LOCUS       NM_001401496           10156 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 9A
            (Ppp1r9a), transcript variant 4, mRNA.
ACCESSION   NM_001401496 XM_006505071
VERSION     NM_001401496.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10156)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10156)
  AUTHORS   Edler,M.C., Salek,A.B., Watkins,D.S., Kaur,H., Morris,C.W.,
            Yamamoto,B.K. and Baucum,A.J. 2nd.
  TITLE     Mechanisms Regulating the Association of Protein Phosphatase 1 with
            Spinophilin and Neurabin
  JOURNAL   ACS Chem Neurosci 9 (11), 2701-2712 (2018)
   PUBMED   29786422
REFERENCE   3  (bases 1 to 10156)
  AUTHORS   Wu H, Cottingham C, Chen L, Wang H, Che P, Liu K and Wang Q.
  TITLE     Age-dependent differential regulation of anxiety- and
            depression-related behaviors by neurabin and spinophilin
  JOURNAL   PLoS One 12 (7), e0180638 (2017)
   PUBMED   28700667
  REMARK    GeneRIF: two homologs neurabin and spinophilin play important yet
            distinct roles in the regulation of anxiety- and depression-like
            behaviors in an age-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10156)
  AUTHORS   Che P, Chen Y, Lu R, Peng N, Gannon M, Wyss JM, Jiao K and Wang Q.
  TITLE     Spinophilin Is Indispensable for the alpha2B Adrenergic
            Receptor-Elicited Hypertensive Response
  JOURNAL   PLoS One 10 (8), e0135030 (2015)
   PUBMED   26244553
  REMARK    GeneRIF: Data indicate that In arrestin 3 deficient mice, where the
            alpha2B adrenergic receptor has a stronger binding to spinophilin,
            the hypertensive response is enhanced.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10156)
  AUTHORS   Chen Y, Liu Y, Cottingham C, McMahon L, Jiao K, Greengard P and
            Wang Q.
  TITLE     Neurabin scaffolding of adenosine receptor and RGS4 regulates
            anti-seizure effect of endogenous adenosine
  JOURNAL   J Neurosci 32 (8), 2683-2695 (2012)
   PUBMED   22357852
REFERENCE   6  (bases 1 to 10156)
  AUTHORS   Orioli D, Colaluca IN, Stefanini M, Riva S, Dotti CG and Peverali
            FA.
  TITLE     Rac3-induced neuritogenesis requires binding to Neurabin I
  JOURNAL   Mol Biol Cell 17 (5), 2391-2400 (2006)
   PUBMED   16525025
  REMARK    GeneRIF: Neurabin I mediates Rac3-induced neuritogenesis, possibly
            by anchoring Rac3 to growth cone F-actin.
REFERENCE   7  (bases 1 to 10156)
  AUTHORS   Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito N,
            Hino T, Suzuki-Migishima R, Ogonuki N, Miki H, Kohda T, Ogura A,
            Yokoyama M, Kaneko-Ishino T and Ishino F.
  TITLE     Deletion of Peg10, an imprinted gene acquired from a
            retrotransposon, causes early embryonic lethality
  JOURNAL   Nat Genet 38 (1), 101-106 (2006)
   PUBMED   16341224
REFERENCE   8  (bases 1 to 10156)
  AUTHORS   Ryan XP, Alldritt J, Svenningsson P, Allen PB, Wu GY, Nairn AC and
            Greengard P.
  TITLE     The Rho-specific GEF Lfc interacts with neurabin and spinophilin to
            regulate dendritic spine morphology
  JOURNAL   Neuron 47 (1), 85-100 (2005)
   PUBMED   15996550
REFERENCE   9  (bases 1 to 10156)
  AUTHORS   Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA and
            Colbran RJ.
