LOCUS       NM_145692               1427 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 42
            (Ppp1r42), transcript variant 2, mRNA.
ACCESSION   NM_145692
VERSION     NM_145692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Wang,R. and Sperry,A.O.
  TITLE     PP1 forms an active complex with TLRR (lrrc67), a putative PP1
            regulatory subunit, during the early stages of spermiogenesis in
            mice
  JOURNAL   PLoS One 6 (6), e21767 (2011)
   PUBMED   21738792
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Wang,R., Kaul,A. and Sperry,A.O.
  TITLE     TLRR (lrrc67) interacts with PP1 and is associated with a
            cytoskeletal complex in the testis
  JOURNAL   Biol Cell 102 (3), 173-189 (2010)
   PUBMED   19886865
  REMARK    GeneRIF: Our finding that TLRR is associated with microtubules in
            cultured cells suggests that TLRR may play a common role in
            modulating the cytoskeleton in other cell types besides male germ
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Wang,R. and Sperry,A.O.
  TITLE     Identification of a novel Leucine-rich repeat protein and candidate
            PP1 regulatory subunit expressed in developing spermatids
  JOURNAL   BMC Cell Biol 9, 9 (2008)
   PUBMED   18237440
  REMARK    GeneRIF: Identification of a previously uncharacterized
            leucine-rich repeat protein that is expressed abundantly in the
            testis.[TLRR; NM_027033.1, NM_145692.1]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 4930418G15Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076637.1 and AV253491.1.
            
            On Mar 19, 2014 this sequence version replaced NM_145692.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076637.1, BC022722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1417              AK076637.1         2-1418
            1418-1427           AV253491.1         258-267
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.25 cM"
     gene            1..1427
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="protein phosphatase 1, regulatory subunit 42"
                     /db_xref="GeneID:69312"
                     /db_xref="MGI:MGI:1921138"
     exon            1..65
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            66..284
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1229
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="leucine rich repeat containing 67; testis
                     leucine-rich repeat protein"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 42"
                     /protein_id="NP_663730.1"
                     /db_xref="CCDS:CCDS14817.1"
                     /db_xref="GeneID:69312"
                     /db_xref="MGI:MGI:1921138"
                     /translation="MVRLTVDLIAKNSNLKPRKEETLAQCLKKITHINFSDRNIDSID
                     DLSLCRNLSVLYLYDNRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLG
                     GNYIAVIEGLEGLEELRELHVESQRLPLGEKLLFDPRTLRSLAKSLSTLNISNNNIDD
                     IKDLEILENLNHLIAVDNQLMHVKDLELLLKKLMKLWKMDLNGNPVCLKPKYRDKLIL
                     TSKSLEFLDGKEIKDMERQFLMNWKASKDAKKISKKRRSRSEDASNSYISNFETVHHI
                     VPVYYPQVGKPKVIFFSDVQRYLVHGNASSKCSQEDKTTITEDIGNLSLKESESSLTK
                     NDIHEPHLLQNPKVKENLSEKKE"
     exon            285..451
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            452..590
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            591..707
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            708..825
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            826..957
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1117
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1427
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="hexamer: AGTAAA"
     polyA_site      1230
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="major polyA site"
     regulatory      1402..1407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /note="major polyA site"
ORIGIN      
        1 ggctttggag gagcctggca caaggacact gaccaaacca gttacagacc cgactggaca
       61 gagcgctttt tgaaagtgga agtaatatct aagcctgctt ctggacatgc tgtcaaagtg
      121 gagttctcgc tgagagtttg acttatgcag aaacaatggt tcgactgacg gtggatttaa
      181 ttgccaaaaa cagcaatctt aaacccagaa aagaagagac ccttgcacaa tgcctgaaga
      241 aaataacaca cataaatttc tcagacagaa atatagactc gattgatgac ctctctcttt
      301 gcagaaacct gagtgtttta tatttatatg ataatcgcat tagtcaagtc actaacctga
      361 attacaccac aaatctgacc cacttgtacc tacagaacaa ttgcatttcc tgcattgaaa
      421 acctcagttc actaaagaaa ttggaaaaac tgtatctggg aggcaattac attgcggtca
      481 tagaaggctt ggaaggatta gaagaactaa gagagcttca tgttgaaagt cagaggctcc
      541 ctctaggcga aaagcttctg tttgatccaa gaactcttcg ttctctagcg aaatccctct
      601 ctactttgaa tatcagcaac aataacattg atgacataaa agacttagag atcttggaga
      661 atcttaatca cctgattgca gttgacaacc agctgatgca cgtgaaggac ttggagcttt
      721 tactgaaaaa actgatgaag ctgtggaaaa tggatctaaa tggaaatcct gtttgtctta
      781 aaccaaaata cagggacaaa ctgatactga cgtccaagtc actggaattt cttgatggaa
      841 aagaaataaa agatatggaa agacaattcc taatgaattg gaaagcatcc aaagatgcca
      901 agaaaatcag caagaaaagg aggagcagaa gtgaggatgc aagcaactcc tatataagta
      961 actttgaaac agtacatcac atagttcctg tttattaccc acaggtgggt aagccaaaag
     1021 taatcttctt ctccgatgta cagagatatc ttgtacatgg aaatgcatct tcaaaatgtt
     1081 cccaagaaga taaaactaca attactgaag acatagggaa tctgtccttg aaggaatctg
     1141 aaagctcgct aacaaaaaac gatatccatg aacctcacct tctccaaaat ccaaaagtaa
     1201 aggaaaattt gtctgagaaa aaggagtaaa ttcagcctcg agtgatttga tttcttcata
     1261 gaactaggca acagcatgtt ttgagggttt gtggacttca cttatctcgg tgtgtaagtt
     1321 gtttgatttg tttctttata gaatctgaga ctttgcttta tgtgcgtgaa ttctgggatc
     1381 tatttacttt attagctatt aaataaaatt tgccaggaaa taaaatg
//
