LOCUS       NM_028614               3634 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit A, beta
            (Ppp2r1b), transcript variant 2, mRNA.
ACCESSION   NM_028614
VERSION     NM_028614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3634)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3634)
  AUTHORS   Du,M., Yuan,L., Zhang,Z., Zhang,C., Zhu,M., Zhang,Z., Li,R.,
            Zhao,X., Liang,H., Li,Y., Jiang,H., Qiao,J. and Yin,Y.
  TITLE     PPP2R1B is modulated by ubiquitination and is essential for
            spermatogenesis
  JOURNAL   FASEB J 35 (5), e21564 (2021)
   PUBMED   33913576
  REMARK    GeneRIF: PPP2R1B is modulated by ubiquitination and is essential
            for spermatogenesis.
REFERENCE   4  (bases 1 to 3634)
  AUTHORS   Markenscoff-Papadimitriou,E., Whalen,S., Przytycki,P., Thomas,R.,
            Binyameen,F., Nowakowski,T.J., Kriegstein,A.R., Sanders,S.J.,
            State,M.W., Pollard,K.S. and Rubenstein,J.L.
  TITLE     A Chromatin Accessibility Atlas of the Developing Human
            Telencephalon
  JOURNAL   Cell 182 (3), 754-769 (2020)
   PUBMED   32610082
REFERENCE   5  (bases 1 to 3634)
  AUTHORS   Panicker,N., Coutman,M., Lawlor-O'Neill,C., Kahl,R.G.S., Roselli,S.
            and Verrills,N.M.
  TITLE     Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory
            Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and
            Epidermal Embryonic Development
  JOURNAL   Front Cell Dev Biol 8, 358 (2020)
   PUBMED   32582689
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3634)
  AUTHORS   Liu,J., Ji,W., Sun,S., Zhang,L., Chen,H.G., Mao,Y., Liu,L.,
            Zhang,X., Gong,L., Deng,M., Chen,L., Han,W.J., Chen,P.C., Hu,W.F.,
            Hu,X., Woodward,Z., Liu,W.B., Xiao,Y.M., Liang,S.P., Liu,Y.,
            Liu,S.J. and Li,D.W.
  TITLE     The PP2A-Abeta gene is regulated by multiple transcriptional
            factors including Ets-1, SP1/SP3, and RXRalpha/beta
  JOURNAL   Curr Mol Med 12 (8), 982-994 (2012)
   PUBMED   22827437
  REMARK    GeneRIF: Multiple transcription factors regulate the PP2A-Abeta
            gene.
REFERENCE   7  (bases 1 to 3634)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 3634)
  AUTHORS   Chen,W., Gu,P., Jiang,X., Ruan,H.B., Li,C. and Gao,X.
  TITLE     Protein phosphatase 2A catalytic subunit alpha (PP2Acalpha)
            maintains survival of committed erythroid cells in fetal liver
            erythropoiesis through the STAT5 pathway
  JOURNAL   Am J Pathol 178 (5), 2333-2343 (2011)
   PUBMED   21514445
REFERENCE   9  (bases 1 to 3634)
  AUTHORS   Guenebeaud,C., Goldschneider,D., Castets,M., Guix,C., Chazot,G.,
            Delloye-Bourgeois,C., Eisenberg-Lerner,A., Shohat,G., Zhang,M.,
            Laudet,V., Kimchi,A., Bernet,A. and Mehlen,P.
  TITLE     The dependence receptor UNC5H2/B triggers apoptosis via
            PP2A-mediated dephosphorylation of DAP kinase
  JOURNAL   Mol Cell 40 (6), 863-876 (2010)
   PUBMED   21172653
REFERENCE   10 (bases 1 to 3634)
  AUTHORS   Liu,W.B., Li,Y., Zhang,L., Chen,H.G., Sun,S., Liu,J.P., Liu,Y. and
            Li,D.W.
  TITLE     Differential expression of the catalytic subunits for PP-1 and
            PP-2A and the regulatory subunits for PP-2A in mouse eye
  JOURNAL   Mol Vis 14, 762-773 (2008)
   PUBMED   18432318
  REMARK    GeneRIF: PP-2A is less abundant than PP-1 in the mouse eye and
            appear to be highly regulated by various regulatory subunits; the
            genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta,
            and PP-2A-B alpha/beta/gamma are all differentially expressed.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123614.6, AK136106.1, AK077158.1, BC056218.1, AK010754.1,
            BM932667.1, CX566645.1 and BY687256.1.
