LOCUS       NM_017374               1836 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus protein phosphatase 2 (formerly 2A), catalytic
            subunit, beta isoform (Ppp2cb), mRNA.
ACCESSION   NM_017374 XM_904292
VERSION     NM_017374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Gao R, Li X, Gao H, Zhao K, Liu X, Liu J, Wang Q, Zhu Y, Chen H,
            Xiang S, Zhan Y, Yin R, Yu M, Ning H, Yang X and Li C.
  TITLE     Protein phosphatase 2A catalytic subunit beta suppresses
            PMA/ionomycin-induced T-cell activation by negatively regulating
            PI3K/Akt signaling
  JOURNAL   FEBS J 289 (15), 4518-4535 (2022)
   PUBMED   35068054
  REMARK    GeneRIF: Protein phosphatase 2A catalytic subunit beta suppresses
            PMA/ionomycin-induced T-cell activation by negatively regulating
            PI3K/Akt signaling.
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Yen YT, Chien M, Wu PY and Hung SC.
  TITLE     PP2A in LepR+ mesenchymal stem cells contributes to embryonic and
            postnatal endochondral ossification through Runx2 dephosphorylation
  JOURNAL   Commun Biol 4 (1), 658 (2021)
   PUBMED   34079065
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Zan J, Xu R, Tang X, Lu M, Xie S, Cai J, Huang Z and Zhang J.
  TITLE     RNA helicase DDX5 suppresses IFN-I antiviral innate immune response
            by interacting with PP2A-Cbeta to deactivate IRF3
  JOURNAL   Exp Cell Res 396 (2), 112332 (2020)
   PUBMED   33065113
  REMARK    GeneRIF: RNA helicase DDX5 suppresses IFN-I antiviral innate immune
            response by interacting with PP2A-Cbeta to deactivate IRF3.
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Panicker N, Coutman M, Lawlor-O'Neill C, Kahl RGS, Roselli S and
            Verrills NM.
  TITLE     Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory
            Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and
            Epidermal Embryonic Development
  JOURNAL   Front Cell Dev Biol 8, 358 (2020)
   PUBMED   32582689
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Hussain T, Zhao D, Shah SZA, Sabir N, Wang J, Liao Y, Song Y,
            Hussain Mangi M, Yao J, Dong H, Yang L and Zhou X.
  TITLE     PP2Ac Modulates AMPK-Mediated Induction of Autophagy in
            Mycobacterium bovis-Infected Macrophages
  JOURNAL   Int J Mol Sci 20 (23), 6030 (2019)
   PUBMED   31795474
  REMARK    GeneRIF: This study demonstrated that M. bovis infection increased
            PP2Ac expression in murine macrophages, while nilotinib a tyrosine
            kinase inhibitor (TKI) significantly suppressed PP2Ac expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Chung H, Nairn AC, Murata K and Brautigan DL.
  TITLE     Mutation of Tyr307 and Leu309 in the protein phosphatase 2A
            catalytic subunit favors association with the alpha 4 subunit which
            promotes dephosphorylation of elongation factor-2
  JOURNAL   Biochemistry 38 (32), 10371-10376 (1999)
   PUBMED   10441131
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Gotz J, Probst A, Ehler E, Hemmings B and Kues W.
  TITLE     Delayed embryonic lethality in mice lacking protein phosphatase 2A
            catalytic subunit Calpha
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12370-12375 (1998)
   PUBMED   9770493
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Kato S, Kobayashi T, Kusuda K, Nishina Y, Nishimune Y, Yomogida K,
            Yamamoto M, Sakagami H, Kondo H, Ohnishi M, Chida N, Yanagawa Y and
            Tamura S.
  TITLE     Differentiation-dependent enhanced expression of protein
            phosphatase 2Cbeta in germ cells of mouse seminiferous tubules
  JOURNAL   FEBS Lett 396 (2-3), 293-297 (1996)
   PUBMED   8915006
REFERENCE   9  (bases 1 to 1836)
  AUTHORS   Becker W, Kentrup H, Klumpp S, Schultz JE and Joost HG.
  TITLE     Molecular cloning of a protein serine/threonine phosphatase
            containing a putative regulatory tetratricopeptide repeat domain
  JOURNAL   J Biol Chem 269 (36), 22586-22592 (1994)
   PUBMED   8077208
REFERENCE   10 (bases 1 to 1836)
  AUTHORS   Chen J, Parsons S and Brautigan DL.
  TITLE     Tyrosine phosphorylation of protein phosphatase 2A in response to
            growth stimulation and v-src transformation of fibroblasts
  JOURNAL   J Biol Chem 269 (11), 7957-7962 (1994)
   PUBMED   7510677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK619614.1, AK090311.1, BE847789.1 and AA220297.1.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_017374.4.
