LOCUS       NM_019411               1930 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus protein phosphatase 2 (formerly 2A), catalytic
            subunit, alpha isoform (Ppp2ca), mRNA.
ACCESSION   NM_019411
VERSION     NM_019411.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   Crespo,J.R., Martin-Martin,N., Garcia-Longarte,S.,
            Corres-Mendizabal,J., Carlevaris,O., Astobiza,I., Zabala-Letona,A.,
            Guiu,M., Azkargorta,M., Gonzalez-Lopez,M., Macias-Camara,N.,
            Doan,P., Elortza,F., Mendizabal,I., Westermack,J., Gomis,R.R.,
            Ercilla,A. and Carracedo,A.
  TITLE     The PP2A regulator IER5L supports prostate cancer progression
  JOURNAL   Cell Death Dis 15 (7), 514 (2024)
   PUBMED   39025841
  REMARK    GeneRIF: The PP2A regulator IER5L supports prostate cancer
            progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Rehmani,T., Dias,A.P., Kamal,M., Salih,M. and Tuana,B.S.
  TITLE     Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3
            (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of
            Myocardium without Affecting Hippo Pathway
  JOURNAL   Int J Mol Sci 25 (5), 2888 (2024)
   PUBMED   38474134
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Jiang,Y., Jin,X., Chi,Z., Bai,Y., Manthiram,K., Mudd,P., Zhu,K.,
            Wang,L., Schwartzberg,P.L., Han,Y., Gao,X., Lu,L. and Xu,Q.
  TITLE     Protein phosphatase 2A propels follicular T helper cell development
            in lupus
  JOURNAL   J Autoimmun 136, 103028 (2023)
   PUBMED   37001432
  REMARK    GeneRIF: Protein phosphatase 2A propels follicular T helper cell
            development in lupus.
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Sule,A., Golding,S.E., Ahmad,S.F., Watson,J., Ahmed,M.H.,
            Kellogg,G.E., Bernas,T., Koebley,S., Reed,J.C., Povirk,L.F. and
            Valerie,K.
  TITLE     ATM phosphorylates PP2A subunit A resulting in nuclear export and
            spatiotemporal regulation of the DNA damage response
  JOURNAL   Cell Mol Life Sci 79 (12), 603 (2022)
   PUBMED   36434396
  REMARK    GeneRIF: ATM phosphorylates PP2A subunit A resulting in nuclear
            export and spatiotemporal regulation of the DNA damage response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Hsu,W., Zeng,L. and Costantini,F.
  TITLE     Identification of a domain of Axin that binds to the
            serine/threonine protein phosphatase 2A and a self-binding domain
  JOURNAL   J Biol Chem 274 (6), 3439-3445 (1999)
   PUBMED   9920888
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Smith,G.D., Sadhu,A., Mathies,S. and Wolf,D.P.
  TITLE     Characterization of protein phosphatases in mouse oocytes
  JOURNAL   Dev Biol 204 (2), 537-549 (1998)
   PUBMED   9882488
REFERENCE   8  (bases 1 to 1930)
  AUTHORS   Gotz,J., Probst,A., Ehler,E., Hemmings,B. and Kues,W.
  TITLE     Delayed embryonic lethality in mice lacking protein phosphatase 2A
            catalytic subunit Calpha
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12370-12375 (1998)
   PUBMED   9770493
REFERENCE   9  (bases 1 to 1930)
  AUTHORS   Nishimura,M. and Uyeda,K.
  TITLE     Purification and characterization of a novel xylulose
            5-phosphate-activated protein phosphatase catalyzing
            dephosphorylation of
            fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
  JOURNAL   J Biol Chem 270 (44), 26341-26346 (1995)
   PUBMED   7592845
REFERENCE   10 (bases 1 to 1930)
  AUTHORS   Chen,J., Parsons,S. and Brautigan,D.L.
  TITLE     Tyrosine phosphorylation of protein phosphatase 2A in response to
            growth stimulation and v-src transformation of fibroblasts
  JOURNAL   J Biol Chem 269 (11), 7957-7962 (1994)
   PUBMED   7510677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935177.6.