  TITLE     A protein phosphatase-1gamma1 isoform selectivity determinant in
            dendritic spine-associated neurabin
  JOURNAL   J Biol Chem 279 (21), 21714-21723 (2004)
   PUBMED   15016827
  REMARK    GeneRIF: there is a novel PP1gamma1-selective interaction domain in
            neurabin that may allow for selective regulation and/or subcellular
            targeting of PP1 isoforms
REFERENCE   10 (bases 1 to 10156)
  AUTHORS   Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T and Ishino
            F.
  TITLE     Identification of a large novel imprinted gene cluster on mouse
            proximal chromosome 6
  JOURNAL   Genome Res 13 (7), 1696-1705 (2003)
   PUBMED   12840045
  REMARK    GeneRIF: Ppp1r9a gene, found in a cluster of imprinted genes on
            chromosome 6, is preferentially expressed from the maternal allele
            at embryonic stages, but biallelically expressed in neonatal
            tissues.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068500.4 and AC074225.4.
            
            On Feb 14, 2022 this sequence version replaced XM_006505071.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927935.2585122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 12840045
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC068500.4         83048-83104
            58-1676             AC068500.4         85299-86917
            1677-1809           AC074225.4         41321-41453
            1810-1930           AC074225.4         52843-52963
            1931-2035           AC074225.4         59376-59480
            2036-2171           AC074225.4         72865-73000
            2172-2237           AC074225.4         78426-78491
            2238-2393           AC074225.4         95817-95972
            2394-2447           AC074225.4         106385-106438
            2448-2677           AC074225.4         108986-109215
            2678-2774           AC074225.4         110504-110600
            2775-2946           AC074225.4         110694-110865
            2947-3104           AC074225.4         129402-129559
            3105-3348           AC074225.4         130074-130317
            3349-3436           AC074225.4         138613-138700
            3437-3520           AC074225.4         138791-138874
            3521-3719           AC074225.4         149394-149592
            3720-3839           AC074225.4         151506-151625
            3840-3863           AC074225.4         152389-152412
            3864-4046           AC074225.4         153474-153656
            4047-10156          AC074225.4         154937-161046
FEATURES             Location/Qualifiers
     source          1..10156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.86 cM"
     gene            1..10156
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /note="protein phosphatase 1, regulatory subunit 9A"
                     /db_xref="GeneID:243725"
                     /db_xref="MGI:MGI:2442401"
     exon            1..57
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1676
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..4247
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /note="isoform 2 is encoded by transcript variant 4;
                     neural tissue-specific F-actin binding protein; protein
