LOCUS       NM_080464               7120 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 3A
            (Ppp1r3a), mRNA.
ACCESSION   NM_080464
VERSION     NM_080464.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7120)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7120)
  AUTHORS   Wang,Z., Du,K., Hou,J., Xiao,H., Hu,L., Chen,X., Wang,L. and
            Wang,Y.
  TITLE     Rg1 alleviates oxidative stress and spermatogonium apoptosis in
            D-gal-induced testicular toxicity by activating Akt
  JOURNAL   Redox Rep 28 (1), 2206197 (2023)
   PUBMED   37102430
  REMARK    GeneRIF: Rg1 alleviates oxidative stress and spermatogonium
            apoptosis in D-gal-induced testicular toxicity by activating Akt.
REFERENCE   3  (bases 1 to 7120)
  AUTHORS   Firulli,B.A., George,R.M., Harkin,J., Toolan,K.P., Gao,H., Liu,Y.,
            Zhang,W., Field,L.J., Liu,Y., Shou,W., Payne,R.M., Rubart-von der
            Lohe,M. and Firulli,A.B.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   4  (bases 1 to 7120)
  AUTHORS   Alsina,K.M., Hulsurkar,M., Brandenburg,S., Kownatzki-Danger,D.,
            Lenz,C., Urlaub,H., Abu-Taha,I., Kamler,M., Chiang,D.Y.,
            Lahiri,S.K., Reynolds,J.O., Quick,A.P., Scott,L. Jr., Word,T.A.,
            Gelves,M.D., Heck,A.J.R., Li,N., Dobrev,D., Lehnart,S.E. and
            Wehrens,X.H.T.
  TITLE     Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes
            Atrial Fibrillation
  JOURNAL   Circulation 140 (8), 681-693 (2019)
   PUBMED   31185731
REFERENCE   5  (bases 1 to 7120)
  AUTHORS   Cordero,P., Parikh,V.N., Chin,E.T., Erbilgin,A., Gloudemans,M.J.,
            Shang,C., Huang,Y., Chang,A.C., Smith,K.S., Dewey,F., Zaleta,K.,
            Morley,M., Brandimarto,J., Glazer,N., Waggott,D., Pavlovic,A.,
            Zhao,M., Moravec,C.S., Tang,W.H.W., Skreen,J., Malloy,C.,
            Hannenhalli,S., Li,H., Ritter,S., Li,M., Bernstein,D., Connolly,A.,
            Hakonarson,H., Lusis,A.J., Margulies,K.B., Depaoli-Roach,A.A.,
            Montgomery,S.B., Wheeler,M.T., Cappola,T. and Ashley,E.A.
  TITLE     Pathologic gene network rewiring implicates PPP1R3A as a central
            regulator in pressure overload heart failure
  JOURNAL   Nat Commun 10 (1), 2760 (2019)
   PUBMED   31235787
  REMARK    GeneRIF: Mice lacking Ppp1r3a are protected against
            pressure-overload heart failure. Condition-specific cardiac
            regulatory gene networks identify disease-driven changes in local
            and global topology and pathway organization, illuminating Ppp1r3a
            as a novel predicted heart failure regulator.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7120)
  AUTHORS   Delibegovic,M., Armstrong,C.G., Dobbie,L., Watt,P.W., Smith,A.J.
            and Cohen,P.T.
  TITLE     Disruption of the striated muscle glycogen targeting subunit
            PPP1R3A of protein phosphatase 1 leads to increased weight gain,
            fat deposition, and development of insulin resistance
  JOURNAL   Diabetes 52 (3), 596-604 (2003)
   PUBMED   12606498
  REMARK    GeneRIF: results show that dysfunction of subunit PPP1R3A of
            protein phosphatase 1 leads to weight gain, increased fat
            deposition and insulin resistance
REFERENCE   7  (bases 1 to 7120)
  AUTHORS   Aschenbach,W.G., Suzuki,Y., Breeden,K., Prats,C., Hirshman,M.F.,
            Dufresne,S.D., Sakamoto,K., Vilardo,P.G., Steele,M., Kim,J.H.,
            Jing,S.L., Goodyear,L.J. and DePaoli-Roach,A.A.
