LOCUS       NM_028032               4058 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit B, alpha
            (Ppp2r2a), transcript variant 1, mRNA.
ACCESSION   NM_028032 XM_001003559 XM_001003561 XM_619260 XM_915470 XM_923757
            XM_923760 XM_923767 XM_994820
VERSION     NM_028032.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Sanz-Flores,M., Ruiz-Torres,M., Aguirre-Portoles,C., El Bakkali,A.,
            Salvador-Barbero,B., Villarroya-Beltri,C., Ortega,S., Megias,D.,
            Gerlich,D.W., Alvarez-Fernandez,M. and Malumbres,M.
  TITLE     PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome
            individualization during mitosis
  JOURNAL   Cell Rep 43 (7), 114494 (2024)
   PUBMED   39003739
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Pan,W., Tsokos,M.G., Scherlinger,M., Li,W. and Tsokos,G.C.
  TITLE     The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to
            regulate T cell subset differentiation in systemic autoimmunity
  JOURNAL   Cell Rep 43 (7), 114379 (2024)
   PUBMED   38889006
  REMARK    GeneRIF: The PP2A regulatory subunit PPP2R2A controls NAD[+]
            biosynthesis to regulate T cell subset differentiation in systemic
            autoimmunity.
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Pan,W., Nagpal,K., Suarez-Fueyo,A., Ferretti,A., Yoshida,N.,
            Tsokos,M.G. and Tsokos,G.C.
  TITLE     The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17
            Differentiation through Activation of the GEF-H1/RhoA/ROCK
            Signaling Pathway
  JOURNAL   J Immunol 206 (8), 1719-1728 (2021)
   PUBMED   33762326
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Panicker,N., Coutman,M., Lawlor-O'Neill,C., Kahl,R.G.S., Roselli,S.
            and Verrills,N.M.
  TITLE     Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory
            Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and
            Epidermal Embryonic Development
  JOURNAL   Front Cell Dev Biol 8, 358 (2020)
   PUBMED   32582689
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4058)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
REFERENCE   7  (bases 1 to 4058)
  AUTHORS   O'Shaughnessy,R.F., Welti,J.C., Sully,K. and Byrne,C.
  TITLE     Akt-dependent Pp2a activity is required for epidermal barrier
            formation during late embryonic development
  JOURNAL   Development 136 (20), 3423-3431 (2009)
   PUBMED   19762425
REFERENCE   8  (bases 1 to 4058)
  AUTHORS   Liu,W.B., Li,Y., Zhang,L., Chen,H.G., Sun,S., Liu,J.P., Liu,Y. and
            Li,D.W.
  TITLE     Differential expression of the catalytic subunits for PP-1 and
            PP-2A and the regulatory subunits for PP-2A in mouse eye
  JOURNAL   Mol Vis 14, 762-773 (2008)
   PUBMED   18432318
  REMARK    GeneRIF: PP-2A is less abundant than PP-1 in the mouse eye and
            appear to be highly regulated by various regulatory subunits; the
            genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta,
            and PP-2A-B alpha/beta/gamma are all differentially expressed.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4058)
  AUTHORS   Kuo,Y.C., Huang,K.Y., Yang,C.H., Yang,Y.S., Lee,W.Y. and
            Chiang,C.W.
  TITLE     Regulation of phosphorylation of Thr-308 of Akt, cell
            proliferation, and survival by the B55alpha regulatory subunit
            targeting of the protein phosphatase 2A holoenzyme to Akt
  JOURNAL   J Biol Chem 283 (4), 1882-1892 (2008)
   PUBMED   18042541
  REMARK    GeneRIF: that B55alpha-dependent targeting of the PP2A holoenzyme
            to Akt selectively regulates Akt phosphorylation at Thr-308 to
            regulate cell proliferation and survival.
REFERENCE   10 (bases 1 to 4058)
  AUTHORS   Maeda,T., Hamabe,W., Gao,Y., Fukazawa,Y., Kumamoto,K., Ozaki,M. and
            Kishioka,S.
  TITLE     Morphine has an antinociceptive effect through activation of the
            okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5
            estimated by tail-pinch test in mice
  JOURNAL   Brain Res 1056 (2), 191-199 (2005)
   PUBMED   16102737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030233.6, AK161507.1, AC165148.2 and BC065100.1.
