LOCUS       NP_663730                357 aa            linear   ROD 26-JUN-2024
DEFINITION  protein phosphatase 1 regulatory subunit 42 [Mus musculus].
ACCESSION   NP_663730
VERSION     NP_663730.1
DBSOURCE    REFSEQ: accession NM_145692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 357)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 357)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 357)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 357)
  AUTHORS   Wang,R. and Sperry,A.O.
  TITLE     PP1 forms an active complex with TLRR (lrrc67), a putative PP1
            regulatory subunit, during the early stages of spermiogenesis in
            mice
  JOURNAL   PLoS One 6 (6), e21767 (2011)
   PUBMED   21738792
REFERENCE   5  (residues 1 to 357)
  AUTHORS   Wang,R., Kaul,A. and Sperry,A.O.
  TITLE     TLRR (lrrc67) interacts with PP1 and is associated with a
            cytoskeletal complex in the testis
  JOURNAL   Biol Cell 102 (3), 173-189 (2010)
   PUBMED   19886865
  REMARK    GeneRIF: Our finding that TLRR is associated with microtubules in
            cultured cells suggests that TLRR may play a common role in
            modulating the cytoskeleton in other cell types besides male germ
            cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 357)
  AUTHORS   Wang,R. and Sperry,A.O.
  TITLE     Identification of a novel Leucine-rich repeat protein and candidate
            PP1 regulatory subunit expressed in developing spermatids
  JOURNAL   BMC Cell Biol 9, 9 (2008)
   PUBMED   18237440
  REMARK    GeneRIF: Identification of a previously uncharacterized
            leucine-rich repeat protein that is expressed abundantly in the
            testis.[TLRR; NM_027033.1, NM_145692.1]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 357)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 4930418G15Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076637.1 and AV253491.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076637.1, BC022722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.25 cM"
     Protein         1..357
                     /product="protein phosphatase 1 regulatory subunit 42"
                     /note="leucine rich repeat containing 67; testis
                     leucine-rich repeat protein"
                     /calculated_mol_wt=41020
     Region          27..246
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cd21340"
                     /db_xref="CDD:411060"
     Region          29..50
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          31..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          51..72
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          73..94
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          74..95
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          95..116
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          96..147
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          117..138
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          147..168
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          148..169
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          169..190
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     Region          329..357
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1Z4.1)"
     CDS             1..357
                     /gene="Ppp1r42"
                     /gene_synonym="1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR"
                     /coded_by="NM_145692.2:156..1229"
                     /db_xref="CCDS:CCDS14817.1"
                     /db_xref="GeneID:69312"
                     /db_xref="MGI:MGI:1921138"
ORIGIN      
        1 mvrltvdlia knsnlkprke etlaqclkki thinfsdrni dsiddlslcr nlsvlylydn
       61 risqvtnlny ttnlthlylq nnciscienl sslkklekly lggnyiavie glegleelre
      121 lhvesqrlpl gekllfdprt lrslakslst lnisnnnidd ikdleilenl nhliavdnql
      181 mhvkdlelll kklmklwkmd lngnpvclkp kyrdklilts kslefldgke ikdmerqflm
      241 nwkaskdakk iskkrrsrse dasnsyisnf etvhhivpvy ypqvgkpkvi ffsdvqrylv
      301 hgnasskcsq edkttitedi gnlslkeses sltkndihep hllqnpkvke nlsekke
//
