LOCUS       NM_001364452            4256 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 3B
            (Ppp1r3b), transcript variant 4, mRNA.
ACCESSION   NM_001364452
VERSION     NM_001364452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4256)
  AUTHORS   Uehara,K., Lee,W.D., Stefkovich,M., Biswas,D., Santoleri,D., Garcia
            Whitlock,A., Quinn,W. 3rd, Coopersmith,T., Creasy,K.T., Rader,D.J.,
            Sakamoto,K., Rabinowitz,J.D. and Titchenell,P.M.
  TITLE     mTORC1 controls murine postprandial hepatic glycogen synthesis via
            Ppp1r3b
  JOURNAL   J Clin Invest 134 (7), e173782 (2024)
   PUBMED   38290087
  REMARK    GeneRIF: mTORC1 controls murine postprandial hepatic glycogen
            synthesis via Ppp1r3b.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4256)
  AUTHORS   Monica Shih,M.C., Huang,C.C., Chu,H.P., Hsu,N.C. and Chung,B.C.
  TITLE     Embryonic Steroids Control Developmental Programming of Energy
            Balance
  JOURNAL   Endocrinology 162 (12) (2021)
   PUBMED   34599818
REFERENCE   3  (bases 1 to 4256)
  AUTHORS   Li,Q., Zhao,Q., Zhang,J., Zhou,L., Zhang,W., Chua,B., Chen,Y.,
            Xu,L. and Li,P.
  TITLE     The Protein Phosphatase 1 Complex Is a Direct Target of AKT that
            Links Insulin Signaling to Hepatic Glycogen Deposition
  JOURNAL   Cell Rep 28 (13), 3406-3422 (2019)
   PUBMED   31553910
REFERENCE   4  (bases 1 to 4256)
  AUTHORS   Yang,Y., Liu,S., Lei,Z., Chen,G., Huang,L., Yang,F., Lei,Y.,
            Liu,Y., Yang,L., Liu,W., Lai,L. and Guo,J.
  TITLE     Circular RNA profile in liver tissue of EpCAM knockout mice
  JOURNAL   Int J Mol Med 44 (3), 1063-1077 (2019)
   PUBMED   31524221
REFERENCE   5  (bases 1 to 4256)
  AUTHORS   Stender,S., Smagris,E., Lauridsen,B.K., Kofoed,K.F.,
            Nordestgaard,B.G., Tybjaerg-Hansen,A., Pennacchio,L.A.,
            Dickel,D.E., Cohen,J.C. and Hobbs,H.H.
  TITLE     Relationship between genetic variation at PPP1R3B and levels of
            liver glycogen and triglyceride
  JOURNAL   Hepatology 67 (6), 2182-2195 (2018)
   PUBMED   29266543
  REMARK    GeneRIF: Mice lacking protein phosphatase 1 regulatory subunit 3B
            (PPP1R3B) were deficient in hepatic glycogen, whereas HTGC was
            unchanged. Hepatic overexpression of PPP1R3B caused accumulation of
            hepatic glycogen and elevated plasma levels of ALT, but did not
            change HTGC
REFERENCE   6  (bases 1 to 4256)
  AUTHORS   Kelsall,I.R., Rosenzweig,D. and Cohen,P.T.
  TITLE     Disruption of the allosteric phosphorylase a regulation of the
            hepatic glycogen-targeted protein phosphatase 1 improves glucose
            tolerance in vivo
  JOURNAL   Cell Signal 21 (7), 1123-1134 (2009)
   PUBMED   19275933
REFERENCE   7  (bases 1 to 4256)
  AUTHORS   Cifuentes,D., Martinez-Pons,C., Garcia-Rocha,M., Galina,A., Ribas
            de Pouplana,L. and Guinovart,J.J.
  TITLE     Hepatic glycogen synthesis in the absence of glucokinase: the case
            of embryonic liver
  JOURNAL   J Biol Chem 283 (9), 5642-5649 (2008)
   PUBMED   18165236
REFERENCE   8  (bases 1 to 4256)
  AUTHORS   Niimi,T., Kurotani,R., Kimura,S. and Kitagawa,Y.
  TITLE     Identification and expression of alternative splice variants of the
            mouse Ppp1r3b gene in lung epithelial cells
  JOURNAL   Biochem Biophys Res Commun 349 (2), 588-596 (2006)
   PUBMED   16949035
  REMARK    GeneRIF: analysis of expression of alternative splice variants of
            the mouse Ppp1r3b gene in lung epithelial cells
REFERENCE   9  (bases 1 to 4256)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   10 (bases 1 to 4256)
  AUTHORS   Munro,S., Cuthbertson,D.J., Cunningham,J., Sales,M. and Cohen,P.T.