  TITLE     The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is
            essential for activation of glycogen synthase by exercise
  JOURNAL   J Biol Chem 276 (43), 39959-39967 (2001)
   PUBMED   11522787
REFERENCE   8  (bases 1 to 7120)
  AUTHORS   Lanner,C., Suzuki,Y., Bi,C., Zhang,H., Cooper,L.D.,
            Bowker-Kinley,M.M. and DePaoli-Roach,A.A.
  TITLE     Gene structure and expression of the targeting subunit, RGL, of the
            muscle-specific glycogen-associated type 1 protein phosphatase,
            PP1G
  JOURNAL   Arch Biochem Biophys 388 (1), 135-145 (2001)
   PUBMED   11361130
REFERENCE   9  (bases 1 to 7120)
  AUTHORS   Suzuki,Y., Lanner,C., Kim,J.H., Vilardo,P.G., Zhang,H., Yang,J.,
            Cooper,L.D., Steele,M., Kennedy,A., Bock,C.B., Scrimgeour,A.,
            Lawrence,J.C. Jr. and DePaoli-Roach,A.A.
  TITLE     Insulin control of glycogen metabolism in knockout mice lacking the
            muscle-specific protein phosphatase PP1G/RGL
  JOURNAL   Mol Cell Biol 21 (8), 2683-2694 (2001)
   PUBMED   11283248
  REMARK    GeneRIF: Disruption of the Ppp1r3a gene does not result in either
            fat deposition or insulin resistance, but PPP1r3a is essential for
            control of glycogen metabolism by exercise.
REFERENCE   10 (bases 1 to 7120)
  AUTHORS   Tang,P.M., Bondor,J.A., Swiderek,K.M. and DePaoli-Roach,A.A.
  TITLE     Molecular cloning and expression of the regulatory (RG1) subunit of
            the glycogen-associated protein phosphatase
  JOURNAL   J Biol Chem 266 (24), 15782-15789 (1991)
   PUBMED   1651919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084518.1, BC109007.1 and AC140470.3.
            
            On Apr 11, 2007 this sequence version replaced NM_080464.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109007.1, AK084719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01766828
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK084518.1         2-29
            29-3348             BC109007.1         1-3320
            3349-7120           AC140470.3         65433-69204
FEATURES             Location/Qualifiers
     source          1..7120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 6.31 cM"
     gene            1..7120
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /note="protein phosphatase 1, regulatory subunit 3A"
                     /db_xref="GeneID:140491"
                     /db_xref="MGI:MGI:2153588"
     exon            1..813
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..3298
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase type-1 glycogen targeting
                     subunit; protein phosphatase 1 glycogen-associated
                     regulatory subunit; protein phosphatase 1, regulatory