            
            On Mar 29, 2011 this sequence version replaced NM_028032.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065100.1, AK161507.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CT030233.6         45010-45051
            43-2422             AK161507.1         1-2380
            2423-3665           AC165148.2         162486-163728       c
            3666-4058           BC065100.1         3636-4028
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     gene            1..4058
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="protein phosphatase 2, regulatory subunit B, alpha"
                     /db_xref="GeneID:71978"
                     /db_xref="MGI:MGI:1919228"
     exon            1..382
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1719
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B alpha isoform isoform 1"
                     /protein_id="NP_082308.1"
                     /db_xref="CCDS:CCDS56967.1"
                     /db_xref="GeneID:71978"
                     /db_xref="MGI:MGI:1919228"
                     /translation="MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLA
                     TGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWL
                     PQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPM
                     DLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIK
                     PANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPS
                     NRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLC
                     SLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVL
                     KPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN"
     exon            383..457
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            458..555
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            556..721
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            722..834
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1012
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1177
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1347
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1439
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..4037
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2402..2407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="hexamer: AATAAA"
     polyA_site      2423
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="major polyA site"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="hexamer: AATAAA"
     polyA_site      3423
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
     regulatory      3440..3445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="hexamer: AACAAA"
     polyA_site      3463
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="hexamer: AATAAA"
     polyA_site      3868
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
     regulatory      4011..4016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
                     /note="hexamer: AATAAA"
     polyA_site      4037
                     /gene="Ppp2r2a"
                     /gene_synonym="2410004D02Rik; B55; mKIAA1541"
ORIGIN      
        1 aagtgacgtc accggccagc cagcgggcgc cattttgaaa gtggagtcgc ctgtccctgc
       61 cgccgcggcc gccgtcgctg tcctagccgc cgctgccgcc gccactacta ccgccgccgc
      121 cgccgctact gccgccgctg ccgtctccac cgcgagagaa ggagcacgag acgggacgcc
      181 cctgagtgaa cgccaccatc ctgccgaccg ctccacccgg gccgcttcct ttccgccccg
      241 gtcccggtcc cctcccccct caggtgccat ccgcctccat ccgcgccctc gatcccccca
      301 tccccaggtg tgggggctga gccccggtcg cggagacccc gacgagcccg gcagggtcac
      361 catttgcagc gcgacatggc aggagctgga ggagggaatg atattcagtg gtgtttttct
      421 caggtgaaag gagcagtaga tgatgacgta gcagaagcag atataatttc tacagtagag
      481 tttaatcatt ctggagaatt actagccaca ggagataaag gtgggagagt tgtcatcttt
      541 caacaagagc aggagaacaa aatccagtct catagcagag gagaatacaa tgtttacagc
      601 accttccaga gccatgagcc agaatttgac tacttgaaaa gcttagaaat agaagagaag
      661 atcaacaaaa ttaggtggtt accccagaaa aatgctgccc agtttttatt gtctaccaac
      721 gataaaacaa taaaattatg gaaaatcagt gaaagagaca aaagaccaga aggctataac