            
            On Nov 8, 2013 this sequence version replaced NM_028614.2.
            
            Transcript Variant: This variant (2) uses an alternate 3' structure
            and contains a 3' terminal exon which extends past a splice site
            that is used in variant 3. It encodes isoform b, which has a
            shorter and distinct C-terminus, compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056218.1, SRR7974084.11641.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC123614.6         202439-202481
            44-909              AK136106.1         2-867
            910-1110            AK077158.1         864-1064
            1111-1737           BC056218.1         1105-1731
            1738-1880           AK010754.1         395-537
            1881-2532           BM932667.1         1-652
            2533-3209           CX566645.1         112-788
            3210-3259           BC056218.1         3204-3253
            3260-3634           BY687256.1         27-401
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..3634
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /note="protein phosphatase 2, regulatory subunit A, beta"
                     /db_xref="GeneID:73699"
                     /db_xref="MGI:MGI:1920949"
     exon            1..175
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1867
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /EC_number="3.1.3.16"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform b"
                     /protein_id="NP_082890.2"
                     /db_xref="CCDS:CCDS40626.1"
                     /db_xref="GeneID:73699"
                     /db_xref="MGI:MGI:1920949"
                     /translation="MAGAAGPGSGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSI
                     KKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLL
                     PPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSAC
                     GLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKTEIV
                     PLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDLEALVMPTLRQAAEDKSWRVRYMVA
                     DKFSELQKAVGPKIALSDLIPAFQSLLRDCEAEVRAAAAHKVRELCENLPAEGRETVI
                     MNQILPYIKELVSDTNQHVKSALASVIMGLSTVLGKENTIEHLLPLFLAQLKDECPEV
                     RLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEF
                     FDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYL
                     HRMTTLFCINALSEACGKEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTN
                     ALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA"
     exon            176..266
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..367
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            368..600
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..748
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..904
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1019
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1090
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1225
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1399
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1460
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1615
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1758
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1850
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..3634
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3259
                     /gene="Ppp2r1b"
                     /gene_synonym="2410091N08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgggg cgtggtctgg gcacggggcc ttcggcggcg accagccaga ggaggaagaa
       61 catggcgggc gcagcagggc cagggtccgg tccgggggca gcgggtggag atggagacga
      121 ttcgctctac ccgatcgcgg ttttaatcga cgagctccgc aatgaggacg tgcagctccg
      181 tctcaacagt attaagaagt tatcaactat agctctagca ctcggggtag aaaggactcg
      241 aacggaactg ctgcctttcc ttacagatac tatttatgat gaagatgagg tgctgttagc
      301 tctcgccgag cagctgggaa atttcactgg tttggtgggc ggtcctgact ttgcccactg
      361 tctgctgcct cctttggaaa gtttggctac ggtggaggag actgtcgttc gagacaaggc