                     (inhibitor) subunit 3A"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3A"
                     /protein_id="NP_536712.2"
                     /db_xref="CCDS:CCDS19917.1"
                     /db_xref="GeneID:140491"
                     /db_xref="MGI:MGI:2153588"
                     /translation="MEPAEEPGQISKDNFLEVPNLSDSVCEDEEVKATFKPGFSPQPS
                     RRGSGSSEDMYLDTPTSASRRVSFADSLGFSLVSVKEFDCWELPSVSTDFDLSGDVFH
                     TDEYVLSPLFDLPSSKEKLMEQLQVQKAVLESAEHLPGSSMKGIIRVLNISFEKLVYV
                     RMSLDDWQTHYDILAEYVPNSCDGETDQFSFKISLVPPYQKEGGKVEFCIRYETSAGT
                     FWSNNNGTNYILVCQKKRKEPEPVKPLEEAPSRQIKGCLKVKSRSKEEPLLAPEENKF
                     ETLKFTESYIPTIICSHEDKDDLGANHPNVDDINKKHDEHNGKELDLMINQRLITSQD
                     EKNTFATDTVNFTNKAEGSEKKQAYHEINTDLFMGPLSPSLSAESSLKRDFYHSRSSS
                     PGNEYGHPHSEEIISDMGEKGPSLGDTSSDELMQLELCSKEDLDDNANPANGSGRVCS
                     SFDQRMACGLKNNEAGIKKTGIQDYKYSHGDSTKLEESNASSRDDYAKVDNKKEKQTC
                     LGVNENPSKNFQSVFQTQEGHMGYPKISTEGDKANNQDLTSLLSKDITANTWAVTVDP
                     CPSTNAKRSWREVGSGSNLEPGTSDLSSPRNFSPLTDDHLFQADRENSDSSNPENQNM
                     NTRHRKKWNVLETQSETSETESDIAKHTKEQAEYKDMWEKTDNSRNLKATPTEHLFTC
                     RETECYGLSSLADHGITEKAQAVTAYIIKTTLESTPESASARGKAIIAKLPQETAGND
                     RPIEVKETAFDPHEGRKDDSHYSLCHGDTAGVIHDNDFERESHLDICNLRVDEMKKEK
                     TTSTCFPQKTYDKEKHGIGSVTSIDEPSQVITGNQKATSKLDLHLGVLPTDRAIFQAN
                     ADLELLQELSRRTDFNAVPSAFNSDTASASRDSSQVYRHCSKKSVPSYGEEKAVTNTT
                     LQSIPTKSEYNWHPESEVLGHAMSKPEDVFKSSEIMKSGSGGERGGGPILQQKEGSLE
                     NSQGPMFFTNEPLENLDEASSENEGLMHSGQSQCYLGDKGLVSSASATVSTQELEAQG
                     RESLLSISTNSKIPYFLLFLIFLATVYYYDLMIGLAFYLFSLYWLYWEGGRQRESVKK
                     K"
     exon            814..875
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1000
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..7120
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7098..7103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /note="hexamer: AATAAA"
     polyA_site      7120
                     /gene="Ppp1r3a"
                     /gene_synonym="GM; RG1; RGL"
                     /note="major polyA site"
ORIGIN      
        1 actcttattt gataaatcag agagaccaat ggagcccgct gaagaacctg gtcagattag
       61 caaagataac tttttagaag ttcctaatct gtctgattct gtgtgtgagg atgaagaagt
      121 taaggcgacc ttcaagcctg gcttctcccc tcagccaagc agacgcgggt caggatcttc
      181 ggaagacatg tatctggaca ctccaacctc agcttcccgg agagtttcct ttgctgacag
      241 cctgggattc agccttgtgt ctgttaaaga atttgattgc tgggaactac ccagtgtttc
      301 aactgatttt gacttaagtg gggatgtttt ccacacagat gaatatgttt tatctccact
      361 gtttgacttg ccttcttcaa aagaaaagct tatggaacaa ctccaagtcc agaaagccgt
      421 gctggagtcc gctgaacacc ttcccgggtc aagcatgaag ggcattattc gagtcctgaa