      781 ttgaaagagg aagatggaag atatagagat cctactacag tcactacgct acgggtgccc
      841 gtatttaggc ccatggatct aatggtggaa gccagtccac ggagaatatt tgccaacgcc
      901 cacacttatc acatcaactc aatttctatc aatagtgatt atgaaaccta cttatcagca
      961 gatgatttgc gaattaatct ctggcatctg gaaattacag acaggagttt taatattgtg
     1021 gatatcaagc ctgccaatat ggaagagctc acggaggtga tcacggctgc agaatttcac
     1081 cccaacagct gtaacacgtt tgtgtacagc agcagtaaag gaactattcg gttatgtgac
     1141 atgagggcat ctgcgctctg tgacaggcat tctaaactgt ttgaagaacc tgaagatccc
     1201 agcaacaggt catttttttc tgaaatcatc tcctctattt ctgatgtaaa attcagccat
     1261 agcggtcgtt atatgatgac tagagactat ttgtcagtca aaatttggga cttgaatatg
     1321 gagaacaggc ccgtggagac ataccaggta catgaatacc tcagaagtaa actttgctca
     1381 ctgtatgaaa acgactgcat atttgacaaa tttgaatgtt gttggaatgg gtctgacagt
     1441 gttgtcatga ctggatccta caataatttc ttcagaatgt tcgacaggaa cacaaagcgg
     1501 gatataaccc tagaagcatc acgagagaac aataagcctc gcacggtttt gaagccacgc
     1561 aaagtctgtg caagtggcaa gcgaaagaaa gatgaaataa gtgttgacag cctagacttc
     1621 aacaagaaaa tccttcatac agcctggcat cccaaggaaa acatcattgc tgtagcaact
     1681 acaaacaatc tgtatatatt tcaagacaaa gtgaattagg ctggcattct ctgcagagga
     1741 gccacttcct gcttagtgag atagttgaat ctagcattca tacctataag agagcggtcc
     1801 attgtggcgc ccctttccag tgtttgacag tgtgccattc aacaacacat ttgatagcct
     1861 catggagaaa gctgtgtgga tgcatcccag gctgttttcc atgtctgcta gccatttagg
     1921 gaagggaagg gcacttttaa tttaatgact tcttgcacca tcttgcctgg tggactggac
     1981 tggactgtgt cagcattgat gtactccact ttttatgcct tccattgtga tgacgtcaaa
     2041 cacagtgaac gccttcagtc atgctatgga atttgtgtat cctcattact gtatcatttg
     2101 tggggtacac ccctcccctc ttttttaaat taaatacagc tcattcttac tgtggcttgt
     2161 agcattcctc ctctctggcc tcctggactc ttccctccat ctctcaccct tgccctttcc
     2221 accttgtctc ggtggtggcg tattcaaaaa aggaagaacg aaagcacaca aaatgggtca
     2281 ggttggggtc agtggtaatg ggggaatatg ttacgaacaa atgttttaat aacagttggc
     2341 tgtaatcact ccttgccatg tctggcactg aaaataagga aaaaaaaaaa aactactact
     2401 gaataaaagt gacaaagaat ggagaatctg gttttctttt tctttttcat ctacctcttt
     2461 aaaccaatgt tttgtgtcat atccttgggc gcaatgaaat gaagtgggtt tctattgtct
     2521 ccttggtttt ttttgtgaac tatttttaac gagtgttctt ttccatggag cctgggagag
     2581 gatcatggtt ctgtgcgtcc atgtgtttga atatacatga ctgttaagag ttcacagtct
     2641 agaaatggct agaaggttct ggggtttttg ttttgttttt gtttttatgt gtctgtgctt
     2701 gatttatctg ttaacaaagt tgctgtcaat gagaaccaca gttgaggagc ttcactctga
     2761 agtcttcttc cagtgcttca tttctttgcc ttaggaaata ccaagtagac aagttgactt
     2821 ttctcgctgt tcaggcacag tagactggaa ttccgtctgg aagtaacgtg gtagatgaaa
     2881 ccggatgctg cactaaagag ctgttttgta ctaattgctg tggaatcact gaattgtact
     2941 ttgccataga tacgtctttt ggttttccaa aggtatattc gggacaagct tttaaaggta
     3001 cggtgatgca tggactgcaa cagctgcgta agcaccagat gtgtgatgat ccacagtgtt
     3061 ccagtgctga ggccctagcc aaagatggag agtgtcccag ttagtgtggg atggaccgtg
     3121 gtcagtcctg caggaagctt tatggagaga gaatggactt tatttttaaa agatgaatga
     3181 gcaggcattt atatgagaat ggtagtatat tttgattgaa cagtaatata acaatgttga
     3241 atatagagga ctctgcgtgc ttatatattc ccactgccta ttgttcttca gtaatgaaaa
     3301 tgattaaaca actccaccac aattccctct acacttacac atatattatg tcttgtacgt
     3361 taatattttt agcgcacagg agaaatttta tgtaataaag ttactgtatc ttttggagtt
     3421 aaatttgaat ttgtatttaa acaaaatgtc tgataattct taatggcact tttactaatt
     3481 tatttggggg ttgtgggtgc attcttaatc tctttctttc tttggcttgt atagttgcga
     3541 atctagaagg atccacaata caaagttttg atgggataat ttctcatatc ctttgggata
     3601 gtggcattcc tatggtttgg ctttgagcca ccaagcagtc agtagaagtc tttttttttt
     3661 tttttctcaa atggtagttt ttatgattct cacccatcac tataaggctt agttttgtat
     3721 agttggaaga gacctgtcaa cttaagatat caggaatgct attaataacc tataataatt
     3781 gtttttctaa tatatttggt gtagcaaact aagcccagcc actcatttta tatagtcaac
     3841 tttttattaa taaaacttat agaataaatg tcttgtcaac ttgattgtat tttgctaatc
     3901 tctgacgatc catacaaata tttaaccctc ttgtaatgtt tttgaagtgc tggaattttt
     3961 ttgaagatct ctcattctgt taaaagtcag ttttcacttg gtggctgggc aataaaaatt
     4021 ggtaatatat aaacctaaaa aaaaaaaaaa aaaaaaaa
//
