LOCUS       NM_001401494           10132 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 9A
            (Ppp1r9a), transcript variant 5, mRNA.
ACCESSION   NM_001401494
VERSION     NM_001401494.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10132)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10132)
  AUTHORS   Edler,M.C., Salek,A.B., Watkins,D.S., Kaur,H., Morris,C.W.,
            Yamamoto,B.K. and Baucum,A.J. 2nd.
  TITLE     Mechanisms Regulating the Association of Protein Phosphatase 1 with
            Spinophilin and Neurabin
  JOURNAL   ACS Chem Neurosci 9 (11), 2701-2712 (2018)
   PUBMED   29786422
REFERENCE   3  (bases 1 to 10132)
  AUTHORS   Wu H, Cottingham C, Chen L, Wang H, Che P, Liu K and Wang Q.
  TITLE     Age-dependent differential regulation of anxiety- and
            depression-related behaviors by neurabin and spinophilin
  JOURNAL   PLoS One 12 (7), e0180638 (2017)
   PUBMED   28700667
  REMARK    GeneRIF: two homologs neurabin and spinophilin play important yet
            distinct roles in the regulation of anxiety- and depression-like
            behaviors in an age-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10132)
  AUTHORS   Che P, Chen Y, Lu R, Peng N, Gannon M, Wyss JM, Jiao K and Wang Q.
  TITLE     Spinophilin Is Indispensable for the alpha2B Adrenergic
            Receptor-Elicited Hypertensive Response
  JOURNAL   PLoS One 10 (8), e0135030 (2015)
   PUBMED   26244553
  REMARK    GeneRIF: Data indicate that In arrestin 3 deficient mice, where the
            alpha2B adrenergic receptor has a stronger binding to spinophilin,
            the hypertensive response is enhanced.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10132)
  AUTHORS   Chen Y, Liu Y, Cottingham C, McMahon L, Jiao K, Greengard P and
            Wang Q.
  TITLE     Neurabin scaffolding of adenosine receptor and RGS4 regulates
            anti-seizure effect of endogenous adenosine
  JOURNAL   J Neurosci 32 (8), 2683-2695 (2012)
   PUBMED   22357852
REFERENCE   6  (bases 1 to 10132)
  AUTHORS   Orioli D, Colaluca IN, Stefanini M, Riva S, Dotti CG and Peverali
            FA.
  TITLE     Rac3-induced neuritogenesis requires binding to Neurabin I
  JOURNAL   Mol Biol Cell 17 (5), 2391-2400 (2006)
   PUBMED   16525025
  REMARK    GeneRIF: Neurabin I mediates Rac3-induced neuritogenesis, possibly
            by anchoring Rac3 to growth cone F-actin.
REFERENCE   7  (bases 1 to 10132)
  AUTHORS   Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito N,
            Hino T, Suzuki-Migishima R, Ogonuki N, Miki H, Kohda T, Ogura A,
            Yokoyama M, Kaneko-Ishino T and Ishino F.
  TITLE     Deletion of Peg10, an imprinted gene acquired from a
            retrotransposon, causes early embryonic lethality
  JOURNAL   Nat Genet 38 (1), 101-106 (2006)
   PUBMED   16341224
REFERENCE   8  (bases 1 to 10132)
  AUTHORS   Ryan XP, Alldritt J, Svenningsson P, Allen PB, Wu GY, Nairn AC and
            Greengard P.
  TITLE     The Rho-specific GEF Lfc interacts with neurabin and spinophilin to
            regulate dendritic spine morphology
  JOURNAL   Neuron 47 (1), 85-100 (2005)
   PUBMED   15996550
REFERENCE   9  (bases 1 to 10132)
  AUTHORS   Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA and
            Colbran RJ.
  TITLE     A protein phosphatase-1gamma1 isoform selectivity determinant in
            dendritic spine-associated neurabin
  JOURNAL   J Biol Chem 279 (21), 21714-21723 (2004)
   PUBMED   15016827
  REMARK    GeneRIF: there is a novel PP1gamma1-selective interaction domain in
            neurabin that may allow for selective regulation and/or subcellular
            targeting of PP1 isoforms
REFERENCE   10 (bases 1 to 10132)
  AUTHORS   Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T and Ishino
            F.
