LOCUS       NM_001290574            3499 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 3F
            (Ppp1r3f), transcript variant 1, mRNA.
ACCESSION   NM_001290574 XM_006527685
VERSION     NM_001290574.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Kelsall,I.R., Voss,M., Munro,S., Cuthbertson,D.J. and Cohen,P.T.
  TITLE     R3F, a novel membrane-associated glycogen targeting subunit of
            protein phosphatase 1 regulates glycogen synthase in astrocytoma
            cells in response to glucose and extracellular signals
  JOURNAL   J Neurochem 118 (4), 596-610 (2011)
   PUBMED   21668450
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B.,
            Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and
            Ramsdell,F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731793.18.
            
            On Feb 3, 2022 this sequence version replaced NM_001290574.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059275.1, SRR10662774.675442.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1055              AL731793.18        137469-138523       c
            1056-1108           AL731793.18        128457-128509       c
            1109-1188           AL731793.18        128083-128162       c
            1189-3499           AL731793.18        122797-125107       c
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.4 cM"
     gene            1..3499
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /note="protein phosphatase 1, regulatory subunit 3F"
                     /db_xref="GeneID:54646"
                     /db_xref="MGI:MGI:1859617"
     exon            1..1055
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2457
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1, regulatory (inhibitor) subunit 3F"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3F
                     isoform 1"
                     /protein_id="NP_001277503.1"
                     /db_xref="CCDS:CCDS72328.1"
                     /db_xref="GeneID:54646"
                     /db_xref="MGI:MGI:1859617"
                     /translation="MARTAPVEPPLRHPAPPSPAAGEPRASAEAAVAPRRVLFADEAL
                     GLPLAQLRRYRPWGGPGAGKMAAATGQDGGGGGADEEDDGEDGDEGEEEEEAFPDPSP
                     PCPVPAGGGFYLVPTFSLPPALGRLERLGRVMVELEALLPPPGAVPGGSGVWVPGGRP
                     PVVRGLVRVLNRSFEKAVHVRASHDGWATFCDHPARYVPRSPPGAGVGGTGAGDPLLD
                     PGLGLGPGQMSASSPDDGGCTDRFAFQLPFAEGASDGARLDFVVRYETPEGTFWANNH
                     GRNYTVLLRIAPAPTPTDAEGLPQQQQLQQLEPQPECQGPVEAEARQLKSCMKPVRRR
                     PFEEEPRMRSADDNTLAEHPDVRESLGPLLAPTPLRPWPQMTLQQVPEVMLTSNPQEE
                     GDIPRSNPPVAFTEVRQAPAIRILPATCGLGGPPRDQASGPDASDRAAGSFLEPTQQQ
                     VEAAWESGGGRKAPMVGALTDEPARGLEIVSGLDELLGEDTIDQELEQLYLSHLSRLR
                     AVAAAGGGEGTSPTHALGILTDRDLILKWPGPERALNSALAEEITLHYARLGCGVELI
                     KDTEDPDDEGEGEDGLSITPSSPEGGSPKESPPEILSGARSVIATMGDVWVPWAERSS
                     SRCDSPVVLGTQGQFTENPEKGMGKDTKSLHLNRVIVGMSKSPGEAGTESQMEELPTE
                     RESSWVPSSEKELPLPVQQEQSPALLGPTGTEVCLSSVAKPHVNSQEEEGGSLNLESP
                     KRSPMPAAPAECACGLAPQLWGPLTQTLGVLAGLVMVPVALNSGVSLLVLVLCLSLAW
                     FS"
     exon            1056..1108
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1188
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..3499
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /note="hexamer: AATATA"
     polyA_site      3123
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /note="major polyA site"
     regulatory      3476..3481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
                     /note="hexamer: AATAAA"
     polyA_site      3499
                     /gene="Ppp1r3f"
                     /gene_synonym="DXImx48e; R3F; RF3; Sfc15"
ORIGIN      
        1 gcccccgccg gtcccaccgc cggtgccgtc ggtgccgccg ccgccgccgc cgatatggcg
       61 cgcacggccc ctgtggagcc accgctgcgg catcccgcgc ccccgtcgcc ggctgcggga
      121 gagccccgcg cctcggctga ggcggcggtg gccccgcgga gggtgctgtt cgctgacgag
      181 gccctggggc tgcctctggc gcagctacgc cgctaccggc cgtggggcgg gcccggggcg
