LOCUS       NM_172261               4345 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 9B
            (Ppp1r9b), mRNA.
ACCESSION   NM_172261
VERSION     NM_172261.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4345)
  AUTHORS   Stickel,K.C., Shah,N.R., Claeboe,E.T., Orr,K.S., Mosley,A.L.,
            Doud,E.H., Belecky-Adams,T.L. and Baucum,A.J.
  TITLE     Mechanisms of spinophilin-dependent pancreas dysregulation in
            obesity
  JOURNAL   Am J Physiol Endocrinol Metab 327 (2), E155-E171 (2024)
   PUBMED   38630048
  REMARK    GeneRIF: Mechanisms of spinophilin-dependent pancreas dysregulation
            in obesity.
REFERENCE   2  (bases 1 to 4345)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4345)
  AUTHORS   Morris,C.W., Watkins,D.S., Shah,N.R., Pennington,T., Hens,B.,
            Qi,G., Doud,E.H., Mosley,A.L., Atwood,B.K. and Baucum,A.J. 2nd.
  TITLE     Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to
            the Postsynaptic Density and Cell Type Specifically Mediates
            Excessive Grooming
  JOURNAL   Biol Psychiatry 93 (11), 976-988 (2023)
   PUBMED   36822932
  REMARK    GeneRIF: Spinophilin Limits Metabotropic Glutamate Receptor 5
            Scaffolding to the Postsynaptic Density and Cell Type Specifically
            Mediates Excessive Grooming.
REFERENCE   4  (bases 1 to 4345)
  AUTHORS   Salek,A.B., Claeboe,E.T., Bansal,R., Berbari,N.F. and Baucum,A.J.
            2nd.
  TITLE     Spinophilin-dependent regulation of GluN2B-containing
            NMDAR-dependent calcium influx, GluN2B surface expression, and
            cleaved caspase expression
  JOURNAL   Synapse 77 (3), e22264 (2023)
   PUBMED   36738175
REFERENCE   5  (bases 1 to 4345)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4345)
  AUTHORS   Carmody,L.C., Bauman,P.A., Bass,M.A., Mavila,N., DePaoli-Roach,A.A.
            and Colbran,R.J.
  TITLE     A protein phosphatase-1gamma1 isoform selectivity determinant in
            dendritic spine-associated neurabin
  JOURNAL   J Biol Chem 279 (21), 21714-21723 (2004)
   PUBMED   15016827
REFERENCE   7  (bases 1 to 4345)
  AUTHORS   Tsukada,M., Prokscha,A., Oldekamp,J. and Eichele,G.
  TITLE     Identification of neurabin II as a novel doublecortin interacting
            protein
  JOURNAL   Mech Dev 120 (9), 1033-1043 (2003)
   PUBMED   14550532
  REMARK    GeneRIF: The coiled-coil domain of neurabin II binds to a DCX
            region encompassing the C-terminal portion of the second DCX repeat
            and the N-terminal portion of the Ser/Pro-rich domain.
REFERENCE   8  (bases 1 to 4345)
  AUTHORS   Brady,A.E., Wang,Q., Colbran,R.J., Allen,P.B., Greengard,P. and
            Limbird,L.E.
  TITLE     Spinophilin stabilizes cell surface expression of alpha
            2B-adrenergic receptors
  JOURNAL   J Biol Chem 278 (34), 32405-32412 (2003)
   PUBMED   12738775
  REMARK    GeneRIF: role in stabilizing cell surface expression of alpha
            2B-adrenergic receptors
REFERENCE   9  (bases 1 to 4345)
  AUTHORS   Stafstrom-Davis,C.A., Ouimet,C.C., Feng,J., Allen,P.B.,
            Greengard,P. and Houpt,T.A.
  TITLE     Impaired conditioned taste aversion learning in spinophilin
            knockout mice
  JOURNAL   Learn Mem 8 (5), 272-278 (2001)
   PUBMED   11584074
REFERENCE   10 (bases 1 to 4345)
  AUTHORS   Feng,J., Yan,Z., Ferreira,A., Tomizawa,K., Liauw,J.A., Zhuo,M.,
            Allen,P.B., Ouimet,C.C. and Greengard,P.
  TITLE     Spinophilin regulates the formation and function of dendritic
            spines
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 9287-9292 (2000)
   PUBMED   10922077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY508450.1 and AI841686.1.