  TITLE     Identification of a large novel imprinted gene cluster on mouse
            proximal chromosome 6
  JOURNAL   Genome Res 13 (7), 1696-1705 (2003)
   PUBMED   12840045
  REMARK    GeneRIF: Ppp1r9a gene, found in a cluster of imprinted genes on
            chromosome 6, is preferentially expressed from the maternal allele
            at embryonic stages, but biallelically expressed in neonatal
            tissues.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068500.4 and AC074225.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR11927936.2862958.1,
                                    SRR11927937.5486755.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 12840045
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC068500.4         83048-83104
            58-1676             AC068500.4         85299-86917
            1677-1809           AC074225.4         41321-41453
            1810-1930           AC074225.4         52843-52963
            1931-2035           AC074225.4         59376-59480
            2036-2171           AC074225.4         72865-73000
            2172-2237           AC074225.4         78426-78491
            2238-2393           AC074225.4         95817-95972
            2394-2447           AC074225.4         106385-106438
            2448-2677           AC074225.4         108986-109215
            2678-2774           AC074225.4         110504-110600
            2775-2946           AC074225.4         110694-110865
            2947-3104           AC074225.4         129402-129559
            3105-3348           AC074225.4         130074-130317
            3349-3436           AC074225.4         138613-138700
            3437-3520           AC074225.4         138791-138874
            3521-3719           AC074225.4         149394-149592
            3720-3839           AC074225.4         151506-151625
            3840-4022           AC074225.4         153474-153656
            4023-10132          AC074225.4         154937-161046
FEATURES             Location/Qualifiers
     source          1..10132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.86 cM"
     gene            1..10132
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /note="protein phosphatase 1, regulatory subunit 9A"
                     /db_xref="GeneID:243725"
                     /db_xref="MGI:MGI:2442401"
     exon            1..57
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1676
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..4223
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /note="isoform 3 is encoded by transcript variant 5;
                     neural tissue-specific F-actin binding protein; protein
                     phosphatase 1, regulatory (inhibitor) subunit 9A;
                     neurabin-1"
                     /codon_start=1
                     /product="neurabin-1 isoform 3"
                     /protein_id="NP_001388423.1"
                     /db_xref="GeneID:243725"
                     /db_xref="MGI:MGI:2442401"
                     /translation="MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQK
                     TKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAIIAKTRGKGRPSSPQRRMKP
