LOCUS       NM_016854               2696 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 3C
            (Ppp1r3c), mRNA.
ACCESSION   NM_016854
VERSION     NM_016854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Nitschke,S., Sullivan,M.A., Mitra,S., Marchioni,C.R., Lee,J.P.Y.,
            Smith,B.H., Ahonen,S., Wu,J., Chown,E.E., Wang,P., Petkovic,S.,
            Zhao,X., DiGiovanni,L.F., Perri,A.M., Israelian,L., Grossman,T.R.,
            Kordasiewicz,H., Vilaplana,F., Iwai,K., Nitschke,F. and
            Minassian,B.A.
  TITLE     Glycogen synthase downregulation rescues the amylopectinosis of
            murine RBCK1 deficiency
  JOURNAL   Brain 145 (7), 2361-2377 (2022)
   PUBMED   35084461
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Keinan,O., Valentine,J.M., Xiao,H., Mahata,S.K., Reilly,S.M.,
            Abu-Odeh,M., Deluca,J.H., Dadpey,B., Cho,L., Pan,A., Yu,R.T.,
            Dai,Y., Liddle,C., Downes,M., Evans,R.M., Lusis,A.J., Laakso,M.,
            Chouchani,E.T., Ryden,M. and Saltiel,A.R.
  TITLE     Glycogen metabolism links glucose homeostasis to thermogenesis in
            adipocytes
  JOURNAL   Nature 599 (7884), 296-301 (2021)
   PUBMED   34707293
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Lopez-Soldado,I., Guinovart,J.J. and Duran,J.
  TITLE     Increased liver glycogen levels enhance exercise capacity in mice
  JOURNAL   J Biol Chem 297 (2), 100976 (2021)
   PUBMED   34284060
  REMARK    GeneRIF: Increased liver glycogen levels enhance exercise capacity
            in mice.
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Hu,W., Dong,A., Karasaki,K., Sogabe,S., Okamoto,D., Saigo,M.,
            Ishida,M., Yoshizumi,M. and Kokubo,H.
  TITLE     Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac
            differentiation
  JOURNAL   Sci Rep 11 (1), 3588 (2021)
   PUBMED   33574455
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Greenberg,C.C., Danos,A.M. and Brady,M.J.
  TITLE     Central role for protein targeting to glycogen in the maintenance
            of cellular glycogen stores in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 26 (1), 334-342 (2006)
   PUBMED   16354703
  REMARK    GeneRIF: These data indicate that disruption of PTG expression
            resulted in the uncoupling of PP1 activity from glycogen
            metabolizing enzymes, the enhancement of glycogenolysis, and a
            dramatic decrease in cellular glycogen levels.
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Greenberg,C.C., Meredith,K.N., Yan,L. and Brady,M.J.
  TITLE     Protein targeting to glycogen overexpression results in the
            specific enhancement of glycogen storage in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 278 (33), 30835-30842 (2003)
   PUBMED   12805359
  REMARK    GeneRIF: PTG overexpression in 3T3-L1 adipocytes discretely
            stimulates PP1 activity against glycogen synthase and
            phosphorylase, resulting in a marked and specific increase in
            glucose uptake and storage as glycogen.
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Crosson,S.M., Khan,A., Printen,J., Pessin,J.E. and Saltiel,A.R.
  TITLE     PTG gene deletion causes impaired glycogen synthesis and
            developmental insulin resistance
  JOURNAL   J Clin Invest 111 (9), 1423-1432 (2003)
   PUBMED   12727934
  REMARK    GeneRIF: These data suggest that PTG plays a critical role in
            glycogen synthesis and is necessary to maintain the appropriate
            metabolic balance for the partitioning of fuel substrates between
            glycogen and lipid.
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   O'Doherty,R.M., Jensen,P.B., Anderson,P., Jones,J.G., Berman,H.K.,
            Kearney,D. and Newgard,C.B.
  TITLE     Activation of direct and indirect pathways of glycogen synthesis by
            hepatic overexpression of protein targeting to glycogen
  JOURNAL   J Clin Invest 105 (4), 479-488 (2000)
   PUBMED   10683377
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Printen,J.A., Brady,M.J. and Saltiel,A.R.
  TITLE     PTG, a protein phosphatase 1-binding protein with a role in
            glycogen metabolism
  JOURNAL   Science 275 (5305), 1475-1478 (1997)
   PUBMED   9045612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054739.1.
