
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Yan,Z., Fedorov,S.A., Mumby,M.C. and Williams,R.S.
  TITLE     PR48, a novel regulatory subunit of protein phosphatase 2A,
            interacts with Cdc6 and modulates DNA replication in human cells
  JOURNAL   Mol Cell Biol 20 (3), 1021-1029 (2000)
   PUBMED   10629059
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Voorhoeve,P.M., Hijmans,E.M. and Bernards,R.
  TITLE     Functional interaction between a novel protein phosphatase 2A
            regulatory subunit, PR59, and the retinoblastoma-related p107
            protein
  JOURNAL   Oncogene 18 (2), 515-524 (1999)
   PUBMED   9927208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054122.1, CB723063.1, CF735315.1, AK143212.1 and BC096544.1.
            
            On Jul 21, 2009 this sequence version replaced NM_011154.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The resulting isoform
            (2) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-786               AK054122.1         1-786
            787-1343            CB723063.1         97-653
            1344-1799           CF735315.1         118-573
            1800-4144           AK143212.1         2077-4421
            4145-4180           BC096544.1         3862-3897
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..4180
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /note="protein phosphatase 2 (formerly 2A), regulatory
                     subunit B'', delta"
                     /db_xref="GeneID:19054"
                     /db_xref="MGI:MGI:1335093"
     exon            1..362
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1697
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /EC_number="3.1.3.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein phosphatase 2, regulatory subunit B, alpha;
                     serine/threonine-protein phosphatase 2A regulatory subunit
                     B'' subunit alpha; protein phosphatase 2A, 59 kDa
                     regulatory subunit B; protein phosphatase 2, regulatory
                     subunit (59 kDa); protein phosphatase 2 (formerly 2A),
                     regulatory subunit B'', alpha; serine/threonine-protein
                     phosphatase 2A regulatory subunit B'' subunit delta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit delta isoform 2"
                     /protein_id="NP_035284.2"
                     /db_xref="GeneID:19054"
                     /db_xref="MGI:MGI:1335093"
                     /translation="MPERPPIRALRRDPDDPAVRQALASLARGSDLVFPSRFQKWLRD
                     FRQVHAHRKEEPPPQSPPPGHSVPAFYFPCGRPPPRPQDTEDAIALVECAFEGLPRGR
                     AGLGDMAVVAKACGCPLYWKAPLFYAAGGERTGSVSVHMFVAMWRKVLLTCHDDAARF
                     VRLLGHPGCSGLIQEDFVPFLQDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNR
                     SWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYVIYCKFWELDLDRDLT
                     IDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADFVWFLLSEEDKTTPT
                     STEYWFRCMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRC
                     PGRITLRDLKQCGLAGEFFDAFFNVDKYLAREQREQAGTPQDTDSDPAASAWDRYAAE
                     EYDFLVAEEAMAEDDDDHDEGSDPIDLYGLADEDCDDLEPL"
     exon            363..560
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            561..664
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            665..767
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            768..842
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            843..929
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1086
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1135
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1225
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1401
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1520
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1633
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..4149
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /note="major polyA site"
     regulatory      2370..2375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /note="hexamer: AATAGA"
     polyA_site      2391
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
                     /note="hexamer: AATAAA"
     polyA_site      4149
                     /gene="Ppp2r3d"
                     /gene_synonym="PP2A B''-PR59; PP2A PR59; Ppp2r3; Ppp2r3a;
                     PR59"
ORIGIN      
        1 gaaccgcagc gaccccgtgg gagagaaaag gaaaagcaca gacccgaggg aggacagaac
       61 cgcgggtgaa ccccacggtg acccaggtga cgtcatgacc gcgctgcagg gtcgcggatc
      121 gcgctgagcg cggccctcgc gaatcgcccg ggtccccggg gtcgcaggcc acacccacgg
      181 attcgcaggc cgggccctac cctgctcgag ccacgcccac catgccggag cgcccgccca
      241 tacgagccct gcgccgcgac cctgacgacc cagcggtgcg ccaggctctg gcgtcgctgg