                     KEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSVHESGQNHRYS
                     PKKEKGGGTEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSEPPGAL
                     TSGKAESADYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSKPPSNKQDTDTEDAQKSDA
                     VPVPEVAQKGTSLASLPSEESQLSTEAEDVTTAQPEALDSTDKDSPEEPSAENQAMPK
                     SHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFE
                     SSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEE
                     EIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVEL
                     EKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTDGGAAQRDGRIQVNDQIVEVDGISL
                     VGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQ
                     YDADDDENTVAELQGVSGNCNNNNNRFLKTGEYATDEEEDEGGPILPSGDVAIEVFEL
                     PENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQ
                     LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQ
                     QKELDFIKRQEVERKKREEVEKAHLLEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNN
                     IFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSV
                     KNRRQRPTRTRLYDSVSSTDGEDSLERKAWRVSSPESECGVTLLTPVTSPRAFSSHHT
                     TESPGGSQHPEGDPFSSISGDTSSSSTSASDHDTEDSPCCHQATEKALQEKDDDKYPK
                     SLRTSSSFVVQRGKIKQKFADLGAPLRRNPNKGKKRKDKEKEASRFSAGSRIFRSKLE
                     NWKSKPSSAAQASTRSPCMPFSWFNESRKGSYSFRNLPSAPSPLQPSPETQVSDKTGS
                     KNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDEILDDGQSPKHTQSQNRA
                     VHEWSVQQVSHWLMSLSLDQYVPEFSAQSISGEQLLQLDGNKLKALGMTSSQDRALVK
                     KKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTADQP"
     exon            1677..1809
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1930
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2035
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2171
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2237
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2393
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2447
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2677
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2774
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2946
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3104
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3348
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3436
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3520
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3719
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3839
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4022
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..10132
                     /gene="Ppp1r9a"
                     /gene_synonym="2810430P21Rik; 4930518N04Rik; 5330407E15;
                     A230094E16Rik; neurabin-I; NRB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttcgctg ctgggctccc tctctttgcg gccctagagt taatcccatc agccgagatg
       61 aacctctagt cttgctttga aaaaagctat tttgtgtaac tcttgactgt gaatacattt
