LOCUS       NM_026391               2079 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B, delta
            (Ppp2r2d), transcript variant 1, mRNA.
ACCESSION   NM_026391
VERSION     NM_026391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Sanz-Flores,M., Ruiz-Torres,M., Aguirre-Portoles,C., El Bakkali,A.,
            Salvador-Barbero,B., Villarroya-Beltri,C., Ortega,S., Megias,D.,
            Gerlich,D.W., Alvarez-Fernandez,M. and Malumbres,M.
  TITLE     PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome
            individualization during mitosis
  JOURNAL   Cell Rep 43 (7), 114494 (2024)
   PUBMED   39003739
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Kim,Y.S., Ko,B., Kim,D.J., Tak,J., Han,C.Y., Cho,J.Y., Kim,W. and
            Kim,S.G.
  TITLE     Induction of the hepatic aryl hydrocarbon receptor by alcohol
            dysregulates autophagy and phospholipid metabolism via PPP2R2D
  JOURNAL   Nat Commun 13 (1), 6080 (2022)
   PUBMED   36241614
  REMARK    GeneRIF: Induction of the hepatic aryl hydrocarbon receptor by
            alcohol dysregulates autophagy and phospholipid metabolism via
            PPP2R2D.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Pan,W., Scherlinger,M., Yoshida,N., Tsokos,M.G. and Tsokos,G.C.
  TITLE     PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell
            Expansion and Inhibits Tumor Growth in Melanoma
  JOURNAL   J Immunol 209 (3), 621-628 (2022)
   PUBMED   35831019
  REMARK    GeneRIF: PPP2R2D Suppresses Effector T Cell Exhaustion and
            Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Pan,W., Sharabi,A., Ferretti,A., Zhang,Y., Burbano,C., Yoshida,N.,
            Tsokos,M.G. and Tsokos,G.C.
  TITLE     PPP2R2D suppresses IL-2 production and Treg function
  JOURNAL   JCI Insight 5 (19), 138215 (2020)
   PUBMED   32897879
  REMARK    GeneRIF: PPP2R2D suppresses IL-2 production and Treg function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Zhou,P., Shaffer,D.R., Alvarez Arias,D.A., Nakazaki,Y., Pos,W.,
            Torres,A.J., Cremasco,V., Dougan,S.K., Cowley,G.S., Elpek,K.,
            Brogdon,J., Lamb,J., Turley,S.J., Ploegh,H.L., Root,D.E.,
            Love,J.C., Dranoff,G., Hacohen,N., Cantor,H. and Wucherpfennig,K.W.
  TITLE     In vivo discovery of immunotherapy targets in the tumour
            microenvironment
  JOURNAL   Nature 506 (7486), 52-57 (2014)
   PUBMED   24476824
  REMARK    GeneRIF: In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis
            and enhanced T-cell proliferation as well as cytokine production
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   O'Shaughnessy,R.F., Welti,J.C., Sully,K. and Byrne,C.
  TITLE     Akt-dependent Pp2a activity is required for epidermal barrier
            formation during late embryonic development
  JOURNAL   Development 136 (20), 3423-3431 (2009)
   PUBMED   19762425
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066022.1.