      481 catttctttt gagaagttag tgtatgtgcg catgtctttg gatgactggc agacacatta
      541 tgacatttta gcagaatatg ttcctaactc gtgcgacggt gagactgacc aattctcttt
      601 taagatttca ttggttccac cttatcaaaa agagggcggt aaagtggagt tttgtatacg
      661 ctatgaaact tctgctggca cattttggtc aaataataat ggcacaaatt atatattggt
      721 ttgtcaaaag aagaggaagg agccagagcc tgtaaagcca ttggaagaag cacctagcag
      781 acaaataaaa ggctgcttaa aggtaaaatc acgcagtaaa gaagaaccat tgctagcacc
      841 agaagaaaat aaatttgaga ctttaaagtt cacagagtcc tacatcccaa caatcatttg
      901 ttctcacgag gacaaggatg acttgggagc caatcatcca aatgtagacg atatcaacaa
      961 gaagcatgac gaacacaatg gaaaggagct agacttgatg ataaaccaac ggttaataac
     1021 ttcccaggat gaaaagaata catttgcaac agatacagtc aattttacaa ataaagctga
     1081 agggtcagag aagaagcaag cttaccatga aatcaacact gacttgttca tggggccttt
     1141 gtctccaagt ttatcagcag aaagttcctt aaagcgagat ttctatcata gcagaagttc
     1201 ttccccagga aatgaatatg gtcatccaca ttcagaagaa attatttcag atatgggaga
     1261 aaaaggtcca tcactgggag acactagttc tgatgagtta atgcaattgg aactctgcag
     1321 caaggaagac ctggatgata atgccaaccc agccaatggg agtggcagag tgtgctcttc
     1381 cttcgatcaa agaatggcat gtggtctcaa gaataatgaa gcaggaatca agaaaactgg
     1441 aatacaagat tacaaatatt cacatggaga ttccacaaaa ttggaagagt caaatgcatc
     1501 ttccagagat gattatgcca aagtcgataa taaaaaggag aagcaaacat gcttaggtgt
     1561 taatgaaaac ccaagcaaga attttcaatc agtattccag acccaagagg gacacatggg
     1621 gtacccaaaa ataagcactg aaggggataa agctaataac caagacttga caagtctact
     1681 gagcaaagat attacagcta acacctgggc ggtgacagtg gatccctgtc cttccacaaa
     1741 tgcaaaaagg agttggagag aagttggaag tggtagcaat ttagaaccag gaactagtga
     1801 tcttagttct ccaaggaatt tcagccctct gactgatgat catctttttc aagctgacag
     1861 ggaaaactca gactctagca atcctgaaaa tcagaatatg aacacacgac atagaaaaaa
     1921 atggaacgtt ctggaaaccc agtcagaaac aagtgagact gaatcagata tagccaagca
     1981 taccaaagaa caagcagagt ataaagacat gtgggaaaaa acagataaca gtaggaatct
     2041 gaaagctact cctacagaac acttgtttac ctgccgagag acagaatgct acggactgtc
     2101 ttctcttgct gatcatggta ttactgagaa agcacaagca gttacagctt atataattaa
     2161 gacaacatta gaaagtactc cagaaagcgc gtctgctaga ggaaaagcaa taattgctaa
     2221 gctacctcaa gagacagcag gaaatgacag gcccatcgag gtaaaagaaa cagcgtttga
     2281 tccacatgaa gggaggaaag atgattcaca ttattccctt tgtcatggag atacagcagg
     2341 tgtaatccat gacaatgatt ttgaaaggga gtcacattta gatatttgta atttacgtgt
     2401 ggatgaaatg aagaaggaga aaaccacatc tacgtgcttt cctcagaaga catatgacaa
     2461 ggagaaacat ggaattggaa gtgtaacatc tatagacgaa ccttcacagg tcattacagg
     2521 caatcaaaaa gctacgtcaa aactggattt acatttggga gtgttaccaa cagacagagc
     2581 aatattccaa gcaaatgcag atcttgagct gcttcaagaa ttatcaagga gaacagactt
     2641 caacgccgtt ccctctgcat ttaactcaga cactgccagc gcttctcggg acagctctca