            
            On Jun 3, 2007 this sequence version replaced NM_016854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054739.1, BC052769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 31.89 cM"
     gene            1..2696
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /note="protein phosphatase 1, regulatory subunit 3C"
                     /db_xref="GeneID:53412"
                     /db_xref="MGI:MGI:1858229"
     exon            1..52
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..992
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 5; protein phosphatase 1 binding protein PTG;
                     protein phosphatase 1, regulatory (inhibitor) subunit 3C;
                     PP1 subunit R5; protein targeting to glycogen; protein
                     phosphatase 1 regulatory subunit 5; protein targeting to
                     glicogen"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3C"
                     /protein_id="NP_058550.1"
                     /db_xref="CCDS:CCDS37968.1"
                     /db_xref="GeneID:53412"
                     /db_xref="MGI:MGI:1858229"
                     /translation="MSCTRMIHVLDPRPLTSSVMPVDMAMRICLAHSPPLKSFLGPYN
                     GFQRRNFVNKLKPLKPCLSVKQEAKSQSEWKSPHNQAKKRVVFADSKGLSLTAIHVFS
                     DLPEEPAWDLQFDLLDLNDISSSLKLHEEKNLVFDFPQPSTDYLSFRDRFQKNFVCLE
                     NCSLQDRTVTGTVKVKNVSFEKKVQVRITFDTWKTYTDVDCVYMKNVYSSSDSDTFSF
                     AIDLPRVIPTEEKIEFCISYHANGRIFWDNNEGQNYRIVHVQWKPDGVQTQVAPKDCA
                     FQQGPPKTEIEPTVFGSPRLASGLFPEWQSWGRVENLTSYR"
     exon            53..2676
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /note="hexamer: AATAAA"
     polyA_site      2676
                     /gene="Ppp1r3c"
                     /gene_synonym="Ppp1r5; PTG"
                     /note="major polyA site"
ORIGIN      
        1 gggtgcggtt gtcgcggtcg ccgctgcctc tcggtccaat gagctgcacc agaatgatcc
       61 atgtgctaga tccacgtcct ttgacaagtt ccgtcatgcc cgtggacatg gccatgagga
      121 tttgcttggc tcattcacca cctctgaaga gtttcctggg tccttacaat ggttttcaac
      181 gaagaaattt tgtgaataaa ttgaaacctt tgaaaccatg tctcagtgtc aagcaggaag
      241 ccaaatcgca gagtgagtgg aagagcccac acaaccaagc caagaagcgg gtcgtgtttg
      301 cggactccaa ggggctgtca ctcactgcta tccatgtctt ctccgacctt ccagaagaac
      361 cagcgtggga cctgcagttt gatctcttgg accttaacga tatctcctcc agcttaaaac
      421 ttcacgagga gaaaaatttg gtttttgatt ttccccagcc ctcaaccgac tacttaagtt
      481 tccgggaccg ctttcagaag aactttgtct gcctcgagaa ctgctctttg caagatcgga
      541 cggtgaccgg gacagtgaaa gtgaagaatg tgagctttga gaagaaggtt caggtccgga
      601 tcacctttga cacctggaaa acctacacag atgtggactg tgtctacatg aagaatgttt
      661 acagcagctc agacagcgac accttctcct ttgccatcga cttgccccgt gtcattccaa
      721 ctgaggagaa aattgagttc tgcatttctt atcacgctaa tgggaggatc ttctgggaca
      781 acaatgaggg tcagaattac agaattgtcc atgtgcaatg gaaacctgac ggagtgcaga
      841 ctcaggtggc acccaaagac tgtgcattcc aacaggggcc ccctaagact gagatagagc
      901 ccacagtctt tggcagtcca aggcttgcta gcggcctctt cccagagtgg cagagctggg
      961 ggagagtgga gaacttgacc tcctatcgat gagttaggca atctacacac tgcccttgtc
     1021 tgatcataat cctcatgcaa ttctagatct gtattgctca atattaggaa gtcgtagtta
     1081 ctttctatca gtagatttag gtatgagctg ttggggcctg gctatagaag ctatagctac
     1141 ttgagaattc attgttgggg gtttttgagg gtgatgccac cagctttgtt ctgaaggatc
     1201 aaggacagcc tgggaactag ttttatacaa gcgacacctt tttttgggag gtgcatcatt
     1261 tccctctcag ttcaccagct ttcactttga ccaaggaaag gtttgaggac tgttgatggt
     1321 gatggaacgc tgtggtaagg gtgtgaggaa tgtgaaatgt atatgccgag ggctcgagtc
     1381 agcggaggag ccatggttaa gtggatatta agccattggt gggaacacat aaagttatct
     1441 tgtgtttcag aatgggttct gcaggcttct cctgaggaaa tagctcaaag atgggaaaga
     1501 aatccattct atgcatcctt gtataggaaa ataaaaggat gttggatggt actgggggag
     1561 aagatgaact gaagaatcaa gatcttgagg gctagagatg tagctcagtt ggtagtgtgc
     1621 ttgcctcgca tgcatgaaga cctgggttcc aggtctagca tcatacagct gggggtggca
     1681 gcacatgcct ctaatcccag tatgttatag ggaaggcaga ggcaggagga ttagaaatcc
     1741 aaggtcatcc ttggcacaca gaaagttgga ggctagcttg ggctagtcaa gtccctgtct
     1801 caaggaaatg atgatatcaa aagatctcaa gtgaatcctt tcagtttaaa catggtctac
     1861 caggaaccat gttttagaga gtgttgaagc acatctggct ttgcattctt aattggataa
     1921 gcggctttgt gatgaaggca tcactcttgg gttcttgcta cagaatgctg cctgacatca
     1981 ggcatgttgt caccagtgac tagcagcatg tagggactcc acatcgtgtc aaagagagct
     2041 ctttcagtgc ctccattaaa ccacaacact gtagctgttt aaaccagtta cctgaatgct
     2101 catctaataa ctcatgaatg tttaggacct tatttgaagg tctattcact ggtgtccttc
     2161 tgaaatcatc aggagggcca tcagtgtaca caactcacgt ccttcatatt gaaggtgact
     2221 catctttctg ccacactttt tcaatgtgac atttgaagtg gggactgaca ccagagtctc
     2281 aatgcaagaa tccaggacct tgcacatgaa agtatcggtc tatctcgtgc ctaattttgt
     2341 cttgctgttt taatttctag tcaaaatgct tttaaaaagt gtagatatga attattttga
     2401 atgtgaactg tttttgcgtg cgcataaatc cactttgtgg gatcttgagg acaggtgtcc
     2461 tgggttgatt gtccggtgtg catgtacttt gaggtgagtt gggaaagtgc agtggattgt
     2521 aatgtatgtg atctgccatg ctggaaaaac actattggga tacctcccct gtgatggtat
     2581 ttgaggtttg gctagcatcc ataagttctc tgctgtaaat acctacattg tccctatgag
     2641 cctctcactt ttagaataaa tgtgcttggt aaaagaaaaa aaaaaaaaaa aaaaaa
//