                     phosphatase 1, regulatory (inhibitor) subunit 9A;
                     neurabin-1"
                     /codon_start=1
                     /product="neurabin-1 isoform 2"
                     /protein_id="NP_001388425.1"
                     /db_xref="GeneID:243725"
                     /db_xref="MGI:MGI:2442401"
                     /translation="MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQK
                     TKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAIIAKTRGKGRPSSPQRRMKP
                     KEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSVHESGQNHRYS
                     PKKEKGGGTEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSEPPGAL
                     TSGKAESADYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSKPPSNKQDTDTEDAQKSDA
                     VPVPEVAQKGTSLASLPSEESQLSTEAEDVTTAQPEALDSTDKDSPEEPSAENQAMPK
                     SHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFE
                     SSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEE
                     EIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVEL
                     EKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTDGGAAQRDGRIQVNDQIVEVDGISL
                     VGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQ
                     YDADDDENTVAELQGVSGNCNNNNNRFLKTGEYATDEEEDEGGPILPSGDVAIEVFEL
                     PENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQ
                     LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQ
                     QKELDFIKRQEVERKKREEVEKAHLLEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNN
                     IFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSV
                     KNRRQRPTRTRLYDSVSSTDGEDSLERKAWRVSSPESECGVTLLTPVTSPRAFSSHHT
                     TESPGGSQHPEGDPFSSISGDTSSSSTSASDHDTEDSPCCHQATEKALQEKDDDKYPK
                     SLRTSSSFVVQRGKIKQKFADLGAPLRRNPNKGKKRKDKEKEASRFSAGSRIFRSKLE
                     NWKSKPSSAAQASTRSPCMPFSWFNESRKGSYSFRNLPSAPSPLQPSPETQVSDKTGS
                     KNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPK
                     HTQSQNRAVHEWSVQQVSHWLMSLSLDQYVPEFSAQSISGEQLLQLDGNKLKALGMTS
                     SQDRALVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTAD
                     QP"
     exon            1677..1809
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1930
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2035
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2171
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2237
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2393
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2447
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2677
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2774
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2946
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3104
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3348
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3436
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3520
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3719
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3839