            
            On Oct 30, 2009 this sequence version replaced NM_172261.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY508450.1, SRR1660811.124403.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4303              AY508450.1         1-4303
            4304-4345           AI841686.1         1-42                c
FEATURES             Location/Qualifiers
     source          1..4345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..4345
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /note="protein phosphatase 1, regulatory subunit 9B"
                     /db_xref="GeneID:217124"
                     /db_xref="MGI:MGI:2387581"
     exon            1..1707
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2790
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /note="neurabin-II; spinophilin"
                     /codon_start=1
                     /product="neurabin-2"
                     /protein_id="NP_758465.2"
                     /db_xref="CCDS:CCDS25268.1"
                     /db_xref="GeneID:217124"
                     /db_xref="MGI:MGI:2387581"
                     /translation="MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKA
                     AHHKKYGSNVHRIKSMFLQMGTTAGPPGEAGGGAGMAEAPRASDRGVRLSLPRASSLN
                     ENVDHSALLKLGTSVSERVSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSVPAASG
                     GDKEAVARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKA
                     DSRTGLHRAPGPPRAAGAPQVNSKLVTKRSRVFQPPPPPPAPSGDGATEKERGPGGQQ
                     PPQHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTP
                     ATTASPAPEEPKAEAVPEEEAAASVATLERGVDNGRAPDMAPEEVDESKKEDFSEADL
                     VDVSAYSGLGEDSGGSALEEDDEEDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIH
                     FSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGI
                     SIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAA
                     SVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETG
                     EYATDEDEELSPTFPGGEMAIEVFELAENEDALSPVEMEPEKLVHKFKELQIKHAVTE
                     AEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEH
                     LRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLL
                     DKISELEGNLQTLRNSNST"
     exon            1708..1840
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1961
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2066
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2202
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2355
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2409
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2639
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2736
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..4330
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /note="hexamer: AATAGA"
     polyA_site      4053
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
     regulatory      4311..4316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /note="hexamer: CATAAA"
     polyA_site      4329
                     /gene="Ppp1r9b"
                     /gene_synonym="SPL; Spn"
                     /note="major polyA site"
ORIGIN      
        1 ttcgcgggct gggcgcgcgg tcccagcagc tccagccagc ctccgcttct tcaatttggg
       61 tgggggcgac cgcaccaggc cgctagagct ttcgaagggg gctggctgtc tttggcagct
      121 tggttggggg aggcgaccca cacagggcgc tcggagattt ttttttttta aagcagggtt
      181 aactgttttt tggcagcttg gtttctgggg gactctatag aaggcctttc gggatttctt
      241 tctttggggg gagggggcgg tggtcccgac ttggccagcc gcctgctgga ggggggcagc
      301 ggggagcagg gggatgcgaa cccggctccc ccaaccatga tgaagacgga gcctcggggg
      361 cccgggggtc ccctccggag cgcctccccg caccgcagcg cctacgaagc gggcatccag
      421 gcactaaagc ctcccgatgc acccgggccc gacgaggcac ccaaggcggc ccaccataag
      481 aaatatggct ccaacgtcca ccgcatcaaa agtatgttcc tgcagatggg caccaccgcg
      541 gggccgccgg gtgaggcagg cggaggcgca ggcatggccg aggccccacg ggcgtccgat
      601 cgcggggtgc gcctgtccct gccgcgggcc agcagcctga acgagaacgt agaccacagt
      661 gccctgctca agctgggcac cagtgtgtcg gagcgcgtga gccgcttcga ctccaagccc
      721 gcgccctcgg cgcagcccgc tcctccgccg cacccgccgt cccggctgca ggagacgcgg
      781 aagctgttcg aacggagcgt ccccgcggcc tcgggtggcg acaaggaggc cgtggcgcgg
      841 cggctgctga ggcaggagcg cgccggcctg caggaccgga agctggacgt cgtggtgcgc
