LOCUS       NM_146154               2060 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 8 (Ppp1r8),
            transcript variant 1, mRNA.
ACCESSION   NM_146154
VERSION     NM_146154.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Jonkhout,M.C.M., Vanhessche,T., Ferreira,M., Verbinnen,I.,
            Withof,F., Van der Hoeven,G., Szeker,K., Azhir,Z., Lien,W.H., Van
            Eynde,A. and Bollen,M.
  TITLE     Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle
            Arrest and Premature Senescence in Adult Mice
  JOURNAL   J Invest Dermatol 144 (10), 2162-2175 (2024)
   PUBMED   38431220
  REMARK    GeneRIF: Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell
            Cycle Arrest and Premature Senescence in Adult Mice.
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   McKee,C., Shrager,P., Mazumder,A.G., Ganguly,A., Mayer,A.,
            Foley,K., Ward,N., Youngman,M., Hou,H. and Xia,H.
  TITLE     Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS
            Tau Phosphorylation and Myelination During Development
  JOURNAL   Mol Neurobiol 59 (12), 7486-7494 (2022)
   PUBMED   36198882
  REMARK    GeneRIF: Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1)
            Regulates CNS Tau Phosphorylation and Myelination During
            Development.
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Verbinnen,I., Jonkhout,M., Liakath-Ali,K., Szeker,K., Ferreira,M.,
            Boens,S., Rouget,R., Nikolic,M., Schlenner,S., Van Eynde,A. and
            Bollen,M.
  TITLE     Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin
            Inflammation
  JOURNAL   J Invest Dermatol 140 (8), 1576-1588 (2020)
   PUBMED   31972250
  REMARK    GeneRIF: Phosphatase Regulator NIPP1 Restrains Chemokine-Driven
            Skin Inflammation.
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Rong,Y., Ji,S.Y., Zhu,Y.Z., Wu,Y.W., Shen,L. and Fan,H.Y.
  TITLE     ZAR1 and ZAR2 are required for oocyte meiotic maturation by
            regulating the maternal transcriptome and mRNA translational
            activation
  JOURNAL   Nucleic Acids Res 47 (21), 11387-11402 (2019)
   PUBMED   31598710
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   Liu,Y., Zhao,L.W., Shen,J.L., Fan,H.Y. and Jin,Y.
  TITLE     Maternal DCAF13 Regulates Chromatin Tightness to Contribute to
            Embryonic Development
  JOURNAL   Sci Rep 9 (1), 6278 (2019)
   PUBMED   31000741
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Van Eynde,A., Nuytten,M., Dewerchin,M., Schoonjans,L., Keppens,S.,
            Beullens,M., Moons,L., Carmeliet,P., Stalmans,W. and Bollen,M.
  TITLE     The nuclear scaffold protein NIPP1 is essential for early embryonic
            development and cell proliferation
  JOURNAL   Mol Cell Biol 24 (13), 5863-5874 (2004)
   PUBMED   15199142
  REMARK    GeneRIF: NIPP1(-/-) embryos showed severely retarded growth at
            embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early
            embryonic lethality was not associated with increased apoptosis but
            correlated with impaired cell proliferation.
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Llorian,M., Beullens,M., Andres,I., Ortiz,J.M. and Bollen,M.
  TITLE     SIPP1, a novel pre-mRNA splicing factor and interactor of protein
            phosphatase-1
  JOURNAL   Biochem J 378 (Pt 1), 229-238 (2004)
   PUBMED   14640981
REFERENCE   8  (bases 1 to 2060)
  AUTHORS   Jin,Q., van Eynde,A., Beullens,M., Roy,N., Thiel,G., Stalmans,W.
            and Bollen,M.
  TITLE     The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1
            (NIPP1), interacts with the polycomb group protein, embryonic
            ectoderm development (EED), and functions as a transcriptional
            repressor
  JOURNAL   J Biol Chem 278 (33), 30677-30685 (2003)
   PUBMED   12788942
REFERENCE   9  (bases 1 to 2060)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2060)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY293277.1, AK032022.1 and BQ749177.1.