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..3863
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3864..4046
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..10156
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttcgctg ctgggctccc tctctttgcg gccctagagt taatcccatc agccgagatg
       61 aacctctagt cttgctttga aaaaagctat tttgtgtaac tcttgactgt gaatacattt
      121 ctaatacagc ctttggaatc gtcacgggac aagtgtgcca tttgagcggc cctgtgcctg
      181 gtcagacact ggggattgag aagagaggtc tgtttggctt tttggttgtt tttcccagtg
      241 accattatga gcattggctt ttcacccttg aagtaaacat gttgaaggcg gaatcttcag
      301 gggagcggac cactctcaga agtgcctctc ctcacaggaa tgcgtacaga acagagttcc
      361 aggcactgaa aagtactttt gacaaaccca agtcagatgg ggaacagaaa acgaaagaag
      421 gtgagggctc ccagcagagc agaggtagaa agtatggctc caatgtcaac agaattaaaa
      481 atctatttat gcagatgggt atggaaccca gcgagaatgc tgctatcatt gccaaaacca
      541 gggggaaagg taggccctcg tcccctcaga gaagaatgaa gcccaaagag tttgtggaga
      601 aaacggatgg ctcagtggtt aagttggagt cctctgtctc tgaacgaatc agtagatttg
      661 acacaatgca tgatggccct tcgtatgcta agttcacgga gactcgaaag atgtttgaga
      721 gaagtgtgca tgagtcaggg caaaaccatc gctattcccc aaagaaagag aaaggtggag
      781 ggactgaacc acaggatgag tggggtggct ccaagtccaa cagaggcagc agtgattcct
      841 tggacagcct gagcccccgg acggaagcgg tctctcctac tgtgagtcag ctgagtgctg
      901 tgtttgagaa cagtgagcct ccaggtgctc tcacttctgg gaaggctgag agcgctgact
      961 actcggtgac cgggcactac cccctcaatt taccatctgt taccgtcacc aatctggata
     1021 cctttggccg tctcaaggat tctaattcga agcctccatc aaacaaacaa gatactgata
     1081 cagaggatgc tcagaagagc gatgctgtgc cagtaccgga agtggctcag aaaggtacct
     1141 ctttagcttc attgcctagt gaagagagcc agctgagcac ggaagccgag gacgtcacaa
     1201 cagctcaacc agaggctctg gacagcactg ataaagacag tcctgaggaa ccctctgctg
     1261 aaaaccaggc aatgccaaag tctcatatcc tttccccacg gaacgagccg ttagaagatg
     1321 ctgaagctaa tgtggttggg agtgagagag ctcagcatca gaagaaagac ctgacaggtg
     1381 gtgacctaac ctcccctgat gcttctgcat ccagctgtgg aagagaagta cctgaagact
     1441 caaacagttt tgagagttcc cacgtataca tgcatagtga ctataacgtg tatagggtga
     1501 gatccaggta taactcagac tggggagaga caggcacgga gcaagatgag gaggaagaca
     1561 gtgacgagaa caattattac cagcctgata tggaatactc ggagatagtt ggcttgccgg
     1621 aagaagaaga aatcccagca aataggaaaa ttaagtttag ttgtgctccg attaaggttt
     1681 tcaacacata ctccaatgaa gactatgacc ggagaaatga cgacgttgac cctgtagccg
     1741 catctgctga gtatgagctt gaaaagcgag tagaaaaact ggaacttttc ccagtggaac
     1801 tggagaaaga cgaggacggg ctgggcataa gcatcattgg aatgggcgtt ggtgctgatg
     1861 ctggattgga gaagctgggg atatttgtca agacagtgac tgacggaggt gctgctcagc
     1921 gggatggcag gattcaagtc aatgaccaga ttgtggaagt tgatggaatc agcctggtgg
     1981 gggtcacaca gaattttgct gcaaccgttc tgcggaatac caagggcaac gtcagattcg
     2041 ttattggacg agaaaaacca ggacaagtga gtgaggttgc ccagttgatc agccagaccc
     2101 tggaacaaga gcggcgacag cgggagcttc tggagcgtca ctatgcccag tatgatgctg
     2161 acgacgatga gaacactgtg gctgaattgc aaggagtgtc tggcaactgc aataacaata
     2221 acaaccgttt ccttaagact ggagagtatg ccactgatga agaagaggat gagggcgggc
     2281 ctattcttcc tagtggtgac gtggccattg aggtctttga gctgcctgag aacgaggaca
     2341 tgttttcccc atctgacctg gacacaagca agctcagcca caagttcaaa gagttgcaaa