      241 ggcaagatgg cggcggcgac cgggcaagat ggcggcggtg gcggggctga tgaggaagac
      301 gatggcgagg atggggatga aggggaggag gaagaggagg cttttcccga tccctctccg
      361 ccgtgccccg ttcccgctgg cggggggttt tacctggtgc ccacattttc gttgccgccc
      421 gcgctgggcc gtctggagcg gttggggcgc gtgatggtgg agttggaggc gctgctgccg
      481 cctcctggag cggttcccgg gggttccggg gtgtgggtgc ctgggggacg cccgccagtg
      541 gtgcgcgggt tggtgcgcgt gctgaaccgc tccttcgaga aggcggtgca cgtgcgggcc
      601 tcacacgacg gttgggctac cttctgcgac cacccagccc gctatgtccc acgcagcccg
      661 cctggggcag gagtgggagg aacaggagca ggagatcccc tcctggatcc cgggctaggc
      721 ctgggccctg gccagatgtc agcctcctca cccgacgacg gtggctgcac tgaccgcttt
      781 gccttccagc tgccctttgc tgagggcgcg agcgatgggg cgcgcctcga cttcgtggtg
      841 cgctatgaga cccccgaggg cactttctgg gccaacaacc atggccgcaa ctacactgtc
      901 ctgctccgga tcgcacccgc tcccacaccc actgatgccg aagggctgcc ccagcagcag
      961 cagctgcagc agctggagcc acagcctgag tgccagggtc ctgtggaggc tgaggccagg
     1021 cagctgaaga gctgcatgaa gccggtgagg cgcaggcctt ttgaagaaga gccaaggatg
     1081 aggagtgcgg acgataatac cctagcagaa catcctgatg ttcgagagtc actaggtccc
     1141 ctgttggccc ctacccctct ccgtccatgg ccccagatga cacttcagca ggtgcccgaa
     1201 gttatgttga ccagcaaccc tcaagaagaa ggtgacatcc ccagaagcaa cccacctgtg
     1261 gcttttacag aggtccgcca ggcacctgcc atcaggattc ttccagcaac ctgtggcctg
     1321 ggtggccccc caagggacca ggcctcaggg cccgatgcaa gtgatagagc tgctggctcc
     1381 ttcctggaac ccacccagca gcaggtggag gctgcgtggg aaagtggagg gggtcgaaag
     1441 gcccctatgg taggggctct gacagatgag cccgccaggg gtctggagat tgtgagtggc
     1501 ttggatgagt tgcttggtga agacaccatt gaccaggagt tggagcagct ctacctgtct
     1561 cacctgagcc gcttgagagc tgtggcagcg gcgggtggcg gggaaggcac ttcccccact
     1621 catgccctgg gcatactcac agaccgtgac ctgatcttga agtggcctgg ccccgagagg
     1681 gccctgaaca gtgctctggc cgaggagatc acgctgcact atgcgcgcct gggctgtggc
     1741 gtggagctca tcaaggacac tgaagaccca gatgacgagg gggagggtga agatgggctc
     1801 tccatcactc cttctagccc tgaagggggc agccctaagg aatcgcctcc agaaatcctc
     1861 tctggagccc gctctgtgat agctactatg ggagatgtgt gggttccatg ggcagagcgc
     1921 tctagctcta gatgtgatag cccagtggtt ctgggaacac agggtcagtt cactgagaat
     1981 ccagagaaag ggatgggcaa ggacaccaag tctctgcacc tgaatagggt aatagttggg
     2041 atgagcaagt cccctgggga ggctgggacg gaaagccaga tggaggagct acctactgag
     2101 cgggaaagca gctgggtacc tagttctgag aaagagctgc ctctaccagt ccagcaagag
     2161 cagagtcctg ccctccttgg tcccacaggg actgaagtct gtctgtctag tgtagccaag
     2221 cctcatgtga actcccagga agaagagggt ggaagcctga atcttgagtc cccaaagagg
     2281 tctcccatgc cagcggcccc tgcagaatgt gcgtgtgggt tggctcctca gctctggggg
     2341 cccttgaccc aaactttggg tgtactggct gggctcgtta tggtccccgt ggctttgaac
     2401 agcggtgtgt cccttctggt gctggtgctg tgcctctctc tggcctggtt ctcgtagggg
     2461 ctgccgggag ggttaggttc caacagcagg tttcctcctc tctgggatct ggagattgac
     2521 agtccctctg tcaccccaga gtgttgagat gagacccagg gcctgtggag tgagggactt
     2581 tgattttgag agtgcttgac tggagagagg ccttcccatc tctgagctct ccagccagaa
     2641 gcaggcttcc tgcagtagta tttgtggagt ggaatacaat ggtggatggt gtgagaaatt
     2701 ttagaatgga accaggcatg cccccccccc acctacccaa cccaagcctg tatttatttt
     2761 tgtataattc tctggatgag ggagagtggt catgagctgg tcttggggca caattaccca
     2821 gagatatatt tattaacaac caacctgtgc aacctgctgg agctttattt ttaatttaat
     2881 ttatatagag tacatattat tatatgccac aatagagctc tatgagaaat gatgtgtctt
     2941 gctgtgctgg tctcctgttt gggcctgagt gtatagggta gtcacattct ggggaatggc
     3001 tgtggtccat gttgggagag aagatggcca cggccatacc tactgctgcc tcttcaatgt
     3061 gtccttgagg atctgtatct ctttgccttg tggtcctaat atatgtggtc ctttggtcgt
     3121 gcatattttg tctgggagcc tgtgtctgtg tatatgggtg gtttcggtgg gagccgagag
     3181 gaaggattgg ttttagtcat gcggctgagg tggtggctat gctcagctgt aggtatggag
     3241 gcatggatta gcgacaaggt ttggaggtga ctgcagcttt tgacactagc agggagaccc
     3301 ctgaaacccc taaatgggga aggccccaga aaggagttaa tgtactgtga aaaaatttgt
     3361 atcaggtttg ttgtccccag acattgcatt tctactccaa acaggatacc cagaagcttt
     3421 aaaagaaagg ttagatacat ttattgcatg caaataaaaa ctcttggcat agcaaaataa
     3481 aacacaatat atttattta
//