            
            On Mar 19, 2014 this sequence version replaced NM_146154.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025479.1, SRR1660817.121887.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               BY293277.1         2-292
            292-1960            AK032022.1         102-1770
            1961-2060           BQ749177.1         338-437
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.97 cM"
     gene            1..2060
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /note="protein phosphatase 1, regulatory subunit 8"
                     /db_xref="GeneID:100336"
                     /db_xref="MGI:MGI:2140494"
     exon            1..113
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1113
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear inhibitor of protein phosphatase 1; protein
                     phosphatase 1, regulatory (inhibitor) subunit 8"
                     /codon_start=1
                     /product="nuclear inhibitor of protein phosphatase 1
                     isoform 1"
                     /protein_id="NP_666266.1"
                     /db_xref="CCDS:CCDS18736.1"
                     /db_xref="GeneID:100336"
                     /db_xref="MGI:MGI:2140494"
                     /translation="MAAAVNSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIID
                     EKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLE
                     PHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEE
                     TELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPS
                     VGRFRNMVQTAVVPVKKKRMEGSGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSETGS
                     QPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVAINPTPNPAVYNPEAVNEPKKKK
                     YAKEAWPGKKPTPSLLI"
     exon            114..174
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..328
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..549
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..694
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..759
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..2042
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2042
                     /gene="Ppp1r8"
                     /gene_synonym="6330548N22Rik; NIPP1"
                     /note="major polyA site"
ORIGIN      
        1 gagctcttag tttcccggcg tgcttcagac ccgccaaatg ggagggggag acgcaagatg
       61 gcggcagccg tgaactccgg ctccagcctc ccgctgttcg actgcccgac ttgggcaggt
      121 aaaccaccac ctggcttaca tctggatgtg gtgaaaggag acaagctaat tgagaagctg
      181 attattgatg agaaaaagta ttacttattt gggaggaacc ccgatctgtg tgacttcact
      241 atcgaccacc agtcatgctc tcgagtccac gcagcgctgg tgtaccacaa acacctgaag
      301 agagttttct tgatagacct caacagcaca catggcactt tcttgggtca cattcggctg
      361 gaacctcaca agcctcaaca gattcccatc gattctacgg tctcatttgg cgcgtccacg
      421 agggcataca ctctgcgaga gaagcctcag acattgccat cggctgtgaa aggagatgag
      481 aagatgggcg gagaggatga tgaactcaag ggcttgttgg gacttcccga agaggagacc
      541 gagctggata acctgacaga gttcaacact gcccacaaca agcggatttc aaccctcact
      601 attgaggagg ggaacctgga catccagaga ccaaagagga agaggaagaa ctcaagggtg
      661 accttcagtg aggatgacga gatcatcaac ccagaggacg tggatccgtc tgttggtcgg
      721 ttccggaaca tggtgcagac agcagtggtt ccagtcaaga agaagcggat ggagggctct
      781 ggctctctgg gcctggagga gtcggggagc aggcgcatgc agaactttgc cttcagtgga
      841 ggactatatg ggggcctgcc ccccacacac agtgaaacgg gctcccagcc gcatggcatt
      901 catgggacag cgctcattgg tggcttgccc atgccatacc cgaacctcgc ccctgatgtg
      961 gacttgactc ctgttgtgcc atcagcagtg gccataaatc ccacaccaaa ccctgcagtc
     1021 tataaccctg aggctgtgaa tgaacccaag aagaagaaat acgcgaagga ggcttggccg
     1081 ggcaagaagc ccacaccttc cttactgatt tgatattttg gttatggaga gggtggggag
     1141 gggggtggag ggatgacaag gggagctact gaactaggga gaaaactttc catgtgtgca
     1201 gtatcgtctt tcagaaagtc tcctgaggtc ccaaccatgt aatactgaga ccaggggtgg
     1261 ggctaaagta ccagtaagga ctgagtcagg cagcttgaag tgtagagaga ggcttcccag
     1321 tcccttctga gccgactgtc ctggcgatgt ccctgtgcca cctattagga ctgttttatg
     1381 tgaagtcgct catgggaggc atctggagca atgagagggt agagcctcat tagttaatat
     1441 tcccttccct cgggagaccc aagtaacaga gcggttgcat ggataccagg ttggttgaca
     1501 ctgttcattt aaaccacagt aaacgagtgt cctcttgtgc ctgtggtttt gagatctaat
     1561 aggccattct gtgtcatgtc tggtggcatg aggccatttt gagttcccct catctgtagc
     1621 cagtgtcaca ggacaggcta atgggtttgt acagtattgt tggactttac ctatgtttct
     1681 tgtccacact gaaaactcat ttagttcgag tgcagcctcc tccctgtggc ctcactgttg
     1741 gtgtgtgccc tgaggcagtt cctggtgaac aggaagacta tactgcaagg accaggtgtg
     1801 tgttaggaga acacctcagt tttggtttgg aggctcctct cccctgaccc ccccctcacc
     1861 ccccatgaga gttcttcaga tctccagaat agacctggct aacaggagac aaggtaggaa
     1921 ccattgtacg agctttgtac agatttgtac atttgtgtaa taggcctttt ctgctttaag
     1981 tgtagctttt tacctgtaac ctttattaca ttgtaaatta aatgtaactt ttgtcaattg
     2041 ggaaaaaaaa aaaaaaaaaa
//
