LOCUS       NM_023200               3668 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 7 (Ppp1r7),
            mRNA.
ACCESSION   NM_023200 XM_489811
VERSION     NM_023200.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3668)
  AUTHORS   Goswami,S., Korrodi-Gregorio,L., Sinha,N., Bhutada,S.,
            Bhattacharjee,R., Kline,D. and Vijayaraghavan,S.
  TITLE     Regulators of the protein phosphatase PP1gamma2, PPP1R2, PPP1R7,
            and PPP1R11 are involved in epididymal sperm maturation
  JOURNAL   J Cell Physiol 234 (3), 3105-3118 (2019)
   PUBMED   30144392
  REMARK    GeneRIF: The three regulators (PPP1R2, PPP1R7, and PPP1R11)share
            localization with PP1gamma2 in the head and the principal piece of
            sperm. We show that the association of inhibitors to PP1gamma2
            changes during epididymal sperm maturation. In immotile caput
            epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2,
            whereas in motile caudal sperm, all three inhibitors are bound as
            heterodimers or heterotrimers.
REFERENCE   2  (bases 1 to 3668)
  AUTHORS   Chiang,D.Y., Alsina,K.M., Corradini,E., Fitzpatrick,M., Ni,L.,
            Lahiri,S.K., Reynolds,J.O., Pan,X., Scott,L. Jr., Heck,A.J.R. and
            Wehrens,X.H.T.
  TITLE     Rearrangement of the Protein Phosphatase 1 Interactome During Heart
            Failure Progression
  JOURNAL   Circulation 138 (15), 1569-1581 (2018)
   PUBMED   29669786
  REMARK    GeneRIF: Ppp1r7 may play a central role in regulating the PP1
            interactome by acting as a competitive molecular 'sponge' of PP1c
            during heart failure progression.
REFERENCE   3  (bases 1 to 3668)
  AUTHORS   Chiang,D.Y., Lebesgue,N., Beavers,D.L., Alsina,K.M., Damen,J.M.,
            Voigt,N., Dobrev,D., Wehrens,X.H. and Scholten,A.
  TITLE     Alterations in the interactome of serine/threonine protein
            phosphatase type-1 in atrial fibrillation patients
  JOURNAL   J Am Coll Cardiol 65 (2), 163-173 (2015)
   PUBMED   25593058
REFERENCE   4  (bases 1 to 3668)
  AUTHORS   Wurzenberger,C., Held,M., Lampson,M.A., Poser,I., Hyman,A.A. and
            Gerlich,D.W.
  TITLE     Sds22 and Repo-Man stabilize chromosome segregation by
            counteracting Aurora B on anaphase kinetochores
  JOURNAL   J Cell Biol 198 (2), 173-183 (2012)
   PUBMED   22801782
REFERENCE   5  (bases 1 to 3668)
  AUTHORS   Katschinski,D.M., Marti,H.H., Wagner,K.F., Shibata,J., Eckhardt,K.,
            Martin,F., Depping,R., Paasch,U., Gassmann,M., Ledermann,B.,
            Desbaillets,I. and Wenger,R.H.
  TITLE     Targeted disruption of the mouse PAS domain serine/threonine kinase
            PASKIN
  JOURNAL   Mol Cell Biol 23 (19), 6780-6789 (2003)
   PUBMED   12972598
REFERENCE   6  (bases 1 to 3668)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   7  (bases 1 to 3668)
  AUTHORS   Ceulemans,H., Van Eynde,A., Perez-Callejon,E., Beullens,M.,
            Stalmans,W. and Bollen,M.
  TITLE     Structure and splice products of the human gene encoding sds22, a
            putative mitotic regulator of protein phosphatase-1
  JOURNAL   Eur J Biochem 262 (1), 36-42 (1999)
   PUBMED   10231361
REFERENCE   8  (bases 1 to 3668)
  AUTHORS   Hashimoto,Y., Abe,M., Kiuchi,Y., Suzuki,A. and Yamakawa,T.
  TITLE     Genetically regulated expression of UDP-N-acetylgalactosamine:
            GM3(NeuGc) N-acetylgalactosaminyltransferase [EC 2.4.1.92] activity
            in mouse liver
  JOURNAL   J Biochem 95 (6), 1543-1549 (1984)
   PUBMED   6432773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031983.1 and AC124669.8.