     2401 tcaaacatgc agttacagaa gcagagattc aaaaattgaa gaccaagctt caagcagccg
     2461 aaaatgagaa agtaaggtgg gaactagaaa agaaccaact gcaacagaat atagaagaga
     2521 ataaagaacg gatgctgaag ttggagagct actggatcga ggctcagaca ttatgtcata
     2581 cggtgaatga gcatctcaaa gagactcaga gccagtacca agccctggaa aagaaataca
     2641 acaaagcaaa gaagctgatc aaagacttcc agcaaaaaga gctcgatttc atcaagagac
     2701 aggaagtaga aagaaagaag cgggaggagg tggaaaaggc tcacctgctt gaagtccaag
     2761 gcctgcaagt tcggattaga gatttggagg ctgaggtgtt cagactacta aagcaaaatg
     2821 ggacccaggt taacaacaac aacaacatct ttgagagaag accatctccc ggggaagtct
     2881 cgaaaggaga cactatggag aatgtggaag tcaagcaaac atcctgtcag gacggcttga
     2941 gccaagacct gaatgaagca gtcccagaga cagagcgcct ggattcgaaa gcattgaaaa
     3001 cccgggccca gctctctgtg aagaacaggc gccagaggcc cacaaggaca cggctctatg
     3061 acagcgtcag ctcaactgat ggggaggaca gcctggagag gaaggcttgg agagtttctt
     3121 ctccagaatc ggagtgtggt gtcacactcc tcacccccgt gacgagccct agggccttct
     3181 catcccacca cacgactgag tctccaggag gatcacagca tccagaaggg gaccctttct
     3241 cctctatctc gggagacact tcatcctcct cgacttcagc atccgatcat gacacagaag
     3301 actctccttg ctgccaccaa gccactgaga aagcgttaca agagaaagat gatgacaaat
     3361 atcctaaatc actaagaaca tccagttcat ttgtggtaca aagaggaaaa attaagcaga
     3421 agtttgcgga tctgggggca cctttgcgaa ggaatcccaa caaggggaag aaacggaaag
     3481 acaaagaaaa ggaagccagt aggttttctg ctggtagcag aatcttcaga agcaagttgg
     3541 agaactggaa aagcaaacca agctctgcag ctcaggcctc cacccgctct ccttgcatgc
     3601 ctttctcatg gtttaatgaa agccggaaag gatcctattc cttcaggaac ctgccttcag
     3661 ctccaagccc ccttcagcct tctcctgaga ctcaagtctc agataaaaca gggtccaaga
     3721 atttcacctt caatgatgac ttcagtccaa gcagtaccag ctcagcagac ctgagtggct
     3781 taggagcaga acccaaaacg ccagggctct cccagtcctt ggcactgtcc tcggatgaga
     3841 gcctggatat gatagatgac gagatccttg acgatggaca gtctcccaaa cacactcaga
     3901 gtcagaatcg ggccgttcat gaatggagtg tgcagcaggt gtcccactgg ttaatgagcc
     3961 tcagtctgga ccagtacgtg cctgaattca gtgcccagag catcagtggg gagcagctcc
     4021 tgcagctgga tggaaataaa ctgaaggctc ttggaatgac atcatcccag gaccgggcac
     4081 tggttaaaaa aaaactgaag gaaatgaaga tgtctctcga gaaggctcgc aaggcccagg
     4141 agaaaatgga aaaacaaaga gagaagctga ggaggaagga acaagagcaa atgcagagga
     4201 agtctaagaa gtcggaaaag atgacttcca cagccgatca accgtgagca gtgaggcctc
     4261 acctcttcca gtagttgggg aagtttgaga gaagtcccgc cccttcctgc ccccactctc
     4321 ctgccgagga tgaagaagaa attgatggga taacaccatt gtaggcggtt aaagaactgt
     4381 gtgttgaatg cactcttgat tttaacctcc taaaataacc cctcgccatc acctttggtt
     4441 tattgacaaa ccagaattat catttttgtc ttctacttac caacatccaa tgttgtgtta
     4501 agtgtgcagt gccactcgta ggagcagcct gacccagcca atgagagcag gactcactct
     4561 ggggctgtga gtggagtacc cagaattctc agtgagagcc cctgaaactg aggtggtagc
     4621 ttctgactgt gggtgtagag atgatacctg ccttgagata ggggagtgcc cctcaattct
     4681 gactgtagag caagtcagtt ctgttgtggg gatgtgggtg cccagcacac aattgccaac
     4741 tgagggaaag aggaaacaag tgtgctatcc acttgctggg aatcagaatg agagggaaaa
     4801 atagtagcta tttaattcta gaagggaaaa gccttaagca cacagatgtg ggtgtacttt
     4861 ggggcttgga ggacagcatt ttcctccagg tattgttgaa caaagaagaa gaaaacgtca
     4921 gagtgtagtg caaccatgga tgttgggatc tgctgcgttg tttgccagtg ctgcaccaag
