LOCUS       NM_016891               2256 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein phosphatase 2, regulatory subunit A, alpha
            (Ppp2r1a), mRNA.
ACCESSION   NM_016891
VERSION     NM_016891.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2256)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2256)
  AUTHORS   Rehmani,T., Dias,A.P., Kamal,M., Salih,M. and Tuana,B.S.
  TITLE     Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3
            (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of
            Myocardium without Affecting Hippo Pathway
  JOURNAL   Int J Mol Sci 25 (5), 2888 (2024)
   PUBMED   38474134
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2256)
  AUTHORS   Chen,L., Guo,P., Li,W., Jiang,X., Zhao,Q., Li,D., Wang,Q., Xiao,Y.,
            Xing,X., Pang,Y., Aschner,M., Zhang,L. and Chen,W.
  TITLE     Protein phosphatase 2A regulates cytotoxicity and drug resistance
            by dephosphorylating AHR and MDR1
  JOURNAL   J Biol Chem 298 (5), 101918 (2022)
   PUBMED   35405096
  REMARK    GeneRIF: Protein phosphatase 2A regulates cytotoxicity and drug
            resistance by dephosphorylating AHR and MDR1.
REFERENCE   4  (bases 1 to 2256)
  AUTHORS   Hu,W., Wang,Z., Zhang,H., Mahaman,Y.A.R., Huang,F., Meng,D.,
            Zhou,Y., Wang,S., Jiang,N., Xiong,J., Westermarck,J., Lu,Y.,
            Wang,J., Wang,X., Shentu,Y. and Liu,R.
  TITLE     Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and
            Cognitive Dysfunction Through CIP2A/PP2A Signaling
  JOURNAL   Neurotherapeutics 19 (2), 570-591 (2022)
   PUBMED   35286657
  REMARK    GeneRIF: Chk1 Inhibition Ameliorates Alzheimer's Disease
            Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A
            Signaling.
REFERENCE   5  (bases 1 to 2256)
  AUTHORS   Yen,Y.T., Chien,M., Wu,P.Y., Ho,C.C., Ho,C.T., Huang,K.C.,
            Chiang,S.F., Chao,K.S.C., Chen,W.T. and Hung,S.C.
  TITLE     Protein phosphatase 2A inactivation induces microsatellite
            instability, neoantigen production and immune response
  JOURNAL   Nat Commun 12 (1), 7297 (2021)
   PUBMED   34911954
  REMARK    GeneRIF: Protein phosphatase 2A inactivation induces microsatellite
            instability, neoantigen production and immune response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2256)
  AUTHORS   Ram,P.T.
  TITLE     Overexpression of tightly regulated proteins: protein phosphatase
            2A overexpression in NIH 3T3 cells
  JOURNAL   Methods Enzymol 345, 551-555 (2002)
   PUBMED   11665638
  REMARK    GeneRIF: protein phosphatase 2A overexpression in NIH 3T3 cells
REFERENCE   7  (bases 1 to 2256)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   8  (bases 1 to 2256)
  AUTHORS   Nanahoshi,M., Tsujishita,Y., Tokunaga,C., Inui,S., Sakaguchi,N.,
            Hara,K. and Yonezawa,K.
  TITLE     Alpha4 protein as a common regulator of type 2A-related
            serine/threonine protein phosphatases
  JOURNAL   FEBS Lett 446 (1), 108-112 (1999)
   PUBMED   10100624
REFERENCE   9  (bases 1 to 2256)
  AUTHORS   Hsu,W., Zeng,L. and Costantini,F.
  TITLE     Identification of a domain of Axin that binds to the
            serine/threonine protein phosphatase 2A and a self-binding domain
  JOURNAL   J Biol Chem 274 (6), 3439-3445 (1999)
   PUBMED   9920888
REFERENCE   10 (bases 1 to 2256)
  AUTHORS   Matsuzawa,S., Tamura,T., Mizuno,Y., Kobayashi,S., Okuyama,H.,
            Tsukitani,Y., Uemura,D. and Kikuchi,K.
  TITLE     Increase in potential activities of protein phosphatases PP1 and
            PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/lpr mice
  JOURNAL   J Biochem 111 (4), 472-477 (1992)
   PUBMED   1319990
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC109204.21.