            
            On Dec 20, 2006 this sequence version replaced NM_017374.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058582.1, AK090311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               CK619614.1         1-368
            369-794             AK090311.1         2-427
            795-1271            BE847789.1         53-529
            1272-1826           AK090311.1         905-1459
            1827-1836           AA220297.1         191-200
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.63 cM"
     gene            1..1836
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /note="protein phosphatase 2 (formerly 2A), catalytic
                     subunit, beta isoform"
                     /db_xref="GeneID:19053"
                     /db_xref="MGI:MGI:1321161"
     exon            1..398
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1226
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /EC_number="3.1.3.16"
                     /note="PP2A-beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit beta isoform"
                     /protein_id="NP_059070.1"
                     /db_xref="CCDS:CCDS22233.1"
                     /db_xref="GeneID:19053"
                     /db_xref="MGI:MGI:1321161"
                     /translation="MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            399..608
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     exon            609..782
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     exon            783..872
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1034
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1153
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1836
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2cb"
                     /gene_synonym="D8Ertd766e; PP2Ac"
                     /note="putative"
ORIGIN      
        1 gaaagagcga gagggccgtg gccagagcgc ggagaggcct gcgggtggca gcgggcgggc
       61 gggcgccgtc gggccggagc cgagccgagc tgcgccgcgc tctgcgctcc gagccgtaag
      121 cccttcgccg cgccccaggc gcgtggccgg ggccgggcgg ggcgggcgct cccggaggcc
      181 ggggcccgcg gctgcccgct gggcttgggc ggggcgcggg ctgcgcgctc cgcggctcgg
      241 tggtcccgcc gggggccggc ggcgggggag gcggcgggga cgcgcggctc gccgccatgg
      301 acgacaaggc gttcaccaag gagctggacc agtgggtgga gcagctgaac gagtgtaagc
      361 agctgaacga gaaccaagtg cggacgctgt gcgagaaggc taaggaaatt ttaacgaaag
      421 aatcaaatgt gcaagaggtc cgctgtcctg ttaccgtctg tggagatgtg catggccaat
      481 tccatgacct tatggagctc ttcagaattg gtgggaaatc accagatacg aactacctat
      541 tcatggggga ctatgtagac agagggtact actctgtgga gactgtgact cttcttgtag
      601 cattaaaggt gcgctatcca gagcgcatca caatattgcg aggaaatcac gaaagccggc
      661 agatcacaca agtgtatggc ttttatgatg agtgcctacg gaagtatgga aatgccaacg
      721 tgtggaaata ctttacagat ctctttgatt atcttccact tacagcttta gtagatggac
      781 agatattctg cctccacggt ggcctgtctc catccataga tacactggac cacataagag
      841 ccctggatcg cttgcaagaa gttccacatg agggcccaat gtgtgatctc ttatggtcag
      901 atccggatga ccgtggcggc tggggcattt ctccacgtgg tgctggctac acatttggac
      961 aagacatttc tgaaacattt aaccatgcca acggtctcac actggtgtct cgtgctcacc
     1021 agcttgtaat ggaaggatat aactggtgcc atgatcggaa tgtggtcacc atttttagtg
     1081 cgcccaatta ctgctaccgt tgtgggaacc aggctgctat catggaatta gatgacactt
     1141 taaaatattc atttcttcag tttgacccag cacctcgtcg tggagagcct catgtgaccc
     1201 ggcgcacccc agactacttc ctgtaaattc ctccccagga cctgtctttg tatgtggaag
     1261 tatacctggc tttttaaaat atatatatat acatatatat ttaaaaacaa cagttatttg
     1321 tgtttctgta acaaattgtg atatgtcttg acattaaaac acatcatgga ccaaaacgtg
     1381 ccatactaat gatgagcggt tagcacaatg tgaactctag cacactgttg tagatgagtc
     1441 agcccacagc ctgcctgctg ggcggtagtg accatttttc ttgactggtt aagcaaaaag
     1501 ggtcactgac tgcttcgtct cctttgcgct tacttggaaa tttagttaac aagtttaact
     1561 ggcatggatt atagagttgg agttttattt tttaagaatt cacaagctga cttccacttc
     1621 aattcataat cctttatttt attgaaatgt atgactaact gaagaagaga ttcttgggag
     1681 tatgttgtca taacattaaa gagatttcct ttaaagtttc ctaaactaaa ttactgttgg
     1741 atgttgagct gcatatttct gtatatttgt catgacagtg cttgcatcct atttggtgta
     1801 ctgaacaaat aaaatttccg atttagagaa aaacat
//
