LOCUS       NM_027531               2547 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B, beta
            (Ppp2r2b), transcript variant 1, mRNA.
ACCESSION   NM_027531 NR_073583
VERSION     NM_027531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Zhou,C., Liu,H.B., Jahanbakhsh,F., Deng,L., Wu,B., Ying,M.,
            Margolis,R.L. and Li,P.P.
  TITLE     Bidirectional Transcription at the PPP2R2B Gene Locus in
            Spinocerebellar Ataxia Type 12
  JOURNAL   Mov Disord 38 (12), 2230-2240 (2023)
   PUBMED   37735923
  REMARK    GeneRIF: Bidirectional Transcription at the PPP2R2B Gene Locus in
            Spinocerebellar Ataxia Type 12.
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Rodriguez-Rodriguez,N., Madera-Salcedo,I.K., Cisneros-Segura,J.A.,
            Garcia-Gonzalez,H.B., Apostolidis,S.A., Saint-Martin,A.,
            Esquivel-Velazquez,M., Nguyen,T., Romero-Rodriguez,D.P.,
            Tsokos,G.C., Alcocer-Varela,J., Rosetti,F. and Crispin,J.C.
  TITLE     Protein phosphatase 2A B55beta limits CD8+ T cell lifespan
            following cytokine withdrawal
  JOURNAL   J Clin Invest 130 (11), 5989-6004 (2020)
   PUBMED   32750040
  REMARK    GeneRIF: Protein phosphatase 2A B55beta limits CD8+ T cell lifespan
            following cytokine withdrawal.
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   O'Shaughnessy,R.F., Welti,J.C., Sully,K. and Byrne,C.
  TITLE     Akt-dependent Pp2a activity is required for epidermal barrier
            formation during late embryonic development
  JOURNAL   Development 136 (20), 3423-3431 (2009)
   PUBMED   19762425
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Liu,W.B., Li,Y., Zhang,L., Chen,H.G., Sun,S., Liu,J.P., Liu,Y. and
            Li,D.W.
  TITLE     Differential expression of the catalytic subunits for PP-1 and
            PP-2A and the regulatory subunits for PP-2A in mouse eye
  JOURNAL   Mol Vis 14, 762-773 (2008)
   PUBMED   18432318
  REMARK    GeneRIF: PP-2A is less abundant than PP-1 in the mouse eye and
            appear to be highly regulated by various regulatory subunits; the
            genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta,
            and PP-2A-B alpha/beta/gamma are all differentially expressed.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Maeda,T., Hamabe,W., Gao,Y., Fukazawa,Y., Kumamoto,K., Ozaki,M. and
            Kishioka,S.
  TITLE     Morphine has an antinociceptive effect through activation of the
            okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5
            estimated by tail-pinch test in mice
  JOURNAL   Brain Res 1056 (2), 191-199 (2005)
   PUBMED   16102737
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Beaulieu,J.M., Sotnikova,T.D., Marion,S., Lefkowitz,R.J.,
            Gainetdinov,R.R. and Caron,M.G.
  TITLE     An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic
            neurotransmission and behavior
  JOURNAL   Cell 122 (2), 261-273 (2005)
   PUBMED   16051150
REFERENCE   10 (bases 1 to 2547)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101740.7, BC088979.1 and AC140245.3.
            
            On or before Apr 3, 2020 this sequence version replaced
            NR_073583.1, NM_027531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066007.1, AK039592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               AC101740.7         111622-112140       c
            520-2485            BC088979.1         1-1966
            2486-2547           AC140245.3         66202-66263         c
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.75 cM"
     gene            1..2547
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="protein phosphatase 2, regulatory subunit B, beta"
                     /db_xref="GeneID:72930"
                     /db_xref="MGI:MGI:1920180"
     exon            1..764
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     CDS             695..2026
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B beta isoform isoform 1"
                     /protein_id="NP_081807.1"
                     /db_xref="GeneID:72930"
                     /db_xref="MGI:MGI:1920180"
                     /translation="MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDK
                     GGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQN
                     AAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMV
                     EATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANM
                     EELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSF
                     FSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYE
                     NDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRK
                     VCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN"
     exon            765..862
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1028
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1141
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1319
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1484
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1654
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1746
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2547
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="hexamer: AACAAG"
     polyA_site      2088
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="major polyA site"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="hexamer: CATAAA"
     polyA_site      2153
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="hexamer: GATAAA"
     polyA_site      2404
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="hexamer: AATAAA"
     polyA_site      2485
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
     regulatory      2513..2518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
                     /note="hexamer: AATAAA"
     polyA_site      2547
                     /gene="Ppp2r2b"
                     /gene_synonym="2900026H06Rik; 6330404L05Rik;
                     E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12"
ORIGIN      
        1 gcagcaggag cagcagcacc agcagcagct gcgagtgcgc ccctgtgggt gtgagggtga
       61 gagcgctggc gctggccgca gcgcccagcc tagctccccg ccagctttcc tagcccccgc
      121 ctgcgggagc cgccctctcg tgggaccagc accctcatct cagcaaggca agcctgaatc
      181 ctgcccctgc catctcgcca ctgcagtgtg ggtccggaaa ggcaccattt tgtcgcggct
      241 gcccgctctc ccagggggag gaaagctctt attttttgca ttttggagcc gctgcctgcc
      301 aaggggaacc tgttgggcat ctccccagcc ctacttggga acgtctcctg agcggtcagg
      361 caggactaga cccctcgtgg gggacacaga gcttcctggt acccggaggc agaggaggca
      421 gacgcagcat cctcgttggg aattggagct gaagtgagcg caccgtgcgg gaggagccac
      481 cgcatccgcg gagaaccgag tggaggaggt gacagctcca ttgccgggtt tttattttct
      541 tctctctccg cctccccgtc tcctcctcag gctcggacca tggtgcagtc ccactggctc
      601 ccctgccccc ctctcctgtg agactggctg cggggtggga tcatggatac ttgtctgccg
      661 gcttctggtt cccacgcaag taagcctgct gtcaatggag gaggacattg atacccgcaa
      721 aatcaacaac agtttcctgc gcgaccacag ctatgcaacc gaagctgaca ttatctctac
      781 ggtagaattc aaccacacgg gagagttact agcgacgggg gacaaggggg gtcgggtcgt
      841 aatatttcag cgagaacagg agagtaaaaa ccaggttcat cgtaggggtg aatacaatgt
      901 ttacagcaca ttccagagcc atgaacccga gttcgattac ctgaaaagtt tagaaataga
      961 agaaaaaatc aataagataa gatggctccc tcaacaaaac gcagcttact ttcttctgtc
     1021 taccaacgat aaaactgtga agctgtggaa agtcagtgag cgggataaga ggccagaagg
     1081 ctacaacctg aaagatgagg agggccggct ccgggatcct gccaccatca caaccctgcg
     1141 ggtgcctgtc ctgagaccca tggacctgat ggtggaggcc accccacgaa gagtgtttgc
     1201 caatgcgcac acgtaccaca tcaactctat atctgtcaac agcgactatg agacctacat
     1261 gtctgctgat gacctgagga ttaatctgtg gaactttgag ataaccaatc agagttttaa
     1321 tatcgtggac atcaagccag ccaacatgga ggagctcaca gaggtgatca ctgcagctga
     1381 gttccacccc caccactgca acaccttcgt atacagcagc agcaagggga caatccggct
     1441 gtgtgacatg cgtgcatctg cgctgtgtga caggcacacc aagttttttg aagaaccgga
     1501 agatccaagc aacagatcgt ttttctctga aatcatctct tcaatttcgg atgtgaaatt
     1561 cagccacagt gggaggtata tcatgaccag agactatctg accgtgaaag tctgggacct
     1621 caacatggaa aatcgcccca ttgagacata ccaggttcat gactacctcc gcagcaagtt
     1681 gtgctccctc tatgaaaacg actgcatttt tgataaattt gagtgtgtat ggaatgggtc
     1741 agacagcgtc atcatgacag gctcctacaa taacttcttc aggatgttcg accgaaacac
     1801 caagcgtgat gtgacccttg aggcctcaag ggaaaacagc aaaccccggg ctatcctcaa
     1861 accccgaaaa gtgtgcgtcg ggggcaagcg aagaaaagat gagatcagtg ttgacagtct
     1921 ggactttagc aaaaagatct tgcatacagc ttggcatcct tcagaaaaca ttatagcagt
     1981 ggcggctacg aataacttat atatattcca agacaaggtt aactagaagg acgagctact
     2041 acttagtctc acatactgaa tactagtcaa aacaagtttt taaatgttcc tttgggtctt
     2101 cattttgatg cattgacttt catttcccta tgcataaaac aattggaata gaacttttaa
     2161 aaggagttca atgttcccca actccccaat tctaagagac gtctgtcaaa ctcggtaggc
     2221 ttgggacact tctgtttaga cttgagagct gccaactggc aggaattctt ccatagtcga
     2281 cttgaatttc tgatgcgttc tcgttcattg cccacttctc tctggtgggt tctgtgtttt
     2341 gtttctaggt gtctgctgcg ataaaatgag attgtctgta gtatttaagg agaaaaagag
     2401 ataaggtttt ttttttaatt aagcattcca tttgtttgaa aaaaatcaac aacaaaaaaa
     2461 aaaaataaac actgtttact cttaagagtt tcctctttgt gaaaaatata ataataaatc
     2521 aggcctggcc agtatgtttc ccaccca
//