      421 tgtggagtcg ctgaggcaga tctcgcagga gcacactcct gttgcccttg aagctcattt
      481 tgtgcctctg gtgaagcgcc tggcaagcgg ggactggttc acgtcgcgca cgtctgcatg
      541 tggcttgttc agcgtttgct atcccagagc ttcaaatgct gtcaaggcag agattcgaca
      601 gcacttccgt tctctctgct cggatgatac accaatggtg cgacgtgctg ctgcttccaa
      661 attgggtgaa tttgcaaaag ttttggaatt agacagtgtg aaaactgaaa ttgtcccatt
      721 gttcacgaat ttggcttcag atgaacagga ctctgtgcgg ctgctagctg tggaagcctg
      781 cgtcagcatt gcccagttac tgtctcagga ggacctggaa gccttggtaa tgcctacact
      841 tcgacaagca gcagaagata agtcctggcg ggttcgatat atggtggctg acaagttttc
      901 agagctccag aaagcggtgg gccctaagat tgcactcagc gacctcatcc ccgccttcca
      961 gagcctcctc cgagactgcg aagctgaagt ccgagcagcc gctgcccaca aagtaagaga
     1021 gctttgtgag aacctgcccg ctgaaggtag agagactgta attatgaatc aaatcctgcc
     1081 ctatataaag gaattagtgt ctgataccaa ccaacatgtc aagtcagcgc tagcttctgt
     1141 aattatggga ttatctacag ttttgggcaa agagaatacc attgaacatc ttctgcctct
     1201 atttttagct cagttaaagg acgagtgtcc agaagttcgt ttaaatatca tctccaattt
     1261 ggattgtgtg aatgaagtga ttggaatccg tcagctctct cagtctctcc ttccggccat
     1321 agtggaactg gctgaagatg ccaagtggag ggtccgcctg gctatcattg agtacatgcc
     1381 gctgctggct ggccagctgg gtgtggagtt ctttgatgaa aaactcaatt ctttgtgtat
     1441 ggcctggctt gtggatcatg tctatgccat tcgggaggca gccaccaaca acctcatgaa
     1501 gttagtccag aagttcggta cagagtgggc ccagaatacc attgtcccta aagtgttggt
     1561 aatggcaaat gaccctaact acttacacag aatgaccacg ctcttctgca ttaatgcact
     1621 gtctgaagcc tgtggtaagg aaataaccac taagcaaatg ttgcccatcg tgttgaaaat
     1681 ggcaggagac caggtagcaa atgtccgctt caatgtggcc aaatcactgc agaaaattgg
     1741 accgattcta gacaccaacg ccttgcaggg ggaagtgaag ccggtgctgc agaaattggg
     1801 tcaggacgaa gacatggatg tcaaatattt tgcacaggaa gctataagtg ttcttgcctt
     1861 ggcataaaga tgaacaggag ggaaaagcct ttactaaatt cttatcacag atctctagtc
     1921 aatgtgttct tgccctgggt ggagaaaaat ggaaaccttc aagatctcat ccaagcaaat
     1981 ggcaacaaca tagaagaaat cagatttcag tgacttgatt ctctctacac atgacctcag
     2041 actgacttga cttctctctg ttgggataac tgtacgctct tcttctgccc agttgctgat
     2101 gctcctcata cagtcatctc ttgagtgtct cccagggttt ctctccagca ccattgaggc
     2161 tcctgcctcc tcccttttga atcaggcccc agccacttac gattccagac agaccctgga
     2221 tggatttgga ccccgacacg gagtggagtg aatcccttat tgtttacaca tctctgtgtg
     2281 gcgctccatc tttccaatgt taagagtaaa tggtttagaa taacttattt atatctgctt
     2341 ggagctaata ttgagatttg actgtagcga aagccacatg ctcctggttt cgatggtccg
     2401 catcagcatc tcacatgaag gagatgtgga aggctaacga atggctggtc tggttttcat
     2461 ttgctcagtt tgactgtaat catgtcatgc aggagctgga agtgggtgta tcttgctgct
     2521 aatgtgtgat gttgaaagaa aacaatttca acggctcagc actgtgactg ccttcaaaaa
     2581 ctcagaagaa actttagtgc ctcctactaa gttgtggttc tactgtttca ttgtgaagtg
     2641 ttgtgtttca agtaagtgta ggaaccagtg gccccaggct ctgctcccag cactgttagt
     2701 gagcattgtg ctgttgcgat accgtgcagt accaaactga agcttccttg ctcagtgttt
     2761 tcttgtggtg tgggtgatgc tagaactttt ttctactttt gcagtaaaat ttcattaata
     2821 tgtccagaaa tttaaggtga caggtcaagc tgaagggttt gctgaagcaa attaattgtg
     2881 tctatggaag gctgctggac actaatttta ggaagtaccc ccttctcagt gggtgtgcct
     2941 gtgaccagtg tccctgctct gtcataaccc agcccttcca ggagcagcgc acacatcaca
     3001 cttttcctga atatccctgt gggtaattta aatattttca tctgactcct tgtctcgggt
     3061 ggactcaagt taatgaggct ttactgcggc ctgttttact caatgcatca taccatgtag
     3121 tttgatgttt ccattttggt ttctgaattg ttgattttac ttacaaatcc ttttagatat
     3181 aacaagccct gttctgtttt gtgaaggccc aaagatacct acaaatcttt gtacattaaa
     3241 catgttacat aaaaccaaat tgtgtaaatg cttttaagtt tatcatacct tagaaaaaca
     3301 gaacagaccg tttctatcag agaccatgtg cctgcatttt aaactgctgg ttacttctta
     3361 gtaagttttc atttttgtgt tctagggcca aagtttgact attttcctaa gcattttagt
     3421 gccttaaatt agtctgctgt aaacatttta atttcacagt ttctttttcg tcacctgcag
     3481 gctgtattcc tctttaatga ttagttttat atttgagaga gataattgtc ttgattgtgg
     3541 aaatgtgcat tgggacagct gcttcacctt tggttggaaa tgccacatgg tacactcact
     3601 cgggaataaa cctctaaagt gtctctgctc ccct
//