  TITLE     Human skeletal muscle expresses a glycogen-targeting subunit of PP1
            that is identical to the insulin-sensitive glycogen-targeting
            subunit G(L) of liver
  JOURNAL   Diabetes 51 (3), 591-598 (2002)
   PUBMED   11872655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY784264.1, BC060261.1 and BC079666.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060261.1, AI115058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY784264.1         2-18
            18-4243             BC060261.1         1-4226
            4244-4256           BC079666.1         4217-4229
FEATURES             Location/Qualifiers
     source          1..4256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..4256
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /note="protein phosphatase 1, regulatory subunit 3B"
                     /db_xref="GeneID:244416"
                     /db_xref="MGI:MGI:2177268"
     exon            1..92
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            93..4248
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..972
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /note="PP1 subunit R4; protein phosphatase 1 regulatory
                     subunit 4; hepatic glycogen-targeting protein phosphatase
                     1 regulatory subunit GL; protein phosphatase 1, regulatory
                     (inhibitor) subunit 3B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3B"
                     /protein_id="NP_001351381.1"
                     /db_xref="CCDS:CCDS22243.1"
                     /db_xref="GeneID:244416"
                     /db_xref="MGI:MGI:2177268"
                     /translation="MAVDIQYSYSSMAPSLRRERFTFKISPKLSKPLRPCIQLGSKDE
                     ASGMVAPAVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPFNITELLDNIVSLT
                     TAESESFVLDFPQPSADYLDFRNRLQTNHVCLENCVLKDKAIAGTVKVQNLAFEKVVK
                     IRMTFDTWKSFTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQ
                     AYWDSNKGKNYRITRAELRSSPGKIEPYNGPDFGISFDQFGSPRCSFGLFPEWPSYLG
                     YEKLGPYY"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /note="hexamer: AATATA"
     polyA_site      4248
                     /gene="Ppp1r3b"
                     /gene_synonym="6430576E21; GL; PTG"
                     /note="major polyA site"
ORIGIN      
        1 agttcagtgg cagcaatcaa ccctgacact tctctcaggc tctcccatga ggccagcgag
       61 cagcggcccc ggctgcggcg ccgccgggag agactgctag ccggctcgcc tagcgtgatg
      121 gctgtggaca tccaatacag ctacagcagt atggcccctt ctttacgcag agagcgcttc
      181 accttcaaga tctcccccaa actgagcaag cccctgaggc cttgtatcca gctgggcagc
      241 aaggatgaag ccagtggaat ggtggccccc gcagtgcagg agaagaaggt gaagaagcgg
      301 gtgtccttcg ccgacaacca ggggctggcc ctgacaatgg tgaaagtgtt ctcggaattc
      361 gatgacccac tagatattcc ctttaacatc accgagctcc tagacaacat cgtgagtctg
      421 acgacagcag agagcgagag ctttgttttg gattttccgc agccttccgc agattactta
      481 gacttcagaa atcgccttca gaccaaccac gtctgcctag aaaactgtgt gctgaaggat
      541 aaggccatcg cgggcaccgt gaaggtccag aacctggcct tcgagaaggt tgtgaagatc
      601 aggatgacat ttgacacctg gaaaagcttc acagatttcc cttgtcagta tgtgaaggac
      661 acttacgctg gttcagacag ggacacattc tcctttgaca tcagcttacc cgagaaaatt
      721 cagtcttacg aaagaatgga gtttgccgtg tgctacgagt gtaacggcca ggcgtactgg
      781 gacagcaaca aaggcaaaaa ctacaggatc acccgggctg aactccgatc ctctccggga
      841 aagattgagc cgtacaatgg accagatttt ggaatctctt ttgaccagtt tgggagccct
      901 cggtgttcct ttggcctgtt tccagagtgg cctagttatc tgggatatga aaagctgggg
      961 ccctactact agtgactgca ggtgacagtc cgtggctcag atcaagatgg aggcgagaga
     1021 acggaaggcc agaggaaagt tgaactgcca ctaggcgtgg tttttgaaaa gacaggctcc
     1081 tgttcacctt tttcttaaac cagcaagtcc agcgtgtttc catcacaccc ggtttcttgc
     1141 tcagaggagt ggagcggtgc tgatcctctg tggcatccgg gttggccaca agggaatgcg