      121 ctaatacagc ctttggaatc gtcacgggac aagtgtgcca tttgagcggc cctgtgcctg
      181 gtcagacact ggggattgag aagagaggtc tgtttggctt tttggttgtt tttcccagtg
      241 accattatga gcattggctt ttcacccttg aagtaaacat gttgaaggcg gaatcttcag
      301 gggagcggac cactctcaga agtgcctctc ctcacaggaa tgcgtacaga acagagttcc
      361 aggcactgaa aagtactttt gacaaaccca agtcagatgg ggaacagaaa acgaaagaag
      421 gtgagggctc ccagcagagc agaggtagaa agtatggctc caatgtcaac agaattaaaa
      481 atctatttat gcagatgggt atggaaccca gcgagaatgc tgctatcatt gccaaaacca
      541 gggggaaagg taggccctcg tcccctcaga gaagaatgaa gcccaaagag tttgtggaga
      601 aaacggatgg ctcagtggtt aagttggagt cctctgtctc tgaacgaatc agtagatttg
      661 acacaatgca tgatggccct tcgtatgcta agttcacgga gactcgaaag atgtttgaga
      721 gaagtgtgca tgagtcaggg caaaaccatc gctattcccc aaagaaagag aaaggtggag
      781 ggactgaacc acaggatgag tggggtggct ccaagtccaa cagaggcagc agtgattcct
      841 tggacagcct gagcccccgg acggaagcgg tctctcctac tgtgagtcag ctgagtgctg
      901 tgtttgagaa cagtgagcct ccaggtgctc tcacttctgg gaaggctgag agcgctgact
      961 actcggtgac cgggcactac cccctcaatt taccatctgt taccgtcacc aatctggata
     1021 cctttggccg tctcaaggat tctaattcga agcctccatc aaacaaacaa gatactgata
     1081 cagaggatgc tcagaagagc gatgctgtgc cagtaccgga agtggctcag aaaggtacct
     1141 ctttagcttc attgcctagt gaagagagcc agctgagcac ggaagccgag gacgtcacaa
     1201 cagctcaacc agaggctctg gacagcactg ataaagacag tcctgaggaa ccctctgctg
     1261 aaaaccaggc aatgccaaag tctcatatcc tttccccacg gaacgagccg ttagaagatg
     1321 ctgaagctaa tgtggttggg agtgagagag ctcagcatca gaagaaagac ctgacaggtg
     1381 gtgacctaac ctcccctgat gcttctgcat ccagctgtgg aagagaagta cctgaagact
     1441 caaacagttt tgagagttcc cacgtataca tgcatagtga ctataacgtg tatagggtga
     1501 gatccaggta taactcagac tggggagaga caggcacgga gcaagatgag gaggaagaca
     1561 gtgacgagaa caattattac cagcctgata tggaatactc ggagatagtt ggcttgccgg
     1621 aagaagaaga aatcccagca aataggaaaa ttaagtttag ttgtgctccg attaaggttt
     1681 tcaacacata ctccaatgaa gactatgacc ggagaaatga cgacgttgac cctgtagccg
     1741 catctgctga gtatgagctt gaaaagcgag tagaaaaact ggaacttttc ccagtggaac
     1801 tggagaaaga cgaggacggg ctgggcataa gcatcattgg aatgggcgtt ggtgctgatg
     1861 ctggattgga gaagctgggg atatttgtca agacagtgac tgacggaggt gctgctcagc
     1921 gggatggcag gattcaagtc aatgaccaga ttgtggaagt tgatggaatc agcctggtgg
     1981 gggtcacaca gaattttgct gcaaccgttc tgcggaatac caagggcaac gtcagattcg
     2041 ttattggacg agaaaaacca ggacaagtga gtgaggttgc ccagttgatc agccagaccc
     2101 tggaacaaga gcggcgacag cgggagcttc tggagcgtca ctatgcccag tatgatgctg
     2161 acgacgatga gaacactgtg gctgaattgc aaggagtgtc tggcaactgc aataacaata
     2221 acaaccgttt ccttaagact ggagagtatg ccactgatga agaagaggat gagggcgggc
     2281 ctattcttcc tagtggtgac gtggccattg aggtctttga gctgcctgag aacgaggaca
     2341 tgttttcccc atctgacctg gacacaagca agctcagcca caagttcaaa gagttgcaaa
     2401 tcaaacatgc agttacagaa gcagagattc aaaaattgaa gaccaagctt caagcagccg
     2461 aaaatgagaa agtaaggtgg gaactagaaa agaaccaact gcaacagaat atagaagaga
     2521 ataaagaacg gatgctgaag ttggagagct actggatcga ggctcagaca ttatgtcata
     2581 cggtgaatga gcatctcaaa gagactcaga gccagtacca agccctggaa aagaaataca