            
            On Feb 1, 2019 this sequence version replaced NM_023200.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129024.1, AF222867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               AK031983.1         776-1314
            540-1001            AK031983.1         1316-1777
            1002-1002           AC124669.8         173442-173442
            1003-1481           AK031983.1         1779-2257
            1482-1482           AC124669.8         173922-173922
            1483-1792           AK031983.1         2259-2568
            1793-1793           AC124669.8         174233-174233
            1794-2734           AK031983.1         2570-3510
            2735-3668           AC124669.8         175175-176108
FEATURES             Location/Qualifiers
     source          1..3668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.24 cM"
     gene            1..3668
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /note="protein phosphatase 1, regulatory subunit 7"
                     /db_xref="GeneID:66385"
                     /db_xref="MGI:MGI:1913635"
     exon            1..84
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            85..216
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            217..272
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            273..338
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            339..469
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            470..632
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            633..749
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            750..854
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            855..941
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            942..3668
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1297..1302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /note="hexamer: ATTAAA"
     polyA_site      1328
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /note="major polyA site"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /note="hexamer: TATAAA"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
     polyA_site      3668
                     /gene="Ppp1r7"
                     /gene_synonym="2310014J01Rik; SDS22"
ORIGIN      
        1 gacagattcc ggaaagggaa agagcagcca atatggcggc agagcgcggc gcggggcagc
       61 aacagtcgca ggagatgatg gaggttgaca ggcgggttga atctgaagaa tcaggtgatg
      121 aggaagggaa gaagcatggt ggcggcggca tcgtggcaaa cctcagcgag cagagcctga
      181 aggatggagt agatcggggt gcagaagacc cagaagagga acatgagctg gcagtagata
      241 tggaaaccat caacctggac cgagatgcag aggatgttga tctgactcac tatcgaattg
      301 gaaagattga aggcttggag gtgctaaaga aagtgaagtc actctgcctt cgtcaaaacc
      361 taattaaatg cattgaaaac ctggaagaac tgcagagtct tcgagaactg gatctctatg
      421 ataatcagat caagaagatt gagaatcttg aggcactgac agaattggag gttctagata
      481 tttcttttaa tatgctgagg aacattgaag ggattgacaa actgacacag ctgaaaaaac
      541 tcttcttggt caacaataaa atcaataaaa ttgagaacat aagcaattta catcaactgc
      601 aaatgttgga gctggggtct aaccggattc gggcaattga aaatatcgac acattaacca
      661 acctggagag tttgtttctg gggaaaaaca aaattacaaa acttcagaac ctggatgcac
      721 ttaccaacct gacagtcctc agtgtgcaga gcaaccggct agcaaagatc gaaggtctac
      781 agagcttggt gaacctgcgg gaactatacc tcagcaacaa tggtatcgag gttatcgagg
      841 gcctggagaa caacaacaaa ctcaccatgt tggatattgc atcaaataga ataaaaaaga