     4981 tgtttgacca gcactgacaa actgcacagc tccttcccca gccacacact gagccggaaa
     5041 ctgactttga aggaaaccaa tgtcttcagg tttcttctcc tgggacattc tggctggcct
     5101 tcacaatcat gaagttgtca catattttct actcagaatt tcccaagtgg gctcagttag
     5161 tgttttaaca aatgtgcttt taaggactta aacgtagaga tactggttag aaatttaaga
     5221 tttgagtaac agtcaaccac agaacttttt ttcttgtttt tttgtacaca taattctttc
     5281 ctgtgaagga cagccatctt ttacatttta gagacatttt gaatgacttt ctaagccatt
     5341 ctcttccata ttctagagag ttacagattt gtggaaaaca gtacacggga cagactttta
     5401 cagtgtaaga gctgatgttt cttaagtcca gtattaggga ttccagtctt tcaccaccct
     5461 gagttgagtg caggagacta ggggaggagg agaacagaaa ctcttctgga gacatttcac
     5521 accctggggg ttttatttat ttgcttgcct ttagttttgc tctttttgct tatgtatcta
     5581 actctcatta ctgcattaat tctaaaaacc tgatatcatt tgctttcgga tggactgatt
     5641 tcagagtaga gctggaggcc agatgaaacc ttggacttca gggtatttcc ttcctttccc
     5701 ccagcaggcc cttgtgctgc ccgcaggcct gtacacatct cctctgcatg cacaggtatg
     5761 cagggcctgc atcaggctcc agagttagga caggaatctg ataggataga ggtcggctgc
     5821 ctgtgtggcc tcactttgta ttttaacatt gtgacttttc atttttatcg ttattactat
     5881 ttttgtaaca tgaattctga cattatctga actagaaact taatcctatc ctttctccca
     5941 gagcctgctt ctgtttctgg cccgagcact tctgtaagtt ctggtccttc tggtacagat
     6001 tcacgtcagt ccgaaacatg atgtgggagt ctcattacgc tctgcacaaa ccagacctgc
     6061 ttcacggttt tctcgaggag tagggtgctg ggtgctgggt gctgggtgct gggtgcttct
     6121 atctcagatg ctgatgcttc gccacttact aagattttga gaaaacaaga gacatgctcc
     6181 tgaactacac attcagtaac tctttcctaa tgccagaagt ctaagcaaaa ctctggcaat
     6241 tctaatactt gttattgtac gtatcagcca tttttctttt ctttggggga aaaaaagctg
     6301 gactgcactg gaagcttctg tgtgttcatt ttcgagagtg aaaacagaag ggtgatgatt
     6361 ttaagttgtg tttacacttt gatgatagtt gaaaatgaat gtatatattg gaaatgtctg
     6421 taagtctgcc ctgcctgtaa cttatgacct cttatattgc gtttcttaaa tacagtgttc
     6481 tcactgtgac tttattaaca ctccatgctt ggatcagcgt acatctggca gttacaaatc
     6541 aaactaatgt tccttacatc attagtttat agtttagtca ttgtaatctt taagttaaat
     6601 tattgcaatc ttaaaccaaa atgagttctt ttaacgttgc tacttaaaac tagtaaaatc
     6661 gtaaagggct cttgattgca ctgttcagca aaggataaga gatggactgg ttggtccggt
     6721 gtggaaacaa agtgaaggac ctcagatctt gtgagcgttt tgacttcttg ttagctcctt
     6781 tattggctgt agtgcatgat aataattgag tttccaacgt cttgcacaat gctttcttta
     6841 atgctgtggt tttcagggtt tatacaactt aaagagaatt gttgcttcat ggactttaag
     6901 gatttcggac agtttttaag ctatcaacaa atgaacagaa ggggttgtct gcatattgtg
     6961 aactgtactc tagtgaagac tagtgggtcc caccagaaac caaaagtgtt tggggtacaa
     7021 tatatgttcg ggtgtcaggg tacatggtga ggccctgcca taggtagaga gcattgtagg
     7081 agtagattct gggtcagggt tccactaaag aactgtgcac tggatgtctg tgattaagat
     7141 catctccttt aaggcaactt atccttatgt gatcacgtct ttctcctccc cagcatcagg
     7201 agggtactgt tagagcagaa accctgctct atctacttta gcactcgatc gaagcctgcc
     7261 attactatcg tgacagcaaa gtccctctga aaccatctgc catccttctg ctggggttgg
     7321 gatggacttc ctgctcccca cctcgtgtag acttttaaaa taccgcagta gtttctgatc
     7381 acactatgaa aggagctaat gccaaactca gtttgcaaga ggcacaacat gtgactacct
     7441 actttatgtt cttttatttc aggaaacaaa gtagcagagg agagagtact cccactactg
     7501 ctcatgccca atagtgttca ccctgagatc ttaaatacct taggcctaag cttcaagaat