     2641 acaaagcaaa gaagctgatc aaagacttcc agcaaaaaga gctcgatttc atcaagagac
     2701 aggaagtaga aagaaagaag cgggaggagg tggaaaaggc tcacctgctt gaagtccaag
     2761 gcctgcaagt tcggattaga gatttggagg ctgaggtgtt cagactacta aagcaaaatg
     2821 ggacccaggt taacaacaac aacaacatct ttgagagaag accatctccc ggggaagtct
     2881 cgaaaggaga cactatggag aatgtggaag tcaagcaaac atcctgtcag gacggcttga
     2941 gccaagacct gaatgaagca gtcccagaga cagagcgcct ggattcgaaa gcattgaaaa
     3001 cccgggccca gctctctgtg aagaacaggc gccagaggcc cacaaggaca cggctctatg
     3061 acagcgtcag ctcaactgat ggggaggaca gcctggagag gaaggcttgg agagtttctt
     3121 ctccagaatc ggagtgtggt gtcacactcc tcacccccgt gacgagccct agggccttct
     3181 catcccacca cacgactgag tctccaggag gatcacagca tccagaaggg gaccctttct
     3241 cctctatctc gggagacact tcatcctcct cgacttcagc atccgatcat gacacagaag
     3301 actctccttg ctgccaccaa gccactgaga aagcgttaca agagaaagat gatgacaaat
     3361 atcctaaatc actaagaaca tccagttcat ttgtggtaca aagaggaaaa attaagcaga
     3421 agtttgcgga tctgggggca cctttgcgaa ggaatcccaa caaggggaag aaacggaaag
     3481 acaaagaaaa ggaagccagt aggttttctg ctggtagcag aatcttcaga agcaagttgg
     3541 agaactggaa aagcaaacca agctctgcag ctcaggcctc cacccgctct ccttgcatgc
     3601 ctttctcatg gtttaatgaa agccggaaag gatcctattc cttcaggaac ctgccttcag
     3661 ctccaagccc ccttcagcct tctcctgaga ctcaagtctc agataaaaca gggtccaaga
     3721 atttcacctt caatgatgac ttcagtccaa gcagtaccag ctcagcagac ctgagtggct
     3781 taggagcaga acccaaaacg ccagggctct cccagtcctt ggcactgtcc tcggatgaga
     3841 tccttgacga tggacagtct cccaaacaca ctcagagtca gaatcgggcc gttcatgaat
     3901 ggagtgtgca gcaggtgtcc cactggttaa tgagcctcag tctggaccag tacgtgcctg
     3961 aattcagtgc ccagagcatc agtggggagc agctcctgca gctggatgga aataaactga
     4021 aggctcttgg aatgacatca tcccaggacc gggcactggt taaaaaaaaa ctgaaggaaa
     4081 tgaagatgtc tctcgagaag gctcgcaagg cccaggagaa aatggaaaaa caaagagaga
     4141 agctgaggag gaaggaacaa gagcaaatgc agaggaagtc taagaagtcg gaaaagatga
     4201 cttccacagc cgatcaaccg tgagcagtga ggcctcacct cttccagtag ttggggaagt
     4261 ttgagagaag tcccgcccct tcctgccccc actctcctgc cgaggatgaa gaagaaattg
     4321 atgggataac accattgtag gcggttaaag aactgtgtgt tgaatgcact cttgatttta
     4381 acctcctaaa ataacccctc gccatcacct ttggtttatt gacaaaccag aattatcatt
     4441 tttgtcttct acttaccaac atccaatgtt gtgttaagtg tgcagtgcca ctcgtaggag
     4501 cagcctgacc cagccaatga gagcaggact cactctgggg ctgtgagtgg agtacccaga
     4561 attctcagtg agagcccctg aaactgaggt ggtagcttct gactgtgggt gtagagatga
     4621 tacctgcctt gagatagggg agtgcccctc aattctgact gtagagcaag tcagttctgt
     4681 tgtggggatg tgggtgccca gcacacaatt gccaactgag ggaaagagga aacaagtgtg
     4741 ctatccactt gctgggaatc agaatgagag ggaaaaatag tagctattta attctagaag
     4801 ggaaaagcct taagcacaca gatgtgggtg tactttgggg cttggaggac agcattttcc
     4861 tccaggtatt gttgaacaaa gaagaagaaa acgtcagagt gtagtgcaac catggatgtt
     4921 gggatctgct gcgttgtttg ccagtgctgc accaagtgtt tgaccagcac tgacaaactg
     4981 cacagctcct tccccagcca cacactgagc cggaaactga ctttgaagga aaccaatgtc
     5041 ttcaggtttc ttctcctggg acattctggc tggccttcac aatcatgaag ttgtcacata