     1201 caggatggtg ccagaagggt ctggagagga gccaagctgg caaggacaga ggaagctggc
     1261 ctctcttcca cacttggact ctgaaagtca cccagaaacc aatctccagc cttaccattg
     1321 acctcgaggt cctgtccccg ctcatggctt tccatgcgtc tccttcattc cacgagtact
     1381 ccgaagggag ccacctcagt tctgggacac actggcctga ttgataccca gcagcctcag
     1441 aagagggccg ggggcgggcg ctttctgtgc gagctctttc actacacttc ctcccgctac
     1501 agtctatcca gtgatctgga caagagagac aaagcaaata agtagctcgt gtctgggata
     1561 ggcattccct cccccctctc tcctcctgac ccctccttta tattccagaa gagagcaaca
     1621 tattagttac tagaaagtca ttggttccca tgtggggtca cagggtacag cactgggaca
     1681 aggtgggaca gtctgaactt ttagcttttc ctcttggatg ttgggggagc ttttgaagca
     1741 ccgtttcacc cggagttacc agaagaggac tcaatgacaa gatgcatttc cacttgcctg
     1801 gccggtgtgt gtgaactgtt tgtgtttgaa gagagtcata gctctcatgt ctcctggagc
     1861 ctccacttca gtgccttgtc tgaggctttc aaatagcaag actggcatct cctcgagtcc
     1921 tccagactgt gcttagatat atattcatat tcaggatgct ttatgaaccc ccaaggacat
     1981 tgatcgggtg tttttattta tggtgtgtat tataaaaaga taggggagaa aaacctcacg
     2041 tttttctatg ttattttaaa tgtttgtcaa ctctgaggta tcagatgaag ttttcttaac
     2101 catattggag tgcaatgcgc tttcatacgc tagcgtgaga ctcctggagt tcttaccctt
     2161 gggtgaaccc ccaaaccctg tgatttttct ctagggcaaa ttagaattat aggggagatt
     2221 tttttaaatg cgagtttgta gaattagggg tgttgttttg ttttggaagt ttgataaaag
     2281 atgcctgttt catttcctta ctgaagtgat gtttccctga gacaagacag aaaggagcag
     2341 agtctcatgg tttcggaggt gggggccact ggacgtagcc ctgtgccctc tggctttata
     2401 agttagcatc aggcagacat caaatgtttt taatcctagc atgtgtggtt tattttttat
     2461 cttaactttt tcacttttga agattcaaat gttttgactt tttaaatgtt attttctatg
     2521 atttcttatt cctaaaactg gtactagtct gtaatctgtg ctttgtatat tgtgcctctc
     2581 ccagatgggt ggcgatctgg gattgcatgc tgattatctg tgaggaaatc atctttgtgc
     2641 catgaggctg aagctggggc caggagtttg tgttttatct aagcaggcca tgtatctcct
     2701 agatgggtgt actttaaatg ttccggattt gttgaccaga gcagctaggt tgaaattgga
     2761 tagaaagcaa aactgctctc tatgggtcat gcattgtgtg ttaagaagga aggcagccaa
     2821 gggcactgtt tcttacatag atgcagacta aagatcataa aatggctggg ggcgggggcg
     2881 aggtacggaa tggaatctgt tcagtggtat ggatgatctt cagacattcc gagtcaaaat
     2941 ataaaatatg gtaattccat gttatatgtc cctcctaaag cagacatacc ctcaccccct
     3001 tttgcccaga tttgccccag ctttcttgct cacgagcact gcttgaaagc cccccagcca
     3061 gcacacctgg ggtgcacacc cactgctcag ctccaggggc atgttgtgcc tttgcctgct
     3121 caccaggacc cttcccttga agcagtccgt gggctgtgct tgacttcctt atcaaggctg
     3181 tcactcagag acagaagagt cttccttctg ctttctgcct ccaatacagc cctccttctt
     3241 ttgacccagt ctgtcccatg actctgagat agcctcggga gctgcattta gaaactctat
     3301 gcattgttca gagttcacca ctgtagacaa atttacgcag ctcagaagac gacaggcccc
     3361 ttgcttgaag atcccacggc aagtttgacc tggaggtctg tcttcatgca gttcttggct
     3421 aggatgatgg atggatccta atccccagac attgtgatcc aggaagggaa ggcaacccca
     3481 ttctttgttc catatttatt tccccaaatt ccctggggtg ctttggcaaa atgggtacaa
     3541 taaataagct agaccataag acatgtttct tgtaagaagc cgtttgagtg ttgtaagaat
     3601 attttctcta gaaagctagg aaggcataat ggaagtctgt agttctgcag aaactaaagc
     3661 aacttgagtc aatggtggga gttattttat ccctgagatg taagcttggt ggctcctgat
     3721 tctgggaaat ctgcactcag ccgcatctcc tggcatgatc acagaaactg cagataagat
     3781 gttcccgaaa ttctgggatc ttacctctaa cgggatcgtc cagagtcact caaagacatt
     3841 tctcttgctg aggttctgtg agatgcctcc agctccatca gcaaagctgt gagtgtttcc
     3901 acggttttgc tgcagttccc agaggcccct ggggcacgtg gacttctaga gtgcacacgt
     3961 gatgatgtta cacttttgct ttaatgtgaa cattcaactg acgggcttgt cgtcattgta
     4021 tgcctacatg tgccttgttc agaaacttct gcatgtttgt aagacatatt tttgtataca
     4081 ttggtagagg ggaaatgcac tttaaaaaaa atcacaagaa tggatgtgtg tgtgtgtgtg
     4141 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tggtggaaga gaatgatttc
     4201 tttgtatctc aaaagcaaaa acgtaataaa tatagaaaga aaagaaaaaa aaaaaa
//