      301 ctcggggcag cgatctggtg tttccgtcgc gcttccagaa gtggctgcgg gacttccggc
      361 aggtccatgc ccacaggaag gaggagcccc cgccccagtc cccaccccct ggccacagcg
      421 tccccgcctt ctacttccct tgcggtcgac ccccgccccg tccccaggac acggaggatg
      481 ccatcgccct cgtggagtgc gcgttcgagg ggctgcctcg tgggagggcg ggtctgggcg
      541 acatggccgt ggttgccaag gcctgtggct gccctctgta ctggaaggcc ccgctgttct
      601 acgctgcggg cggcgagcgc acaggctctg tatccgtgca catgttcgta gctatgtggc
      661 gcaaagtcct gctgacctgc catgatgatg ctgcgcggtt cgtgcggctg ctgggccacc
      721 ccgggtgtag tggcctcatc caggaggact ttgtgccctt cctgcaggat gtggtgaact
      781 cgcacccggg cctggccttc ctgagggcag cgaaggactt ccactcacgt tacatcacca
      841 cagtgattca gaggatcttc tacacagtaa accggtcatg gtcagggatg atctcgcgtg
      901 aggagctaag gcgcagcagc ttcctgcagg ctgtgtcaca gttggaggta gagcctgaca
      961 tcaaccgcat gacgtcgttc ttctcttatg agcatttcta tgtcatctac tgcaagttct
     1021 gggagctcga cctcgaccgc gacctcacca ttgacaggag cgacctcgca cgccatgggg
     1081 acggggccat ctcctccaga atgattgacc gcatcttctc aggggccgtc accagggcga
     1141 ggctgccccg aaaggtcggg aagctgagct acgcagactt tgtatggttc ctgctctccg
     1201 aggaggacaa gactacgccc accagcaccg agtactggtt ccgttgcatg gacctggacg
     1261 gtgacggcgc tctctccatg tttgagctcg agttcttcta tgaggagcag gcccagcgca
     1321 tggccgcccg gggtgtggag cccctcccct tccacgacct tgcacgccag gtgctcgacc
     1381 tcgtcgcccc gcgctgcccc ggccggatca cgctgcgcga cctgaagcag tgcggcctgg
     1441 cgggtgagtt cttcgacgcc ttcttcaacg tggacaagta cctggcacgg gagcagcgcg
     1501 agcaggcggg gactccgcag gacactgact ccgaccccgc ggcatctgcc tgggacaggt
     1561 atgccgccga ggagtacgac ttcctcgtgg ccgaggaggc catggcagag gacgacgacg
     1621 accatgacga agggtccgac cccatagatc tctacggcct tgctgacgag gactgcgacg
     1681 acctggagcc tctgtgacgc cctactgtgc gcccaggaac tgcgcacttg tgcctcccag
     1741 tgatccctcc caaggcaggg gtgacatcgg gggctcgggg tgtgacctcc tccccgtggc
     1801 ctgcagccct gctgtgtgca gggtgcctca cacatgacgt ttgtgggttt gttttttttt
     1861 taataaaaag tttgatttgt tttttcaccc tggggtgcac agtcaggctc tcaggggtgg
     1921 gcaacacggt gggcggtggg cagtcaggcc aacctcccgc gatccctcag gagaatgaca
     1981 cgcccacttc ctgtttagga cacacacccc acttccagtg tgagactccc atttcccaca
     2041 cttttcctct tgttctcatt gacatacatg ccccgcccac tcattagcat gaagctgttc
     2101 tctatggtcc agcttcttat tagcatagcc ccgcccacct gttatgcttt aggttttctc
     2161 tgcaggaagg ccacctcagt agcataaagc tcattagtat gtgcaggtcc atttacatgc
     2221 acaccctgcc cctcattagc atactcatta gtatgcataa atggcatgaa cataacaggg
     2281 tcggggtcag gtagggttga gttaggttag tggtacatgt gtacatgtat gttgtgtgtg
     2341 taagtatcca catgtttgct gcgtatgtaa atagagcatt gtacgataga acatggccca
     2401 ttgtcaactt ttaattccta cgaatgacag aacttaaaac atcacctttc tccattctga
     2461 ccacagcagt gtgttttcca gaagaatggt cgacacttag tagggttcag tggtcacaaa
     2521 tagatgagcg gtatcatcgc gaccccttct gaccaaaggc ggtcacgtgt ttgtcctgat
     2581 gcaatgagga cacagaggtc aggtgtgcgg tgccaccttg cggaagaaag aagtcagcgc
     2641 atctgagccg tcctctccca cggtagctgt gggggctttg tgtccatgag tgggaggagg
     2701 actgagtcgc ccacaccaca aggctccttt ctcaacagaa acccagtctc acttttaaag
     2761 gaaatggaca cttgatttcc tgtaagattc gtgcgcatcc ctcaatccag caaaaatcca
     2821 taggtaggac tctcagtctc atgaaaatgg ttggcgaccc ggggcactga acgccatttg
     2881 acaactcggt ccagcgtctt ccatctaatc caacggaaca atgcctcgaa atatccacct
     2941 aaaattcatg tcagatgtca tgagtcatcc aagctaatgg catagtttat aaaatgccct
     3001 agcgagcact tggttgtttg tggttgcagg acacgaagaa gaaagggcct gtcttggtgg
     3061 tggcccactg tttgttaaaa gctcaggtag gagggcagaa gcaggtagat atcggagtag
     3121 aacatcctag tttgtataca tagttccagg ctaaatacaa acagaaacaa atctttgatt
     3181 accaaatata attttcagta attgacaccc aaaatgaaca tgtcattgca gatgtgtgtc
     3241 ccttctgagt gcagtgtaag atcaaactta tcatgccaag ataacattca tgagaaaata
     3301 aaccagggac accaaggaga ttagaacagc agtaatagtc ctggagtaat ggtcctgtgg
     3361 ttaagagtac tggcaattgt tcccaaggtc ctgagttcaa ttcccaggaa ccacatggtg
     3421 cctcacaatc atctacagtg agatctggtg ccctcttctg acctgcaggc atgcacacag
     3481 gcagaatgct gtatatataa taaatctttt aaaaactaaa aaagtaatta tgtttggaaa
     3541 gctacattca ttttatttag aaagtacaac tatgccaggc agtggtggcg cacgcctttg
     3601 atcccagcac ttgggaggca gaggcaggcg gatttctgag ttcgaggcca gcctggtcta
     3661 cagagtgagt tccaggacag ccagggctac acagagaaac cctccacact gccacactgt
     3721 tcccaacaag gccacaactc ctaaaagtac cactatactc ctctgcaatc tctcaggact
     3781 ttaacttttt ctgacctact cttttcattt ttctctttca caaaatatgt gttctatcat
     3841 tttattgaaa tattctagaa cccaacatta gtgcattacc ttctatggat actctaattt
     3901 aaatacacat ctatgaagat tcagtgttac catccacata agacacaaca cgtggtattt
     3961 gtctttctgg gtctgggata tatcactcag aataattatg tctctgtcca ttaatctgta
     4021 aatttgattt ttttgcacag ctcatttcca ttgtgtatat gaaccatata ttcattatcc
     4081 tttcatcaat tacattacat ctgggttgtt tggatttcct gttttgaata aagtagcaag
     4141 aaacatgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