            
            On Apr 28, 2007 this sequence version replaced NM_019411.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076110.1, BC003856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AL935177.6         47766-48092
            328-537             AL935177.6         62062-62271
            538-711             AL935177.6         66929-67102
            712-801             AL935177.6         67611-67700
            802-963             AL935177.6         68085-68246
            964-1082            AL935177.6         69875-69993
            1083-1930           AL935177.6         70844-71691
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.86 cM"
     gene            1..1930
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /note="protein phosphatase 2 (formerly 2A), catalytic
                     subunit, alpha isoform"
                     /db_xref="GeneID:19052"
                     /db_xref="MGI:MGI:1321159"
     exon            1..327
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1155
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /EC_number="3.1.3.16"
                     /note="PP2A-alpha"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit alpha isoform"
                     /protein_id="NP_062284.1"
                     /db_xref="CCDS:CCDS24666.1"
                     /db_xref="GeneID:19052"
                     /db_xref="MGI:MGI:1321159"
                     /translation="MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            328..537
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            538..711
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            712..801
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            802..963
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1082
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1930
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /note="hexamer: AATAAA"
     polyA_site      1795
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /note="major polyA site"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /note="hexamer: AATAAA"
     polyA_site      1901
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
     polyA_site      1920
                     /gene="Ppp2ca"
                     /gene_synonym="PP2A"
                     /note="major polyA site"
ORIGIN      
        1 attacagaaa gccgagtccc gagctagggc gagcggagga ggaggcacag cggccggcgg
       61 ccgagcactg cggagcgagc cagcgggccg gcgccagcgc ccagcagccg cctggggccg
      121 cagaaagcac cccgggagag cggcggcggc gtgtgcgtgt ggcccgggtg cgggcggcgg
      181 cgcgggagca gcgcggagcg gcagccggtt cgggcgggcg gcatcatgga cgagaagttg
      241 ttcaccaagg agctggacca gtggatcgag cagctgaacg agtgcaagca gctctccgag
      301 tcccaggtca agagcctctg cgagaaggct aaagaaatcc tgacaaaaga atccaacgtt
      361 caagaggttc gatgtccagt cactgtgtgt ggagatgtac atgggcaatt tcatgatctc
      421 atggaactct ttagaattgg tggtaaatca ccagatacaa attacctgtt tatgggagac
      481 tatgtggaca gaggatatta ctctgttgaa acagttacac tgcttgtagc tcttaaggtt
      541 cgttaccgag agcgcatcac catactccga gggaatcacg agagcagaca gatcacacag
      601 gtttatgggt tctacgacga gtgtttaagg aaatacggaa atgcaaatgt ttggaaatac
      661 ttcacagacc tttttgacta tcttcctctc actgccttgg tggatgggca gatcttctgt
      721 ctacacggtg gtctgtcacc atccatagac acactggatc acatccgagc actcgatcgc
      781 ctacaggaag ttcctcatga gggtccaatg tgtgacttgc tgtggtcaga tccagatgac
      841 cgtggtggct gggggatatc tcctcgggga gctggttata cctttggcca agatatttct
      901 gagacattta atcatgccaa tggcctcacg ttggtgtcca gagctcacca gctggtgatg
      961 gagggatata actggtgcca tgaccggaac gtagtaacaa ttttcagtgc tccaaactat
     1021 tgctatcgtt gtggtaacca agctgcaatc atggaacttg acgacactct taagtattct
     1081 ttcttgcagt ttgacccagc acctcgtaga ggcgagccac atgtcactcg tcgtacccca
     1141 gactacttcc tgtaatgaaa atgtaaactt gtacagtatt gccatgaacc gtatattgac
     1201 ctaatggaaa tgggaagagc aacagtaact ccaaagtgtc agaaaatagt taacattcaa
     1261 aaacttgttt tcacacggac caaaagatgt gccatataaa atacaaagcc tcttgtcatc
     1321 aacagccgtg accactttag aatgaaccag ttcattgcat gctgacgcga cattgttggt
     1381 caagaatcca gtttctggca tagcgctatt tgtagttact tttgctttct tgagagactg
     1441 cagatatagg attaaacatt aacacccgtg agtccagttg acttcactta gctgtagctt
     1501 actcagcatg actgtagatg aggatagcaa acaatcattg gagcttaatg aacattttta
     1561 aataagtacc aaggcctccc ctcttgttgt gtttctttca gggataccat taatttaatt
     1621 gtatgatttg tctgcactca gtttctcccc ttctcaaatc tcagccccgc gttgttcttt
     1681 gttactgtca gaaaacctgg tgagttgttt tgaacagaac tgtttccctc ctgtaagatg
     1741 atgttactgc acaagtcacc gcagtgtttt cataataaac ttgagaactg agaaagtcag
     1801 gtttgaattg tatcagtggg cacgactggt gctgtttatt aacaagataa atctattgat
     1861 caatttcaga atttgtagaa tcccaggtaa agaaaaataa agatcaaggc cactgtgtaa
     1921 cctctctggc
//