     2701 agtttacaga cactgctcta aaaaatcagt accttcttac ggtgaagaga aagcagttac
     2761 taacacaacc ctccagtcta ttcctaccaa atcagaatat aattggcacc cagaaagtga
     2821 ggtcttgggc catgccatgt ctaaacctga agatgttttc aaaagttcag aaataatgaa
     2881 atcaggtagt ggaggagaac gaggcggggg tccgattctc caacaaaaag aaggtagctt
     2941 ggaaaactcc cagggcccga tgttttttac caatgagcct cttgagaatc tggatgaagc
     3001 aagttctgaa aatgaagggt taatgcattc tggacagtca cagtgttatc tgggtgacaa
     3061 aggattagtg agctctgctt ctgctactgt ctctacgcag gaactcgaag ctcaaggcag
     3121 ggagtctctg ctttcaatat ccaccaactc taaaatacca tatttccttt tgtttctgat
     3181 atttcttgca actgtctact actatgactt aatgataggc ttggcgttct accttttttc
     3241 attatactgg ttgtactggg aaggggggag gcaaagagag tctgttaaga aaaagtgagc
     3301 ttggcacagt tgctattctc tcttgaaaga taagctattt agtcccaaac atttggaatg
     3361 gcaggagaga ctattcattg ttcaaagaat cagtgcagtt tttctcttga aggatcattt
     3421 aaaaaggaat gcgtatgaag tttgctcctt catataagta attattctat ataggaccat
     3481 tatgcttgga tcattaaata cctatatgaa tatgagatgt gaagcacgtc aagttggaat
     3541 taggtacagc tgttgctcct tagcaggctg tgaagttgaa atgcttcatg tctcttcact
     3601 atttaaagtg cgatttcctg caatcatttc tttcacagta aagctttgga tatttttttt
     3661 ccctgagagc actttcctcc taggttttta aaaaaataga taaaacatgg agagatattt
     3721 tttcttttag tccctagaat ttgccatgaa aatttcattt agcactgtgt actctatcag
     3781 cacatattga tagatcaaat attaaaattt ctgtttatgc ctttaagaaa atacccatgt
     3841 actttgcaat atgaaaacgt aaattggaaa tatgttttat gcacactcac attatacttt
     3901 atgtgcatac cattgtatct ctttgtaccc atgatgtcag ggttttcata caccaatttt
     3961 aactttgttt gtttattttt atttagttga atgtgtagac tgtaacacaa atggacaatt
     4021 ttaatgttaa gtgttgtcca gacatgaaaa ttctaacatt ctatcatcat tgtttcaagg
     4081 tgattttgca cctaccttgt agttcttaac ctgtgggtta caaccccttt ggaggctgca
     4141 tatcagatat ttatgttatc attcacaaca gtgagcagaa ttacagttat gaagtataaa
     4201 caaaacaaac ttatggctgg ggtcaccaca acatgtggca ctctattaaa gggtcacaac
     4261 attaaaaagg ttgagaacca ctgctataga acataaggcc ttaagtaata atataataga
     4321 tgctaaaatg gtttgttctt cctggtagtt cctttgtttt cgattagttg ttaatatttt
     4381 cttatagtag ggagatgaat tttatcctaa gtaaatttac agaacaaact ccttgtctgg
     4441 taatatccat tttgtcatct ttgggttatg agacaatcac tcaaaacttt aagcaggcaa
     4501 aatatgtata gttgaaagca tactgaaaac gaagtgaaca tagactatag cagtgatttg
     4561 gctactgtaa ttataggtaa aggtataaaa taatggagca ttttttagtt aaatggaaat
     4621 actgtcaaga tttatacaaa atttatttca gcaattttat tgaataattg taatatacaa
     4681 agccctgtgc tattctatgg gggtccttag ataaactgag tatatcgatc cctgtatata
     4741 gcaaaataat gtatttttaa ctgggttgga gtatgaaaaa tgtcagagaa ggattctatt
     4801 gaatgtttat ctttcatgga aagttctttc agggaaagtt aaacagaaaa tagtatgata
     4861 tttttattta cttataacta taaaattaca tgccatctca tatatctcac aactataaaa