     5101 ttttctactc agaatttccc aagtgggctc agttagtgtt ttaacaaatg tgcttttaag
     5161 gacttaaacg tagagatact ggttagaaat ttaagatttg agtaacagtc aaccacagaa
     5221 ctttttttct tgtttttttg tacacataat tctttcctgt gaaggacagc catcttttac
     5281 attttagaga cattttgaat gactttctaa gccattctct tccatattct agagagttac
     5341 agatttgtgg aaaacagtac acgggacaga cttttacagt gtaagagctg atgtttctta
     5401 agtccagtat tagggattcc agtctttcac caccctgagt tgagtgcagg agactagggg
     5461 aggaggagaa cagaaactct tctggagaca tttcacaccc tgggggtttt atttatttgc
     5521 ttgcctttag ttttgctctt tttgcttatg tatctaactc tcattactgc attaattcta
     5581 aaaacctgat atcatttgct ttcggatgga ctgatttcag agtagagctg gaggccagat
     5641 gaaaccttgg acttcagggt atttccttcc tttcccccag caggcccttg tgctgcccgc
     5701 aggcctgtac acatctcctc tgcatgcaca ggtatgcagg gcctgcatca ggctccagag
     5761 ttaggacagg aatctgatag gatagaggtc ggctgcctgt gtggcctcac tttgtatttt
     5821 aacattgtga cttttcattt ttatcgttat tactattttt gtaacatgaa ttctgacatt
     5881 atctgaacta gaaacttaat cctatccttt ctcccagagc ctgcttctgt ttctggcccg
     5941 agcacttctg taagttctgg tccttctggt acagattcac gtcagtccga aacatgatgt
     6001 gggagtctca ttacgctctg cacaaaccag acctgcttca cggttttctc gaggagtagg
     6061 gtgctgggtg ctgggtgctg ggtgctgggt gcttctatct cagatgctga tgcttcgcca
     6121 cttactaaga ttttgagaaa acaagagaca tgctcctgaa ctacacattc agtaactctt
     6181 tcctaatgcc agaagtctaa gcaaaactct ggcaattcta atacttgtta ttgtacgtat
     6241 cagccatttt tcttttcttt gggggaaaaa aagctggact gcactggaag cttctgtgtg
     6301 ttcattttcg agagtgaaaa cagaagggtg atgattttaa gttgtgttta cactttgatg
     6361 atagttgaaa atgaatgtat atattggaaa tgtctgtaag tctgccctgc ctgtaactta
     6421 tgacctctta tattgcgttt cttaaataca gtgttctcac tgtgacttta ttaacactcc
     6481 atgcttggat cagcgtacat ctggcagtta caaatcaaac taatgttcct tacatcatta
     6541 gtttatagtt tagtcattgt aatctttaag ttaaattatt gcaatcttaa accaaaatga
     6601 gttcttttaa cgttgctact taaaactagt aaaatcgtaa agggctcttg attgcactgt
     6661 tcagcaaagg ataagagatg gactggttgg tccggtgtgg aaacaaagtg aaggacctca
     6721 gatcttgtga gcgttttgac ttcttgttag ctcctttatt ggctgtagtg catgataata
     6781 attgagtttc caacgtcttg cacaatgctt tctttaatgc tgtggttttc agggtttata
     6841 caacttaaag agaattgttg cttcatggac tttaaggatt tcggacagtt tttaagctat
     6901 caacaaatga acagaagggg ttgtctgcat attgtgaact gtactctagt gaagactagt
     6961 gggtcccacc agaaaccaaa agtgtttggg gtacaatata tgttcgggtg tcagggtaca
     7021 tggtgaggcc ctgccatagg tagagagcat tgtaggagta gattctgggt cagggttcca
     7081 ctaaagaact gtgcactgga tgtctgtgat taagatcatc tcctttaagg caacttatcc
     7141 ttatgtgatc acgtctttct cctccccagc atcaggaggg tactgttaga gcagaaaccc
     7201 tgctctatct actttagcac tcgatcgaag cctgccatta ctatcgtgac agcaaagtcc
     7261 ctctgaaacc atctgccatc cttctgctgg ggttgggatg gacttcctgc tccccacctc
     7321 gtgtagactt ttaaaatacc gcagtagttt ctgatcacac tatgaaagga gctaatgcca
     7381 aactcagttt gcaagaggca caacatgtga ctacctactt tatgttcttt tatttcagga
     7441 aacaaagtag cagaggagag agtactccca ctactgctca tgcccaatag tgttcaccct
     7501 gagatcttaa ataccttagg cctaagcttc aagaatgtcc acaggtcaga tttagcatct
     7561 gggcctctat ggcttgtgct gatgatgaag aattctcttt tgggatcttt gcttgatagg
