LOCUS       NM_021529               2353 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B'', gamma
            (Ppp2r3c), transcript variant 1, mRNA.
ACCESSION   NM_021529 XM_983098
VERSION     NM_021529.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2353)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2353)
  AUTHORS   Kitabatake,M., Soma,M., Zhang,T., Kuwahara,K., Fukushima,Y.,
            Nojima,T., Kitamura,D. and Sakaguchi,N.
  TITLE     JNK regulatory molecule G5PR induces IgG autoantibody-producing
            plasmablasts from peritoneal B1a cells
  JOURNAL   J Immunol 194 (4), 1480-1488 (2015)
   PUBMED   25601926
  REMARK    GeneRIF: findings suggest that G5PR is involved in both the
            survival of B cells and the differentiation of peritoneal B1a cells
            into autoantibody-producing plasma cells.
REFERENCE   4  (bases 1 to 2353)
  AUTHORS   Zwaenepoel,K., Louis,J.V., Goris,J. and Janssens,V.
  TITLE     Diversity in genomic organisation, developmental regulation and
            distribution of the murine PR72/B' subunits of protein phosphatase
            2A
  JOURNAL   BMC Genomics 9, 393 (2008)
   PUBMED   18715506
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2353)
  AUTHORS   Xing,Y., Wang,X., Igarashi,H., Kawamoto,H. and Sakaguchi,N.
  TITLE     Protein phosphatase subunit G5PR that regulates the JNK-mediated
            apoptosis signal is essential for the survival of CD4 and CD8
            double-positive thymocytes
  JOURNAL   Mol Immunol 45 (7), 2028-2037 (2008)
   PUBMED   18022237
  REMARK    GeneRIF: G5PR regulates the thymocyte unique apoptotic signal
            involved in JNK-mediated Caspase-3 activation but not in Bim
            activation.
REFERENCE   6  (bases 1 to 2353)
  AUTHORS   Huq Ronny,F.M., Igarashi,H. and Sakaguchi,N.
  TITLE     BCR-crosslinking induces a transcription of protein phosphatase
            component G5PR that is required for mature B-cell survival
  JOURNAL   Biochem Biophys Res Commun 340 (1), 338-346 (2006)
   PUBMED   16343422
REFERENCE   7  (bases 1 to 2353)
  AUTHORS   Xing,Y., Igarashi,H., Wang,X. and Sakaguchi,N.
  TITLE     Protein phosphatase subunit G5PR is needed for inhibition of B cell
            receptor-induced apoptosis
  JOURNAL   J Exp Med 202 (5), 707-719 (2005)
   PUBMED   16129705
  REMARK    GeneRIF: G5PR is required for the B cell receptor-mediated
            proliferation associated with the prevention of activation-induced
            cell death in mature B cells.
REFERENCE   8  (bases 1 to 2353)
  AUTHORS   Kamnasaran,D., Chen,C.P., Devriendt,K., Mehta,L. and Cox,D.W.
  TITLE     Defining a holoprosencephaly locus on human chromosome 14q13 and
            characterization of potential candidate genes
  JOURNAL   Genomics 85 (5), 608-621 (2005)
   PUBMED   15820313
REFERENCE   9  (bases 1 to 2353)
  AUTHORS   Kono,Y., Maeda,K., Kuwahara,K., Yamamoto,H., Miyamoto,E.,
            Yonezawa,K., Takagi,K. and Sakaguchi,N.
  TITLE     MCM3-binding GANP DNA-primase is associated with a novel
            phosphatase component G5PR
  JOURNAL   Genes Cells 7 (8), 821-834 (2002)
   PUBMED   12167160
REFERENCE   10 (bases 1 to 2353)
  AUTHORS   Nayak,B.P., Tuteja,R., Manivel,V., Roy,R.P., Vishwakarma,R.A. and
            Rao,K.V.
  TITLE     B cell responses to a peptide epitope. V. Kinetic regulation of
            repertoire discrimination and antibody optimization for epitope
  JOURNAL   J Immunol 161 (7), 3510-3519 (1998)
   PUBMED   9759871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166323.5.