     7561 gtccacaggt cagatttagc atctgggcct ctatggcttg tgctgatgat gaagaattct
     7621 cttttgggat ctttgcttga taggattaat ttgtacctta aaattatata agaagaaaat
     7681 ggttgcattt atacagctat tctaagttgt ttataaacgt gagaggttag aaaattttga
     7741 ggaggaccat taacatttaa caagggtatt taagatgatt ctggaagatg gaggggaaat
     7801 gattctaaaa gaaacttctg tacattggat gcatatcaca ctgtcataca ctgggatcgt
     7861 taagaattac caaattctat gtgagtaact taagcctctt cccacatagc tggtgataag
     7921 aaacatctca ctttggggag caggcattag gagggtttat gtcacttggc ttcaacgcta
     7981 agaccctact gttacctgga tggaagagta attaagaaag gatggtccta gttttcacat
     8041 gttttcttac ttgctttgag tcagggctcc ccatgtctag ttctaaagca gagcttgtgg
     8101 aggtgaggtc aaacttaaag catctatgct tccttccaaa actgttctca ttgtgaaagg
     8161 acaaagggag gggacagtct ccagacagca tttacaggaa gtctgtttag tctctggtca
     8221 gtcctgaaag tcagactgag tgtactggcc agttttgttt gcttttgtct tgaatagtta
     8281 gagtcccatg aaatgtagcc ctgattcaaa acattgggag tggcaggaat atcaccaaag
     8341 aaaacacata ttaatacctt gaagataaca tggaagaagc tagagtgagt agttagaggg
     8401 aaaggggaag cctgtacagt aaactgccct ctggagatag tgcgagctcc tcacacaaac
     8461 acacccactt gcacttgcgc gcgcgcgcgc gcacgcgcgc acacacacac acacacacac
     8521 acacacacac acacacacac acacacgcac actgcctcct ggaaggttgg ctccctacga
     8581 ctctggtctg taagcacctg ggtctggatc ctccgagtag ggggcagaag aaggtccatg
     8641 cttccctgcc gctgcccaac cccaccccac cccacccccc gaccgttagg gatccagcga
     8701 tgtgcaagac agtgtacaag cagtaagaga agaagccaca aattctcagt tctgtgcatg
     8761 ccacttgtgt aggtgtcaga gctgtgtgtg tgaatatatc cccacctgac acacacacat
     8821 atatacctta agcacgtggc acaaaaatat actcaccgtg gactgcagtg atgtcagtta
     8881 ggaccctggg ctgtaatagt ggcaacaccg ccacttttta tgttgtgtat acattgaatg
     8941 gctcatagat ttttaagaga tttttttttt tttaatgtaa gtatcctact aaatgcactt
     9001 atgcttctaa atgtttatat attttggtaa aattgattta ctagatcttt agtattgtat
     9061 tttagtaagg taaattttcc tcagatattt gattaatgct ttgatgtcaa gattgcacat
     9121 tttttagtta gaactcagaa gctattatgc agcttggggc attttcaact gcaggatgcc
     9181 cgcagttttc ttgactaaat tgcactgtgt gttctcgtgt atcagctccc acctcagtag
     9241 ccatgatgct tctgtcacta actgctggct ctctggtggc agtattctgt cgtgtgacca
     9301 ctatgtactt cctaagccat ccgcttgtaa tggcattttg gttgccacca aaaataacac
     9361 aaaggggcct gagtatacgc tgttgcaagc tgtatacttc atttccttcg gctggtttat
     9421 gcacgcacac aagtttcttg ttaaagattg aagcactcag ccatgaaata acaattggcc
     9481 agaaataccc taaattgcct ttaccaaaag aaaaaaaaaa aaaaaaaaaa aagcaggaag
     9541 cgatgcccag gccagatagc tctttccagc agcatcaggt tcaatcggtg aataacaagc
     9601 agcgctcagc gtacatacgt gggctctcct caggattatt taatgtcata actactgctt
     9661 ttgtattttt taatgatgtt ttgatgaaac cacttctaag tctgctatag attactgaca
     9721 aggccagaca gctgaaaacg acaggggaag gaagttccgt tctactgtaa gacttgactt
     9781 atgttcgccc ttccttatat actgctagaa aggaaagtgc tttgtaaagc attaaagtct
     9841 ggaaagtatg cacagcacag gacctgaact ttttaatttg tacgttttgc tgtctggtca
     9901 tttgcatggg agaaacagca gtgccacacc taatttgttc tctggcgctt cgttagtgtg
     9961 tgctgtttcc aatggcattc tttacttttc agttttcaga ggcattcaaa gcaaactctg
    10021 ctgtcagtgg accattgttt tccgaccatc taaaaaatac ctgtgattaa acttaacttg
    10081 ttagtgtaaa taaatctctt gccaatgagt attattgttg ttagataatg aatgcaataa
    10141 aggaaataca gaggtc
//