      901 tttaacggca gcaccgaggc gctggacaag ctggatgctg acgccgtgtc gccgacggtc
      961 agccagctca gtgcggtctt cgagaaagcc gactcgagga ccggccttca ccgtgcaccc
     1021 ggcccccctc gggcagccgg ggcgccccag gtcaactcga agctggtcac taagcggtcc
     1081 cgggtgttcc agccaccgcc gccgcctccc gccccgtcgg gggatggcgc gaccgagaag
     1141 gagcgtggcc ccggagggca gcagccccca cagcaccggg tggcccctgc ccgacctccg
     1201 cctaagccgc gggaggtgcg caagatcaag ccggtggagg ttgaagaaag tggggagtct
     1261 gaggccgagt cggctcccgg ggaagtgatc caggccgagg tgacggtcca tgcagccttg
     1321 gagaatggca gcaccccggc caccacagcc agccctgcac ccgaggaacc caaggccgaa
     1381 gcggtccccg aggaggaggc ggcggcgtca gtggcgacgc tagagagggg ggtggacaat
     1441 ggccgggccc cggacatggc acctgaggag gtggatgaat ccaagaagga ggacttctcg
     1501 gaagcggact tggtggatgt gagcgcctac agtggactcg gggaggactc tgggggcagt
     1561 gccctggagg aggacgatga agaagacgaa gaggacgggg agccccccta tgagccggag
     1621 tcagggtgtg tggagattcc cgggctctca gaggaagagg acccggcccc gagccggaag
     1681 atccatttca gcaccgcacc gatccaagta ttcagcacct actccaacga ggactatgac
     1741 cgacgcaatg aggatgtgga tcccatggca gcctctgcgg aatatgagct agagaagcga
     1801 gtggagaggt tggagctgtt tcctgtggag ctggagaagg actctgaggg cttgggcatc
     1861 agcatcattg gcatgggcgc cggagccgac atgggcctgg agaagctggg catcttcgtc
     1921 aagactgtga ctgagggtgg tgcagcccat cgggatggca ggatccaagt gaacgacctg
     1981 ctggtggagg tggatgggac gagcctggtg ggagtgaccc agagctttgc agcctctgta
     2041 cttaggaaca ccaaaggccg agtgcggttc atgattggcc gggagcggcc tggagaacag
     2101 agtgaagtgg cccagctaat tcagcagacc ttggagcagg agcgatggca gcgggagatg
     2161 atggagcaga gatacgccca gtatggagag gatgatgagg agacaggaga gtatgccacc
     2221 gacgaagatg aagaactgag cccaacgttc ccagggggtg aaatggccat tgaggtgttt
     2281 gaactagcag agaacgagga tgcgctgtcc cccgtggaga tggagcccga aaagctggtg
     2341 cacaagttca aggagctcca gatcaagcat gctgtcactg aagcggaaat ccagcagctg
     2401 aaacggaagt tgcagagtct ggagcaggag aaagggcgct ggcgggtaga gaaggcccag
     2461 ctggagcaga gcgtggagga gaataaggag cggatggaga agctagaggg ctactggggt
     2521 gaggcccaga gcctgtgcca ggctgtggat gagcacctgc gggagaccca ggcccagtat
     2581 caggccctgg agcgcaagta cagcaaggcc aagcgtctca tcaaggacta ccagcaaaag
     2641 gagatcgagt tcctgaaaaa agagacagcc cagcgtcggg tactggaaga gtcggagcta
     2701 gccaggaagg aggaaatgga caaacttctg gacaagatct cagaactgga aggaaacctg
     2761 cagacactga ggaactccaa ttctacttaa caggaataac tccttggccg gacaataata
     2821 atcccctccc attatcctca ccccctgtcc tcaatcccca ccccacccct accagcctgg
     2881 ggacaggtgc cccgacttcc cctactcctc caccccacct cccccagctt cagggaccag
     2941 agggcccata ttacaggccc ctttagggtg gccagggcag acaatgctgg ctggaagagt
     3001 ggtctccttg ccctgtgggg ctgaggcgca gaggccgaga gaagctaaga gctggcctgg
     3061 gtggtggatg gacacgagga cctgcagacc aaactgccag actttataac ctccagcctg
     3121 tgtctctgga ccggagtgga gctggggctc tcccagcatc tcaccacttg gaggctgctc
     3181 cctgcccaca gggtccgtat ggcccctggg cctcttgact tgagattctc cgttcttggc
     3241 cctttcctct tcccccatca ttgtgctgtc tgttgcattc tggcctcctg cttggagggg
     3301 ttgcctcaac atctcccacc cctgctcccc atcccaggag ggatagagcc cacccttgag
     3361 ccagaggctg ggcctgggcc tgcactgatt tgtatccttc agggggaggt gattgggcgt
     3421 cgggggaagg gtcagtccag cacacctggg gtccagcacc cctttcctag gaagggcaac
     3481 agccctcaac ttctccttgt gcctcccctc tcccaggtgc caaacagcca taggcgtcct
     3541 cctggaactg ccctgaggcc actctgggct tctggtttcc ttggtctagc ccaggaatgc
     3601 caggagggag ggaggtcagc ttagatggtg tgcctgcaga gctctccctg gggagctagg
     3661 ccctgcctag ggccacacct ggaggccttg tattaccatc gaggagactc tgcctcccct
     3721 cttcccctcc cccgctgttt tccaacgttt tcactggagg gcaaaatttt actaatcttt
     3781 ttggagacca gggctgcttg ctgtcagcct gctttctaag tgaaattgac tcagtttccc
     3841 cactttaacc ccaaattggg gcttggacca agggaggtga gaccccctca ggtaccctcc
     3901 cctttcagaa tccatctctt gccacttcca cattaccacc cttgccctaa gcctaaattt
     3961 ctgttccttt ttttcttctt ttgaaaacga cccagttcta tccttttcgg tttctccgag
     4021 tcccctgtaa atagaccatg ccatcaatca gtatttcttg cccgtctctt ccgtccctag
     4081 acgtgccccc gactccccgg aaagagctgg ctgtcactgt gcccggcccc tgcacttcac
     4141 ccaggcagat ggagggggtg gagccgggtg ggcgggtcct cgatgtactt ccggttttga
     4201 ccggcagcgc tcctgccccg cccttggagg accccgtctc tgtatataat atatatatgt
     4261 atgtattgtt cctggttttg tacggaccat gccctctgtc aggtcgtccc cataaaagca
     4321 gcccccagag aaaaaaaaaa aaaaa
//