      901 ttgagaatat cagccatctg acagaactgc aagaattctg gatgaatgac aatctactgg
      961 agagctggag tgaccttgat gagctgaagg gtgccaggag tctggagacc gtgtacctgg
     1021 agcgcaaccc cctgcagaag gatccacaat accggcggaa ggtcatgctg gccttaccct
     1081 ctgtgcggca gatcgacgcc acatacgtca ggttctgagc cctccttgct cctcacctgg
     1141 tccctctcct caaaagaact tcccagccac ggttttttaa tctacctatt gctcctgatg
     1201 tcgtcactat accaacagtc acaacccaat ggcaataata aggcactggt ggcacctggc
     1261 ctgtgatgct acacaccatt tggagatgcc aacactatta aatcttgcca cgcggtcttc
     1321 ctggtgaatt gatgaaagtt attgtagcca tggagagaat gcaggccttg ttgcagtcat
     1381 ttgctcttcc aatccgtcta tgtccttacc ttggtgggca ttctgggctg ccccagcaga
     1441 ccttcaagtt ggtttaagta gtcatgactc acaagagcac actggatagt ctttcagacc
     1501 aattttggaa agaaaaaaat tttccttgca aattttaaaa aagaaaagat tatatttaat
     1561 ttttttttga gtaaaagatg gcccaatgtc tgaagctgta atcctcagtg cccttccaac
     1621 atgagcgacg gctgagcaca gcacactggg cactctgtgc ccttattccc acttggtaaa
     1681 agctggaata tggagagctt cgctccctat cacccagcta tgttaaacct aagtgattat
     1741 cagaaacgtc cacccctgaa ctcttggcca ctgggcactg gtcatggctc ctgttctcac
     1801 ccacgtcctc tggccttatt tagatgaagt ttctatgagc aaactcccag ggtgtaagtc
     1861 taatgctgca agagcactgt cctccccacg cctccgactt cctctttcac acagtgagaa
     1921 ctaactgtgg tcaccaaagg cccctgagct tccagggttc tagttctacg ctgtcccaga
     1981 tggggccact aactgccaca tgtagcaatt gctattcata tctaatccat tggatttatt
     2041 catctcttca tctgtgctca cactttatct gctcagaggc cacatatcat ggaaggtatc
     2101 cattcctatc atcccagaag gttctggaaa atgctgctct agactgttta gtattagtga
     2161 aatagcttgc tctgaactga gaagcatgtg cccaggtgtc caagctaacc agtaggccaa
     2221 ctgcccagga gttcgcaatg tcagaatggc tacatgaggt ttaacaagaa actgtgtgat
     2281 ctcaatctgt gcaccatctc cctgacaaga aataagctct tagcaaggaa cactgggtgc
     2341 agcaaggtgc agcccagaga acactgtgct gtaaccctgg aatcgttcca agcaccattc
     2401 acgtcagaat aagagaaaaa catcttagac ccacaggact gaaatgtagg tgtgcctgct
     2461 gcagtcactc acaggagccc tacacacgtg cacgtggctt ctacagagtg tagagagaga
     2521 agtaatggag tgggagaaca ggcatcaaaa ccccagtgcc atctcaagga ggtccctgca
     2581 gcattcagtt gggggaaatg tctccaaatg aattggaatt ctggagttag gaaaaaatgc
     2641 caaaaaatta ttccttaaaa caggtctagg tcccaggaag aatttccaga atctagcact
     2701 ggctgagtcc cagttgtgat aatagaaaat gcccctaaaa gtcgtctgct tggttggttg
     2761 gtttggtttg gtttttttcc atacagggtt tctctgtgta gccctggctg tcctggaact
     2821 cactctgtag accaggctgg cctcgaactc agaaatccgc ctgcctctgc ctcccaagtg
     2881 ctgggattaa aggcatgcgc taccaccacc tggcacccct aaaaatctta acaaatacag
     2941 tacagaagta aaaacactgc ttttacataa gaacataaat gcaaaggtct gaaatcaaag
     3001 atcagcaaat caaagactac tgattcttca ccaagaaggt tttatctcag gaataaatgc
     3061 agggatggtt taagagcaga caggactggc cggggtgcag gcctgtaata ccagccactc
     3121 aggaggctga gggaagagga tgaaaagtta aagcatgcct tagcaacagg gtgaaattga
     3181 ggccagcctg ggcaacgtaa tgaaaccctt tcaaagagta acaatggggc tgcgaggata
     3241 gctgaagaat agaatacctg cctagcttgt agaggaccct gggttcaatt cctaataagg
     3301 ggaagaaaag taagcagaac cagaatttac ataaatcacc acttagtgca gtaaaagaaa
     3361 aaaataccaa ttaatgttat aaagattcaa ttgtatatat tcctggattt cttttcaagg
     3421 aaaaagcatt attgtcatta gcactatgca tgatgtctga atgtggttgt gggcacacgt
     3481 gtgctgtggc acagcatgtg aacctcaaag ggcagatttg tagagttggt tctccttcat
     3541 gtgagttctg ggaattgaac ttaggttgtc aggcttatgc agcaagcaat ttccctgtta
     3601 aaccatccca tcagttctgt attcctggat ttttatttct ttataaataa aaagatgtct
     3661 taaaggtt
//
