LOCUS       NM_172994               4091 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B, gamma
            (Ppp2r2c), transcript variant 1, mRNA.
ACCESSION   NM_172994 XM_911136
VERSION     NM_172994.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4091)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4091)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4091)
  AUTHORS   Panicker,N., Coutman,M., Lawlor-O'Neill,C., Kahl,R.G.S., Roselli,S.
            and Verrills,N.M.
  TITLE     Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory
            Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and
            Epidermal Embryonic Development
  JOURNAL   Front Cell Dev Biol 8, 358 (2020)
   PUBMED   32582689
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4091)
  AUTHORS   Leong,W., Xu,W., Wang,B., Gao,S., Zhai,X., Wang,C., Gilson,E.,
            Ye,J. and Lu,Y.
  TITLE     PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's
            transgenic mice
  JOURNAL   Aging (Albany NY) 12 (8), 6880-6890 (2020)
   PUBMED   32291379
  REMARK    GeneRIF: PP2A subunit PPP2R2C is downregulated in the brains of
            Alzheimer's transgenic mice.
REFERENCE   5  (bases 1 to 4091)
  AUTHORS   Tao,G., Li,Z., Wen,Y., Song,X., Wei,S., Du,H., Yang,Z., Xu,Z. and
            You,Y.
  TITLE     Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic
            Eminence-Derived Cortical Interneuron Migration
  JOURNAL   Front Mol Neurosci 12, 75 (2019)
   PUBMED   31001083
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4091)
  AUTHORS   Sents,W., Meeusen,B., Kalev,P., Radaelli,E., Sagaert,X.,
            Miermans,E., Haesen,D., Lambrecht,C., Dewerchin,M., Carmeliet,P.,
            Westermarck,J., Sablina,A. and Janssens,V.
  TITLE     PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes
            Cancer Development
  JOURNAL   Cancer Res 77 (24), 6825-6837 (2017)
   PUBMED   29046336
REFERENCE   7  (bases 1 to 4091)
  AUTHORS   Zhang,Y., Jiang,X., Qin,C., Cuevas,S., Jose,P.A. and Armando,I.
  TITLE     Dopamine D2 receptors' effects on renal inflammation are mediated
            by regulation of PP2A function
  JOURNAL   Am J Physiol Renal Physiol 310 (2), F128-F134 (2016)
   PUBMED   26290374
REFERENCE   8  (bases 1 to 4091)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   9  (bases 1 to 4091)
  AUTHORS   O'Shaughnessy,R.F., Welti,J.C., Sully,K. and Byrne,C.
  TITLE     Akt-dependent Pp2a activity is required for epidermal barrier
            formation during late embryonic development
  JOURNAL   Development 136 (20), 3423-3431 (2009)
   PUBMED   19762425
REFERENCE   10 (bases 1 to 4091)
  AUTHORS   Kaji,K., Nichols,J. and Hendrich,B.
  TITLE     Mbd3, a component of the NuRD co-repressor complex, is required for
            development of pluripotent cells
  JOURNAL   Development 134 (6), 1123-1132 (2007)
   PUBMED   17287250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC169036.3 and AC115722.12.