            
            On May 22, 2020 this sequence version replaced NM_021529.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168298.1, AK163192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC166323.5         141452-141537       c
            87-288              AC166323.5         141131-141332       c
            289-416             AC166323.5         137431-137558       c
            417-521             AC166323.5         136948-137052       c
            522-634             AC166323.5         136315-136427       c
            635-732             AC166323.5         132319-132416       c
            733-803             AC166323.5         131041-131111       c
            804-936             AC166323.5         128197-128329       c
            937-992             AC166323.5         127128-127183       c
            993-1068            AC166323.5         126976-127051       c
            1069-1205           AC166323.5         126458-126594       c
            1206-1343           AC166323.5         123314-123451       c
            1344-1403           AC166323.5         121451-121510       c
            1404-2353           AC166323.5         119393-120342       c
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.9 cM"
     gene            1..2353
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /note="protein phosphatase 2, regulatory subunit B'',
                     gamma"
                     /db_xref="GeneID:59032"
                     /db_xref="MGI:MGI:1930009"
     exon            1..86
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            87..288
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1592
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /note="phosphatase subunit gene g4-1; protein phosphatase
                     subunit G5PR"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit gamma"
                     /protein_id="NP_067504.2"
                     /db_xref="CCDS:CCDS36450.1"
                     /db_xref="GeneID:59032"
                     /db_xref="MGI:MGI:1930009"
                     /translation="MDWKDVLRRRLASPNTDPKRKKSEQELKDEEMDLFTKYYSEWKG
                     GRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFL
                     LDKHQIPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQF
                     FNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFY
                     VCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSAL
                     RVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFV
                     LALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKD
                     EIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSADL
                     DDT"
     exon            289..416
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            417..521
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            522..634
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            635..732
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            733..803
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            804..936
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            937..992
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1068
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1205
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1343
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1403
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..2353
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /note="hexamer: AATATA"
     polyA_site      2353
                     /gene="Ppp2r3c"
                     /gene_synonym="4930511A21Rik; 5730412A08Rik; G4-1; G5pr"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacgcgc taaatgccca agcgaagaag tcacgcaggc ttcttctggc ctttagaaat
       61 ccggcttggt gagctgcgac acctccccaa ggcttccgcc cgtgcccaag atggcgtcca
      121 ggcgtcctaa ttaacttcca cctgtcttgg cgaagtctga cgtcgcggct ggcagtgggt
      181 ggagctctta acaaactgca aatgtagggt cctctgagcg ggagtcaacc atggactgga
      241 aagacgtgct tcgccggcgg ttagcgtcgc ccaacacgga tccaaagagg aaaaaaagcg
      301 aacaagaatt aaaagatgaa gaaatggatt tatttaccaa atactactca gagtggaaag
      361 gaggtagaaa aaacacaaac gagttctata agaccatacc ccggttttat tacaggttgc
      421 cagctgaaga tgaagtctta ctacagaaat tacgagagga atctagagct gtctttctac
      481 agaggaaaag cagagaactc ttagataacg aagagttgca gaacttatgg tttttgctgg
      541 ataaacacca gataccacct atgattggag aggaagcaat gatcaattat gaaaattttt
      601 tgaaggttgg tgaaaaggct ggaccaaagt gcaagcaatt ttttactgca aaagtctttg
      661 ccaaactcct tcatacagat tcatatggac gaatttccat catgcagttc tttaactacg
      721 tcatgcgaaa agtttggctg catcagacaa gaataggact cagtttatat gatgttgctg
      781 gccaaggata ccttcgggaa tcagacctgg agaactacat cctggagctg atcccgacgc
      841 tgccacagct ggacgggctg gagaagtcct tctactcctt ctatgtctgc actgcagtca
      901 ggaagttctt cttcttcttg gaccctctaa gaacagggaa gatcaaaatt caagatattt
      961 tggcatgcag ttttctagat gatttactgg agctaagaga tgaggaattg tccaaagaaa
     1021 gtcaagaaac aaattggttt tctgctcctt ctgccctgag ggtctatggt cagtatttga
     1081 atcttgataa agatcataat ggcatgctaa gtaaagagga gctctcccgt tacggaacag
     1141 caaccatgac caatgtcttc ttagaccgag ttttccagga gtgtctcact tacgatggag
     1201 aaatggacta taagacctac ctggactttg ttcttgcctt agaaaacaga aaggagcctg
     1261 cagctctgca gtacattttc aaactgctgg acattgagaa caagggatac ctgaatgtct
     1321 tttcccttaa ttatttcttt agggccatac aagaactaat gaaaatccat ggacaggatc
     1381 ctgtgtcatt tcaagatgtc aaggatgaaa tctttgacat ggtcaaacca aaggatcctt
     1441 tgaaaatctc acttcaggat ttaatcaaca gtaatcaagg agacacagtc actaccattc
     1501 taattgatct caatggcttc tggacctacg agaacagaga agcccttgtt gcaaatgaca
     1561 acgagaactc tgcagatctt gatgacacat gatctctgca aaatagactt cttcataaag
     1621 atgcttgaat gctgcatgca acactgttga agcagaatcc ttagaaacgt tctaaataaa
     1681 actcatcaca tgcctgtaca acacagcaaa tatcttgctt actagagtgt tggttgcagt
     1741 cagaacaatt tgaaagtaat aggaccaact attggttttt tattaagtgg taaagtaagt
     1801 cctagttctg tctaactcag aaatggaaag taagatttgc tgtagttagc cgtggagttt
     1861 attcatgtgg aattacaata tttgttcttc aagaagattg gggacaggag acttcccatc
     1921 agagtagcac cattgcattt ctgattcaaa gctttaggtg tggctttggt tgttttgaga
     1981 catggtctca ctatgtagcc ctgactggcc tggaacttgc tatgtggacc aagttggcct
     2041 ttaaccttga actcttaaga gagacacctg cctctgcctc ccaggtgctg aggttaaagg
     2101 tgagtgcctc tgtgcctatc gtttttgggg tttttgttgt tgtttttgta tttcttgtgt
     2161 gtgcacacca gagcacacat ggaggtcagt agacattgtt gtgattcttg cctttcccca
     2221 cgtgggttct ggagatcaga ttcaggttct cggcttccca gcaagcgctt gtacccagca
     2281 tcctcttgcc ttcccaagat ttttttgttt tgtttttttt gtttttttaa atatagtgtt
     2341 ttcaaagaaa gta
//