            
            On Nov 17, 2006 this sequence version replaced NM_016891.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006606.1, AK054239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC109204.21        168107-168236       c
            131-221             AC109204.21        162257-162347       c
            222-322             AC109204.21        158975-159075       c
            323-555             AC109204.21        157670-157902       c
            556-703             AC109204.21        156838-156985       c
            704-859             AC109204.21        156578-156733       c
            860-974             AC109204.21        154856-154970       c
            975-1045            AC109204.21        154680-154750       c
            1046-1180           AC109204.21        154167-154301       c
            1181-1354           AC109204.21        153051-153224       c
            1355-1415           AC109204.21        152677-152737       c
            1416-1570           AC109204.21        151951-152105       c
            1571-1713           AC109204.21        150974-151116       c
            1714-1805           AC109204.21        148360-148451       c
            1806-2256           AC109204.21        147785-148235       c
FEATURES             Location/Qualifiers
     source          1..2256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.4 cM"
     gene            1..2256
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /note="protein phosphatase 2, regulatory subunit A, alpha"
                     /db_xref="GeneID:51792"
                     /db_xref="MGI:MGI:1926334"
     exon            1..130
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1822
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /EC_number="3.1.3.16"
                     /note="serine/threonine protein phosphatase A subunit type
                     2A; protein phosphatase PP2A"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A alpha isoform"
                     /protein_id="NP_058587.1"
                     /db_xref="CCDS:CCDS28432.1"
                     /db_xref="GeneID:51792"
                     /db_xref="MGI:MGI:1926334"
                     /translation="MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGV
                     ERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEET
                     VVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSS
                     AVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQD
                     SVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP
                     EITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELV
                     SDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVN
                     EVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAW
                     LVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVL
                     SEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEK
                     LTQDQDVDVKYFAQEALTVLSLA"
     exon            131..221
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            222..322
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            323..555
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            556..703
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            704..859
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            860..974
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1045
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1180
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1354
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1415
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1570
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1713
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1805
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2256
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2239..2244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /note="hexamer: AATAAA"
     polyA_site      2256
                     /gene="Ppp2r1a"
                     /gene_synonym="6330556D22Rik; PP2A; PP2Aa; PR65"
                     /note="major polyA site"
ORIGIN      
        1 cggattccgc ctggagctcg ctgctgcctg atagaaacgc cagggagcca agatggcagc
       61 tgccgacggt gacgattcgc tctatcctat tgcggtgctc atagatgaac tccgcaatga
      121 ggacgttcag cttcgtctca atagtatcaa gaagctctcc acaattgcct tggcccttgg
      181 ggttgaacgg accagaagtg agctcctgcc cttccttaca gataccattt atgatgaaga
      241 tgaggtcctc ttggccttgg ctgaacagct gggaaccttc acaactttgg tgggagggcc
      301 tgagtatgtg cactgtctgc tgccacccct tgagtcactg gccacagtgg aagagacagt
      361 agtgcgagac aaggcggtag aatccttgcg ggccatctct catgagcact caccttccga
      421 tctagaggct cactttgtgc ctctggtaaa gcggctggcg ggtggagact ggttcacctc
      481 ccgcacctcg gcctgtggtc tcttctcagt ttgctacccc cgagtatcca gtgccgtgaa
      541 ggcagaactt cgacagtact tccggaacct gtgctcagat gacaccccca tggtgcggcg
      601 ggccgctgcc tccaagctgg gggaatttgc caaggtactg gagctggaca atgtcaagag
      661 tgagatcatt cccatgttct ctaacctggc ctctgacgag caggactcgg tgcggctgct
      721 ggcagtggag gcatgtgtga atattgccca gcttctgcca caggaggacc tggaggcctt
      781 agtgatgccc accttgcgac aggctgctga ggacaagtct tggcgtgttc gctacatggt
      841 ggccgacaag ttcacagagc tccagaaagc agtggggcct gagatcacca agacagatct
      901 ggtgcctgcc ttccagaacc tgatgaagga ctgtgaggcc gaggtgaggg ccgcagcctc
      961 ccacaaggtc aaagagttct gtgaaaatct ctcagctgac tgccgggaga atgtgatcat
     1021 gactcagatc ttgccctgca tcaaggagct tgtgtcagat gccaaccaac atgtcaagtc
     1081 agcactggct tcagtcatca tgggcctctc tcccattctg ggcaaagaca acaccatcga
     1141 acacctcttg cccctgttct tggctcagct gaaggatgag tgtcctgaag tccgactgaa
     1201 tatcatctcc aacctggatt gtgtgaacga ggtgattggc atcaggcagc tctctcagtc
     1261 cctgcttcct gccatcgtgg aactagctga agatgccaag tggcgagtgc ggctggccat
     1321 cattgaatac atgcctctgc tggctggaca gcttggtgtg gaattttttg atgagaaact
     1381 aaactctttg tgtatggcct ggctagtgga tcatgtctat gctatccgtg aggctgccac
     1441 cagcaacctt aagaaattag tagagaagtt cgggaaggag tgggcccatg ccactatcat
     1501 ccccaaggtc ttagccatgt ctggagaccc taactacctg caccgaatga ctacactctt
     1561 ctgcatcaat gtgttgtctg aggtctgtgg acaggatatc accaccaagc acatgctgcc
     1621 cacagttctt cgtatggcag gggacccagt tgccaatgtc cgcttcaatg tggccaagtc
     1681 actccagaag ataggaccca ttcttgataa cagcaccctg cagagtgaag tcaagcccat
     1741 cctggagaag ctgacccagg accaggatgt ggatgtcaag tactttgccc aggaggctct
     1801 gactgttctc tctcttgcct gatgctggaa gaagaagcat tgccggcctc tggtgtccac
     1861 cctccaaccc ccacaaagtt acctccctta gggaggtggt gggggcaaat gactgtcact
     1921 ccctgtgcat ggtctgaccc caggctcctc ccccagcacg gttcggttcc tcctctgtag
     1981 cctgggaaga cttctctgtc cacctcccaa ggggctggag cagtacaagt tgttgcagga
     2041 cagcagcctg aaaagaaggg ctggttgttc ctgcccatat tgggagagat gggagcatcc
     2101 taggtcactg gcttttgctg ctgtaatggg gacccctccc ccatctactt accaccaccc
     2161 tttcccaacc ccaaccatgt tttttgtgtg tcaattgtgc catttttatt ttattccttt
     2221 ccctactgta cacggagaaa taaaggtgta gaaata
//