            
            On Sep 30, 2022 this sequence version replaced NM_172994.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059811.1, AK032023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AC169036.3         204724-205104
            382-479             AC115722.12        151589-151686       c
            480-645             AC115722.12        148204-148369       c
            646-758             AC115722.12        147011-147123       c
            759-936             AC115722.12        143241-143418       c
            937-1101            AC115722.12        134393-134557       c
            1102-1271           AC115722.12        127417-127586       c
            1272-1363           AC115722.12        125010-125101       c
            1364-4091           AC115722.12        119576-122303       c
FEATURES             Location/Qualifiers
     source          1..4091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.28 cM"
     gene            1..4091
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="protein phosphatase 2, regulatory subunit B, gamma"
                     /db_xref="GeneID:269643"
                     /db_xref="MGI:MGI:2442660"
     exon            1..381
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1655
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B gamma isoform isoform 1"
                     /protein_id="NP_766582.1"
                     /db_xref="CCDS:CCDS19244.1"
                     /db_xref="GeneID:269643"
                     /db_xref="MGI:MGI:2442660"
                     /translation="MGEDTDTRKINHSFLRDHSYVTEADVISTVEFNHTGELLATGDK
                     GGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQN
                     AAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMV
                     EVSPRRTFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANM
                     EDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSF
                     FSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYE
                     SDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRR
                     VCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH"
     exon            382..479
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            646..758
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            759..936
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1101
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1271
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1363
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..4091
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3290..3295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="hexamer: ATTAAA"
     polyA_site      3325
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="major polyA site"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="hexamer: AATAAA"
     polyA_site      4051
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="hexamer: AACAAA"
     polyA_site      4091
                     /gene="Ppp2r2c"
                     /gene_synonym="6330548O06Rik; IMYPNO; IMYPNO1; PR52"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgcgcg tcccctcgcc gccgccaccg ccaggcgccc ggacgcagcg cgaacggagc
       61 ggccgggatg cgcgcccgag ccccggcccg ccccacgctg cggccgccgc ctgcccgcct
      121 tacgctcgcc tgagcgcggc gcccgcccgc ccatccccga ccacccgacc gcgatgcccg
      181 ccctcccggg ccccggcggc ccgagaccct gctaggctgc ggcggcatgg cccgcgcgcc
      241 cggcgcgacc tctgtggatt gcatcggtgt gcggcggcgg ggcatgccca gggcaccggg
      301 cgcggccttc aatgggcgag gacacggaca cgcggaaaat taaccacagc ttcctgcggg
      361 accacagcta tgtgacagaa gctgacgtca tctccactgt cgagttcaac cacactgggg
      421 aactgctcgc cacaggtgac aagggtggcc gggtggttat cttccagcgg gaaccagaga
      481 gtaagaacgc acctcacagc cagggtgagt acgatgtata cagcaccttc cagagccacg
      541 agccggagtt tgactacctg aagagcctgg agatagagga gaaaatcaac aagatcaaat
      601 ggctcccgca gcagaacgcc gcgcactcgc tgctgtccac caatgataaa actatcaaat
      661 tatggaagat taccgaacga gacaagaggc ccgagggcta caacctgaag gatgaggagg
      721 gaaagctgaa ggacctgtcc acggtgacgt cactgcaggt gcctgtgctg aagcccatgg