     4921 ttataagaaa ataaaaatct ttaaaatgac ttatcatgtg atacttagtg gtttgctaaa
     4981 gtttctttac gtgcacaact atttctcaaa ctggtaattg catgcttttc tcaaggctcc
     5041 ttaaaaatga gtcattggct ttagcttttt agttgaccaa atgcaaacat cctgaagtag
     5101 aatgcaggtc aaatatttgc tttttgagaa gcatacttct atcaaatgca agtggaattc
     5161 ctttaagcag tccttagaaa ttatctctaa aattgttgcc ctcatatttt tttgtcagga
     5221 ctaagttaag ttggagttaa agttagcatt ccaccagctc tttatagctt agaggttttt
     5281 cttaattcta tgttttaaga gttttagtca acatagctta tctctgtaat gtaaaggaca
     5341 ctattttatg agcaccggtg ccccaaacag aattcttccc ttaaatgatc agcgtaactc
     5401 cctttccctc ctctatttga tttctggtaa cattaactca ccaaaggttc tcatgcattt
     5461 gtaataaaac aggaacaagc ttcaaaggat tttaaacact atttagttgt gtgtttcttt
     5521 gatgcaaaga agaaatactg gattgaactg acttttcaaa cattacttat agaactttaa
     5581 ataaaggtac aaggacactt gaaaggactg ctctatgagg aggttgagtt tgtcagtctc
     5641 ttttggtcac atctctatga tgaataaaaa tgagtgttag gatgaacttg tagcctctgc
     5701 cgacaaggac ttggctatgg accatcttgg taaaggccat tttttttttt tttatccata
     5761 gatgccagtt tcacatctca ccacactttg actatgggta taatgagggc atagcagagt
     5821 aattaccaat gaggatcttt acatatgcca ttcttatttt aaataagaaa tatgatttaa
     5881 tcattgctat ccttatcttt ctggggttct cagtcttaga cacggacctc taaaaactaa
     5941 ctgagaagtt tagcaatgct atgtaataca aaacaacagt ctttttaaga actctgacat
     6001 ctagaagcta tcaacatcac aataaaattc tcaaccagaa taaaatgact gagtggttta
     6061 tatccactct tcaacattta ggaatgttgg gtcagtagaa ctatattttc ttgaggagct
     6121 ctaatacgtg gataataaat ttttcaaggc ctatctatag tcaaatattt gtcactattt
     6181 tgtcaaaaca ggacgttctt ttacctcatc ttacaccagt actctggtta agtgaaaaca
     6241 ttgtaaatgg ccagaccaaa tatggggaaa taagtaagat attttttctc tatccagtgg
     6301 tagttataga gctttgaaaa tatttttgtt ttacattgat ggatgttaat cccttttata
     6361 tattaataaa gtaaaaagct aaacaaacag agctagggaa aatatcggag ttgactctac
     6421 ttatctcctt taagatagca ggcttttctt ttacatgtcc attgactctg gaaactggac
     6481 ttcacagtaa ggaccacctt tttggtgtta accctgtctt aagtagtttc ttgccaggca
     6541 ccgcctcagt tgtgaatctc tggagagatt agttaaaagg gttactgtta ttcaattgat
     6601 taaccatggt tgcttttgta ttttgggggg ggggttataa taaaaatctt gtcagcacaa
     6661 cttaatttcc atcatttgaa acatgtgtga taaatattct actgtttata ccacaggact
     6721 caaactttaa aaattacaaa ttggatttta aagaagctac cagcctagct tggaatgtgc
     6781 acgtattttg aaataaattg ttctattgtt gttgctaaaa ccttattaaa caaatattta
     6841 aaatattaat caattttaaa agtccaatat ttttatttta tattatttta atatgtggaa
     6901 aattatacac agaacattga cttttcaaaa attaaacagt acattgtgca aaaccttaat
     6961 aaaaatttcc ctatgtcgtt tttactacat ccaatgtttg taaattgcca gaaaataaag
     7021 taagatgtca attacagtaa aggattctgg aatcattttg acttaactaa agacctcaca
     7081 gtagcctgtg atatataaat aaatcatttc tctggtttga
//