            
            On Feb 22, 2004 this sequence version replaced NM_026391.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066022.1, AK129386.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 82.95 cM"
     gene            1..2079
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /note="protein phosphatase 2, regulatory subunit B, delta"
                     /db_xref="GeneID:52432"
                     /db_xref="MGI:MGI:1289252"
     exon            1..130
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1485
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B delta isoform isoform 1"
                     /protein_id="NP_080667.1"
                     /db_xref="CCDS:CCDS21950.1"
                     /db_xref="GeneID:52432"
                     /db_xref="MGI:MGI:1289252"
                     /translation="MAGAGGGGCPAGGNDFQWCFSQVKGAVDEDVAEADIISTVEFNY
                     SGDLLATGDKGGRVVIFQREQENKGRAHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKI
                     NKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRV
                     PILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSF
                     NIVDIKPANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHAKFFE
                     EPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMEGRPVETHQVHEY
                     LRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRNTRRDVTLEASRENS
                     KPRASLKPRKVCTGGKRKKDEISVDSLDFNKKILHTAWHPMESIIAVAATNNLYIFQD
                     KIN"
     exon            131..223
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            224..321
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            322..487
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            601..778
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            779..943
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1205
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..2054
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /note="hexamer: AATAAA"
     polyA_site      1726
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="Ppp2r2d"
                     /gene_synonym="1300017E19Rik; D7Ertd753e; MDS026"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaaatt ccctccccgg cggcggcgac ggtggcggca gcggcggcgg cggtggcggc
       61 cggggctgag cgctcggagc gcctcggtcg gccgcgctcg gctgggcgcg tcccgcccgc
      121 gccatggcag gagctggagg cggcggctgc ccggcgggcg gcaacgactt ccagtggtgc
      181 ttctcgcagg tgaagggcgc tgtcgacgag gacgtggcgg aagccgacat catctccacc
      241 gttgagttta actactctgg agaccttctt gcaacaggag acaaaggtgg cagagttgtt
      301 attttccagc gggaacaaga gaataaaggc cgcgctcact ctaggggaga gtacaatgtt
      361 tacagtacct ttcagagtca tgagccagag tttgactatt tgaaaagtct agaaattgaa
      421 gaaaaaatta ataaaatcag gtggttaccg caacagaatg ctgctcattt tctactctct
      481 acaaatgata aaactattaa attatggaaa ataagtgaac gggataaaag agcagaaggt
      541 tataacttga aagatgaaga tggacgactt cgagacccat ttagaattac ggcactacgg
      601 gttccaatat tgaagcccat ggaccttatg gtagaagcaa gtccacgacg aatttttgca
      661 aatgctcata catatcacat aaattccatt tcagtaaata gtgatcatga aacatatctc
      721 tctgcagatg atctgagaat taacctatgg catttagaaa tcacagatag aagcttcaac
      781 attgtggaca tcaagccagc taatatggag gagctgacag aagtcatcac tgccgcagag
      841 ttccacccac atcagtgcaa tgtatttgtt tacagcagca gcaagggcac catcaggctg
      901 tgtgacatgc gttcctctgc cctatgtgac aggcatgcca agttttttga agagccagaa
      961 gatcccagca gtagatcctt cttctcagaa ataatctcat ctatatctga tgtcaagttc
     1021 agccacagtg gtcgatacat gatgaccaga gactatctgt cggtgaaggt ctgggacctc
     1081 aacatggagg gcaggcctgt ggagacccac caggtacatg agtacctgcg aagcaagctc
     1141 tgctccttgt atgagaacga ctgcatcttt gacaagttcg agtgctgctg gaacggttca
     1201 gacagtgcca ttatgacggg gtcctacaac aacttcttta gaatgtttga tagaaacact
     1261 cggagggatg ttacactgga agcctcaaga gagaacagca aaccccgagc cagcctgaag
     1321 ccccggaaag tatgtacagg gggtaagaga aagaaagacg agattagcgt ggacagtttg
     1381 gacttcaata agaagatcct ccacacagcc tggcacccca tggagagcat tattgctgta
     1441 gctgccacca ataacttgta tatattccag gacaaaatta attaagaaaa ctgactggag
     1501 gaccaagtgt tgtcttgcat atgtacgccg gtcaattagt tttcctgtca aaaaaggcat
     1561 tgtcctctcc attgagaata gtggcgcact tctacttccc taatagatac aggagaagaa
     1621 gggctctcag ctggagtcgg aagagatgag tgccgctgct gaagggaaaa cctgctcgaa
     1681 gctgaattgg tggactctgc tcaataaagg ccattactca aatgtattta tttaagtctg
     1741 agccttcctt tccagtttat agaccaaaaa actaacatct gagaggaaaa aaaaaagctc
     1801 atcaaatctc tctccagctc ttccctctgt ctctgccatc catccctggg ccttatcctg
     1861 gacatggtgt ggccaccacc cacgttcctc tctggccctg gagccccagt gggctgcatc
     1921 accctccgct ggtgcatggt gcgtgggtgc ccgagcaggc tcaggcagct ctactcaccc
     1981 actgcactgc cgtcacatct tctgtggagc tacttaataa acacaacaca ctgtgaagtg
     2041 tttttaaacc caaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