      781 acctgatggt ggaggtgagc ccaagaagga cctttgccaa tggccacacc taccacatca
      841 actccatctc cgtcaacagc gactgtgaga cgtacatgtc agcggacgac ctacgcatca
      901 acctctggca tctggccatc actgatcgga gcttcaacat tgtagacatc aagccagcca
      961 acatggagga cctcacggag gtgatcacag catccgagtt ccatccgcac cactgcaacc
     1021 tcttcgtcta cagcagcagc aagggctccc tgcggctctg tgacatgcgg gcagctgcct
     1081 tgtgcgacaa gcactccaag ctctttgaag agcccgagga ccccagcaac cgctccttct
     1141 tttcagagat catctcctcg gtgtccgacg tgaagttcag ccacagtggg cgctacatgc
     1201 tcacgaggga ttacctcacg gtcaaggtct gggacctgaa catggaggcg aggcccatag
     1261 agacctacca ggtccacgac tacctgcgga gtaagctctg ttccctgtat gagagtgact
     1321 gcatctttga caagtttgag tgtgcctgga atgggagtga cagtgtcatc atgacagggg
     1381 cctacaacaa cttcttccgc atgttcgacc gtaacaccaa gagggacgtg acactggaag
     1441 cctcgcggga gagcagcaaa cccagagcgg tgctcaagcc aaggcgcgtg tgtgtgggtg
     1501 gcaagcggcg gcgtgacgac atcagtgtgg acagcttgga cttcaccaag aagatcctgc
     1561 acacggcctg gcacccagct gagaatatca ttgccattgc agccaccaac aacctgtaca
     1621 tcttccagga taaggtcaac tctgacatgc actagctggc ctcagtggcc ctcccggcca
     1681 cctctgtaag aggacaggat gagtgtggtg gccatttgtg gggacatgag tcccaaggct
     1741 ggagttggct tggatggtaa ttgccagttt aaacaaagga aagggggaag ccccagttac
     1801 aggcggataa agcagatgtg cccggtccag ggctcctttg tttacggccc tcctgtctct
     1861 ggctgggcct ttcattatta tcaggacttt attcatgtcc agggtgggtc agttcctatc
     1921 agggaaagtc aagctggtcc atgatggggc tccagagaaa gttcataggg cagtcaggat
     1981 ctgcagatcc tcaagggagc cagccagcca tgtgcgctgg ctcagagctg ctgcttcatg
     2041 ttggattttg gacagaattc tcactgagtg ctggttgtgg cagcttgtca cttgggtgtt
     2101 tggaatgtct ttcggtattc taggtgccag gcctgggcag gttctgagaa gcagagccaa
     2161 agtcgtaggg ttaatcgtga ggcagggccg ggtccctcgg gtgggttttt ccaggctaag
     2221 gcaagtcctg agaagcagga ctggggaccc tgtgtggctg tggccctcac ctcactgccg
     2281 tccgtttgtg agcccactgc acgctggaca tggtgctcag cccatggtgg ctgtggctgg
     2341 atccccgcag cccactttgt gatggctttg ctgtcaccct tccatgctag ccagtcatct
     2401 tccccatggc cgacagccgg tcctgtccct gactgtagaa tcctcatgcc cacgagacag
     2461 gtgtccgctc atttccataa ctcccagctg agatccaggc tctgctggag ctggggttag
     2521 taaccgtccc ctctgaatac aggagggaac caaggctctg agcagagaag tggggtgcct
     2581 agggagtcat accccgaggg ctgagctggt gtcccatttc caacccgcca cacacgggtg
     2641 actggttttc aagcagcatt ccaagggaag gttttagaag ggaaacattt ccacgccagg
     2701 cattcagtgc aggcgagctg gtgacaagat gtcacaagag agagaagatg gagaagagtg
     2761 gcatccttgc ttgcctctca agatgcacgt caccgacact gtacctgcag ctttctcctc
     2821 acccttccgg ctgctcccca aggaggttgc atgcagccag gcagccccag aggacgtttt
     2881 ctcagacctc ctcagggcca caggtgagtg gccattcatt tcatagtgac ccctactcca
     2941 tcctcattcc tgaaatccca gaactgcagg gcttggcgtt ttgaccctgg aagcagagag
     3001 cagaggggct ttggttttta caacatggac tgccacccag gaaacagatg tgatggagtt
     3061 ttttttctct ctctctctct ctcagtggat caaggtatcc ttgtgtgtgt caaagcacaa
     3121 accgcatgca cactcacttc tggccatgta tttacacaga aactgggtcc attacatttt
     3181 ttggcttttt ttttcctaag tcaacgtgaa tgaagaatgt ttatcactgt aaaattcagg
     3241 cgctctggac agtattatat gtacatattg accctgattc aagctagcaa ttaaaagatc
     3301 ggcgactttc ccctcttgta aagaagttga agaatgtggc cagtcgtatt taatcccatt
     3361 gaagccaaaa tcctggtgag agggccttac acactggcct ggatctctgg cacacccatc
     3421 tgcctttgcg gtttggcgtt agagaagatt cgccttggag gctggaggct gctatgaggt
     3481 cataggtttc acacataatg tcttcaaagt caaatcttac acggtcttca aaaggagggg
     3541 tcttgcacat ggccctagtt tccagacttc tgtttgaaat gtcgggtatc aaagtagaaa
     3601 ggaaaaagag agacagaaaa agatctcaga agaaaaaaaa ataagtcttt gggacccgaa
     3661 gaaatcaccc aggttcagag cggactgcta ataataatgt gtgtattgat cgaggaaaaa
     3721 gtgcggaggg gggaggggcg gtgtgaaaaa tggcagaagg accagagcct tgcaagccac
     3781 agactttgcc actttactct gcttaagttc tctggtcttg agtacgtggc atttcccata
     3841 atcattacga cattgttggg gttttgagtt tgttttcttc tgctttgatt cttctctgag
     3901 ggtgacgccc ttggagggtg ttgggtatct acgtgctggt aacatagtca ggcccagtca
     3961 cttggggttc tgtggctcat aggtgcattc ttttttttct tcggtgtctc acaaattatc
     4021 caactgttga ataaaattat aaatatgtta ataccagctt tttccaataa aataacaaat
     4081 gttacatcta a
//