     7621 attaatttgt accttaaaat tatataagaa gaaaatggtt gcatttatac agctattcta
     7681 agttgtttat aaacgtgaga ggttagaaaa ttttgaggag gaccattaac atttaacaag
     7741 ggtatttaag atgattctgg aagatggagg ggaaatgatt ctaaaagaaa cttctgtaca
     7801 ttggatgcat atcacactgt catacactgg gatcgttaag aattaccaaa ttctatgtga
     7861 gtaacttaag cctcttccca catagctggt gataagaaac atctcacttt ggggagcagg
     7921 cattaggagg gtttatgtca cttggcttca acgctaagac cctactgtta cctggatgga
     7981 agagtaatta agaaaggatg gtcctagttt tcacatgttt tcttacttgc tttgagtcag
     8041 ggctccccat gtctagttct aaagcagagc ttgtggaggt gaggtcaaac ttaaagcatc
     8101 tatgcttcct tccaaaactg ttctcattgt gaaaggacaa agggagggga cagtctccag
     8161 acagcattta caggaagtct gtttagtctc tggtcagtcc tgaaagtcag actgagtgta
     8221 ctggccagtt ttgtttgctt ttgtcttgaa tagttagagt cccatgaaat gtagccctga
     8281 ttcaaaacat tgggagtggc aggaatatca ccaaagaaaa cacatattaa taccttgaag
     8341 ataacatgga agaagctaga gtgagtagtt agagggaaag gggaagcctg tacagtaaac
     8401 tgccctctgg agatagtgcg agctcctcac acaaacacac ccacttgcac ttgcgcgcgc
     8461 gcgcgcgcac gcgcgcacac acacacacac acacacacac acacacacac acacacacac
     8521 acgcacactg cctcctggaa ggttggctcc ctacgactct ggtctgtaag cacctgggtc
     8581 tggatcctcc gagtaggggg cagaagaagg tccatgcttc cctgccgctg cccaacccca
     8641 ccccacccca ccccccgacc gttagggatc cagcgatgtg caagacagtg tacaagcagt
     8701 aagagaagaa gccacaaatt ctcagttctg tgcatgccac ttgtgtaggt gtcagagctg
     8761 tgtgtgtgaa tatatcccca cctgacacac acacatatat accttaagca cgtggcacaa
     8821 aaatatactc accgtggact gcagtgatgt cagttaggac cctgggctgt aatagtggca
     8881 acaccgccac tttttatgtt gtgtatacat tgaatggctc atagattttt aagagatttt
     8941 ttttttttta atgtaagtat cctactaaat gcacttatgc ttctaaatgt ttatatattt
     9001 tggtaaaatt gatttactag atctttagta ttgtatttta gtaaggtaaa ttttcctcag
     9061 atatttgatt aatgctttga tgtcaagatt gcacattttt tagttagaac tcagaagcta
     9121 ttatgcagct tggggcattt tcaactgcag gatgcccgca gttttcttga ctaaattgca
     9181 ctgtgtgttc tcgtgtatca gctcccacct cagtagccat gatgcttctg tcactaactg
     9241 ctggctctct ggtggcagta ttctgtcgtg tgaccactat gtacttccta agccatccgc
     9301 ttgtaatggc attttggttg ccaccaaaaa taacacaaag gggcctgagt atacgctgtt
     9361 gcaagctgta tacttcattt ccttcggctg gtttatgcac gcacacaagt ttcttgttaa
     9421 agattgaagc actcagccat gaaataacaa ttggccagaa ataccctaaa ttgcctttac
     9481 caaaagaaaa aaaaaaaaaa aaaaaaaagc aggaagcgat gcccaggcca gatagctctt
     9541 tccagcagca tcaggttcaa tcggtgaata acaagcagcg ctcagcgtac atacgtgggc
     9601 tctcctcagg attatttaat gtcataacta ctgcttttgt attttttaat gatgttttga
     9661 tgaaaccact tctaagtctg ctatagatta ctgacaaggc cagacagctg aaaacgacag
     9721 gggaaggaag ttccgttcta ctgtaagact tgacttatgt tcgcccttcc ttatatactg
     9781 ctagaaagga aagtgctttg taaagcatta aagtctggaa agtatgcaca gcacaggacc
     9841 tgaacttttt aatttgtacg ttttgctgtc tggtcatttg catgggagaa acagcagtgc
     9901 cacacctaat ttgttctctg gcgcttcgtt agtgtgtgct gtttccaatg gcattcttta
     9961 cttttcagtt ttcagaggca ttcaaagcaa actctgctgt cagtggacca ttgttttccg
    10021 accatctaaa aaatacctgt gattaaactt aacttgttag tgtaaataaa tctcttgcca
    10081 atgagtatta ttgttgttag ataatgaatg caataaagga aatacagagg tc
//
